Early Intervention in Psychiatry最新文献

{"title":"Politicising Recovery: Why Early Intervention Must Move Beyond the Imperative of Functioning","authors":"Jordan Sibeoni,&nbsp;Jeanne Aquili,&nbsp;Sovady Bora,&nbsp;Naya Tarabichi,&nbsp;Solène Carbonnel,&nbsp;Augustin Behaghel,&nbsp;Anne Revah-Levy","doi":"10.1111/eip.70256","DOIUrl":"https://doi.org/10.1111/eip.70256","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To articulate the politicisation of recovery as a conceptual and clinical framework for early intervention in psychosis and to argue why the field must move beyond the imperative of functioning.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Observation</h3>\u0000 \u0000 <p>Early intervention for ultra-high-risk states and first-episode psychosis has improved symptomatic outcomes, yet a persistent gap remains between remission and functional recovery, while social and environmental determinants shape both onset and course. This gap partly reflects an implicitly autoplastic model of recovery, helping young people adjust to social conditions that remain unexamined, a drift intelligible within cognitive capitalism, where functioning itself becomes the imperative.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Conceptual and narrative analysis drawing on critical and survivor-led accounts of the recovery movement, Langer's autoplastic/alloplastic dialectic, Pichon-Rivière's <i>grupo operativo</i> and eco-phenomenological accounts of selfhood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>We define the politicisation of recovery as the expansion of clinical and institutional practices that support the young person's capacity to act within, interpret and sometimes transform the conditions shaping their lived world; the restoration of agency, not collective social change, is the criterion. We describe three levels at which early intervention, a field born as a reform movement, already enacts this politics without naming it: the therapeutic relationship and case management, the group as a small-scale world and the institution through peer involvement and reflexivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>We discuss three tensions the framework must navigate, responsibility, stratification and dependency and their implications for outcome measurement and research, where instruments sensitive to perceived control, empowerment and meaningful participation should complement functional indicators such as NEET status.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Stakeholder-Informed Approach to the Development and Implementation of National Digital Registry and Learning Healthcare System (LHS) for Psychosis: Findings From the EPICare Platform","authors":"Rachel Upthegrove,&nbsp;Melanie Lafanechere,&nbsp;Megan A. Pope,&nbsp;India Francis-Crossley,&nbsp;John Ainsworth,&nbsp;Sophie M. Allan,&nbsp;Tumelo Bogatsu,&nbsp;Niyah Campbell,&nbsp;Richard J. Drake,&nbsp;Sonia Johnson,&nbsp;Mohammad Zia Ul Haq Katshu,&nbsp;Graham K. Murray,&nbsp;Sarah A. Sullivan,&nbsp;Justin Waring,&nbsp;Pauline Whelan,&nbsp;Sian L. Griffiths,&nbsp;James B. Kirkbride","doi":"10.1111/eip.70264","DOIUrl":"https://doi.org/10.1111/eip.70264","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Early Intervention in Psychosis services were established throughout England over two decades ago, yet despite aiming to optimise care, less than 40% of patients achieve full clinical recovery and notable inequities persist in accessing NICE-recommended treatments. Fragmented electronic health record systems and limited systematic data capture conceal how disparities in care delivery and effectiveness affect recovery and remission. The Early Psychosis Informatics into Care, EPICare, programme aims to develop a national, learning healthcare system incorporating a standardised core dataset and clinician dashboard to support equitable, data-driven care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Our stakeholder co-design approach comprised three interlinked work packages delivered between 2021 and 2022. Using participatory co-design, we conducted four multi-stakeholder workshops and preparatory lived experience sessions with people with lived experience, clinicians, informaticians, academics, and policymakers. We identified essential data elements using adapted “MoSCoW” card sort methodology, refined content, and developed dashboard requirements. Parallel informatics and implementation research assessed technical feasibility, data maturity, and harmonisation requirements and evaluated anticipated barriers and facilitators to future adoption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Consensus was achieved on core EPICare dataset “must haves” including sociodemographic variables, routine treatment interventions, Patient- and Clinician-Reported Outcome Measures, and longitudinal symptom data. Stakeholders defined key dashboard features, prioritising usability and alignment with clinical workflow. Substantial variation in Trust-level data infrastructure informed flexible technical architecture to mitigate implementation risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>EPICare stakeholder engagement delivered the blueprint for a co-designed, technically feasible and nationally scalable specification for a psychosis learning healthcare system, enabling progression to platform development and piloting across five Early Intervention in Psychosis services in the NHS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived National Resilience and Mental Well-Being Among Emerging Adults at Risk for Depression: Indirect Associations Through Peace of Mind and Life Satisfaction","authors":"Jerome Visperas Cleofas","doi":"10.1111/eip.70253","DOIUrl":"https://doi.org/10.1111/eip.70253","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Emerging adulthood is a developmentally sensitive period during which broader societal conditions may be relevant to mental health, particularly among individuals already experiencing elevated depressive distress. Guided by the psychosocial pathways model, this study examined the association between perceived national resilience and mental well-being among Filipino emerging adults at risk for depression and estimated parallel indirect associations through peace of mind and life satisfaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional online survey included 920 emerging adults aged 18–29 years residing in the Greater Manila Area who scored ≥ 7 on the depression component of the Kessler Psychological Distress Scale. Parallel mediation analysis adjusted for age, sex assigned at birth and household income and used 5000 bias-corrected bootstrap resamples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Perceived national resilience was positively associated with mental well-being (total effect: <i>B</i> = 1.395, 95% CI [1.072, 1.720], <i>β</i> = 0.314). Significant indirect associations were observed through peace of mind (<i>B</i> = 0.739, 95% CI [0.593, 0.890], <i>β</i> = 0.166) and life satisfaction (<i>B</i> = 0.077, 95% CI [0.014, 0.165], <i>β</i> = 0.017). The full model explained 43.7% of the variance in mental well-being.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Perceived national resilience and proximal psychological assets were associated with mental well-being among emerging adults at risk for depression. Peace of mind represented the stronger indirect pathway, supporting attention to both perceived societal conditions and individual psychological resources in preventive and early mental health research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Cohort Study of Hospitalised Patients With First-Episode Substance-Induced Psychosis and First-Episode Psychosis: Comparing Long-Acting Injectable Antipsychotic Use and Post-Discharge Outcomes","authors":"John D. Eun,&nbsp;Matt Iles-Shih,&nbsp;Suelynn Ren,&nbsp;Kevin A. Hallgren,&nbsp;Adam Kuczynski","doi":"10.1111/eip.70250","DOIUrl":"https://doi.org/10.1111/eip.70250","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Clinicians may not recommend long-acting injectable antipsychotics (LAI-APs) for patients diagnosed with first-episode substance-induced psychosis (FESIP), despite the risk of transition from FESIP to schizophrenia and the effectiveness of LAI-AP in early psychosis. We compared LAI-AP use and post-discharge outcomes between patients with first-episode psychosis (FEP) and those with FESIP during their index psychiatric hospitalisation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study using electronic health record data from patients aged 18–39 who were discharged from inpatient psychiatry units at a public academic hospital between 2021 and 2024. Outcomes included administration of any LAI-AP during the index hospitalisation, documented recommendation of any LAI-AP, psychiatric rehospitalisation and emergency department (ED) encounters after discharge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cohort included 90 patients with FEP and 84 patients with FESIP. Only one (1.2%) patient with FESIP received an LAI-AP compared with 10 (11.1%) with FEP (OR = 0.10, 95% CI = 0.002–0.71); LAI-AP was recommended to one (1.2%) patient with FESIP compared with 30 (33.3%) with FEP (OR = 0.02, 95% CI = 0.0006–0.16). Rehospitalisation occurred in 41 (45.6%) patients with FEP and 38 (45.2%) with FESIP; post-discharge ED encounters occurred in 50 (55.6%) and 52 (61.9%) patients, respectively. Time to first rehospitalisation and ED encounter after discharge did not differ between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite similar post-discharge outcomes between patients with FEP and FESIP, administration or recommendation of an LAI-AP was rarer among those with FESIP. Our findings highlight uncertainty in treatment decision-making and support further research to guide early intervention strategies in patients with substance-induced psychosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis Exposure in First-Episode Psychosis Should Be Treated as a Time-Varying Clinical Target: A Taiwan Perspective","authors":"Lien-Chung Wei,&nbsp;Ding-Lieh Liao","doi":"10.1111/eip.70259","DOIUrl":"https://doi.org/10.1111/eip.70259","url":null,"abstract":"","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Dysglycemia and Dyslipidemia in First-Episode, Untreated Chinese Patients With Major Depressive Disorder at Different Ages of Onset","authors":"Hang Tan,&nbsp;Zhanjin Wang,&nbsp;Jie Ma,&nbsp;Zhan Wang,&nbsp;Xiang Yang Zhang","doi":"10.1111/eip.70246","DOIUrl":"https://doi.org/10.1111/eip.70246","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Dysglycemia, a common ailment in MDD patients, lacks research regarding its variance across the age of onset (AOO). Therefore, we investigated the correlation between fasting blood glucose (FBG) abnormalities and blood lipids in first-onset, untreated patients with MDD and to determine the factors that influence glycemic abnormalities in patients differentiated by age of onset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>The study enrolled 1718 Han Chinese outpatients with drug-naïve, first-episode MDD from a general hospital. Anxiety, depression, and psychotic symptoms were evaluated using the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Clinical Global Impression of Severity Scale (CGI-S), and Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively. we divided patients into early age of onset (EAO, &lt; 45 years) and middle age of onset (MAO, ≥ 45 years) groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MAO patients, compared to EAO patients, displayed higher scores on the HAMD, HAMA, CGI-S, and PANSS positive scales. Furthermore, they exhibited elevated serum levels of thyroid stimulating hormone (TSH), FBG, total cholesterol (TC), and low-density lipoprotein (LDL-C). In MAO patients, FBG correlated with TSH, triglycerides (TG), and TC, while only TSH correlated with FBG in EAO patients. Path analysis revealed a significant indirect effect of FBG on lipid levels through depressive symptoms, accounting for 35.46% of the total association in EAO patients and 16.22% in MAO patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Age-stratified analyses revealed that MDD-associated metabolic dysregulation in younger patients (&lt; 45 years) was mediated by psychiatric symptoms, warranting depression-focused interventions, whereas older patients (≥ 45 years) demonstrated direct metabolic dysfunction, necessitating integrated psychiatric-metabolic management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Analysis of Anxiety and Depression Symptoms in Help-Seeking Youth: A Two-Wave Study","authors":"Xia Hu,&nbsp;Ya Wang,&nbsp;Gui-fang Chen","doi":"10.1111/eip.70254","DOIUrl":"https://doi.org/10.1111/eip.70254","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Anxiety and depression often co-occur in youth, but the symptom-level processes driving this comorbidity remain unclear. Network theory conceptualizes mental disorders as systems of interacting symptoms. We applied a two-wave longitudinal network approach to examine depression and anxiety symptoms comorbidity in help-seeking youth (<i>N</i> = 836, aged 10–24).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Observation</h3>\u0000 \u0000 <p>Depression and anxiety were measured using the Zung Self-Rating Depression Scale and Zung Self-Rating Anxiety Scale respectively. We estimated Gaussian graphical models at baseline (T1) and follow-up (T2, 3–12 months later), and used a Cross-Lagged Panel Network (CLPN) model to assess predictive relations between symptoms across time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Results revealed that symptom networks tightened even as symptoms decreased; <i>feelings of uselessness</i> and <i>panic</i> were central symptoms at both time points, <i>poor sleep</i> consistently served as the pivotal bridge between anxiety and depression at both baseline and follow-up, while <i>crying spells</i> and <i>stomach pain</i> emerged as early drivers of wider symptom spread.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>These results suggest that intervening on these symptoms may disrupt anxiety–depression cycles. This study supports the use of network models to identify targets for early intervention in youth mental health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct and Indirect Effects of Workplace Bullying on Psychotic Experiences Among Tunisian Workers: The Intermediate Role of Shame","authors":"Feten Fekih-Romdhane,&nbsp;Khalil Maagli,&nbsp;Majda Cheour,&nbsp;Souheil Hallit","doi":"10.1111/eip.70237","DOIUrl":"10.1111/eip.70237","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although extensive research interest has been paid to the pathways between early experiences of school-age bullying and psychosis onset, knowledge about the effects of bullying victimization in adulthood and the workplace context remains surprisingly scarce. This study aimed to uncover how shame can serve as a mediator between workplace bullying and psychotic experiences (PEs) in a non-clinical population of Arabic-speaking workers from Tunisia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study using a web-based approach was conducted during the period from August to December 2024 among Tunisian workers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Internal shame acted as a partial mediator between the two dimensions of workplace bullying and PEs. External shame fully explained the relationship between person-related bullying and PEs, whereas it only partially mediated the relationship between work-related bullying and PEs. Specifically, higher work- and person-related bullying was significantly associated with higher internal/external shame, and internal/external shame was significantly associated with greater PEs. Finally, higher work- and person-related bullying was directly associated with greater PEs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results shed light on the urgent need for the development of policy actions and organizational support systems to help create safe working environments and minimize the occurrence and negative consequences of bullying behaviours on workers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotic Vulnerability in Adolescents With Obsessive-Compulsive Disorder: First Longitudinal Evidence From a Prospective Pilot Study","authors":"Davide Fausto Borrelli,&nbsp;Luca Gambolò,&nbsp;Anna Di Donna,&nbsp;Carlo Marchesi,&nbsp;Matteo Tonna","doi":"10.1111/eip.70244","DOIUrl":"10.1111/eip.70244","url":null,"abstract":"<div>\u0000 <section>\u0000 <h3> Aim</h3>\u0000 <p>Childhood-onset Obsessive-Compulsive Disorder (OCD) has been associated with an increased vulnerability to psychosis, yet no prospective studies have examined this risk in paediatric populations.</p>\u0000 </section>\u0000 <section>\u0000 <h3> Methods</h3>\u0000 <p>In this pilot prospective study, 59 adolescents with a primary diagnosis of OCD were assessed at baseline for psychotic vulnerability, measured through Cognitive-Perceptual basic symptoms (COPER) and the high-risk criterion Cognitive Disturbances (COGDIS), as well as for OCD severity and psychosocial functioning. The number of subjects who developed a first episode of psychosis (FEP) during the 18-month follow-up period was evaluated. Logistic regression and moderation analyses were performed.</p>\u0000 </section>\u0000 <section>\u0000 <h3> Results</h3>\u0000 <p>During the follow-up period, 18.6% of participants presented with a FEP. These patients were older and displayed poorer psychosocial functioning compared with those who did not develop a FEP. Logistic regression identified higher COPER symptoms and lower psychosocial functioning as the only significant predictors of FEP. Although moderation effects were not statistically significant, exploratory simple slopes suggested that both COPER and COGDIS symptoms were more strongly associated with psychosis onset in adolescents with lower psychosocial functioning.</p>\u0000 </section>\u0000 <section>\u0000 <h3> Conclusions</h3>\u0000 <p>This study highlights a notable rate of progression to psychosis among adolescents with OCD over an 18-month period. Despite methodological limitations, our findings offer preliminary evidence that COPER symptoms and impaired psychosocial functioning are key risk factors in adolescents with OCD for progression to psychosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility Trial of a Health Behaviours Promotion Group for Youth at Clinical High Risk for Psychosis","authors":"Bernalyn Ruiz-Yu,&nbsp;Tanya Diaz,&nbsp;Daniella Hernandez,&nbsp;Jamie Zinberg,&nbsp;David J. Miklowitz,&nbsp;Carrie E. Bearden","doi":"10.1111/eip.70231","DOIUrl":"10.1111/eip.70231","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Development of new evidence-based interventions for youth who are at clinical high risk for psychosis (CHR-P) is needed. Health behaviours and lifestyle habits such as physical activity, sleep, and substance abuse are modifiable risk factors for a variety of health outcomes. We assessed the feasibility and acceptability of a novel health behaviour-focused psychosocial intervention for youth at CHR-P.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a non-randomized feasibility trial, youth aged 13–17 who met CHR-P criteria participated in a 9-week health behaviour promotion group that provided psychoeducation and skills training regarding stress management, sleep, physical activity, nutrition, mitigating substance use, and health behaviour goal setting. Primary outcomes included feasibility and pre-to post-intervention change in health behaviours and symptoms. The secondary outcome explored the social validity of the intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 18 invited participants, seven enrolled, and five completed at least two-thirds of the intervention, indicating modest feasibility and good retention in those who enrolled. There were no significant pre-post changes across measures of health behaviours or symptoms. Participants endorsed the goals of the intervention as meaningful and congruent with their treatment goals. Among those who enrolled, the group format was described as acceptable, while the didactic style was less preferred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Findings of this study showed the intervention to be modestly acceptable and feasible. Changes in health behaviours and symptoms were not significant but trended in the expected direction. Future trials are needed to refine the intervention and assess effectiveness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Clinicaltrials.gov Identifier: NCT05532683</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}