Early Intervention in Psychiatry最新文献

{"title":"Feasibility Trial of a Health Behaviours Promotion Group for Youth at Clinical High Risk for Psychosis","authors":"Bernalyn Ruiz-Yu,&nbsp;Tanya Diaz,&nbsp;Daniella Hernandez,&nbsp;Jamie Zinberg,&nbsp;David J. Miklowitz,&nbsp;Carrie E. Bearden","doi":"10.1111/eip.70231","DOIUrl":"10.1111/eip.70231","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Development of new evidence-based interventions for youth who are at clinical high risk for psychosis (CHR-P) is needed. Health behaviours and lifestyle habits such as physical activity, sleep, and substance abuse are modifiable risk factors for a variety of health outcomes. We assessed the feasibility and acceptability of a novel health behaviour-focused psychosocial intervention for youth at CHR-P.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a non-randomized feasibility trial, youth aged 13–17 who met CHR-P criteria participated in a 9-week health behaviour promotion group that provided psychoeducation and skills training regarding stress management, sleep, physical activity, nutrition, mitigating substance use, and health behaviour goal setting. Primary outcomes included feasibility and pre-to post-intervention change in health behaviours and symptoms. The secondary outcome explored the social validity of the intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 18 invited participants, seven enrolled, and five completed at least two-thirds of the intervention, indicating modest feasibility and good retention in those who enrolled. There were no significant pre-post changes across measures of health behaviours or symptoms. Participants endorsed the goals of the intervention as meaningful and congruent with their treatment goals. Among those who enrolled, the group format was described as acceptable, while the didactic style was less preferred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Findings of this study showed the intervention to be modestly acceptable and feasible. Changes in health behaviours and symptoms were not significant but trended in the expected direction. Future trials are needed to refine the intervention and assess effectiveness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Clinicaltrials.gov Identifier: NCT05532683</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untreated Psychosis and Healthcare-Seeking Behaviour in Pakistan: A Qualitative Study With Young People, Carers, Traditional Healers, and Healthcare Professionals","authors":"Noor Sanauddin,&nbsp;Lisa Dikomitis,&nbsp;Abdul Jalil Khan,&nbsp;Mian Mukhtar ul Haq Azeemi,&nbsp;Muhammad Firaz Khan,&nbsp;Saima Sheikh,&nbsp;Nishani Fonseka,&nbsp;Abbie Milner,&nbsp;Syed Muhammad Uzair Shah,&nbsp;Ishfaq Tariq Azeemi,&nbsp;Shumaila Hamid,&nbsp;Syeda Fatima Jamal,&nbsp;Aimee Sargeant,&nbsp;Saeed Farooq","doi":"10.1111/eip.70233","DOIUrl":"10.1111/eip.70233","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Prolonged delay between the onset of the first episode of psychosis (FEP) and initiation of treatment is common in lower- and middle-income countries (LMICs), including Pakistan. This qualitative study explored perspectives of young persons with FEP, carers, healthcare professionals, and traditional and spiritual healers (TSHs) on drivers of delayed diagnosis and treatment of FEP, to suggest interventions aimed at addressing factors contributing to prolonged duration of untreated psychosis (DUP) in Pakistan and similar contexts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a qualitative study in Peshawar, Pakistan using focused ethnography as a research design. We first conducted focused ethnography using participant observation with 15 TSHs. Subsequently, data was collected through semi-structured interviews (<i>n</i> = 26) and focus group discussions (<i>n</i> = 6) with FEP individuals (age 14–25), their carers, and healthcare professionals. We used framework analysis, combining inductive and deductive thematic approaches to analyse the data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three themes emerged from the analysis in relation to care pathways in psychosis: (1) moral-spiritual explanations legitimise spiritual healings; (2) stigma renders psychiatric disclosure socially risky; and (3) structural exclusion of inaccessibility of mental health from primary care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Psychosis remains untreated for a prolonged time as families navigate a moral-spiritual landscape that makes TSHs the only legitimate healers, stigma makes psychiatric disclosure a threat to family honour, and absent or dismissive services make biomedical care unreachable. Engagement with TSHs represents an underutilised opportunity to develop collaborative care models that reduce the duration of untreated psychosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meeting Family Education and Support Needs in the Early Psychosis Context: Description and Evaluation of a Pragmatic Family Program","authors":"Melissa Holland,&nbsp;Stephen Parker,&nbsp;Naomi Sanders,&nbsp;Joanne Flear,&nbsp;Tessa Clarkson,&nbsp;Kylie Burke","doi":"10.1111/eip.70228","DOIUrl":"10.1111/eip.70228","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Despite a solid evidence base, mental health services often struggle to implement family interventions as part of routine psychosis care. Barriers to implementation include staff lacking training, supervision and confidence, as well as organisations lacking resources and prioritising crisis-focused interventions. Specific barriers in the early psychosis context include family readiness and interest, access limitations, and lack of perceived alignment with their needs and preferences. This paper describes and evaluates a pragmatic family education and support program in an Australian public mental health Early Psychosis service.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This uncontrolled pre-post study used routinely collected data. Data were retrospectively sourced from clinical and administrative records for the 2022–2023 period, during which a low-intensity (four-session) multi-family group program was run on four occasions. A routine voluntary pre- and post-participation survey was completed, which included consideration of the extent to which the program met participants' needs. Data were primarily considered using repeated measures <i>t</i>-tests and Cohen's <i>d</i> as a measure of effect size.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Less than half of the families invited to the program participated (38.8%). Despite the program's low intensity, it was reported to meet the needs of most participating families and caregivers. Participants reported significantly increased knowledge of psychosis and reported higher levels of coping with symptoms at post compared with pre-intervention measures. An increased number of sessions attended predicted improvements in knowledge (limited to ‘relapse’) but not coping.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A low-intensity family education program in the early psychosis project may meet the needs of most families and caregivers who are willing to engage. However, improvements in coping were modest and variable across participants, and the clinical significance of this change should be interpreted cautiously. Such a program may be inadequate to consistently meet the needs of all families engaged with an early psychosis service. Public mental health services need to continue to find better ways to engage and support the families of people experiencing early psychosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullying Victimisation and Mental Health: The Mediating Role of Peer and Family Social Support","authors":"C. Shannon,&nbsp;K. Higgins,&nbsp;G. Kelly,&nbsp;C. Mulholland,&nbsp;B. Korimbocus,&nbsp;J. A. Jordan","doi":"10.1111/eip.70225","DOIUrl":"https://doi.org/10.1111/eip.70225","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Adverse childhood experiences have been consistently linked to a range of mental health related difficulties in adulthood. One such experience is bullying, which has been shown to predict psychotic symptoms. This study aimed to explore whether bullying victimisation in early adolescence is associated with certain mental health outcomes (psychosis, depression and cannabis abuse) and whether this is mediated by the individuals' perception of social support from peers and family.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study performed secondary data analysis of a prospective cohort study, the Belfast Youth Development Study (BYDS). It used longitudinal data from 2087 participants from ages 12–21 years and performed path analysis (using Mplus V8) between bullying and the above mental health outcomes and mediators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed a direct path from bullying to psychotic symptoms (estimate = 0.10; SE = 0.0; <i>p</i> = 0.030) as well as an indirect path mediated by peer attachment, parental attachment and depression symptoms (estimate = 0.01; bootstrapped 95% CIs 0.01, 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Being bullied in childhood is directly associated with a greater risk of having psychotic symptoms as an adult. There is also an indirect path from bullying in childhood to psychosis symptoms as an adult mediated by peer attachment, parental attachment, and depression. Interventions should be aimed at addressing bullying and strengthening social support from peers and family.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Religiosity and Engagement in Early Intervention Programme for First-Episode Psychosis","authors":"Alona Schneidman,&nbsp;David Roe,&nbsp;Yaara Zisman-Ilani,&nbsp;Carmit-Noa Shpigelman","doi":"10.1111/eip.70245","DOIUrl":"https://doi.org/10.1111/eip.70245","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>While religious beliefs are known to affect help-seeking pathways, little is known about how they shape engagement in first-episode psychosis (FEP) care. The purpose of the present study is to explore how religious belief, religious identity and cultural norms shape engagement with FEP care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Semi-structured interviews were conducted with 23 NAVIGATE participants in Israel. The sample comprised 11 Ultra-Orthodox (UO) and 12 non-observant (Non-Obs) Jewish FEP participants. Thematic analysis was used to identify themes related to religious factors in FEP care engagement and the therapeutic alliance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two main themes emerged. The first focused on how faith contributed to participation in NAVIGATE by framing FEP care as God's will and viewing therapy as a spiritual experience. The second focused on trust issues, emphasising autonomy and collaborative decision-making. Across both themes, the therapeutic relationship emerged as a critical independent source of NAVIGATE engagement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Findings indicate that religiosity shapes day-to-day engagement throughout FEP care, extending beyond initial help-seeking. Implications are discussed with a focus on dialogue, psychoeducation and communication and on combining religious responsiveness with a strong therapeutic alliance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication Non-Adherence in First Episode Psychosis: A Systematic Review","authors":"James Hunt,&nbsp;Anna Georgiades","doi":"10.1111/eip.70234","DOIUrl":"https://doi.org/10.1111/eip.70234","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Despite the efficacy of antipsychotics, medication non-adherence remains common among individuals with a First Episode of Psychosis (FEP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review was conducted in accordance with the PRISMA 2020 guidelines to summarise the existing evidence base regarding the reasons, attitudes, and beliefs underlying both medication non-adherence and adherence in FEP, as well as psychosocial interventions designed to promote medication adherence in psychosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventy-six studies were eligible for inclusion. Nineteen reasons for medication non-adherence in FEP were identified, which were synthesised into 10 overarching themes: Insight and Perceived Need, Autonomy and Control, Trust and the Therapeutic Relationship, Cultural and Spiritual Factors, Side Effects and Perceived Inefficacy, Social and Family Influences, Stigma, Practical Barriers, Substance Use and Symptom-Driven Factors. Facilitators of adherence included illness insight, motivation to recover and fear of relapse, trust in clinicians, acceptance of the bio-psychosocial model, experiencing positive treatment outcomes, use of digital reminders and social support. A range of psychosocial interventions demonstrated effectiveness for enhancing medication adherence in psychosis. This included Cognitive Behaviour Therapy, psychoeducation, motivational interviewing, adherence therapy, assertive community treatment, and adherence-focused psychosocial skills training, particularly when delivered in combination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Medication non-adherence in FEP is shaped by a complex interplay of personal, relational, cognitive, cultural and systemic influences. Addressing these factors in the design and delivery of psychosocial interventions may serve to improve medication adherence outcomes in early psychosis. To support clinical application, this review also provides a fictitious clinician–client transcript along with Socratic questions and CBT strategies to assist clinicians in assessing and promoting medication adherence in FEP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Language Models for Individualized Psychoeducational Tools for Psychosis: A Cross-Sectional Study","authors":"Musa Yilanli,&nbsp;Ian McKay,&nbsp;Daniel I. Jackson,&nbsp;Emre Sezgin","doi":"10.1111/eip.70230","DOIUrl":"https://doi.org/10.1111/eip.70230","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aimed to evaluate the quality of GPT-4–generated responses to commonly asked psychosis-related psychoeducational questions from patients, caregivers and relatives in a first-episode psychosis programme. Evaluation focused on accuracy, clarity, inclusivity, completeness, clinical utility and overall quality.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Design&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This cross-sectional study employed a qualitative evaluation design. GPT-4, accessed via the ChatGPT interface, generated responses to 20 psychosis-related psychoeducational questions. These questions were developed through iterative discussion and consensus among clinicians working in a first-episode psychosis treatment programme, informed by commonly encountered questions from patients, caregivers and relatives in clinical practice and are provided in Appendix A. The generated responses were subsequently evaluated for their potential clinical applicability.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Primary Outcome&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;ChatGPT was presented with 20 psychoeducational questions derived from real-world clinical interactions with patients, caregivers and relatives. Two experts in psychosis independently assessed the responses using a structured six-domain rubric: accuracy (1–3), clarity (1–3), inclusivity (1–3), completeness (0–1), clinical utility (1–5) and overall quality (1–4), where lower scores indicate poorer performance and higher scores indicate stronger performance across domains. Discrepancies in ratings were resolved through discussion and consensus.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Using a structured evaluation rubric, LLM-generated responses were assessed across accuracy, clarity, inclusivity, completeness, clinical utility and overall quality. Responses were generally coherent, well-organized and readable across all 20 psychoeducational questions. Performance was strongest in accuracy (M ± SD = 2.88 ± 0.22), clarity (2.93 ± 0.18), completeness (0.93 ± 0.18) and clinical utility (4.35 ± 0.52), indicating that responses were largely correct, understandable and clinically relevant. Inclusivity scores were comparatively lower (2.30 ± 0.41). A descriptive linguistic analysis showed that responses were written at a relatively high Flesch–Kincaid Grade Level (FKGL) (mean = 15.59 ± 1.59), indicating increased reading complexity. Although responses addressed core aspects of the questions, some lacked sufficient nuance for complex or individualized clinical scenarios.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 ","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148617178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outpatient Young Adults with Concurrent Disorders: A Naturalistic Study of Clinical Characteristics and DBT Skills Training Outcomes","authors":"Kiefer D. Cowie,&nbsp;Asher Weller,&nbsp;Melissa Griffin,&nbsp;Dafna Sara Rubin-Kahana,&nbsp;Mahalia Dixon,&nbsp;Jake Ross,&nbsp;Bahar Amani,&nbsp;Susan Dickens,&nbsp;Lisa D. Hawke,&nbsp;Joanna Henderson,&nbsp;Darren Courtney","doi":"10.1111/eip.70235","DOIUrl":"https://doi.org/10.1111/eip.70235","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>This naturalistic study characterized clinical profiles of outpatient young adults with concurrent substance use and nonsubstance mental health symptoms in addition to evaluating reach and outcomes of a dialectical behaviour therapy skills training group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Descriptive statistics were generated to characterize demographic and clinical profiles of young adults (<i>N</i> = 612) who initiated services at a psychiatric specialty clinic between June 2016 and January 2020. Chi-square, independent <i>t</i>-tests and logistic regression models were used to examine factors associated with engagement with dialectical behaviour therapy skills training group. Paired samples <i>t</i>-tests were utilized to evaluate psychiatric symptom and functional impairment outcomes associated with group completion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Self-report measures indicated a high rate of substance use and co-occurring nonsubstance mental health concerns in the sample as a whole. Young adults who engaged in group programming differed significantly from those who did not on several clinical and demographic variables; however, no variables were significantly associated with group engagement in regression models. While referral and attendance rates were relatively low (30.6% and 15.4% of total sample), for those completing dialectical behaviour therapy skills training group we observed positive pre-post change outcomes on measures of psychiatric symptoms and functioning (<i>d</i> = 0.35–0.69).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Taken together, these findings provide initial support for offering dialectical behaviour therapy skills training as an adjunctive intervention for young adults with concurrent disorders. Future research identifying factors for enhancing engagement and examining outcome with more controlled conditions are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Role of Oxidative Stress Parameters in the Spectrum of Preschool Anxiety Disorders","authors":"Elifnur Cuhacioglu,&nbsp;Özlem Dogan,&nbsp;Humeyra Hilal Ozturk,&nbsp;Merve Cikili-Uytun","doi":"10.1111/eip.70242","DOIUrl":"https://doi.org/10.1111/eip.70242","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study sought to clarify the contribution of oxidative stress to anxiety disorders in preschool-aged children by examining whether serum levels of Nrf2, Keap1, Sestrin-2, Superoxide Dismutase, and GABPa play etiological roles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The sample included 65 children aged 3–6 years, comprising 22 children diagnosed with anxiety disorders, 22 with subclinical anxiety, and 21 healthy controls. Anxiety disorders were evaluated using a preschool-age psychiatric assessment. Parents completed the Preschool Anxiety Scale, the Short Temperament Scale for Children, and the CBCL 1.5–5 years forms. Venous blood samples were collected from all participants. Serum levels of Nrf2, Keap1, Sestrin-2, superoxide dismutase, and GABPa were then measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nrf2 levels differed significantly among all three groups (<i>p</i> &lt; 0.05), whereas GABPa levels differed significantly only between the anxiety and control groups (<i>p</i> &lt; 0.05). Positive correlations were observed between levels of Nrf2 and GABPa and both the duration and severity of anxiety disorders. Receiver operating characteristic analyses indicated that Nrf2 levels had significant predictive value for the diagnosis of anxiety disorders (<i>p</i> &lt; 0.001), whereas GABPa levels did not reach statistical significance (<i>p</i> = 0.06).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results identify potential biological markers associated with anxiety disorders in preschool-aged children and suggest that Nrf2 may represent a potential candidate biomarker, pending confirmation in larger, longitudinal studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Dietary Intake of Young People With a First Episode of Psychosis From the Time of Presentation to Six Months Follow-Up","authors":"Brian O'Mahony,&nbsp;Andrew Thompson,&nbsp;Adele Morrin,&nbsp;Brian O'Donoghue","doi":"10.1111/eip.70226","DOIUrl":"10.1111/eip.70226","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Antipsychotic medications stimulate appetite and weight gain, contributing to high obesity rates in people with psychotic disorders. It is unknown if these dietary effects habituate over time. This study aimed to determine the dietary intake of young people with a first-episode psychosis at the time of presentation and at three- and six-months of follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We assessed dietary patterns at baseline, 3 months, and 6 months in participants diagnosed with first-episode psychosis who had minimal prior antipsychotic exposure. We analysed data from the PHAstER randomised-controlled trial, assessing changes in food consumption and Australian Dietary Guideline compliance using signed-rank tests with corrections for multiple testing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 77 PHAstER study participants, 70 participants (91%) provided dietary data at baseline and 46 (60%) at 3 and 6 months. Dietary intake patterns and compliance with dietary guidelines remained consistent across all three timepoints. At baseline, few met recommended intake of three major food groups: vegetables (13%), dairy (20%) and fruit (24%). 64% of participants had a high intake of discretionary food (food high in saturated fat/sugars). At baseline, but not at three- or six-months, higher education levels were associated with healthier dietary patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Participants consistently reported unhealthy diets that did not adhere to guidelines, with no significant change over 6 months. This study reinforces the inequity of dietary health in people with psychosis, particularly those with lower levels of education. Dietary advice and support represent interventions with high marginal gain in this cohort, and should be part of routine clinical care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148600359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}