Exploring Behavioural Patterns in Youth Predisposed to Bipolar Disorder and the Role of Interpersonal Trauma Using the Adolescent Brain Cognitive Development (ABCD) Dataset

IF 2.1 4区医学 Q3 PSYCHIATRY

Early Intervention in Psychiatry Pub Date : 2025-05-30 DOI:10.1111/eip.70058

Christina Ghaleb, Danielle Penney, Katie M. Lavigne, Delphine Raucher-Chéné

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引用次数: 0

Abstract

Introduction

Bipolar disorder (BD) is a severe, persistent disorder that causes functional impairment. Besides heritability, environmental factors, such as traumatic experience, impact the development of BD. Little is known about the early developmental signs of this disorder; therefore, this study aims to look at the impact of interpersonal trauma on the early developmental signs of BD. Specifically, differences in psychopathological behaviours were investigated between (1) at-risk children and controls and (2) at-risk children who experienced an interpersonal traumatic event and those who did not.

Methods

Using the Adolescent Brain Cognitive Development (ABCD) dataset, participants with a first-degree relative with BD were identified (N_at-risk = 625) and matched on sex and age to a control group (N_control = 625). The Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) was used to assess interpersonal trauma and psychopathological symptoms. The trauma (N_trauma = 198) and no-trauma sub-groups (N_no-trauma = 428) were built from the at-risk population. Group comparison was conducted on depressive, manic and anxiety symptoms.

Results

Compared to controls, at-risk children exhibited a significantly greater number of manic symptoms at baseline and 2-year follow-up, and anxiety symptoms at follow-up. No significant differences were found between the trauma and no-trauma groups at either baseline or follow-up.

Discussion

These results confirm the presence of early symptoms in at-risk children, in line with the staging model of BD. Extended longitudinal research is needed to further investigate the potential specific role of trauma on its early behavioural patterns.

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利用青少年大脑认知发展（ABCD）数据集探索易患双相情感障碍的青少年行为模式和人际创伤的作用

双相情感障碍（BD）是一种严重的，持续的障碍，导致功能障碍。除了遗传因素外，环境因素，如创伤经历，也会影响双相障碍的发展。因此，本研究旨在探讨人际创伤对双相障碍早期发展体征的影响。具体而言，研究人员调查了(1)高危儿童与对照组之间的精神病理行为差异，以及(2)经历过人际创伤事件的高危儿童与没有经历过人际创伤事件的儿童之间的精神病理行为差异。方法使用青少年大脑认知发展（ABCD）数据集，确定患有双相障碍的一级亲属（Nat-risk = 625），并将性别和年龄匹配到对照组（Ncontrol = 625）。儿童情感障碍和精神分裂症量表（KSADS）用于评估人际创伤和精神病理症状。从高危人群中建立创伤亚组（n外伤= 198）和无创伤亚组（n外伤= 428）。组间比较抑郁、躁狂、焦虑症状。结果与对照组相比，高危儿童在基线和2年随访时表现出明显更多的躁狂症状，并在随访时表现出焦虑症状。无论是基线还是随访，创伤组和非创伤组之间均未发现显著差异。这些结果证实了高危儿童早期症状的存在，符合双相障碍的分期模型。需要进一步的纵向研究来进一步研究创伤对其早期行为模式的潜在具体作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.