{"title":"Emphasising Collaborative and Psychoeducational Approaches for Unusual Sensory Experiences: A Commentary on Hamilton et al. (2025)","authors":"Ying-Tzu Chen, Lien-Chung Wei","doi":"10.1111/eip.70067","DOIUrl":"https://doi.org/10.1111/eip.70067","url":null,"abstract":"","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clevanne Julce, Julie Flahive, Taber Lightbourne, Sriya Podila, Allexis Mahanna, Martha Zimmermann, Radley Christopher Sheldrick, Tiffany A. Moore Simas, Nancy Byatt
{"title":"Descriptive Characteristics of Psychiatric Medication Discontinuation Among Perinatal Women With Depressive Symptoms","authors":"Clevanne Julce, Julie Flahive, Taber Lightbourne, Sriya Podila, Allexis Mahanna, Martha Zimmermann, Radley Christopher Sheldrick, Tiffany A. Moore Simas, Nancy Byatt","doi":"10.1111/eip.70070","DOIUrl":"https://doi.org/10.1111/eip.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>This study examined the prevalence of psychiatric medication discontinuation amongst perinatal women with depressive symptoms and describes characteristics of those who discontinued compared to those who continued medications in pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a cross-sectional analysis using baseline data from the PRogram In Support of Moms study. Amongst 98 women prescribed psychiatric medication, we descriptively assessed sociodemographic characteristics of participants who discontinued versus continued medications. A logistic regression model evaluated the association between depressive symptoms and medication discontinuation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Approximately 65% reported medication discontinuation in pregnancy (95% CI: 55%–74%). Those who discontinued had a median Edinburgh Postnatal Depression Scale (EPDS) score that was 1 point higher than those who continued (<i>p</i> = 0.12). Of those who discontinued medications, 27% were never married, 52% reported annual incomes < $60 000, and 56% were Medicaid-insured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Most participants prescribed psychiatric medications before pregnancy discontinued them in pregnancy. Adequately powered studies are needed to validate findings and to explore mediating factors.</p>\u0000 \u0000 <p><b>Trial Registration:</b> NCT02760004</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aswin Ratheesh, Jesse Gates, Dylan Hammond, Clare Shelton, Craig Macneil, Melissa Hasty M, Arup Dhar, Simon D'Alfonso, Lianne Schmaal, Lars V. Kessing, John F. Gleeson, Chris Davey, Andrew Chanen, Greg Murray, Sue M. Cotton, Patrick D. McGorry, Michael Berk, Mario Alvarez-Jimenez
{"title":"Bipolar Early Intervention Using New Digital Technologies (BLEND): A Pilot Randomised Controlled Trial of a Novel Blended-Digital Early Intervention Model of Care for Youth With Bipolar Disorder I or II","authors":"Aswin Ratheesh, Jesse Gates, Dylan Hammond, Clare Shelton, Craig Macneil, Melissa Hasty M, Arup Dhar, Simon D'Alfonso, Lianne Schmaal, Lars V. Kessing, John F. Gleeson, Chris Davey, Andrew Chanen, Greg Murray, Sue M. Cotton, Patrick D. McGorry, Michael Berk, Mario Alvarez-Jimenez","doi":"10.1111/eip.70060","DOIUrl":"https://doi.org/10.1111/eip.70060","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite evidence for early interventions for bipolar disorder (BD), there are relatively few accessible treatment models. We developed a digitally augmented model of care termed BLEND (BipoLar early interventions using New Digital technologies) which aims to improve mood symptoms in BD. BLEND includes: (a) guideline-concordant pharmacotherapy; (b) in-person psychological therapies blended with digital therapeutic content and (c) digital relapse monitoring. The aim of this study was twofold: (i) describe the acceptability, safety and feasibility of delivering BLEND and (ii) examine the feasibility of an efficacy trial of BLEND compared with enhanced standard care (ESC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We conducted a parallel-group, open-label, 2:1 randomised pilot trial within a youth mental-health outpatient service in Melbourne, Australia. We included youth aged 15–25 years with BD I or II, who had not previously accessed multidisciplinary care. All participants received similar background care. BLEND differed from ESC in having manualised blended digital and in-person psychological therapies and digital relapse monitoring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We randomised 21 young people over a 12-month recruitment period, predominantly female participants (71.4%) with BD Type II (85.7%). Both treatment models were acceptable and safe, but the BLEND group had greater reductions in suicidal ideation. Among components of BLEND, in-person psychological therapy and psychopharmacological interventions could be delivered with fidelity. Digital therapy engagement was high, but participants used digital relapse monitoring variably.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The BLEND model was safe and acceptable and may lead to improvements in suicidality compared with ESC. Concordant with the aims of a pilot study, there is scope for the content to be rationalised based on feedback to improve feasibility of the digital therapy. Relapse monitoring may usefully be extended to depressive symptoms. The next step is to confirm the efficacy of BLEND compared with standard care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Whitson, Zsofi de Haan, Susan Preece, Maureen Swinson, Sue Williams, Karen Smith, Jennifer Bité, Isabel Zbukvic, Magenta B. Simmons
{"title":"Family Peer Worker Perspectives on the Critical Issues for Family Peer Support in Youth Mental Health Settings","authors":"Sarah Whitson, Zsofi de Haan, Susan Preece, Maureen Swinson, Sue Williams, Karen Smith, Jennifer Bité, Isabel Zbukvic, Magenta B. Simmons","doi":"10.1111/eip.70066","DOIUrl":"https://doi.org/10.1111/eip.70066","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Family peer workers form connections with family members of young people attending mental health services and can offer emotional support, relevant information, and referrals based on their own lived experience. Although an increasing number of family peer support programs exist in the youth mental health sector, they are rarely described or reported on. There is a need for greater documentation of the experiences of family peer workers operating in the sector to raise awareness of issues currently facing the workforce and support organisations to make positive changes. We present a detailed description of the factors that impact effective program implementation and delivery from the perspectives of four family peer workers and two supervisors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Organisations should encourage self-care and social connections between family peer workers to reduce the impacts of ongoing mental health challenges, work-related burnout, and isolation. Colleagues should be educated about the field of family peer support to improve role clarity and foster a positive team environment. Within the field, it is vital to develop comprehensive position descriptions, training programs, and onboarding procedures to ensure new employees are adequately equipped. To improve staff retention and compensate those with further education, experience, and skills, organisations may consider offering increased remuneration, negotiating longer-term contracts with a potential for a greater number of workdays, and should create senior lived experience positions. Further research is needed to formally investigate barriers and facilitating factors of program implementation in mental health settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vocational Rehabilitation in Young Adults With Incident Schizophrenia—A Danish Retrospective Cohort Study","authors":"Pernille Pedersen, Birthe Bruun Olsen, Ditte Lammers Vernal, Matilde Poulsen Rydborg, Christiane Gasse, Ole Mors","doi":"10.1111/eip.70062","DOIUrl":"https://doi.org/10.1111/eip.70062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The aim of this study was to compare the multidisciplinary vocational intervention, Morpheus, with standard vocational rehabilitation for young adults with incident schizophrenia undergoing the OPUS specialised early intervention programme. The study evaluated whether the type of vocational intervention was related to attachment to the labour market and educational system, outpatient contacts, hospital admissions and psychotropic drug use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included patients of the OPUS programme in the period from January 1, 2014, to December 31, 2019. Patients at Aarhus University Hospital Psychiatry (Aarhus) were offered the Morpheus intervention, while patients at Aalborg University Hospital (Aalborg) received standard vocational rehabilitation. The study used register and clinical data. The analyses involved logistic and linear regression presented as crude and adjusted models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 404 OPUS patients from Aarhus and 246 OPUS patients from Aalborg, patients participating in the Morpheus intervention (<i>n</i> = 116) were more likely to be employed or enrolled in education 2 and 4 years after diagnosis compared with patients undergoing standard vocational intervention (<i>n</i> = 130). Specifically, the adjusted odds ratio for employment was 1.14 (0.37; 3.45) and 1.51 (0.70; 3.27) at 2 and 4 years, respectively. Morpheus patients were less likely to attend somatic outpatient contacts, which involve consultations or treatment for physical health conditions, as well as psychiatric outpatient contacts. Furthermore, they were less likely to be admitted to somatic departments or to redeem antipsychotic medication. However, Morpheus patients had a higher likelihood of being admitted to psychiatric departments during the periods 0–2 and 2–4 years after diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Young adults with incident schizophrenia receiving the Morpheus intervention within the OPUS treatment did not show statistically significant increased odds of employment or education enrolment compared to those in standard vocational rehabilitation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taylor M. Ward, Jianing Xu, Daniel B. Hall, Xianyan Chen, Sandra Benavides, Henry N. Young, Joshua Caballero
{"title":"Long-Acting Injectable Antipsychotic Use and Discontinuation Rates in Children and Adolescents With Schizophrenia Using Medicaid Claims Data","authors":"Taylor M. Ward, Jianing Xu, Daniel B. Hall, Xianyan Chen, Sandra Benavides, Henry N. Young, Joshua Caballero","doi":"10.1111/eip.70063","DOIUrl":"https://doi.org/10.1111/eip.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The primary objective was to analyse the prescribing and discontinuation rates of long-acting injectable (LAI) antipsychotics among child and adolescent populations. The secondary objective was to assess if racial/ethnic differences existed between LAI antipsychotics and discontinuation rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Children and adolescents (2–17 years old) with schizophrenia or related disorders who received LAI antipsychotics between January 1, 2017 and December 31, 2021 were identified using Merative MarketScan Multi-State Medicaid Database. Descriptive statistics summarised the rates of LAI antipsychotic use. Kaplan–Meier survival curves were examined, and Cox regression analyses conducted to compare the hazard of discontinuation across LAI antipsychotics (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1277 out of 67 502 patients were included in the final analysis. The average age was 15.4 ± 1.7 years (range 7–17 years). Approximately 59% were male, with the most common races identified being Black (48%) and White (38%). Prescribing of LAI second-generation antipsychotics occurred in about 94% of the population. The most common LAI antipsychotics prescribed included paliperidone palmitate 1 month (40%) and aripiprazole formulations (48%). When controlling for age group, gender and plan type, the discontinuation rate for paliperidone and aripiprazole formulations did not differ. However, LAI paliperidone palmitate was associated with a 46% lower hazard of discontinuation for White compared to Black populations (HR = 0.54; <i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite the limited sample, this study explored the frequency of prescribing and discontinuation rates between LAI antipsychotics in children. Future studies may further explain the unique challenges (e.g., reasons for discontinuation) and economic impact LAI antipsychotics present.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jean Addington, Lu Liu, Amy Braun, Cari Jahraus, Kali Brummitt, Jacqueline Stowkowy
{"title":"Treatment Choices for Youth at Clinical High-Risk of Psychosis: Methods of an Open Trial","authors":"Jean Addington, Lu Liu, Amy Braun, Cari Jahraus, Kali Brummitt, Jacqueline Stowkowy","doi":"10.1111/eip.70068","DOIUrl":"https://doi.org/10.1111/eip.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The number of randomised controlled trials (RCT) that address the treatment of youth at clinical high-risk (CHR) of developing psychosis is few. What is most needed are clinical trials that consider the heterogenous outcomes of those at risk of psychosis. This report describes the methods of an 18-month open trial to determine the choices of and adherence to treatment of a CHR sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The methods of the trial including participants and the range and rationale for the measures chosen are presented, Treatment is offered as a step model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We present descriptive baseline data on the first 50/60 participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The end results of this trial will inform the design of larger RCTs for CHR youth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dongfang Wang, Bingna Xu, Andrew Scherffius, Hao Wei, Yukai Li, Huanhuan Chen, Zijuan Ma, Fang Fan
{"title":"A Longitudinal Study of Bidirectional Associations Between Sleep Disturbance and Internet Addiction Among Chinese Adolescents","authors":"Dongfang Wang, Bingna Xu, Andrew Scherffius, Hao Wei, Yukai Li, Huanhuan Chen, Zijuan Ma, Fang Fan","doi":"10.1111/eip.70069","DOIUrl":"https://doi.org/10.1111/eip.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Previous literature suggests that sleep disturbance is linked to Internet addiction, however, there was not sufficient empirical evidence to validate the causal relationships connecting these two variables. Our research intended to investigate these bidirectional associations in an adolescent population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In all, 27 260 adolescents were assessed from December 17 to 26, 2021 and again 6 months later from May 17 to June 5, 2022. To evaluate Internet addiction, researchers employed the Revised Chinese Internet Addiction Scale (CIAS-R), while sleep disturbance was assessed through a four-item questionnaire addressing issues such as: difficulty initiating sleep, difficulty maintaining sleep, early morning awakening, and poor sleep quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sleep disturbance at baseline was linked to a higher probability of developing Internet addiction within 6 months, even after adjusting for relevant covariates. Similarly, individuals with Internet addiction at baseline exhibited a markedly increased risk of developing new-onset disturbance at the six-month follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the bidirectional prospective links between sleep disturbance and Internet addiction among adolescents. The findings hold significant educational and clinical value, offering insights for managing Internet addiction alongside addressing sleep-related issues.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. O. Husain, M. Abid, A. B. Khoso, M. Riaz, F. Ahmed, S. Shakoor, S. Lane, N. Husain, G. Foussias, I. Qurashi, I. B. Chaudhry
{"title":"Anthropometric and Physiological Measures in Individuals With At-Risk Mental State (ARMS) Compared With Individuals With Schizophrenia: Findings From a Lower Middle-Income Country","authors":"M. O. Husain, M. Abid, A. B. Khoso, M. Riaz, F. Ahmed, S. Shakoor, S. Lane, N. Husain, G. Foussias, I. Qurashi, I. B. Chaudhry","doi":"10.1111/eip.70065","DOIUrl":"https://doi.org/10.1111/eip.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with psychosis have reduced life expectancy and this is largely driven by cardiometabolic disease. Cardiometabolic risk increases with age and duration of psychotic illness. Anthropometric and physiologic abnormalities have been identified among individuals with at-risk mental state (ARMS) for psychosis. The prevalence of cardiometabolic disease is disproportionately higher in lower middle-income countries (LMIC); however, literature on cardiometabolic disease in individuals with psychosis spectrum disorders in LMIC is scarce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This is a cross-sectional secondary analysis of data from two large randomised controlled trials that recruited individuals with ARMS (<i>n</i> = 326) and schizophrenia (SCZ; <i>n</i> = 303) from inpatient and outpatient settings in Pakistan. All participants completed anthropometric and physiological assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was a statistically significant difference in BMI between groups, 21.42 (SD = 4.11) in ARMS and 23.31 (SD = 5.41) in the SCZ group (<i>p</i> = 0.001). Although mean values were within the normal range, 17.8% (<i>n</i> = 58) of ARMS individuals and 33.1% (<i>n</i> = 100) SCZ individuals were overweight or obese. Waist circumference was 32.75 in (SD = 3.13) in the ARMS group and 32.16 in (SD = 5.18) in SCZ. Although waist circumference was higher in ARMS, this was not statistically or clinically significant. The pulse rate and blood pressure in both groups were within normal range.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We found evidence of abnormal anthropometric and physiological parameters that would indicate that individuals with psychotic-spectrum disorders in Pakistan are at an elevated cardiometabolic risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}