Treatment Choices for Youth at Clinical High-Risk of Psychosis: Methods of an Open Trial

IF 2.1 4区医学 Q3 PSYCHIATRY

Early Intervention in Psychiatry Pub Date : 2025-06-17 DOI:10.1111/eip.70068

Jean Addington, Lu Liu, Amy Braun, Cari Jahraus, Kali Brummitt, Jacqueline Stowkowy

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Abstract

Introduction

The number of randomised controlled trials (RCT) that address the treatment of youth at clinical high-risk (CHR) of developing psychosis is few. What is most needed are clinical trials that consider the heterogenous outcomes of those at risk of psychosis. This report describes the methods of an 18-month open trial to determine the choices of and adherence to treatment of a CHR sample.

Methods

The methods of the trial including participants and the range and rationale for the measures chosen are presented, Treatment is offered as a step model.

Results

We present descriptive baseline data on the first 50/60 participants.

Conclusion

The end results of this trial will inform the design of larger RCTs for CHR youth.

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临床精神病高危青年的治疗选择：一项公开试验的方法

针对青年精神病临床高危人群（CHR）治疗的随机对照试验（RCT）数量很少。目前最需要的是临床试验，考虑那些有精神病风险的人的异质性结果。本报告描述了一项为期18个月的公开试验的方法，以确定CHR样本的治疗选择和依从性。方法介绍试验的方法，包括受试者，所选措施的范围和基本原理，治疗采用阶梯模型。我们提供了前50/60名参与者的描述性基线数据。结论：该试验的最终结果将为设计更大的CHR青年随机对照试验提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.