Early Intervention in Psychiatry最新文献

{"title":"Long-Acting Injectable Antipsychotic Use and Discontinuation Rates in Children and Adolescents With Schizophrenia Using Medicaid Claims Data","authors":"Taylor M. Ward,&nbsp;Jianing Xu,&nbsp;Daniel B. Hall,&nbsp;Xianyan Chen,&nbsp;Sandra Benavides,&nbsp;Henry N. Young,&nbsp;Joshua Caballero","doi":"10.1111/eip.70063","DOIUrl":"https://doi.org/10.1111/eip.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The primary objective was to analyse the prescribing and discontinuation rates of long-acting injectable (LAI) antipsychotics among child and adolescent populations. The secondary objective was to assess if racial/ethnic differences existed between LAI antipsychotics and discontinuation rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Children and adolescents (2–17 years old) with schizophrenia or related disorders who received LAI antipsychotics between January 1, 2017 and December 31, 2021 were identified using Merative MarketScan Multi-State Medicaid Database. Descriptive statistics summarised the rates of LAI antipsychotic use. Kaplan–Meier survival curves were examined, and Cox regression analyses conducted to compare the hazard of discontinuation across LAI antipsychotics (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1277 out of 67 502 patients were included in the final analysis. The average age was 15.4 ± 1.7 years (range 7–17 years). Approximately 59% were male, with the most common races identified being Black (48%) and White (38%). Prescribing of LAI second-generation antipsychotics occurred in about 94% of the population. The most common LAI antipsychotics prescribed included paliperidone palmitate 1 month (40%) and aripiprazole formulations (48%). When controlling for age group, gender and plan type, the discontinuation rate for paliperidone and aripiprazole formulations did not differ. However, LAI paliperidone palmitate was associated with a 46% lower hazard of discontinuation for White compared to Black populations (HR = 0.54; <i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite the limited sample, this study explored the frequency of prescribing and discontinuation rates between LAI antipsychotics in children. Future studies may further explain the unique challenges (e.g., reasons for discontinuation) and economic impact LAI antipsychotics present.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Longitudinal Study of Bidirectional Associations Between Sleep Disturbance and Internet Addiction Among Chinese Adolescents","authors":"Dongfang Wang,&nbsp;Bingna Xu,&nbsp;Andrew Scherffius,&nbsp;Hao Wei,&nbsp;Yukai Li,&nbsp;Huanhuan Chen,&nbsp;Zijuan Ma,&nbsp;Fang Fan","doi":"10.1111/eip.70069","DOIUrl":"https://doi.org/10.1111/eip.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Previous literature suggests that sleep disturbance is linked to Internet addiction, however, there was not sufficient empirical evidence to validate the causal relationships connecting these two variables. Our research intended to investigate these bidirectional associations in an adolescent population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In all, 27 260 adolescents were assessed from December 17 to 26, 2021 and again 6 months later from May 17 to June 5, 2022. To evaluate Internet addiction, researchers employed the Revised Chinese Internet Addiction Scale (CIAS-R), while sleep disturbance was assessed through a four-item questionnaire addressing issues such as: difficulty initiating sleep, difficulty maintaining sleep, early morning awakening, and poor sleep quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sleep disturbance at baseline was linked to a higher probability of developing Internet addiction within 6 months, even after adjusting for relevant covariates. Similarly, individuals with Internet addiction at baseline exhibited a markedly increased risk of developing new-onset disturbance at the six-month follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the bidirectional prospective links between sleep disturbance and Internet addiction among adolescents. The findings hold significant educational and clinical value, offering insights for managing Internet addiction alongside addressing sleep-related issues.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Choices for Youth at Clinical High-Risk of Psychosis: Methods of an Open Trial","authors":"Jean Addington,&nbsp;Lu Liu,&nbsp;Amy Braun,&nbsp;Cari Jahraus,&nbsp;Kali Brummitt,&nbsp;Jacqueline Stowkowy","doi":"10.1111/eip.70068","DOIUrl":"https://doi.org/10.1111/eip.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The number of randomised controlled trials (RCT) that address the treatment of youth at clinical high-risk (CHR) of developing psychosis is few. What is most needed are clinical trials that consider the heterogenous outcomes of those at risk of psychosis. This report describes the methods of an 18-month open trial to determine the choices of and adherence to treatment of a CHR sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The methods of the trial including participants and the range and rationale for the measures chosen are presented, Treatment is offered as a step model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We present descriptive baseline data on the first 50/60 participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The end results of this trial will inform the design of larger RCTs for CHR youth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric and Physiological Measures in Individuals With At-Risk Mental State (ARMS) Compared With Individuals With Schizophrenia: Findings From a Lower Middle-Income Country","authors":"M. O. Husain,&nbsp;M. Abid,&nbsp;A. B. Khoso,&nbsp;M. Riaz,&nbsp;F. Ahmed,&nbsp;S. Shakoor,&nbsp;S. Lane,&nbsp;N. Husain,&nbsp;G. Foussias,&nbsp;I. Qurashi,&nbsp;I. B. Chaudhry","doi":"10.1111/eip.70065","DOIUrl":"https://doi.org/10.1111/eip.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with psychosis have reduced life expectancy and this is largely driven by cardiometabolic disease. Cardiometabolic risk increases with age and duration of psychotic illness. Anthropometric and physiologic abnormalities have been identified among individuals with at-risk mental state (ARMS) for psychosis. The prevalence of cardiometabolic disease is disproportionately higher in lower middle-income countries (LMIC); however, literature on cardiometabolic disease in individuals with psychosis spectrum disorders in LMIC is scarce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This is a cross-sectional secondary analysis of data from two large randomised controlled trials that recruited individuals with ARMS (<i>n</i> = 326) and schizophrenia (SCZ; <i>n</i> = 303) from inpatient and outpatient settings in Pakistan. All participants completed anthropometric and physiological assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was a statistically significant difference in BMI between groups, 21.42 (SD = 4.11) in ARMS and 23.31 (SD = 5.41) in the SCZ group (<i>p</i> = 0.001). Although mean values were within the normal range, 17.8% (<i>n</i> = 58) of ARMS individuals and 33.1% (<i>n</i> = 100) SCZ individuals were overweight or obese. Waist circumference was 32.75 in (SD = 3.13) in the ARMS group and 32.16 in (SD = 5.18) in SCZ. Although waist circumference was higher in ARMS, this was not statistically or clinically significant. The pulse rate and blood pressure in both groups were within normal range.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We found evidence of abnormal anthropometric and physiological parameters that would indicate that individuals with psychotic-spectrum disorders in Pakistan are at an elevated cardiometabolic risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sessions Abstracts","authors":"","doi":"10.1111/eip.70046","DOIUrl":"https://doi.org/10.1111/eip.70046","url":null,"abstract":"","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 S1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keynote Lectures Abstracts","authors":"","doi":"10.1111/eip.70045","DOIUrl":"https://doi.org/10.1111/eip.70045","url":null,"abstract":"","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 S1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posters Abstracts","authors":"","doi":"10.1111/eip.70047","DOIUrl":"https://doi.org/10.1111/eip.70047","url":null,"abstract":"","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 S1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Programme-Led and Focused Interventions for Early Intervention for Eating Disorders in Youth: A Rapid Review","authors":"Andrea LaMarre,&nbsp;Janessa Porter,&nbsp;Patricia Silva-Roy,&nbsp;Nicole Obeid","doi":"10.1111/eip.70053","DOIUrl":"https://doi.org/10.1111/eip.70053","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Early intervention (EI) for eating disorders (EDs) has been recognised as important for interrupting the onset of ED symptoms and improving outcomes. Despite growing evidence for EI models of service delivery in community-based settings, there is limited clarity on which specific interventions might best suit young people in these contexts. In this rapid review, we aimed to identify and explore the evidence for programme-led and focused interventions applicable to an EI service delivery model for youth with EDs in community-based settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search was conducted in MEDLINE, Web of Science, and PsycINFO databases, focusing on interventions that maximise the use of resources, namely guided self-help and group approaches, for individuals under age 30. Studies were screened for eligibility based on intervention brevity (12 sessions or fewer) and relevance to EI models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Findings indicated that while many interventions reduced ED symptoms, few were explicitly designed for EI. Notably, interventions are skewed towards young adult populations, with fewer interventions addressing paediatric needs. Further, the strength of evidence for interventions varied, with many articles reporting on studies with small sample sizes or results illustrating non-superiority to comparison or control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review highlights the need for further research on programme-led and focused interventions tailored to EI, particularly for younger populations, to build an evidence base and improve early-stage ED treatment options in resource-limited community-based settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening the Community for Individuals at Clinical High Risk (CHR) for Psychosis","authors":"Alexandre Andrade Loch,&nbsp;Anderson Ara,&nbsp;Feten Fekih-Romdhane,&nbsp;Leonardo Peroni de Jesus,&nbsp;Julio Cesar Andrade,&nbsp;Melina Mendonça,&nbsp;Maurício Henriques Serpa,&nbsp;Martinus Theodorus van de Bilt,&nbsp;Wagner Farid Gattaz","doi":"10.1111/eip.70056","DOIUrl":"https://doi.org/10.1111/eip.70056","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The aim of our study was to assess the performance of the Prodromal Questionnaire-16 (PQ-16) and the Perceptual and Cognitive Aberrations scale (PCA) to screen for clinical high risk for psychosis (CHR) in a sample of nonhelp-seeking subjects from São Paulo, Brazil.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Individuals aged 18–35 years were interviewed with the PQ-16 and the PCA. Those with a combined score &gt; 10 on the PQ-16 + PCA were called for assessment with the Structured Interview for Psychosis-Risk Syndromes (SIPS). Seventy-five individuals were deemed as CHR and 99 as healthy comparison; 44 randomly selected individuals (PQ-16 + PCA scores &lt; 10) joined as further controls. All participants had no DSM-5 diagnosis. Scores of the PCA, PQ-16 (total score and distress index), and their combinations were analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All the proposed scorings significantly distinguished between CHR and control subjects. Considering a 7% CHR prevalence in the population, PQ-16 score mathematically showed the best performance (AUC = 0.713), followed by the PQ-16 score + PCA (AUC = 0.701). PQ-16 distress had the worst performance (AUC = 0.642).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Data provides further evidence for the use of the PQ-16 score as an effective instrument to search for CHR states through active screening in the community. Future research should address its potential in helping CHR identification and thus reducing delays in care and minimising the risk of false positives.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed Standards for Implementing Stepped Care Models in Child and Youth Mental Health Service Systems: Results of a Pan-Canadian Delphi Study","authors":"S. Mughal,&nbsp;B. Young,&nbsp;A. Churchill,&nbsp;J. Rash,&nbsp;K. Tee,&nbsp;A. Salmon,&nbsp;J. L. Shah","doi":"10.1111/eip.70057","DOIUrl":"https://doi.org/10.1111/eip.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Stepped care (SC) is being adopted in many countries as a framework for organising mental health care in diverse contexts. However, there is a lack of consistency in how SC has been defined and operationalised, limiting its effective application in practice. We describe the development of standards for implementing SC models in Canadian child and youth mental health (CYMH) contexts using a consensus-based approach. These standards are intended to support systems planners in creating cohesive CYMH systems across Canadian settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study employed learning alliance and Delphi methodologies. A pan-Canadian multi-round Delphi process conducted in English and French was used to derive consensus on the inclusion and wording of individual clauses in the standard. Consensus with a threshold of 70% was set to determine the inclusion of individual clauses in the final standard.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-eight individuals participated in the Delphi study (with a 76.48% retention rate) representing lived experience, service delivery, policy, and research expertise. Over three rounds, 29 clause items were revised and reduced to a final list of 24 clause items comprising SC implementation standards. Participant feedback indicated a desire for reduced ambiguity, considerations of the limitations of patient autonomy, and the need to clarify roles and responsibilities in system-wide activities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>The results of this Delphi study represent the first multi-stakeholder, consensus-driven set of standards for implementing SC in CYMH settings across Canada. With these standards, we aspire to provide a blueprint for mental health systems advocacy and reform toward stronger, more coordinated CYMH systems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}