Early Intervention in Psychiatry最新文献

{"title":"A Fidelity Assessment of Early Psychosis Intervention Services in British Columbia, Canada","authors":"S. Riedlinger,&nbsp;T. Ehmann,&nbsp;S. Tamburri,&nbsp;D. J. Lang","doi":"10.1111/eip.70202","DOIUrl":"10.1111/eip.70202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Established standards and guidelines for early psychosis intervention (EPI) in British Columbia (BC) and across Canada define the intent and scope of individual EPI programs. EPI programs are a critical mental health service both in BC and internationally, providing a range of pharmacological, psychological, and social supports under one service. If EPI principles and practices are applied, positive outcomes are expected, including greater reduction of psychotic symptoms compared to standard treatment, improved treatment adherence, fewer recurrent episodes of psychosis, and greater client satisfaction. Low fidelity, or difficulty adhering to the principles associated with the EPI model, may jeopardize attaining these positive outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Evaluation of program fidelity to established EPI practice standards and guidelines was conducted at 16 mental health service sites in BC that provide care to young adults with early psychosis. Fidelity assessment was performed via utilization of the EPI Fidelity Scale (EPI-FS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on the EPI-FS, two sites (12.5%) met criteria for high fidelity, nine (56.3%) attained moderate fidelity, three (18.8%) attained low fidelity, and two (12.5%) attained very low fidelity. Specialized EPI programs were linked to higher fidelity, while many generic mental health and substance use centres had difficulty following the EPI model. Identified weaknesses included provision of psychological therapy, family education, ongoing program evaluation, and supervision and mentorship for clinicians. Sites with sufficient resources and staff development opportunities had higher overall fidelity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings underscore the importance of equitable resource allocation and the need for specialized EPI services, especially in underserved areas in BC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148445225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care Pathway for Early Intervention in Psychiatry: A Community Mental Healthcare Initiative to Overcome the Treatment Gap in Hauts-de-Seine, France","authors":"Joséphine Caubel,&nbsp;Donia Bouchiba,&nbsp;Diane Fabre,&nbsp;Albane Mansoux,&nbsp;IJbrand Visser,&nbsp;Laurent Lecardeur","doi":"10.1111/eip.70190","DOIUrl":"10.1111/eip.70190","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To develop and describe the implementation and early outcomes of a stepped, transdiagnostic early intervention service (FIPP) for individuals aged 17–30, and to evaluate changes in access, age profile, length of stay, diagnostic mix and community engagement between 2016 and 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Jean Wier outpatient centre is part of the public mental health hospital Érasme, which is part of the GHT PsySudParis group in the metropolis of greater Paris (France). Data and surveys showed a treatment gap in service delivery for young people with emerging psychiatric disorders. A comprehensive reorganisation of mental health services was initiated. Developmental aims were training professionals, service establishment and introducing standardised assessment. Evaluation aims were shifts in access, length of stay and diagnostic distribution.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results show an improved healthcare provision by better trained teams, increased community engagement, a diminished average age of service users, a decreased average length of stay and a diagnostic shift in the day-care program (CARE). Duration of untreated psychosis and disengagement have not yet been objectified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A proactive, structured and collaborative approach in public mental health care can enhance access to early psychiatric care for young adults in France.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis Mental Health Campaigns: A Scoping Review of Strategies and Outcomes","authors":"Kelsey T. Straub,&nbsp;Kara Pemberton,&nbsp;Mackenzie Tennison,&nbsp;Sydney McKinstry,&nbsp;Sarah Kopelovich","doi":"10.1111/eip.70206","DOIUrl":"10.1111/eip.70206","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Early intervention in psychosis is associated with improved outcomes, yet prolonged duration of untreated psychosis remains a major barrier globally. Public health campaigns offer a promising strategy for promoting early detection and help-seeking, although findings on their effectiveness remain mixed. This scoping review examines the characteristics, strategies, and outcomes of psychosis public health campaigns published between 2008 and 2025, with particular attention to metrics that are used to evaluate campaign success.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Six databases were searched for peer-reviewed studies reporting outcomes of psychosis public health campaigns. Studies were included if they reported on campaign effectiveness and used a comparison condition. Data extraction focused on campaign characteristics, strategies, messages, target audiences, and outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nineteen studies describing 14 distinct campaigns met inclusion criteria. Campaigns varied widely in geographic scope, target audiences, duration, and messaging strategies. There was substantial heterogeneity in how duration of untreated psychosis was defined. Although some campaigns demonstrated significant reductions in overall duration of untreated psychosis, most showed mixed effects or improvements in subcomponents only. Campaigns employing multi-modal and sustained engagement strategies were more likely to report positive outcomes. Recent digital campaigns offered targeted outreach but showed inconsistent effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Findings highlight the need for standardized definitions of the duration of untreated psychosis construct and consideration of more proximal outcomes for a public health intervention. Future campaigns should incorporate digital strategies, stakeholder-informed messaging, and alternative success metrics—such as referral volume and service engagement—to more accurately capture impact and guide implementation efforts in diverse settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of Care in Early Intervention in Psychosis Services: A Multi-Perspective Qualitative Study","authors":"Michelle Rickett,&nbsp;Tom Kingstone,&nbsp;David Shiers,&nbsp;Paul French,&nbsp;Belinda Lennox,&nbsp;Mike Crawford,&nbsp;Ryan Williams,&nbsp;Jonathan Woodward,&nbsp;Carolyn Chew-Graham","doi":"10.1111/eip.70199","DOIUrl":"10.1111/eip.70199","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Early Intervention in Psychosis (EIP) services in England are commissioned to provide up to 3 years' support to people experiencing first episode psychosis, but the optimal duration remains debated. This qualitative study aimed to explore how decisions about EIP duration are made and experienced by multiple stakeholders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Qualitative longitudinal study comprising semi-structured interviews with EIP Service Users (SUs), carers, EIP practitioners, GPs, and mental health service commissioners; follow-up interviews with SUs 6–11 months later. Data were collected between September 2022 and September 2024 and informed by information power. Data were thematically analysed by a multidisciplinary team. Patient and carer involvement and engagement were integral to the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 3-year time limit of contact with EIP teams was thought to work well when SUs felt supported and ready for discharge, but constrained shared decision making when they did not. Some participants described early discharge before 3 years, either as a negotiated decision based on wellness and readiness to move on or as a consequence of poor engagement. Others reported extended care beyond 3 years in response to individual needs or delays in transfer to Community Mental Health Teams (CMHTs). This flexibility in duration varied across teams and trusts. Well-managed, relational care was viewed as key to effective discharge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Flexible, person-centred episodes of care and collaborative discharge planning, supported by effective coordination between EIP, primary care, and CMHTs, are essential to sustaining relational practice and ensuring smoother transitions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomised Feasibility Trial of a Service-Coordinated Exercise Intervention in First-Episode Psychosis: Challenges in Implementation and Outcome Assessment","authors":"Brian W. O'Mahony,&nbsp;Elizabeth Wycherley,&nbsp;Karen Daly,&nbsp;Meghan Cowman,&nbsp;Edgar Lonergan,&nbsp;Abigale Owens,&nbsp;Karen O'Mahony,&nbsp;Brian O'Donoghue,&nbsp;Gerard Clarke,&nbsp;Karen O'Connor","doi":"10.1111/eip.70193","DOIUrl":"10.1111/eip.70193","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Psychosis is increasingly recognised as a systemic disorder characterised by interrelated metabolic dysfunction, chronic low-grade inflammation and sedentary lifestyles. Physical exercise is a promising intervention to address this triad. This pilot study investigated the feasibility and systemic impact of a pragmatic exercise intervention within a first-episode psychosis (FEP) service.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a parallel-group randomised controlled trial involving people with FEP, comparing an 8-week structured aerobic and resistance training programme to Treatment As Usual. We assessed feasibility of the intervention and assessments by measuring recruitment, attendance, retention, and engagement with assessments. Exploratory outcome measures spanned physical fitness, metabolic health, psychometric scales and the Cambridge Neuropsychological Test Automated Battery (CANTAB) cognitive battery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study recruited 40 participants, 19 in the intervention and 21 in the control group. At baseline assessment, 23 of 38 had an elevated BMI and 24 of 35 had elevated cholesterol. Study retention was adequate, with only four participants (10%) lost to follow up. However, the assessment battery was poorly completed, highlighting its infeasibility. Fitness outcomes proved especially challenging, with between 11 and 13 participants (27.5% to 32.5%) completing both baseline and endpoint assessments. Of the 19 people recruited to the intervention arm, 7 (36.8%) attended less than half of the 8 sessions. Outcome data were limited by substantial missingness, with no consistent pattern of benefit or harm observed across domains.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Implementing exercise within real-world FEP services is challenging as indicated by the attrition observed in our study. Future research should individualise exercise prescription and minimise participant assessment burden to mitigate attrition.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who Gets FIp? Understanding Contextual Factors in EIP Provision","authors":"Harriet Ferner,&nbsp;Grace Parkyn,&nbsp;Juliana Onwumere,&nbsp;Miriam Fornells-Ambrojo","doi":"10.1111/eip.70184","DOIUrl":"10.1111/eip.70184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Family Intervention for psychosis (FIp) reduces the risk of relapse and improves functioning. However, implementation barriers exist. Being from racially and/or ethnically minoritised groups and experiencing contextual stressors may impact pathways to care and illness progression and prognosis. We aimed to evaluate the delivery of FIp in routine practice in a diverse and deprived inner-city borough. Patterns of engagement with family work and the relationship between ethnicity, social stressors and engagement were explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Socio-demographic, service user data and verbatim information regarding family intervention in an Early Intervention service over a 12-month period were accessed via electronic patient records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>About 48 (21.7%) out of 221 service users received family intervention over a year. Younger service users were more likely to receive FIp, and ethnicity and gender did not influence referrals. About 96% of service users and/or their carers were experiencing on-going social stressors, of which trauma was associated with a longer duration of treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Service users and carers from diverse backgrounds in Early Intervention services who are experiencing high levels of stressors can engage in FIp. Further research to better understand ways to facilitate access and engagement for families with complex needs is needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Reframing of Psychosis Risk Reduces Social Stigma and Desire for Social Distance Among Adolescents: Moderating Roles of Prodromal Experiences, Sex, and Culture","authors":"Ayat Nasser,&nbsp;Yamit Sol-Nottes,&nbsp;Sujoud Saqer,&nbsp;David Roe,&nbsp;Shlomo Mendlovic,&nbsp;Danny Koren","doi":"10.1111/eip.70223","DOIUrl":"10.1111/eip.70223","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Communication about the at-risk mental state may shape not only clinical understanding but also peer-directed social evaluations. Prior work from our group has shown that positively reframing psychosis-risk feedback reduces perceived emotional harm and clinician stigma. The present study examined whether positive reframing influences adolescents' peer-directed social stigma and desire for social distance toward an at-risk youth, and whether these effects are moderated by adolescents' own distressing prodromal experiences, sex, and cultural background.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred eight community-dwelling adolescents were randomly assigned to view either positively or negatively framed simulated clinical feedback about an at-risk youth. Participants then completed measures of social stigma and desired social distance. Prodromal experiences were assessed prior to the experimental manipulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Across stigma and social distance indices, framing effects were directionally consistent with a priori hypotheses, with positive reframing generally associated with lower stigma-related responses. However, effects were selective in magnitude. Statistically significant effects emerged primarily for willingness for limited social proximity, whereas effects for perceived dangerousness were marginal. Effects on other stigma dimensions were more modest and did not reach conventional levels of statistical significance. Framing effects varied by adolescents' own prodromal experiences, and exploratory analyses suggested additional moderation by sex and cultural background.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Positive reframing may shape adolescents' peer-directed social evaluations of the at-risk state in systematic but selective ways. In particular, it may contribute to a reduction in specific aspects of socially consequential stigma, including perceptions of dangerousness that may contribute to social avoidance. These findings underscore the importance of developmentally and culturally sensitive risk communication and highlight positive framing as a context-dependent strategy with potential social implications beyond the clinical encounter.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Beyond Symptom Reduction: A Call to Integrate Well-Being in Psychosis Research and Early Intervention","authors":"Niall Turner,&nbsp;Elizabeth Thomas,&nbsp;Shu-Ping Chen,&nbsp;Ted Brown","doi":"10.1111/eip.70197","DOIUrl":"10.1111/eip.70197","url":null,"abstract":"","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative Delusions and the Symbolic Body: A Hypothesis on the Co-Occurrence of Psychosis and Anorexia in Adolescence","authors":"Yiğit Özaydın,&nbsp;Buket Canlan Özaydın","doi":"10.1111/eip.70198","DOIUrl":"10.1111/eip.70198","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Early-onset psychosis and anorexia nervosa, while traditionally conceptualised as distinct disorders, demonstrate significant clinical overlap, particularly during adolescence. This period of profound bodily and identity transformation is a critical window where both conditions can emerge, sometimes with complex, overlapping symptoms. However, existing explanatory frameworks often fail to account for this comorbidity, leaving a conceptual gap.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This hypothesis paper proposes that anorexia nervosa, when emerging in the context of adolescent psychosis, functions as a ‘negative delusion’. This is not a pathological belief involving the distortion of the symbolic body, but rather its erasure. Drawing on Lacanian psychoanalytic theory, we argue that this erasure stems from a shared structural failure in symbolic integration common to both psychosis and this form of anorexia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The hypothesis is built upon a Lacanian theoretical framework, utilising concepts such as the mirror stage, the paternal function (Name-of-the-Father), the symbolic body and <i>jouissance</i>. The argument is further elucidated through clinical vignettes that illustrate how self-starvation can serve as a defence against psychotic threats by negating the body's symbolic dimension within social and intersubjective meaning.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Implications</h3>\u0000 \u0000 <p>This framework has significant implications for early diagnosis and intervention. Rather than proposing a new diagnostic subtype, it identifies a structural configuration—anorexia functioning as a ‘negative delusion’—that may be operative in a subset of presentations at the intersection of psychosis and eating restriction. By reframing the comorbidity, this paper provides an original perspective on the intertwined failure of symbolic embodiment and its clinical consequences, outlining future research directions in phenomenology and neurobiology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Relationship Between Inflammatory Biomarkers and Negative Symptoms Subtypes in Individuals at Ultra-High Risk for Psychosis","authors":"Dulari Hakamuwa Lekamlage,&nbsp;Ling Min Amelia Ang,&nbsp;Luba Sominsky,&nbsp;Stephen J. Wood,&nbsp;Patrick D. McGorry,&nbsp;Cristina Mei,&nbsp;G. Paul Amminger,&nbsp;Hok Pan Yuen,&nbsp;Melissa Kerr,&nbsp;Jessica Spark,&nbsp;Nick Wallis,&nbsp;Andrea Polari,&nbsp;Shelley Baird,&nbsp;Kate Buccilli,&nbsp;Sarah-Jane A. Dempsey,&nbsp;Natalie Ferguson,&nbsp;Melanie Formica,&nbsp;Marija Krcmar,&nbsp;Amelia L. Quinn,&nbsp;Yohannes Mebrahtu,&nbsp;Arlan Ruslins,&nbsp;Rebekah Street,&nbsp;Cassandra Wannan,&nbsp;Lisa Dixon,&nbsp;Cameron S. Carter,&nbsp;Rachel Loewy,&nbsp;Tara A. Niendam,&nbsp;Martha Shumway,&nbsp;Barnarby Nelson,&nbsp;David Cotter,&nbsp;Subash Susai,&nbsp;Alison R. Yung","doi":"10.1111/eip.70183","DOIUrl":"10.1111/eip.70183","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Negative symptoms are a core component of schizophrenia, affecting up to 60% of individuals with the disorder. They are categorised into primary negative symptoms (PNS), which are intrinsic to the illness, and secondary negative symptoms, which arise from external factors such as depression or medication side effects. They can also be divided into diminished expression and amotivation/anhedonia subtypes. While inflammation has been implicated in schizophrenia and linked to negative symptoms, little is known about whether inflammatory profiles differ between negative symptom subtypes in individuals at Ultra-High Risk (UHR) for psychosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a secondary analysis of 147 UHR participants from the Staged Treatment in Early Psychosis (STEP) study to examine whether inflammatory markers (Alpha-2-Macroglobulin, IL-6, CRP, sICAM-1, sVCAM-1, and suPAR) differed across negative symptom subgroups, using multinomial and binomial logistic regression models adjusted for age, sex, smoking, and BMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, most inflammatory markers were not significantly associated with negative symptom subgroups. However, higher sICAM-1 levels were asscoiated with lower odds of primary negative symptoms compared with no negative symptoms. Additionally, younger age was associated with increased odds of PNS and amotivation, while smoking was associated with higher odds of secondary negative symptoms compared with no negative symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>These findings suggest that inflammation may not broadly distinguish negative symptom subtypes at the UHR stage, although sICAM-1 may play a role in early illness processes. Limitations include sample ascertainment, potential misclassification of negative symptoms, and the relatively small number of participants with PNS. Future studies with larger samples and longitudinal designs are needed to clarify whether inflammatory changes contribute to the emergence of specific negative symptom subtypes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"20 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}