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Chromatin profiling data indicate regulatory mechanisms for differentiation during development in the acoel Hofstenia miamia. 染色质谱分析数据表明了迈阿密霍夫斯氏菌在发育过程中分化的调控机制。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-15 Epub Date: 2025-05-23 DOI: 10.1242/dev.204799
Paul Bump, Kaitlyn Loubet-Senear, Sarah Arnold, Mansi Srivastava
{"title":"Chromatin profiling data indicate regulatory mechanisms for differentiation during development in the acoel Hofstenia miamia.","authors":"Paul Bump, Kaitlyn Loubet-Senear, Sarah Arnold, Mansi Srivastava","doi":"10.1242/dev.204799","DOIUrl":"10.1242/dev.204799","url":null,"abstract":"<p><p>Chromatin profiling data can generate and corroborate hypotheses for regulatory events that underlie the control of gene expression in biological processes. Here, we have profiled chromatin accessibility to build a catalog of putative regulatory DNA during embryonic development in an acoel. Acoels represent an enigmatic phylum-level lineage of animals, the Xenacoelomorpha, which is placed either as a sister group to all other animals with bilateral symmetry or as an early diverging ambulacrarian, positioned equally well to inform the evolution of developmental mechanisms. We focused on the acoel Hofstenia miamia, a new research organism for studying whole-body regeneration that also enables investigations of development from zygote to hatching. We profiled chromatin landscapes encompassing major morphological events during development, and combined transcription factor-binding analyses with single-cell RNA-sequencing data to provide regulatory linkages in a hypothesized differentiation trajectory for epidermis, as well as a new gene regulatory network associated with the formation of muscle. This work enables comparisons of chromatin state during embryogenesis between acoels and other animals, as well as comparisons of embryogenesis to regeneration.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental dynamics of marmoset prefrontal cortical SST and PV interneuron networks highlight primate-specific features. 前额皮质SST和PV中间神经元网络的发育动力学：来自猴子的见解突出了人类特有的特征。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-15 Epub Date: 2025-05-19 DOI: 10.1242/dev.204254
Nafiseh S Hosseini Fin, Adrian Yip, Jack T Scott, Leon Teo, Jihane Homman-Ludiye, James A Bourne
{"title":"Developmental dynamics of marmoset prefrontal cortical SST and PV interneuron networks highlight primate-specific features.","authors":"Nafiseh S Hosseini Fin, Adrian Yip, Jack T Scott, Leon Teo, Jihane Homman-Ludiye, James A Bourne","doi":"10.1242/dev.204254","DOIUrl":"10.1242/dev.204254","url":null,"abstract":"<p><p>The primate prefrontal cortex (PFC) undergoes protracted postnatal development, crucial for the emergence of cognitive control and executive function. Central to this maturation are inhibitory interneurons (INs), particularly parvalbumin-expressing (PV+) and somatostatin-expressing (SST+) subtypes, which regulate cortical circuit timing and plasticity. While rodent models have provided foundational insights into IN development, the trajectory of postmigratory maturation in primates remains largely uncharted. In this study, we characterized the expression of PV, SST, the chloride transporter KCC2, and the ion channels Kv3.1b and Nav1.1 across six PFC regions (areas 8aD, 8aV, 9, 46, 11 and 47L) in the postnatal marmoset. We report a prolonged maturation of PV+ INs into adolescence, accompanied by progressive upregulation of ion channels that support high-frequency firing. In contrast, SST+ INs show a postnatal decline in density, diverging from rodent developmental patterns. These findings reveal distinct, cell type-specific maturation dynamics in the primate PFC and offer a developmental framework for understanding how inhibitory circuit refinement may underlie vulnerability to neurodevelopmental disorders.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Condensin II complex regulates essential gene expression programs during erythropoiesis. 凝血素II复合体调节红细胞生成过程中必需基因表达程序的表达。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-15 Epub Date: 2025-05-19 DOI: 10.1242/dev.204485
Deanna Abid, Kristin Murphy, Zachary Murphy, Nabil Rahman, Michael Getman, Laurie Steiner
{"title":"The Condensin II complex regulates essential gene expression programs during erythropoiesis.","authors":"Deanna Abid, Kristin Murphy, Zachary Murphy, Nabil Rahman, Michael Getman, Laurie Steiner","doi":"10.1242/dev.204485","DOIUrl":"10.1242/dev.204485","url":null,"abstract":"<p><p>Erythropoiesis is characterized by dramatic changes in gene expression in the context of a cell that is rapidly proliferating while simultaneously condensing its nucleus in anticipation of enucleation. The mechanisms that maintain high level expression of erythroid genes and promote nuclear condensation remain poorly understood. Condensin II is a ring-like complex that promotes mitotic chromatin condensation and has roles in regulating interphase chromatin architecture and gene expression. We interrogated the role of Condensin II in erythropoiesis using an erythroid-specific deletion of the Condensin II subunit, Ncaph2. Ncaph2 loss resulted in severe anemia by embryonic day 12.5 with embryonic lethality. Ncaph2 mutant erythroid cells had dysregulated maturation and disrupted cell cycle progression, but surprisingly NCAPH2 was dispensable for nuclear condensation. Genomic studies revealed that NCAPH2 occupied the promoter of key erythroid and cell cycle genes that were downregulated following Ncaph2 loss. Together, our results demonstrate an essential role for NCAPH2 in the gene expression programs that regulate cell cycle progression and erythroid differentiation, and identify a role for the Condensin II complex in the regulation of a lineage-specific differentiation program.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An interview with Muzlifah Haniffa. Muzlifah Haniffa的采访。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-15 Epub Date: 2025-05-22 DOI: 10.1242/dev.204864
{"title":"An interview with Muzlifah Haniffa.","authors":"","doi":"10.1242/dev.204864","DOIUrl":"https://doi.org/10.1242/dev.204864","url":null,"abstract":"<p><p>Professor Muzlifah 'Muzz' Haniffa is a Wellcome Senior Research Fellow, Head of Cellular Genetics Programme at the Wellcome Sanger Institute in Cambridge, UK; Professor of Dermatology and Immunology at Newcastle University, UK; and a Developmental Biological Network Co-Coordinator for the Human Cell Atlas. Muzz's research spans the fields of immunology, dermatology, developmental biology and genomics. We spoke to Muzz on Teams, following her receipt of the 2025 Tickle Medal from the British Society for Developmental Biology, to learn more about her career and her motivations.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In preprints: retinoic acid degradation and tissue stiffness coordinate axolotl limb regeneration. 预印本：维甲酸降解和组织刚度协调蝾螈肢体再生。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-15 Epub Date: 2025-05-22 DOI: 10.1242/dev.204891
Wouter Masselink
{"title":"In preprints: retinoic acid degradation and tissue stiffness coordinate axolotl limb regeneration.","authors":"Wouter Masselink","doi":"10.1242/dev.204891","DOIUrl":"https://doi.org/10.1242/dev.204891","url":null,"abstract":"","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An interview with Helen Skaer. Helen Skaer的采访。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-15 DOI: 10.1242/dev.204901
{"title":"An interview with Helen Skaer.","authors":"","doi":"10.1242/dev.204901","DOIUrl":"https://doi.org/10.1242/dev.204901","url":null,"abstract":"<p><p>Helen Skaer is an Emeritus Professor of Developmental Biology at the University of Cambridge. Using Drosophila as her model organism, her research has provided insight into the development of the renal system. In recognition of this work, she was awarded the 2025 British Society for Developmental Biology's (BSDB) Waddington Medal, which recognises outstanding individuals who have made major contributions to UK Developmental Biology. Helen gave her award lecture at the Biologists @ 100 conference in Liverpool. The conference was organised to celebrate 100 years of The Company of Biologists, and it incorporated the BSDB's Spring Meeting. The week following her lecture, Helen visited The Company of Biologists office to tell us more about her research and what this award means to her.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Notch signaling in neurogenesis. 神经发生中的Notch信号。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-15 Epub Date: 2025-05-27 DOI: 10.1242/dev.204589
Madison McLaren, Jessica Butts
{"title":"Notch signaling in neurogenesis.","authors":"Madison McLaren, Jessica Butts","doi":"10.1242/dev.204589","DOIUrl":"https://doi.org/10.1242/dev.204589","url":null,"abstract":"<p><p>The Notch signaling pathway plays a crucial role in neurogenesis by regulating cell fate specification. However, its complexity poses challenges in uncovering the mechanisms underlying these decisions. This Review explores the intricacies of the Notch pathway, including its diverse activation mechanisms and the influence of post-translational modifications of Notch receptors and ligands on pathway outcomes. We discuss how Notch signaling regulates embryonic neurogenesis via interactions with proneural genes and with other signaling pathways. We also examine the role of Notch in adult neurogenesis, and the therapeutic potential of leveraging Notch signaling to reprogram glia in the adult brain. Lastly, we highlight emerging technologies that measure Notch dynamics and discuss remaining knowledge gaps. Together, these insights underscore the multifaceted role of Notch signaling and outline key directions for future research.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In preprints: unraveling a new non-canonical role of Cyclin D1 in corticogenesis. 预印本：揭示细胞周期蛋白D1在皮质发生中的一个新的非规范作用。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-01 Epub Date: 2025-04-29 DOI: 10.1242/dev.204829
Noriko Osumi, Takako Kikkawa
{"title":"In preprints: unraveling a new non-canonical role of Cyclin D1 in corticogenesis.","authors":"Noriko Osumi, Takako Kikkawa","doi":"10.1242/dev.204829","DOIUrl":"https://doi.org/10.1242/dev.204829","url":null,"abstract":"","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GATA factor Serpent promotes phagocytosis in non-professional phagocytes during Drosophila oogenesis. GATA因子Serpent在果蝇卵发生过程中促进非专业吞噬细胞的吞噬。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-01 Epub Date: 2025-04-29 DOI: 10.1242/dev.204464
Baosheng Zeng, Haley Grayson, Jianjun Sun
{"title":"GATA factor Serpent promotes phagocytosis in non-professional phagocytes during Drosophila oogenesis.","authors":"Baosheng Zeng, Haley Grayson, Jianjun Sun","doi":"10.1242/dev.204464","DOIUrl":"10.1242/dev.204464","url":null,"abstract":"<p><p>Clearance of dying cells is essential for tissue homeostasis and requires both professional and non-professional phagocytes; however, it is unclear what promotes phagocytosis by non-professional phagocytes. Follicle cells of Drosophila egg chambers function as non-professional phagocytes to clear large germ cell debris in mid and late oogenesis, providing an excellent model for the study of non-professional phagocytes. Here, we demonstrate that GATA factor Serpent (Srp) plays an indispensable role in promoting the phagocytic capacity of follicle cells in both processes. Srp is upregulated in follicle cells of degenerating mid-stage egg chambers, and its knockdown results in incomplete clearance of germ cell debris and premature follicle cell death. In addition, Srp is upregulated in stretch follicle cells and is essential for clearing the nurse cell nuclei in late oogenesis. Genetic analysis reveals that Srp acts downstream of JNK signaling to upregulate the expression of the phagocytic receptor Draper as well as other components in the corpse processing machinery. Our findings highlight the crucial role for Srp in non-professional phagocytes during Drosophila oogenesis, which may also be conserved across species.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles for the nucleolus in development and stem cells. 核仁在发育和干细胞中的新作用。
IF 3.7 2区 生物学
Development Pub Date : 2025-05-01 Epub Date: 2025-05-14 DOI: 10.1242/dev.204696
Bryony J Leeke, Imke Staffhorst, Michelle Percharde
{"title":"Emerging roles for the nucleolus in development and stem cells.","authors":"Bryony J Leeke, Imke Staffhorst, Michelle Percharde","doi":"10.1242/dev.204696","DOIUrl":"10.1242/dev.204696","url":null,"abstract":"<p><p>The nucleolus is a membrane-less subnuclear compartment known for its role in ribosome biogenesis. However, emerging evidence suggests that nucleolar function extends beyond ribosome production and is particularly important during mammalian development. Nucleoli are dynamically reprogrammed post-fertilisation: totipotent early mouse embryos display non-canonical, immature nucleolar precursor bodies, and their remodelling to mature nucleoli is essential for the totipotency-to-pluripotency transition. Mounting evidence also links nucleolar disruption to various pathologies, including embryonic lethality in mouse mutants for nucleolar factors, human developmental disorders and observations of nucleolar changes in disease states. As well as its role in ribogenesis, new findings point to the nucleolus as an essential regulator of genome organisation and heterochromatin formation. This Review summarises the varied roles of nucleoli in development, primarily in mammals, highlighting the importance of nucleolar chromatin for genome regulation, and introduces new techniques for exploring nucleolar function.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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