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Correction: Single-cell organogenesis captures complex breast tissue formation in three dimensions. 更正：单细胞器官发生在三维中捕捉复杂的乳房组织形成。
IF 3.6 2区 生物学
Development Pub Date : 2025-10-01 Epub Date: 2025-10-08 DOI: 10.1242/dev.205264
Gat Rauner, Nicole C Traugh, Colin J Trepicchio, Meadow E Parrish, Kenan Mushayandebvu, Charlotte Kuperwasser
{"title":"Correction: Single-cell organogenesis captures complex breast tissue formation in three dimensions.","authors":"Gat Rauner, Nicole C Traugh, Colin J Trepicchio, Meadow E Parrish, Kenan Mushayandebvu, Charlotte Kuperwasser","doi":"10.1242/dev.205264","DOIUrl":"https://doi.org/10.1242/dev.205264","url":null,"abstract":"","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 20","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic and independent roles for Nodal and FGF in zebrafish cardiac progenitor cell migration and asymmetric heart morphogenesis. Nodal和FGF在斑马鱼CPC迁移和不对称心脏形态发生中的协同和独立作用。
IF 3.6 2区 生物学
Development Pub Date : 2025-10-01 Epub Date: 2025-10-10 DOI: 10.1242/dev.204873
Vanessa Gonzalez, Meagan G Grant, Makoto Suzuki, Briana Christophers, Jessica Rowland Williams, Rebecca D Burdine
{"title":"Synergistic and independent roles for Nodal and FGF in zebrafish cardiac progenitor cell migration and asymmetric heart morphogenesis.","authors":"Vanessa Gonzalez, Meagan G Grant, Makoto Suzuki, Briana Christophers, Jessica Rowland Williams, Rebecca D Burdine","doi":"10.1242/dev.204873","DOIUrl":"10.1242/dev.204873","url":null,"abstract":"<p><p>Asymmetric development of the vertebrate heart is driven by a complex sequence of morphogenetic cell movements, coordinated through precise interpretation of signaling cues by the heart primordia. Here, we show that Nodal signaling functions synergistically with FGF to stimulate the migration of cardiac progenitor cells (CPCs) during cardiac jogging - the first morphological asymmetry observed in zebrafish heart development. While Nodal directs the asymmetric migration of CPCs, we find FGF signaling to be dispensable for this asymmetry, suggesting that FGF plays a permissive rather than instructive role. We further demonstrate that Nodal signaling induces asymmetries in actin cytoskeletal dynamics that correlate with the directional migration of CPCs, whereas FGF does not influence this actin asymmetry. In addition to influencing jogging, FGF and Nodal synergize to ensure proper heart looping. We also provide evidence that FGF contributes to heart looping by promoting the differentiation of the second heart field. Together, these findings offer insight into how the spatiotemporal dynamics of signaling pathways regulate the cellular behaviors driving organ morphogenesis.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The people behind the papers - Ksenia Kudryashova and Olga Kyrchanova. 这些报纸背后的人——克谢尼娅·库德里亚绍娃和奥尔加·基尔查诺娃。
IF 3.6 2区 生物学
Development Pub Date : 2025-10-01 Epub Date: 2025-10-13 DOI: 10.1242/dev.205281
{"title":"The people behind the papers - Ksenia Kudryashova and Olga Kyrchanova.","authors":"","doi":"10.1242/dev.205281","DOIUrl":"https://doi.org/10.1242/dev.205281","url":null,"abstract":"<p><p>Hox genes, such as Drosophila Abdominal-B (Abd-B), regulate the morphogenesis of specific anatomical regions along the anteroposterior axis in vertebrates. In their work, Olga Kyrchanova and colleagues find that specific initiator sequences control the activity states of the regulatory domains that direct Abd-B expression in the designated segments during Drosophila development. To know more about their work, we spoke to Ksenia Kudryashova and the corresponding author, Olga Kyrchanova, Group Leader, Institute of Gene Biology, Russian Academy of Sciences, Russia.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 19","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The people behind the papers - Isidora Rovic and Andrea Jurisicova. 这些报纸背后的人——伊西多拉·罗维奇和安德里亚·法理科娃。
IF 3.6 2区 生物学
Development Pub Date : 2025-10-01 Epub Date: 2025-10-06 DOI: 10.1242/dev.205218
{"title":"The people behind the papers - Isidora Rovic and Andrea Jurisicova.","authors":"","doi":"10.1242/dev.205218","DOIUrl":"https://doi.org/10.1242/dev.205218","url":null,"abstract":"<p><p>Proper development of the placental architecture is essential for facilitating nutrient exchange to the fetus. In a new study, Rovic et al. find that disrupted sphingolipid metabolism leads to an aberrant placental phenotype and reduced fetal growth. To learn more about this work, we spoke to first author Isidora Rovic and corresponding author Andrea Jurisicova, Associate Professor at the Lunenfeld-Tanenbaum Research Institute, Toronto, Canada.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 19","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An interview with Azim Surani. 对Azim Surani的采访。
IF 3.6 2区 生物学
Development Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI: 10.1242/dev.205182
Ashley Moffett, Geraldine M Jowett
{"title":"An interview with Azim Surani.","authors":"Ashley Moffett, Geraldine M Jowett","doi":"10.1242/dev.205182","DOIUrl":"https://doi.org/10.1242/dev.205182","url":null,"abstract":"<p><p>Professor Azim Surani is the Director of Epigenomics and Germline Imprinting at the Gurdon Institute in Cambridge, UK. He is this year's recipient of both the prestigious Kyoto Prize and the Paul Ehrlich and Ludwig Darmstaedter prize, recognising his contributions to the discovery of genomic imprinting, the foundation of the modern field of epigenetics. In honour of the 40th anniversary of this seminal work, a Festschrift meeting was held at King's College, Cambridge, UK, titled 'Imprinting, Germlines, and how we got here'. In addition to the meeting notes, we interviewed Professor Surani about his non-traditional and inspirational route into academia.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 19","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differentially expressed fusogens specify myocyte states to drive myogenesis. 差异表达的融合原指定肌细胞状态来驱动肌生成。
IF 3.6 2区 生物学
Development Pub Date : 2025-10-01 Epub Date: 2025-09-30 DOI: 10.1242/dev.204771
Sarah Nahlé, Awais Javed, Loïck Joumier, Yacine Kherdjemil, Julie Sitolle, Konstantin Khetchoumian, Yash Parekh, Wojciech Krezel, Mohan Malleshaiah, Fabien Le Grand, Michel Cayouette, Jean-François Côté
{"title":"Differentially expressed fusogens specify myocyte states to drive myogenesis.","authors":"Sarah Nahlé, Awais Javed, Loïck Joumier, Yacine Kherdjemil, Julie Sitolle, Konstantin Khetchoumian, Yash Parekh, Wojciech Krezel, Mohan Malleshaiah, Fabien Le Grand, Michel Cayouette, Jean-François Côté","doi":"10.1242/dev.204771","DOIUrl":"10.1242/dev.204771","url":null,"abstract":"<p><p>During myogenesis, myocyte fusion leads to the formation of multinucleated muscle fibers, but how exactly this process is initiated remains poorly understood. Here, we performed single-cell RNA-sequencing on mouse somites from E9.5-E11.5 embryos, revealing multiple differentiation states during primary myogenesis. Among these, we identified two unexpected myocyte populations: one expressing both myomaker (Mymk) and myomixer (Mymx) (termed Mc1) and another expressing only Mymk (termed Mc2). Fluorescence in situ hybridization demonstrated that both populations are mononucleated and co-exist within the same somites, with only Mc1 persisting during secondary myogenesis. Lineage tracing using Mymx:Cre; RosaTdT mice demonstrated that the Mc2 cells arise from the Mc1. Mechanistically, we show that Mef2 and Rxr factors positively and negatively regulate Mymx expression, respectively. Additionally, RXRG interacts with MYOD1 and MYOG, modulating their transcriptional activity in luciferase assays. Collectively, our findings uncover two populations among the myocytes that drive primary and secondary fiber formation, challenging the traditional view of vertebrate muscle precursor homogeneity.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Speaking science in a fractured world: making truth land when facts alone cannot. 在一个支离破碎的世界里讲科学：当事实本身无法实现时，让真理落地。
IF 3.6 2区 生物学
Development Pub Date : 2025-10-01 Epub Date: 2025-09-30 DOI: 10.1242/dev.205206
Rebecca M Calisi-Rodríguez, Kevin Alicea-Torres, Jamy C Peng, Nicole A Theodosiou, Crystal D Rogers
{"title":"Speaking science in a fractured world: making truth land when facts alone cannot.","authors":"Rebecca M Calisi-Rodríguez, Kevin Alicea-Torres, Jamy C Peng, Nicole A Theodosiou, Crystal D Rogers","doi":"10.1242/dev.205206","DOIUrl":"https://doi.org/10.1242/dev.205206","url":null,"abstract":"<p><p>Scientific misinformation is a defining challenge of our time. As public trust in science declines and falsehoods spread faster than facts, the scientific community must rethink its role in public discourse. This Perspective draws on a scenario-based workshop entitled 'Truth Matters: Strengthening Science Communication to Counter Misinformation', conducted at the 20th International Congress of Developmental Biology in San Juan, Puerto Rico (June 2025), designed to train scientists in emotionally attuned, culturally responsive and effective communication strategies. At the joint conference with the International Society of Developmental Biology, the Society for Developmental Biology and the Latin American Society for Developmental Biology, we explored why misinformation persists, how identity and social belonging shape belief, and why empathy, not just evidence, is essential to making truth resonate. Here, we offer a call to action along with practical tools: to make scientific knowledge meaningful, we must communicate effectively and ensure it resonates with the broader public.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 19","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The people behind the papers - Gabrielle Audu and Archana Kumari. 这些报纸背后的人——加布里埃尔·奥杜和阿卡娜·库玛丽。
IF 3.6 2区 生物学
Development Pub Date : 2025-10-01 Epub Date: 2025-10-10 DOI: 10.1242/dev.205249
{"title":"The people behind the papers - Gabrielle Audu and Archana Kumari.","authors":"","doi":"10.1242/dev.205249","DOIUrl":"https://doi.org/10.1242/dev.205249","url":null,"abstract":"<p><p>Embryonic development of the tongue is essential for neonatal survival, but the molecular machinery orchestrating this is still unclear. In their latest study, Kumari and colleagues characterise Gas1 expression across the embryonic tongue and demonstrate the necessity of non-muscle Gas1 expression for muscle maturation, revealing the importance of cross-compartmental signals in tongue development. To find out more about the researchers behind the paper and how this story unfolded, we spoke to first author Gabrielle Audu and corresponding author Archana Kumari, Assistant Professor at the Rowan-Virtua School of Osteopathic Medicine in New Jersey, USA.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 19","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cadherin-Integrin-ECM code for presomitic mesoderm fluidity. 一个钙粘蛋白-整合素- ecm编码，用于体前中胚层的流动性。
IF 3.6 2区 生物学
Development Pub Date : 2025-09-25 DOI: 10.1242/dev.204874
Miriam A Genuth, Dörthe Jülich, Andrew T Ton, Sarah J Smith, Emilie Guillon, Mark D Shattuck, Corey S O'Hern, Scott A Holley
{"title":"A Cadherin-Integrin-ECM code for presomitic mesoderm fluidity.","authors":"Miriam A Genuth, Dörthe Jülich, Andrew T Ton, Sarah J Smith, Emilie Guillon, Mark D Shattuck, Corey S O'Hern, Scott A Holley","doi":"10.1242/dev.204874","DOIUrl":"https://doi.org/10.1242/dev.204874","url":null,"abstract":"<p><p>Animal tissues exist within a continuum of fluid to solid states, and transitions between states are important for embryonic development, wound healing and cancer metastasis. Fluid to solid transitions are governed by the ratio of adhesive energy to kinetic energy. Here, we find that presomitic mesoderm solidification is driven by an intrinsic decline in cell speed along with an increase in adhesion mediated by Cadherin 2 in parallel with Fibronectin and its receptor Integrin α5. A computational model of cell-cell adhesion in the central tissue mesenchyme and cell-ECM adhesion on the tissue surface explains the observed phenotypes. Further, we identify negative feedback within the ECM as Fibronectin supports the formation of a separate layer of Fibrillin 2b matrix that inhibits solidification. These data reveal a tissue fluidity code in which solidification is promoted by Cadherin in parallel with Integrin α5 and Fibronectin, whereas negative feedback through Fibrillin 2b promotes fluidization.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Drosophila Dpp/BMP signaling directly regulates dpp transcription for optimal ligand dosage. 果蝇Dpp/BMP信号直接调节Dpp转录以获得最佳配体剂量。
IF 3.6 2区 生物学
Development Pub Date : 2025-09-16 DOI: 10.1242/dev.204488
Yan Zhang, Ying Feng, Xiaolei Ye, Yi Lin, Ling Zeng, Yuting Luo, Lin Zhou, Chenghao Shen, Weiqi Hu, Dong Yan, Xinhua Lin
{"title":"The Drosophila Dpp/BMP signaling directly regulates dpp transcription for optimal ligand dosage.","authors":"Yan Zhang, Ying Feng, Xiaolei Ye, Yi Lin, Ling Zeng, Yuting Luo, Lin Zhou, Chenghao Shen, Weiqi Hu, Dong Yan, Xinhua Lin","doi":"10.1242/dev.204488","DOIUrl":"https://doi.org/10.1242/dev.204488","url":null,"abstract":"<p><p>Precise control of morphogen dosage in the source is essential for establishing developmental patterning and maintaining signaling stability. Here, we demonstrate that in Drosophila wing imaginal discs, the Dpp/BMP signaling modulates its ligand Dpp (Decapentaplegic) expression through direct transcriptional auto-regulation. The results show that reduction of Dpp/BMP signaling upregulates dpp transcription, whereas enhanced signaling represses it. This transcriptional negative feedback mechanism primarily depends on the BMP-Silencer-Element (BMP-SE) complex binding to the BMP-SE motifs at the dpp downstream distal cis-regulatory region. We validated this mechanism through BMP-SE complex interference and BMP-SE motif disruption assays. Our findings extend the morphogen source-sink theory by uncovering that the Dpp/BMP signaling pathway dynamically balances Dpp dosage via transcriptional auto-modulation, thereby ensuring optimal ligand production for signaling homeostasis.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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