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Current Opinion in Immunology最新文献

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Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferons I 型和 III 型干扰素对胃肠道中宿主/病原体相互作用的调节。
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102425
Gowri Kalugotla , Vivien Marmerstein , Megan T Baldridge
{"title":"Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferons","authors":"Gowri Kalugotla ,&nbsp;Vivien Marmerstein ,&nbsp;Megan T Baldridge","doi":"10.1016/j.coi.2024.102425","DOIUrl":"10.1016/j.coi.2024.102425","url":null,"abstract":"<div><p>Interferons (IFNs) are an integral component of the host innate immune response during viral infection. Recent advances in the study of type I and III IFNs suggest that though both types counteract viral infection, type III IFNs act predominantly at epithelial barrier sites, while type I IFNs drive systemic responses. The dynamics and specific roles of type I versus III IFNs have been studied in the context of infection by a variety of enteric pathogens, including reovirus, rotavirus, norovirus, astrovirus, and intestinal severe acute respiratory syndrome coronavirus 2, revealing shared patterns of regulatory influence. An important role for the gut microbiota, including the virome, in regulating homeostasis and priming of intestinal IFN responses has also recently emerged.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102425"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional modulation of antitumor immunity 营养调节抗肿瘤免疫力
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102422
Mingeum Jeong , Nicholas Collins
{"title":"Nutritional modulation of antitumor immunity","authors":"Mingeum Jeong ,&nbsp;Nicholas Collins","doi":"10.1016/j.coi.2024.102422","DOIUrl":"https://doi.org/10.1016/j.coi.2024.102422","url":null,"abstract":"<div><p>The composition and quantity of food we eat have a drastic impact on the development and function of immune responses. In this review, we highlight defined nutritional interventions shown to enhance antitumor immunity, including ketogenic, low-protein, high-fructose, and high-fiber diets, as well as dietary restriction. We propose that incorporating such nutritional interventions into immunotherapy protocols has the potential to increase therapeutic responsiveness and long-term tumor control in patients with cancer.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102422"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of type I and type III interferon induction in response to pathogen sensing 病原体感应对 I 型和 III 型干扰素诱导的调控。
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102424
Hossam Gewaid, Andrew G Bowie
{"title":"Regulation of type I and type III interferon induction in response to pathogen sensing","authors":"Hossam Gewaid,&nbsp;Andrew G Bowie","doi":"10.1016/j.coi.2024.102424","DOIUrl":"10.1016/j.coi.2024.102424","url":null,"abstract":"<div><p>Type I and III interferons (IFN-I and IFN-III) have a central role in the early antimicrobial response against invading pathogens. Induction of IFN-Is and IFN-IIIs arises due to the sensing by pattern recognition receptors of pathogen-associated molecular patterns (from micro-organisms) or of damage-associated molecular patterns (DAMPs; produced by host cells). Here, we review recent developments on how IFN-I and IFN-III expression is stimulated by different pathogens and how the signalling pathways leading to IFN induction are tightly regulated. We also summarise the growing knowledge of the sensing pathways that lead to IFN-I and IFN-III induction in response to severe acute respiratory syndrome coronavirus 2.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102424"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000141/pdfft?md5=d66cd940f767517b6f77bdeb9bd793c2&pid=1-s2.0-S0952791524000141-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The antiviral state of the cell: lessons from SARS-CoV-2 细胞的抗病毒状态：SARS-CoV-2 的启示
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102426
Jérémie Le Pen, Charles M Rice
{"title":"The antiviral state of the cell: lessons from SARS-CoV-2","authors":"Jérémie Le Pen,&nbsp;Charles M Rice","doi":"10.1016/j.coi.2024.102426","DOIUrl":"https://doi.org/10.1016/j.coi.2024.102426","url":null,"abstract":"<div><p>In this review, we provide an overview of the intricate host–virus interactions that have emerged from the study of SARS-CoV-2 infection. We focus on the antiviral mechanisms of interferon-stimulated genes (ISGs) and their modulation of viral entry, replication, and release. We explore the role of a selection ISGs, including <em>BST2</em>, <em>CD74</em>, <em>CH25H</em>, <em>DAXX</em>, <em>IFI6</em>, <em>IFITM1–3</em>, <em>LY6E</em>, <em>NCOA7</em>, <em>PLSCR1</em>, <em>OAS1,</em> RTP4, and <em>ZC3HAV1</em>/<em>ZAP</em>, in restricting SARS-CoV-2 infection and discuss the virus’s countermeasures. By synthesizing the latest research on SARS-CoV-2 and host antiviral responses, this review aims to provide a deeper understanding of the antiviral state of the cell under SARS-CoV-2 and other viral infections, offering insights for the development of novel antiviral strategies and therapeutics.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102426"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141090636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping and modelling human B cell maturation in the germinal centre 人类 B 细胞在生殖中心的成熟图谱和模型。
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102428
Annelise Quig , Viacheslav Kriachkov , Hamish King
{"title":"Mapping and modelling human B cell maturation in the germinal centre","authors":"Annelise Quig ,&nbsp;Viacheslav Kriachkov ,&nbsp;Hamish King","doi":"10.1016/j.coi.2024.102428","DOIUrl":"10.1016/j.coi.2024.102428","url":null,"abstract":"<div><p>The maturation of B cells within the germinal centre (GC) is necessary for antigen-specific immune responses and memory. Dysfunction in the GC can lead to immunodeficiencies, autoimmune diseases, or lymphomas. Here we describe how recent advances in single-cell and spatial genomics have enabled new discoveries about the diversity of human GC B cell states. However, with the advent of these hypothesis-generating technologies, the field should now transition towards testing bioinformatic predictions using experimental models of the human GC. We review available experimental culture systems for modelling human B cell responses and discuss the potential limitations of different methods in capturing <em>bona fide</em> GC B cell states. Together, the combination of cell atlas–based mapping with experimental modelling of lymphoid tissues holds great promise to better understand the maturation of human B cells in the GC response and generate new insights into human immune health and disease.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102428"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000189/pdfft?md5=3f0997409587ae76d78696a7d694c29d&pid=1-s2.0-S0952791524000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Getting the house in order: Cell-intrinsic mechanisms of innate immune defence 编辑综述：整理内务：先天性免疫防御的细胞内在机制
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-02-01 DOI: 10.1016/j.coi.2024.102411
Elizabeth L Hartland, Sunny Shin
{"title":"Editorial overview: Getting the house in order: Cell-intrinsic mechanisms of innate immune defence","authors":"Elizabeth L Hartland,&nbsp;Sunny Shin","doi":"10.1016/j.coi.2024.102411","DOIUrl":"https://doi.org/10.1016/j.coi.2024.102411","url":null,"abstract":"","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"86 ","pages":"Article 102411"},"PeriodicalIF":7.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140000359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure–function of type I and III interferons I 型和 III 型干扰素的结构与功能
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-02-01 DOI: 10.1016/j.coi.2024.102413
Nicole A de Weerd , Aleksandra K Kurowska , Juan L Mendoza , Gideon Schreiber
{"title":"Structure–function of type I and III interferons","authors":"Nicole A de Weerd ,&nbsp;Aleksandra K Kurowska ,&nbsp;Juan L Mendoza ,&nbsp;Gideon Schreiber","doi":"10.1016/j.coi.2024.102413","DOIUrl":"https://doi.org/10.1016/j.coi.2024.102413","url":null,"abstract":"<div><p>Type I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross phosphorylate each other, the associated receptor chains, and signal transducer and activator of transcriptions, with the latter activating IFN-stimulated genes. While there are clear similarities in the biological responses toward type I and type III IFNs, differences have been found in their tropism, tuning of activity, and induction of the immune response. Here, we focus on how these differences are embedded in the structure/function relations of these two systems in light of the recent progress that provides in-depth information on the structural assembly of these receptors and their functional implications and how these differ between the mouse and human systems.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"86 ","pages":"Article 102413"},"PeriodicalIF":7.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis I 型和 III 型干扰素在胃肠道稳态和发病机制中的作用
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-02-01 DOI: 10.1016/j.coi.2024.102412
Austin P Wright, Timothy J Nice
{"title":"Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis","authors":"Austin P Wright,&nbsp;Timothy J Nice","doi":"10.1016/j.coi.2024.102412","DOIUrl":"https://doi.org/10.1016/j.coi.2024.102412","url":null,"abstract":"<div><p>Interferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN’s roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct, with a particularly prominent role for type-III IFN in antiviral protection of the intestinal epithelium. Current studies continue to deepen our understanding of the type- and tissue-specific roles of IFN. This review highlights these advances within the GI tract, including discovery of protective roles for type-III IFNs against nonviral GI pathogens, and discovery of an antiviral homeostatic type-III IFN response within the intestinal epithelium.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"86 ","pages":"Article 102412"},"PeriodicalIF":7.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential induction of T-cell tolerance by tumour fibroblast subsets 肿瘤成纤维细胞亚群对 T 细胞耐受性的不同诱导作用
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-01-18 DOI: 10.1016/j.coi.2023.102410
Zoe MX Chua , Fitsumbhran Tajebe , Mohammed Abuwarwar , Anne L Fletcher
{"title":"Differential induction of T-cell tolerance by tumour fibroblast subsets","authors":"Zoe MX Chua ,&nbsp;Fitsumbhran Tajebe ,&nbsp;Mohammed Abuwarwar ,&nbsp;Anne L Fletcher","doi":"10.1016/j.coi.2023.102410","DOIUrl":"https://doi.org/10.1016/j.coi.2023.102410","url":null,"abstract":"<div><p><span><span>T-cell immunotherapy is now a first-line cancer treatment for </span>metastatic melanoma and some lung cancer subtypes, which is a welcome clinical success. However, the response rates observed in these diseases are not yet replicated across other prominent </span>solid tumour<span><span> types, particularly stromal-rich subtypes with a complex microenvironment that suppresses infiltrating T cells. Cancer-associated fibroblasts (CAFs) are one of the most abundant and pro-pathogenic players in the tumour microenvironment, promoting tumour neogenesis, persistence and </span>metastasis. Accumulating evidence is clear that CAFs subdue anti-tumour T-cell immunity and interfere with immunotherapy. CAFs can be grouped into different subtypes that operate synergistically to suppress T-cell function, including myofibroblastic CAFs, inflammatory CAFs and antigen-presenting CAFs, among other nomenclatures. Here, we review the mechanisms used by CAFs to induce T- cell tolerance and how these functions are likely to affect immunotherapy outcomes.</span></p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"86 ","pages":"Article 102410"},"PeriodicalIF":7.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139488086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment 肿瘤微环境中肿瘤坏死因子通过 TNF 受体 1 和 TNF 受体 2 发出信号的分子机制。
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2023-12-27 DOI: 10.1016/j.coi.2023.102409
Louisa F Alim , Colm Keane , Fernando Souza-Fonseca-Guimaraes
{"title":"Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment","authors":"Louisa F Alim ,&nbsp;Colm Keane ,&nbsp;Fernando Souza-Fonseca-Guimaraes","doi":"10.1016/j.coi.2023.102409","DOIUrl":"10.1016/j.coi.2023.102409","url":null,"abstract":"<div><p>Tumour necrosis factor (TNF) is a primary mediator of inflammatory processes by facilitating cell death, immune cell activation and triggering of inflammation. In the cancer context, research has revealed TNF as a multifaceted cytokine that can be both pro- or anti-tumorigenic depending on what context is observed. We explore the plethora of ways that TNF and its receptors manipulate the functional and phenotypic characteristics in the tumour microenvironment (TME) on both tumour cells and immune cells, promoting either tumour elimination or progression. Here, we discuss the latest cutting-edge TNF-focused biologics currently in clinical translation that modifies the TME to derive greater immune responses and therapeutic outcomes, and further give perspectives on the future of targeting TNF in the context of cancer by emerging technological approaches.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"86 ","pages":"Article 102409"},"PeriodicalIF":7.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791523001280/pdfft?md5=f3a0c85ff3d1c0b3d585d25a6c7f06f1&pid=1-s2.0-S0952791523001280-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139059333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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