环境中的调节性 T 细胞：解读与组织环境的动态相互作用

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-08-01 DOI:10.1016/j.coi.2024.102453

Xiao Huang, Alexander Y Rudensky

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引用次数: 0

摘要

针对病原体的保护性免疫与预防自身免疫之间的微妙平衡需要调节性 CD4+ T（Treg）细胞的精细生成和功能。在此，我们回顾了最近在理解一系列复杂线索方面取得的进展，这些线索汇聚到淋巴和非淋巴器官以及肿瘤中的Treg细胞，以及这些线索如何调节Treg的功能。我们强调了 Treg 细胞的多功能性，它们能够动态地适应局部微环境并发挥广泛的功能，这些功能超出了 Treg 细胞在缓和免疫反应相关炎症的不良影响和抑制自身免疫方面的典型作用。

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Regulatory T cells in the context: deciphering the dynamic interplay with the tissue environment

The delicate balance between protective immunity against pathogens and the prevention of autoimmunity requires finely tuned generation and function of regulatory CD4⁺ T (Treg) cells. Here, we review recent progress in the understanding of a complex set of cues, which converge on Treg cells in lymphoid and nonlymphoid organs and in tumors and how these cues modulate Treg functions. We highlight the versatility of Treg cells underlying their ability to dynamically adapt to local microenvironments and perform a wide range of functions that extend beyond the archetypal role of Treg cells in moderating adverse effects of immune response-associated inflammation and in suppressing autoimmunity.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.