Current Opinion in Immunology最新文献

Metabolomic signaling in sarcoidosis pathogenesis 结节病发病机制中的代谢组学信号

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-10 DOI: 10.1016/j.coi.2025.102715

Humphrey Lotana, Tristan White, Wonder Puryear Drake

引用次数: 0

Optimizing patient-reported outcomes for sarcoidosis 优化结节病患者报告的结果

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.coi.2025.102720

Vivienne Kahlmann , Donald Simon , Marlies S Wijsenbeek , Catharina C Moor

引用次数: 0

Rheumatoid arthritis: revisiting pathogenesis for prevention, stratification, and repair 类风湿关节炎：重新探讨预防、分层和修复的发病机制。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-02-11 DOI: 10.1016/j.coi.2026.102735

Frédéric Coutant , Pierre Miossec

{"title":"Rheumatoid arthritis: revisiting pathogenesis for prevention, stratification, and repair","authors":"Frédéric Coutant , Pierre Miossec","doi":"10.1016/j.coi.2026.102735","DOIUrl":"10.1016/j.coi.2026.102735","url":null,"abstract":"<div><div>The clinical heterogeneity of rheumatoid arthritis (RA) reflects a series of dynamic immunological imbalances rather than a single dominant mechanism. In this review, we propose that RA progression is best understood as a sequence of three functional balances. The first contrasts pathogenic and protective autoantibody functions, determining whether systemic autoimmunity remains subclinical or evolves into inflammatory disease. The second opposes cytokine-driven inflammation to autoantibody-mediated cytokine regulation, including neutralization or facilitation, thereby shaping the intensity and therapeutic responsiveness of synovitis. The third and ultimate balance opposes stromal persistence to tissue repair and dictates structural outcome, even when inflammation appears clinically controlled. By reinterpreting key immunological mechanisms through this framework, we clarify why clinical remission may not prevent joint damage, why functional properties of autoantibodies matter beyond antigen specificity, and why tissue context must be integrated into therapeutic strategies. This tripartite model repositions RA as a disease of evolving equilibria, with implications for prevention, precision stratification, and the restoration of immune–stromal homeostasis.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102735"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell death pathways in graft-versus-host disease 移植物抗宿主病中的细胞死亡途径

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI: 10.1016/j.coi.2026.102740

Allison Pugel , Xue-Zhong Yu , Yongxia Wu

引用次数: 0

Multiple sclerosis: a disease or a syndrome? 多发性硬化：一种疾病还是一种综合症？

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-02-14 DOI: 10.1016/j.coi.2026.102736

Ayse Altintas , Eser Bulus

引用次数: 0

Patterns and trends in sarcoidosis: an epidemiological perspective 结节病的模式和趋势：流行病学观点

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.coi.2025.102723

Ogugua N Obi , Elizabeth V Arkema , Yvette C Cozier

引用次数: 0

A comprehensive study on the effect of alglucosidase alpha and immunomodulation on survival, motor and cardiac outcome, creatine kinase and antibody titers in classic infantile Pompe disease: the Monza experience 对典型庞贝病婴儿生存、运动和心脏预后、肌酸激酶和抗体滴度影响的糖苷酶α和免疫调节的综合研究：蒙扎经验

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-22 DOI: 10.1016/j.coi.2026.102725

Martha C Faraguna , Viola Crescitelli , Sonia Bonanomi , Gaia A Kullmann , Maria L Boffi , Roberta Pretese , Giulia Risca , Lucia M Tedesco , Katia Pozzi , Marta Serafini , Johanna MP van den Hout , Ans T van der Ploeg , Adriana C Balduzzi , Serena Gasperini

{"title":"A comprehensive study on the effect of alglucosidase alpha and immunomodulation on survival, motor and cardiac outcome, creatine kinase and antibody titers in classic infantile Pompe disease: the Monza experience","authors":"Martha C Faraguna , Viola Crescitelli , Sonia Bonanomi , Gaia A Kullmann , Maria L Boffi , Roberta Pretese , Giulia Risca , Lucia M Tedesco , Katia Pozzi , Marta Serafini , Johanna MP van den Hout , Ans T van der Ploeg , Adriana C Balduzzi , Serena Gasperini","doi":"10.1016/j.coi.2026.102725","DOIUrl":"10.1016/j.coi.2026.102725","url":null,"abstract":"<div><div>We report on 13 classic infantile Pompe patients, including four cross-reactive immunological material negative (31%), treated with alglucosidase alpha (rhGAA) at Fondazione IRCCS San Gerardo, Monza, between 2003 and 2024. Median age at rhGAA initiation was 3.3 months, with nine patients (69%) starting on doses > 20 mg/kg/every other week. With a median follow-up of 6.9 years, the 5- and 10-year survival was 92%. Four patients died, and three became ventilator-dependent. Hypertrophic cardiomyopathy normalized in all patients, though electrocardiogram abnormalities persisted in 36%. Walking was achieved by 10 (77%). Ten patients received immune tolerance induction (77%, five primary, two secondary, three both), and seven received long-term sirolimus. Nine developed anti-rhGAA, of whom five (38%) had high-sustained antibody titers (HSAT). All had elevated creatine kinase at diagnosis; creatine phosphokinase normalized over time in four patients on 40 mg/kg/week since start without HSAT. This study offers real-world insight into managing classic infantile Pompe disease and compares the cohort’s outcome to international experiences.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102725"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of stromal cell immunobiology in understanding and managing Sjögren’s disease 基质细胞免疫生物学在理解和管理Sjögren疾病中的作用

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.coi.2025.102714

Valeria Manfrè , Luca Quartuccio , Sara S McCoy

{"title":"The role of stromal cell immunobiology in understanding and managing Sjögren’s disease","authors":"Valeria Manfrè , Luca Quartuccio , Sara S McCoy","doi":"10.1016/j.coi.2025.102714","DOIUrl":"10.1016/j.coi.2025.102714","url":null,"abstract":"<div><div>Sjögren’s disease (SjD) is a systemic, heterogeneous autoimmune disorder, clinically dominated by dryness symptoms resulting from inflammatory infiltration of exocrine glands. To date, no validated and resolutive therapeutic strategies are available. Stromal cells are increasingly recognized as critical players in SjD pathogenesis. Distinct fibroblast subsets, termed ‘immunofibroblasts’, may contribute to tertiary lymphoid structure development and fibrotic tissue remodeling, while sustaining local immune infiltration, thereby representing potential treatment targets. In parallel, mesenchymal stromal cells (MSCs) may represent a therapeutic tool, due to their immunomodulatory and trophic properties demonstrated <em>in vitro</em> and in animal models. These favorable results have prompted early-phase clinical trials using MSCs, which demonstrated preliminary safety and efficacy on salivary and ocular outcomes. Nonetheless, methodological limitations require cautious interpretation of available data, and further investigation of clinical applications is warranted. Stromal cell biology thus offers both mechanistic insight and therapeutic promise, warranting further investigation in rigorously designed randomized controlled trials.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102714"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elderly-onset rheumatoid arthritis as a distinct entity: mechanisms, manifestations, and treatment 老年发作的类风湿性关节炎作为一个独特的实体：机制，表现和治疗

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-13 DOI: 10.1016/j.coi.2025.102721

Shiliang Ma , Xinran Wu , Xuan Zhang, Ketian Li

{"title":"Elderly-onset rheumatoid arthritis as a distinct entity: mechanisms, manifestations, and treatment","authors":"Shiliang Ma , Xinran Wu , Xuan Zhang, Ketian Li","doi":"10.1016/j.coi.2025.102721","DOIUrl":"10.1016/j.coi.2025.102721","url":null,"abstract":"<div><div>Elderly-onset rheumatoid arthritis (EORA), defined as onset at ≥60 years, is a clinically distinct and increasingly prevalent subset of rheumatoid arthritis (RA). This review synthesizes evidence that EORA is not merely late-onset RA but a pathogenically unique entity, driven by immune aging, inflammaging, and other mechanisms like defective immunosuppressive system, age-related somatic mosaicism, and dysbiosis. It frequently presents with heterogeneous features such as acute large-joint involvement and polymyalgia symptoms, often leading to diagnostic delays. Despite similar initial activity to young-onset RA, EORA follows a more aggressive course with severe joint destruction and significant comorbidities. Treatment with conventional disease-modifying antirheumatic drugs is complicated by polypharmacy and high adverse event risks, often leading to undertreatment. A shift to geriatric-centered care, with comprehensive assessment and tailored treat-to-target strategies, is therefore imperative. This review underscores the need to recognize EORA's unique pathophysiology and clinical profile to improve diagnosis, therapy, and outcomes for this growing population.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102721"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the pandemic potential of Zika virus in a changing global landscape 在不断变化的全球环境中评估寨卡病毒大流行的可能性

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.coi.2026.102724

Soumba Traore , Sophia C Chima , Kristina M Adams Waldorf , Jennifer Tisoncik-Go , Megan A O’Connor

{"title":"Evaluating the pandemic potential of Zika virus in a changing global landscape","authors":"Soumba Traore , Sophia C Chima , Kristina M Adams Waldorf , Jennifer Tisoncik-Go , Megan A O’Connor","doi":"10.1016/j.coi.2026.102724","DOIUrl":"10.1016/j.coi.2026.102724","url":null,"abstract":"<div><div>As of 2024, the World Health Organization declared the Zika virus (ZIKV), an emerging flavivirus, as a high-priority pathogen with the potential to cause future Public Health Emergencies of International Concern. Although the last major outbreak of ZIKV occurred in 2015–2016, ongoing ‘silent’ transmission in the Americas, Asia, and Africa indicates that ZIKV remains a global threat. Recent research highlights possible reintroduction of ZIKV into sylvatic reservoirs, identifies mosquito immune cells essential for viral dissemination, uncovers viral protein mutations that affect neurovirulence, and examines how cross-reactive flavivirus immunity shapes disease outcomes. Despite these advances, major challenges persist in surveillance, diagnosis, and the development of effective vaccines or therapeutics. This review synthesizes current knowledge on the global burden of ZIKV, transmission dynamics, and adaptive evolution, emphasizing factors that drive its epidemic potential. Continued research and a One Health approach are crucial to improve understanding of ZIKV biology and strengthen preparedness for future outbreaks.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102724"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0