Current Opinion in Immunology最新文献

Mechanobiology of neutrophil inflammasome signaling in psoriasis 银屑病中性粒细胞炎性体信号传导的机制生物学研究。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-10-17 DOI: 10.1016/j.coi.2025.102680

Yoshiaki Matsushima , Samuel T Hwang , Scott I Simon

{"title":"Mechanobiology of neutrophil inflammasome signaling in psoriasis","authors":"Yoshiaki Matsushima , Samuel T Hwang , Scott I Simon","doi":"10.1016/j.coi.2025.102680","DOIUrl":"10.1016/j.coi.2025.102680","url":null,"abstract":"<div><div>While T cells play a prominent role, polymorphonuclear neutrophils (PMN) are also significant players in the pathogenesis of psoriasis. This review details the mechanobiology of PMN in the amplification of skin inflammation, a process often under-scrutinized compared to T cell pathways. PMN surveillance of skin microcirculation involves selectin-mediated rolling that transitions to stable β<sub>2</sub>-integrin–mediated arrest. Upon tissue recruitment, PMN trigger the NLRP3 inflammasome and NETosis, releasing neutrophil extracellular traps, proinflammatory cytokines including IL-1β and IL-18, and damage-associated molecular patterns. These mediators promote keratinocyte proliferation and recruit additional waves of PMN that contribute to a positive feedback loop that sustains skin inflammation and hyperproliferation of keratinocytes. Consequently, assays measuring PMN activation provide a sensitive biomarker for the progression of psoriatic disease. Furthermore, therapeutically targeting upstream mechanosignaling pathways presents a novel therapeutic avenue to move beyond conventional strategies that block downstream cytokines critical for immunocompetence.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"97 ","pages":"Article 102680"},"PeriodicalIF":5.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiviral responses in peripheral and brain neurons 外周和脑神经细胞的抗病毒反应。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-10-14 DOI: 10.1016/j.coi.2025.102678

Brian Imbiakha , Hana Janova , Michael S Diamond

引用次数: 0

Treating sarcoidosis: when less is more 治疗结节病：少即是多。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-10-13 DOI: 10.1016/j.coi.2025.102679

Niamh Logan , Jessica Raja , Elisabetta A Renzoni

引用次数: 0

Deciphering and harnessing gut microbiota–associated immune regulation in acute graft-versus-host disease 在急性移植物抗宿主病中破译和利用肠道微生物群相关的免疫调节

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-10-10 DOI: 10.1016/j.coi.2025.102676

Emmanuelle Godefroy , Frédéric Altare

{"title":"Deciphering and harnessing gut microbiota–associated immune regulation in acute graft-versus-host disease","authors":"Emmanuelle Godefroy , Frédéric Altare","doi":"10.1016/j.coi.2025.102676","DOIUrl":"10.1016/j.coi.2025.102676","url":null,"abstract":"<div><div>Allogeneic hematopoietic stem cell transplantation represents a curative treatment of choice for numerous severe hematological malignancies. While donor-derived transplanted T cells can limit disease relapse (GvT/GvL effect), they also induce, in 30–50% of the patients, acute graft-versus-host disease (aGvHD), a severe condition with elevated mortality and comorbidity rates. Gut microbiota composition has been associated with aGvHD outcome. This observation created a substantial research interest, and individual gut microbiota commensals have been acknowledged for their ability to promote immune regulation, both locally and systemically, and thus limit aGvHD-related inflammation. The mechanisms by which commensals support immune homeostasis are being decrypted at a remarkable rate. However, the trillions of micro-organisms comprising the gut microbiome interact, both directly and indirectly, with local immune cells, which is all the more critical in the context of heavy conditioning regimens these patients undergo, themselves damaging mucosal tissues and prompting inflammation. Commensals can help preserve the gut barrier integrity by actively limiting deleterious inflammation processes. Mechanistically deciphering the intricate crosstalk between gut microbes and gut immune cells, both at the species level and globally, represents a colossal challenge, but holds great promise in predicting and harnessing numerous pathological processes, including aGvHD. This review aims to examine the acquired knowledge concerning immunoregulatory responses driven by gut microbiota in the context of aGvHD. Recent preclinical and clinical studies harnessing such pathways proved to be encouraging, while substantial hurdles subsist regarding how to successfully harness this complex host/microbiota interplay to constrain aGvHD.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"97 ","pages":"Article 102676"},"PeriodicalIF":5.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing post-transplantation cell therapies to enhance graft-versus-leukemia effects in hematological malignancies 优化移植后细胞疗法以增强移植物抗白血病在血液系统恶性肿瘤中的作用

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-10-10 DOI: 10.1016/j.coi.2025.102675

Simone A Minnie , Melissa M Berrien-Elliott , Melody Smith , Melinda A Biernacki , Marie Bleakley

{"title":"Optimizing post-transplantation cell therapies to enhance graft-versus-leukemia effects in hematological malignancies","authors":"Simone A Minnie , Melissa M Berrien-Elliott , Melody Smith , Melinda A Biernacki , Marie Bleakley","doi":"10.1016/j.coi.2025.102675","DOIUrl":"10.1016/j.coi.2025.102675","url":null,"abstract":"<div><div>Allogeneic hematopoietic cell transplantation (HCT) can cure patients with high-risk hematologic malignancies. Donor T and natural killer (NK) cells contribute to graft-versus-leukemia (GVL) effects that provide relapse protection. Post-HCT relapses often represent inadequate GVL, but alloreactive lymphocytes that confer GVL may also cause graft-versus-host-disease (GVHD). Here, we review recent developments to selectively augment GVL while minimizing GVHD. Insights into the unique mechanisms of post-HCT T cell dysfunction highlight interventions to enhance GVL-mediating T cells. Early clinical data suggest that adoptive transfer of engineered donor T cells, expressing either transgenic T cell receptors specific for minor histocompatibility antigens presented exclusively on recipient hematopoietic cells or chimeric antigen receptors binding surface proteins on malignant cells, can mitigate post-HCT relapse. NK cells, key GVL mediators after haploidentical HCT, can be induced into a highly functional memory-like state and administered to HCT recipients to enhance GVL. These innovations promise much-needed improvements in post-HCT outcomes.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"97 ","pages":"Article 102675"},"PeriodicalIF":5.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The epidermal immune microenvironment plays a central role in the pathogenesis of psoriasis 表皮免疫微环境在银屑病的发病机制中起核心作用

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-10-09 DOI: 10.1016/j.coi.2025.102674

Yuan Zhou, Xiao-Yong Man

引用次数: 0

Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity 层层防御：通过上皮内禀免疫保护呼吸道病毒

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-10-09 DOI: 10.1016/j.coi.2025.102677

Ellen F Foxman

引用次数: 0

When granulomatous inflammation becomes visible: insights into cutaneous sarcoidosis 当可见肉芽肿性炎症时：观察皮肤结节病。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-10-04 DOI: 10.1016/j.coi.2025.102673

Mariam Alam , Avrom S. Caplan , Misha Rosenbach

引用次数: 0

COVID-19 and inflammatory bowel disease — what to know COVID-19和炎症性肠病——需要了解什么？

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-09-30 DOI: 10.1016/j.coi.2025.102661

Anne Godat , Dimitrios Chistoforidis , Thomas Greuter

{"title":"COVID-19 and inflammatory bowel disease — what to know","authors":"Anne Godat , Dimitrios Chistoforidis , Thomas Greuter","doi":"10.1016/j.coi.2025.102661","DOIUrl":"10.1016/j.coi.2025.102661","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) represents a chronic inflammation of the gastrointestinal tract that arises from a complex interplay between a dysregulated immune response in genetically predisposed individuals. IBD can further be classified into its two main subtypes, Crohn’s disease and ulcerative colitis. Both subtypes have shown increasing prevalence and incidence rates worldwide, and IBD is now considered a global epidemic. About three million patients are estimated to suffer from this disease, both in the US and Europe, with most of them requiring maintenance treatment including immunosuppressive agents, putting them at risk for opportunistic infections. In 2020, coronavirus disease 2019 (COVID-19) hit the world with a long pandemic period resulting in dramatic numbers of hospitalizations, Intensive care unit (ICU) admissions, and deaths. Patients with chronic illnesses, such as IBD, were rapidly considered to be at an increased risk for both infection and infection-related complications. For IBD and its treatment, however, evidence over the last few years showed no increased risk for SARS-CoV-2 infection or COVID-related complications. In this review, we will discuss the latest insights about COVID-19 in IBD patients with a particular focus on the disease course of COVID-19 and on IBD-related adverse outcomes.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"97 ","pages":"Article 102661"},"PeriodicalIF":5.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The outcome of severe MIS-C managed at the Italian epicenter of the SARS-CoV-2 epidemic: a follow-up study of 50 consecutive patients 在意大利SARS-CoV-2疫情中心管理的严重misc的结果：对50名连续患者的随访研究

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2025-09-22 DOI: 10.1016/j.coi.2025.102659

Lucio Verdoni , Angelo Mazza , Laura Martelli , Annalisa Gervasoni , Angela Amoroso , Simona Anna Marcora , Paolo Brambilla , Ezio Bonanomi , Greta Carioli , Lorenzo D’Antiga

{"title":"The outcome of severe MIS-C managed at the Italian epicenter of the SARS-CoV-2 epidemic: a follow-up study of 50 consecutive patients","authors":"Lucio Verdoni , Angelo Mazza , Laura Martelli , Annalisa Gervasoni , Angela Amoroso , Simona Anna Marcora , Paolo Brambilla , Ezio Bonanomi , Greta Carioli , Lorenzo D’Antiga","doi":"10.1016/j.coi.2025.102659","DOIUrl":"10.1016/j.coi.2025.102659","url":null,"abstract":"<div><h3>Background</h3><div>During the SARS-CoV-2 pandemic, we described a peak of a Kawasaki-like disease in children, later renamed multisystem inflammatory syndrome in children (MIS-C). We report the long-term outcomes of MIS-C patients who presented to our center.</div></div><div><h3>Methods</h3><div>We recorded clinical features and outcomes in patients with MIS-C admitted to our institution (February 2020–February 2022), focusing on the long-term outcome of those with a severe course.</div></div><div><h3>Results</h3><div>A total of 50 MIS-C patients (mean age 8.8 ± 4.3 years, 16 females) were admitted. In univariate analysis, the predictors of high-risk disease were older age; high CRP, neutrophils, ferritin, D-dimer, and transaminases; and low white blood cells, lymphocytes, platelets, albumin, and sodium. In multivariate analysis, a more severe course of the disease was associated with sodium ≤133 or ferritin >684. In two months, the symptoms disappeared. No relapses occurred during four years of surveillance.</div></div><div><h3>Conclusion</h3><div>The prognosis of MIS-C is favorable, even in severe cases. MIS-C resolves completely as early as eight weeks from onset and is not associated with other events over four years of observation. In our experience, careful and correct stratification in the initial phases has proven essential in setting up the correct treatment, with full recovery in all cases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"97 ","pages":"Article 102659"},"PeriodicalIF":5.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0