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Current Opinion in Immunology最新文献

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Lymphatic messengers: Non-antigen soluble mediators from diseased tissues to draining lymph nodes
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-05 DOI: 10.1016/j.coi.2025.102536
Mir J Howlader , Mehdi Rashighi , Laura Santambrogio , Theresa T Lu
{"title":"Lymphatic messengers: Non-antigen soluble mediators from diseased tissues to draining lymph nodes","authors":"Mir J Howlader ,&nbsp;Mehdi Rashighi ,&nbsp;Laura Santambrogio ,&nbsp;Theresa T Lu","doi":"10.1016/j.coi.2025.102536","DOIUrl":"10.1016/j.coi.2025.102536","url":null,"abstract":"<div><div>Tissues deliver not only antigens and cells via afferent lymphatics to draining lymph nodes during immune responses but also deliver soluble molecules that reflect the state of the tissue. In autoimmune diseases, these signals from affected tissues can potentially impact the magnitude or other characteristics of autoimmune responses generated in lymph nodes. Here, we highlight recent studies illustrating the nature of these soluble signals relevant to lupus skin and in lymphatic fluid draining the gut in inflammatory bowel disease. We also highlight the role of lymph node stromal cells as recipients of lymph borne signals. Identifying the molecules delivered from the tissues and how exactly they modulate immune function in draining lymph nodes will help us to better understand aberrant immunity in disease.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"93 ","pages":"Article 102536"},"PeriodicalIF":6.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143278902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Framing the logic of type 2 immunity 编辑综述：构建 2 型免疫的逻辑。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102523
Caroline L Sokol , Rod A Rahimi
{"title":"Editorial overview: Framing the logic of type 2 immunity","authors":"Caroline L Sokol ,&nbsp;Rod A Rahimi","doi":"10.1016/j.coi.2024.102523","DOIUrl":"10.1016/j.coi.2024.102523","url":null,"abstract":"","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102523"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of bacterial viability governing noncanonical inflammasome activation 控制非典型炎性体活化的细菌活力模式。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102512
Yuhua Shi , J Magarian Blander
{"title":"Patterns of bacterial viability governing noncanonical inflammasome activation","authors":"Yuhua Shi ,&nbsp;J Magarian Blander","doi":"10.1016/j.coi.2024.102512","DOIUrl":"10.1016/j.coi.2024.102512","url":null,"abstract":"<div><div>Noncanonical inflammasomes are instrumental in defense against Gram-negative bacteria, activated primarily by bacterial lipopolysaccharide. This review examines commonalities and distinctions in noncanonical inflammasome activation either by virulence factor activity indicating cellular invasion or by detection of bacterial mRNA signaling the undesired presence of live bacteria in sterile tissue. These inflammasome triggers, alongside other examples discussed, reflect properties exclusive to live bacteria. The emerging picture underscores noncanonical inflammasome activation hinging on detection of indicators of bacterial viability such as the presence of certain molecules or activity of specific processes. The complex interpretation of combinatorial signals is essential for inflammasome activation according to the specific facet of infection confronting the host. Decoding these signals and their convergence on inflammasome activation will inform interventions and therapies for infectious diseases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102512"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccine policies in France and Europe 法国和欧洲的疫苗政策。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102513
Alain Fischer , Patrick Peretti-Watel , Jeremy Ward
{"title":"Vaccine policies in France and Europe","authors":"Alain Fischer ,&nbsp;Patrick Peretti-Watel ,&nbsp;Jeremy Ward","doi":"10.1016/j.coi.2024.102513","DOIUrl":"10.1016/j.coi.2024.102513","url":null,"abstract":"<div><div>This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102513"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the metabolic landscape of regulatory T cells: from autoimmune diseases to tumor microenvironments 导航调节性 T 细胞的代谢景观：从自身免疫性疾病到肿瘤微环境。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102511
Janika Härm , Yu-Tong Fan , Dirk Brenner
{"title":"Navigating the metabolic landscape of regulatory T cells: from autoimmune diseases to tumor microenvironments","authors":"Janika Härm ,&nbsp;Yu-Tong Fan ,&nbsp;Dirk Brenner","doi":"10.1016/j.coi.2024.102511","DOIUrl":"10.1016/j.coi.2024.102511","url":null,"abstract":"<div><div>Regulatory T cells (Tregs) are essential for maintaining immune homeostasis, playing crucial roles in modulating autoimmune conditions and contributing to the suppressive tumor microenvironment. Their cellular metabolism governs their generation, stability, proliferation, and suppressive function. Enhancing Treg metabolism to boost their suppressive function offers promising therapeutic potential for alleviating inflammatory symptoms in autoimmune diseases. Conversely, inhibiting Treg metabolism to reduce their suppressive function can enhance the efficacy of traditional immunotherapy in cancer patients. This review explores recent advances in targeting Treg metabolism in autoimmune diseases and the metabolic adaptations of Tregs within the tumor microenvironment that increase their immunosuppressive function.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102511"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of allergen-specific regulatory T cells in the control of allergic disease 过敏原特异性调节性T细胞在过敏性疾病控制中的作用。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102509
Athanasios Stoumpos , Guido Heine , Carina Saggau , Alexander Scheffold
{"title":"The role of allergen-specific regulatory T cells in the control of allergic disease","authors":"Athanasios Stoumpos ,&nbsp;Guido Heine ,&nbsp;Carina Saggau ,&nbsp;Alexander Scheffold","doi":"10.1016/j.coi.2024.102509","DOIUrl":"10.1016/j.coi.2024.102509","url":null,"abstract":"<div><div>Allergies result from an antigen-specific loss of tolerance against innocuous foreign substances. Allergen immunotherapy (AIT) aims to reverse the pathogenic response and to re-establish physiological tolerance. However, the tolerogenic mechanisms that prevent allergy in healthy and act during AIT are still obscure. Foxp3 expressing ‘regulatory’ CD4 T cells (Tregs) are essential mediators of tolerance against allergens. It remains controversial which antigen specificity of Tregs is required to prevent allergy and the role of allergen-specific Tregs during AIT. Recent work provided precise insight into physiological T cell responses against environmental and food compounds. This identified Treg responses mainly against peptides and proteins not involved in immune pathology, revealing an unexpected role of Treg antigen specificity for tolerance. This review will focus on antigen-specific Treg responses against food and airborne allergens, and the impact of the technological approach utilized for antigen-specific Treg characterization is discussed, with critical points to be addressed in future research.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102509"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemokines that govern T cell activity in tumors 肿瘤中控制T细胞活性的趋化因子。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102510
Thorsten R Mempel, Mohsen Malehmir
{"title":"Chemokines that govern T cell activity in tumors","authors":"Thorsten R Mempel,&nbsp;Mohsen Malehmir","doi":"10.1016/j.coi.2024.102510","DOIUrl":"10.1016/j.coi.2024.102510","url":null,"abstract":"<div><div>Local regulation of T cell–mediated immunity to solid tumors occurs at multiple levels, including their recruitment from the bloodstream to the tumor microenvironment (TME), coordinated crosstalk with different subsets of antigen-presenting cells (APCs) controlling their local survival, proliferation, and effector differentiation, as well as their egress from tumors via lymphatics. At each level, chemokines play essential roles, for instance, by guiding directional T cell migration across blood and lymphatic endothelial barriers or by promoting their spatial proximity and direct physical interactions with APCs to enable functional crosstalk. In this article, we will review recent mechanistic insights into the chemokine axes that guide T cell functions in TMEs in light of the emerging functional state heterogeneity of CD8<sup>+</sup> effector T cells and our growing understanding of how regulatory T cells restrain antitumor activity.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102510"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuberculosis as an unconventional interferonopathy 肺结核是一种非常规的干扰素病。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102508
Russell E Vance
{"title":"Tuberculosis as an unconventional interferonopathy","authors":"Russell E Vance","doi":"10.1016/j.coi.2024.102508","DOIUrl":"10.1016/j.coi.2024.102508","url":null,"abstract":"<div><div>Tuberculosis is caused by <em>Mycobacterium tuberculosis</em>, a bacterium that accounts for more human mortality than any other. Evidence is accumulating for the view that tuberculosis is an interferonopathy — a disease driven by type I interferons. However, how type I interferons exacerbate tuberculosis remains poorly understood. As an infection, tuberculosis is distinct from conventional interferonopathies, which are autoinflammatory diseases. Here I consider the hypothesis that type I interferons promote bacterial replication by impairing key antibacterial immune responses, including those orchestrated by interleukin-1 and interferon γ. Paradoxically, during tuberculosis, the underlying state of impaired antibacterial immunity co-exists with overt (but ineffective) inflammation. Conceiving of tuberculosis as an unconventional interferonopathy may suggest fruitful avenues for therapeutic intervention.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102508"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage barrier responses to oncogenic transformation
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102524
J Magarian Blander
{"title":"Macrophage barrier responses to oncogenic transformation","authors":"J Magarian Blander","doi":"10.1016/j.coi.2024.102524","DOIUrl":"10.1016/j.coi.2024.102524","url":null,"abstract":"<div><div>The well-documented protumorigenic roles of macrophages in advanced cancers can sometimes overshadow their beneficial functions in the earlier stages of tumor development. This essay explores the hypothesis that macrophages play a crucial protective role in premalignant tissues by sensing and responding to early oncogenic transformation. Their activity is closely intertwined with cell-intrinsic barriers to transformation — such as apoptosis, senescence, and DNA repair — which collectively work to suppress malignant progression. Thus, an integrated cell-intrinsic and macrophage response constitutes effective ‘oncogenic monitoring’. In premalignant tissues, macrophages interpret outputs of cell-intrinsic tumor suppression as oncogenic stress signals detected through innate immune sensors, initiating a protective, homeostatic response that mitigates potential progression to malignancy. By recontextualizing macrophage roles in the early immune landscape, it becomes evident that these cells can serve as key protectors, preventing or delaying tumor formation. Understanding this dual role of macrophages — protective in early tumorigenesis and protumorigenic in established cancers — offers new perspectives on harnessing their immune functions for cancer prevention and therapy.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102524"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nucleic acid triggers of autoimmunity and autoinflammation
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-01-30 DOI: 10.1016/j.coi.2025.102535
Kaiyuan Hao, Ann Marshak-Rothstein
{"title":"Nucleic acid triggers of autoimmunity and autoinflammation","authors":"Kaiyuan Hao,&nbsp;Ann Marshak-Rothstein","doi":"10.1016/j.coi.2025.102535","DOIUrl":"10.1016/j.coi.2025.102535","url":null,"abstract":"<div><div>The key role of nucleic acid sensing receptors in the development of autoimmune and autoinflammatory diseases is becoming increasingly apparent. Activation of these sensors has been attributed to the failure of professional scavenger cells to adequately clear cell debris, in many cases due to defective scavenger receptors. However, as now summarized in this review, numerous gain-of-function mutations in the nucleic acid sensing receptors, or in molecules that regulate sensor activity, have now been evaluated in gene-targeted murine strains, and critical components of their downstream pathways have been identified as therapeutic targets. In addition, we are beginning to understand how DNases and RNases play crucial roles in both generating and eliminating the distinct ligands that engage the various nucleic acid sensors. Murine models of disease have further provided important insights regarding the function of and synergy between individual endosomal and cytosolic receptors, as well as cell type restricted functions.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"93 ","pages":"Article 102535"},"PeriodicalIF":6.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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