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Functional subsets of tumor-specific CD8+ T cells in draining lymph nodes and tumor microenvironment 引流淋巴结和肿瘤微环境中的肿瘤特异性 CD8+ T 细胞功能亚群
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-11-26 DOI: 10.1016/j.coi.2024.102506
Qizhao Huang , Lifan Xu , Lilin Ye
{"title":"Functional subsets of tumor-specific CD8+ T cells in draining lymph nodes and tumor microenvironment","authors":"Qizhao Huang ,&nbsp;Lifan Xu ,&nbsp;Lilin Ye","doi":"10.1016/j.coi.2024.102506","DOIUrl":"10.1016/j.coi.2024.102506","url":null,"abstract":"<div><div>Accumulating evidence demonstrates that tumor-specific CD8<sup>+</sup> T cells in tumor-draining lymph nodes (TdLNs) act as an upstream reservoir of exhausted subsets within tumor microenvironment (TME). This reservoir primarily consists of progenitor exhausted CD8<sup>+</sup> T (T<sub>PEX</sub>) cells and newly defined tumor-specific memory subsets (T<sub>TSM</sub>). We propose that these two subsets work together to mediate the antitumor effects of PD-1/PD-L1 immune checkpoint blockade (ICB) in a spatiotemporal manner. Although PD-1/PD-L1 ICB monotherapy drives the proliferation and further differentiation of these subsets, it does not alter the programmed differentiation trajectory from T<sub>TSM</sub> cells to T<sub>PEX</sub> cells, ultimately leading to the development of terminally exhausted CD8<sup>+</sup> T cells. This phenomenon may partly explaining the frequent relapse in patients following initial ICB therapy. In this review, we focus on the phenotypic and functional heterogeneity of tumor-specific CD8<sup>+</sup> T cells in both TdLNs and the TME and discuss the implications of these studies for ICB. Our insights aim to illuminate new strategies for advancing tumor immunotherapies.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102506"},"PeriodicalIF":6.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the neuroimmune axis in the atopic march: mechanisms and implications 解码特应性进展中的神经免疫轴：机制与影响。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-11-22 DOI: 10.1016/j.coi.2024.102507
Laura Brabenec , Surbhi Gupta , Tuany Eichwald , Moutih Rafei , Sebastien Talbot
{"title":"Decoding the neuroimmune axis in the atopic march: mechanisms and implications","authors":"Laura Brabenec ,&nbsp;Surbhi Gupta ,&nbsp;Tuany Eichwald ,&nbsp;Moutih Rafei ,&nbsp;Sebastien Talbot","doi":"10.1016/j.coi.2024.102507","DOIUrl":"10.1016/j.coi.2024.102507","url":null,"abstract":"<div><div>The immune and nervous systems have co-evolved complex mechanisms to sense environmental dangers and orchestrate a concerted response to safeguard tissue and mobilize host defenses. This sophisticated interplay, marked by a shared repertoire of receptors and ligands, influences disease pathogenesis. Neuro-immune interactions in allergic diseases are pivotal for symptom development, from anaphylaxis to chronic conditions like asthma and atopic dermatitis. This review explores the neuro-immune interplay within the atopic march, emphasizing its role in host defense, inflammation resolution, and tissue repair. We delve into the multifaceted functions of nociceptors in orchestrating type 2 immune responses and the progression of allergic disorders, focusing on key regulators such as CGRP-RAMP1 and SP-MRGPRB2/A2. Additionally, we discuss the potential of nociceptor neuron-blocking drugs to target neuro-immunity, offering the possibility of reversing the progression of the atopic march. Altogether, we underscore the need for targeted interventions to disrupt the pathological processes and enhance therapeutic outcomes at various stages of the atopic march.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102507"},"PeriodicalIF":6.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and risk factors for perinatal allergic disease 围产期过敏性疾病的机制和风险因素。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-11-19 DOI: 10.1016/j.coi.2024.102505
Jozef Balla , Abhay PS Rathore , Ashley L St. John
{"title":"Mechanisms and risk factors for perinatal allergic disease","authors":"Jozef Balla ,&nbsp;Abhay PS Rathore ,&nbsp;Ashley L St. John","doi":"10.1016/j.coi.2024.102505","DOIUrl":"10.1016/j.coi.2024.102505","url":null,"abstract":"<div><div>Allergies are among the top causes of chronic disease in children. Their pathogenesis classically involves T helper 2 (Th2)-type inflammation driven by IgE-mediated allergen sensing. Triggers influencing allergic disease occur early in life, including before birth. The immature fetal immune system and mucosal barriers undergo periods of plasticity that are open to longitudinal programming by maternal influence. Evidence supports the importance of the maternal immune system in shaping perinatal immunity, as the transfer of cytokines, antibodies, and cells promotes offspring protection from pathogens. However, the same components may lead to allergic predisposition. Maternal–fetal interactions are further modified by epigenetic, metabolic, dietary, and microbiome-mediated effects. Here, we review how diverse maternal exposures and mediators signal across the placenta and through nursing perinatally to promote future tolerance or enhance reactivity against allergens. Improved understanding of the mechanisms predisposing for allergic disease in early life can guide the development of new therapeutics and preventative lifestyle modifications.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102505"},"PeriodicalIF":6.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B cells spatial organization defines their phenotype and function in cancer “Tell me with whom you consort, and I will tell you who you are” ― Goethe B 细胞的空间组织决定了它们在癌症中的表型和功能 "告诉我你与谁为伍，我就告诉你你是谁"--歌德。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-11-14 DOI: 10.1016/j.coi.2024.102504
Lloyd Bod , Shabnam Shalapour
{"title":"B cells spatial organization defines their phenotype and function in cancer “Tell me with whom you consort, and I will tell you who you are” ― Goethe","authors":"Lloyd Bod ,&nbsp;Shabnam Shalapour","doi":"10.1016/j.coi.2024.102504","DOIUrl":"10.1016/j.coi.2024.102504","url":null,"abstract":"<div><div>The presence of B cells and their subtypes in the tumor environment has been recognized a for very long time. Immunoglobulins specific for more than thousands of tumor-associated antigens were detected in the sera of patients with cancer; however, antibody-mediated cancer cell killing is usually impaired. The role of humoral immune response remained elusive until recently, with new discoveries regarding their contribution in regulating antitumor immunity, particularly during immunotherapy. Humoral immunity has been described to promote or attenuate tumorigenesis and can have opposing effects on therapeutic outcome in different tumor entities. The antagonism effect of B cells depends on their subtypes and immunoglobulin isotypes and is regulated by their spatial distribution and localization. In this short review, we will focus on how the spatial organization of B cells within the tumor microenvironment, tumor-associated lymph nodes, and tertiary lymphoid structures define their fate and function and contribute to the regulation of antitumor immunity.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102504"},"PeriodicalIF":6.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovering mechanisms of macrophage tissue infiltration with Drosophila 用果蝇探索巨噬细胞组织浸润的机制
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-11-12 DOI: 10.1016/j.coi.2024.102502
Daria E Siekhaus , Jasmine A Stanley-Ahmed
{"title":"Discovering mechanisms of macrophage tissue infiltration with Drosophila","authors":"Daria E Siekhaus ,&nbsp;Jasmine A Stanley-Ahmed","doi":"10.1016/j.coi.2024.102502","DOIUrl":"10.1016/j.coi.2024.102502","url":null,"abstract":"<div><div>Much is known about the importance of macrophages for regulating diverse aspects of organismal physiology, alongside their essential roles in inflammation. Relatively unexplored are the processes influencing macrophages’ and monocytes’ ability to invade into the tissues where they carry out these functions. <em>Drosophila</em> plasmatocytes, also called hemocytes, show similarities to vertebrate macrophages in their function and their molecular specification; they have recently been shown to also infiltrate into tissues during development and inflammation. Extravasation across vasculature, into tumors, the brain, and adipose tissue have all been observed. We discuss the striking parallels in some of these systems to vertebrate immune responses, including a requirement for tumor necrosis factor. Finally, we highlight the new pathways regulating infiltration found in the fly that remain as yet unexamined in a vertebrate context.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102502"},"PeriodicalIF":6.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial-immune interactions govern type 2 immunity at barrier surfaces 上皮细胞与免疫系统之间的相互作用制约着屏障表面的 2 型免疫。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-11-10 DOI: 10.1016/j.coi.2024.102501
Alejandra Lopez Espinoza , Tighe Christopher , Elia D Tait Wojno
{"title":"Epithelial-immune interactions govern type 2 immunity at barrier surfaces","authors":"Alejandra Lopez Espinoza ,&nbsp;Tighe Christopher ,&nbsp;Elia D Tait Wojno","doi":"10.1016/j.coi.2024.102501","DOIUrl":"10.1016/j.coi.2024.102501","url":null,"abstract":"<div><div>Allergic diseases are acute and chronic inflammatory conditions resulting from disproportionate responses to environmental stimuli. Affecting approximately 40% of the global population, these diseases significantly contribute to morbidity and increasing health care costs. Allergic reactions are triggered by pollen, house dust mites, animal dander, mold, food antigens, venoms, toxins, and drugs. This review explores the pivotal role of the epithelium in the skin, lungs, and gastrointestinal tract in regulating the allergic response and delves into the mechanisms of tissue-specific epithelial–immune interactions in this context, with recent advances highlighting their roles in the initiation, elicitation, and resolution phases of allergy. Understanding these intricate interactions at epithelial barriers is essential for developing targeted therapies to manage and treat allergic diseases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102501"},"PeriodicalIF":6.6,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic adaptations of ILC2 and Th2 cells in type 2 immunity 2 型免疫中 ILC2 和 Th2 细胞的代谢适应性。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-11-08 DOI: 10.1016/j.coi.2024.102503
Anna K Kania , Efthymia Kokkinou , Erika Pearce, Edward Pearce
{"title":"Metabolic adaptations of ILC2 and Th2 cells in type 2 immunity","authors":"Anna K Kania ,&nbsp;Efthymia Kokkinou ,&nbsp;Erika Pearce,&nbsp;Edward Pearce","doi":"10.1016/j.coi.2024.102503","DOIUrl":"10.1016/j.coi.2024.102503","url":null,"abstract":"<div><div>Type 2 immune responses play a crucial role in host defense against parasitic infections but can also promote the development of allergies and asthma. This response is orchestrated primarily by group 2 innate lymphoid cells (ILC2) and helper type 2 (Th2) cells, both of which undergo substantial metabolic reprogramming as they transition from resting to activated states. Understanding these metabolic adaptations not only provides insights into the fundamental biology of ILC2 and Th2 cells but also opens up potential therapeutic avenues for the identification of novel metabolic targets that can extend the current treatment regimens for diseases in which type 2 immune responses play pivotal roles. By integrating recent findings, this review underscores the significance of cellular metabolism in orchestrating immune functions and highlights future directions for research in this evolving field.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102503"},"PeriodicalIF":6.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue-resident memory cells in antitumoral immunity and cancer immunotherapy 抗肿瘤免疫和癌症免疫疗法中的组织驻留记忆细胞
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-31 DOI: 10.1016/j.coi.2024.102499
Daniel Min , Jacob Fiedler , Niroshana Anandasabapathy
{"title":"Tissue-resident memory cells in antitumoral immunity and cancer immunotherapy","authors":"Daniel Min ,&nbsp;Jacob Fiedler ,&nbsp;Niroshana Anandasabapathy","doi":"10.1016/j.coi.2024.102499","DOIUrl":"10.1016/j.coi.2024.102499","url":null,"abstract":"<div><div>As cancer immunotherapy evolves, tissue-resident memory (T<sub>RM</sub>) cells remain key contributors to the antitumoral immune response due to their ability to mediate local tumor control, high expression of immune checkpoints, potential to respond to immunotherapy, and location across tissue sites where distal tumor metastases occur. This review synthesizes recent findings on the biology of T<sub>RM</sub> cells, their role in cancer, and their interactions with the tumor microenvironment. We also identify several critical research gaps, such as how mechanistic interrogation of T<sub>RM</sub> cell function is required for integration into therapeutics, proposing a focused research agenda to better exploit their potential.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102499"},"PeriodicalIF":6.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic requirements of type 2 lymphocytes in allergic disease 过敏性疾病中 2 型淋巴细胞的代谢需求
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-29 DOI: 10.1016/j.coi.2024.102500
Christopher A Tibbitt , Jonathan M Coquet
{"title":"Metabolic requirements of type 2 lymphocytes in allergic disease","authors":"Christopher A Tibbitt ,&nbsp;Jonathan M Coquet","doi":"10.1016/j.coi.2024.102500","DOIUrl":"10.1016/j.coi.2024.102500","url":null,"abstract":"<div><div>Allergic diseases continue to increase in prevalence across the globe. Decades of research has uncovered the cytokines and transcription factors that are central to the allergic immune response, but only in the last few years have we begun to understand the metabolic requirements of allergic immunity. Here, we discuss the metabolic features of so-called ‘type 2’ lymphocytes, which are heavily implicated in allergy. We highlight the central role that nuclear receptors, such as peroxisome proliferator–activated receptor gamma, play in type 2 lymphocyte biology and explore the influence of dietary and microbial factors in allergic inflammation. In the future, targeting metabolic checkpoints may offer a meaningful way of treating patients with allergic disorders.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102500"},"PeriodicalIF":6.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immunometabolic roots of aging 衰老的免疫代谢根源
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-26 DOI: 10.1016/j.coi.2024.102498
Pierpaolo Ginefra , Helen C Hope , Girieca Lorusso , Patrizia D’Amelio , Nicola Vannini
{"title":"The immunometabolic roots of aging","authors":"Pierpaolo Ginefra ,&nbsp;Helen C Hope ,&nbsp;Girieca Lorusso ,&nbsp;Patrizia D’Amelio ,&nbsp;Nicola Vannini","doi":"10.1016/j.coi.2024.102498","DOIUrl":"10.1016/j.coi.2024.102498","url":null,"abstract":"<div><div>Aging is one of the greatest risk factors for several chronic diseases and is accompanied by a progressive decline of cellular and organ function. Recent studies have highlighted the changes in metabolism as one of the main drivers of organism dysfunctions during aging and how that strongly deteriorate immune cell performance and function. Indeed, a dysfunctional immune system has been shown to have a pleiotropic impact on the organism, accelerating the overall aging process of an individual.</div><div>Intrinsic and extrinsic factors are responsible for such metabolic alterations. Understanding the contribution, regulation, and connection of these different factors is fundamental to comprehend the process of aging and develop approaches to mitigate age-related immune decline. Here, we describe metabolic perturbations occurring at cellular and systemic levels. Particularly, we emphasize the interplay between metabolism and immunosenescence and describe novel interventions to protect immune function and promote health span.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102498"},"PeriodicalIF":6.6,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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