Current Opinion in Immunology最新文献_第2页

Emerging diagnostic techniques in sarcoidosis: a path forward 结节病的新兴诊断技术：前进的道路

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.coi.2025.102716

Nico De Crem , Wim Alfons Wuyts

引用次数: 0

Markers predicting lymphoma development in Sjögren disease: current status and future perspectives 预测Sjögren疾病淋巴瘤发展的标志物：现状和未来展望

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.coi.2025.102717

Konstantinos N Panagiotopoulos , Athanasios G Tzioufas , Andreas V Goules

{"title":"Markers predicting lymphoma development in Sjögren disease: current status and future perspectives","authors":"Konstantinos N Panagiotopoulos , Athanasios G Tzioufas , Andreas V Goules","doi":"10.1016/j.coi.2025.102717","DOIUrl":"10.1016/j.coi.2025.102717","url":null,"abstract":"<div><div>We aim to present recent advancements in predictive markers for lymphomagenesis in SjD, concisely organize existing knowledge, and identify corresponding unmet needs and future perspectives. First, we briefly describe the mechanisms of lymphomagenesis in SjD. Followingly, the reasons justifying the importance of early lymphoma diagnosis in SjD are presented. Subsequently, recent advancements regarding lymphoma risk factors in SjD, both in translational and clinical research, are discussed, and how they fit in the preexisting knowledge landscape. Following, the effects of predicting a high risk of lymphoma development on clinical practice, clinical trials, monitoring strategies, as well as the currently known value of preventive treatment are presented. Lastly, we suggest future perspectives and unmet needs. The paradigm is shifting towards time-sensitive reevaluation of traditional risk factors and analysis of novel markers. Characterization of the exact site of occurrence of pathobiological events is increasingly punctual. Isolated biological B cell hyperactivity seems to be a temporally distant harbinger of lymphomagenesis, while clinical manifestations of B cell hyperactivity potentially signal imminent transition to clinically overt lymphoma. Data regarding protective factors and lymphoma prevention strategies are scarce. Deep learning for lymphoma prediction or automated identification of lymphoma risk factors is completely unexplored. Consensus guidelines regarding lymphoma prediction, monitoring, and prevention are lacking. Further advancements are anticipated in the field of predicting, monitoring, treating, and potentially preventing lymphoma in SjD. That is through refinement of study design, employment of deep learning, and, eventually, development of consensus guidelines to guide both research and clinical practice.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102717"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New autoantibodies in Sjögren's disease Sjögren疾病的新自身抗体

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.coi.2025.102722

Alaa Elsaghir , Torsten Witte

{"title":"New autoantibodies in Sjögren's disease","authors":"Alaa Elsaghir , Torsten Witte","doi":"10.1016/j.coi.2025.102722","DOIUrl":"10.1016/j.coi.2025.102722","url":null,"abstract":"<div><div>Primary Sjögren’s disease (SjD) is a systemic autoimmune disorder where diagnosis relies on the presence of Ro/SS-A and La/SS-B autoantibodies. However, approximately one-third of SjD patients are seronegative, often requiring an invasive minor salivary gland biopsy, which can lead to significant diagnostic delays. This review comprehensively evaluates a wide array of novel autoantibodies to determine their potential as diagnostic biomarkers for Ro/SS-A-negative SjD patients. While many newly identified autoantibodies, such as those targeting ASCA, TRIM38, and PUF60, were found to be strongly associated with Ro/SS-A positivity and thus offer limited utility for seronegative diagnosis, several others show significant promise.</div><div>Notably, autoantibodies targeting functional proteins like the muscarinic M3 receptor (anti-M3R) have demonstrated high diagnostic sensitivity and specificity. Furthermore, systematic screenings have uncovered highly specific markers. One panel of 12 autoantigens (including GMNN, GRAMD1A, and NUP50) identified by human proteome arrays exhibited 54% sensitivity with 100% specificity for Ro/SS-A-negative SjD. Another validated panel combining immunoglobulin G autoantibodies against FNBP4, SNRPC, CCL4, M3R, and KDM6B achieved 46% sensitivity with 95% specificity. Other individual markers, such as anti-NA14 and anti-calponin-3, also show potential for identifying seronegative SjD subsets.</div><div>In conclusion, a growing body of evidence supports the clinical utility of several novel autoantibodies in diagnosing Ro/SS-A-negative SjD. The integration of these biomarkers into clinical practice could significantly improve early and accurate diagnosis, reduce the reliance on invasive procedures, and potentially aid in patient stratification for targeted therapies. Further validation of these markers in large cohorts is warranted.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102722"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A throwback on 25 years in pannexin research 回顾25年来的pannexin研究

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.coi.2025.102718

Daan Peeters, Mathieu Vinken , Raf Van Campenhout

引用次数: 0

Minor salivary gland biopsy in Sjogren’s disease: a diagnostic and prognostic tool toward precision medicine 干燥病的小唾液腺活检：一种精准医学的诊断和预后工具

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI: 10.1016/j.coi.2026.102737

Loukas Chatzis , Athanasios G Tzioufas

{"title":"Minor salivary gland biopsy in Sjogren’s disease: a diagnostic and prognostic tool toward precision medicine","authors":"Loukas Chatzis , Athanasios G Tzioufas","doi":"10.1016/j.coi.2026.102737","DOIUrl":"10.1016/j.coi.2026.102737","url":null,"abstract":"<div><div>Minor salivary gland biopsy occupies a distinctive position in the evaluation of Sjögren disease (SjD), offering diagnostic and prognostic insights that are rarely achievable in other systemic autoimmune conditions. It contributes essential diagnostic information, particularly for patients lacking anti-Ro/SSA antibodies or pediatric patients, and supports identification of key histopathologic features. Beyond its established diagnostic role, the biopsy carries prognostic information related to systemic involvement, B-cell activity, and lymphoma risk, supported by features such as ectopic germinal centers, lymphoepithelial lesions, and molecular monoclonality. Its clinical value extends to incident lymphoma detection and exclusion of diseases that mimic SjD. Emerging technologies — including standardized sampling approaches, digital pathology, and early applications of artificial intelligence — may further enhance diagnostic accuracy and prognostic utility. Although the procedure is generally safe, careful consideration is required to balance clinical benefit with patient burden. Overall, salivary gland biopsy remains a cornerstone for advancing SjD understanding and management.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102737"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPM7 channel-kinase in immunity: new frontiers of an emerging therapeutic target 免疫中的TRPM7通道激酶：一个新兴治疗靶点的新前沿

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI: 10.1016/j.coi.2026.102734

Birgit Karner-Hoeger , Anna Madlmayr , Susanna Zierler

引用次数: 0

A critical look at animal and cellular models in autoinflammatory diseases 对自身炎症疾病的动物和细胞模型的批判性观察

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.coi.2025.102719

Yohei Kirino , Mitsuhiro Takeno

引用次数: 0

Malaria in pregnancy at the frontline: a delicate balance 前线的孕期疟疾：微妙的平衡

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-27 DOI: 10.1016/j.coi.2026.102726

Vivin Kokuhennadige , Elizabeth Aitken , Stephen Rogerson

{"title":"Malaria in pregnancy at the frontline: a delicate balance","authors":"Vivin Kokuhennadige , Elizabeth Aitken , Stephen Rogerson","doi":"10.1016/j.coi.2026.102726","DOIUrl":"10.1016/j.coi.2026.102726","url":null,"abstract":"<div><div>Malaria during pregnancy continues to compromise maternal, fetal, and subsequently infant health. This burden has increased in Africa, though it has decreased elsewhere. Here, we provide a concise review of recent findings on malaria in pregnancy, addressing pathogenesis, immunity, offspring outcomes, and interventions. Placental alterations and inflammation accompanying Plasmodium infection result in maternal morbidity and adverse birth outcomes, with new findings indicating antenatal infection affects infant immune and neurocognitive development. Adverse outcomes from placental infection reduce over successive pregnancies, but the drivers of this protection have been challenging to uncover. Despite parasite resistance to sulfadoxine-pyrimethamine (SP), it still helps improve birth weight as an intermittent preventive treatment in pregnancy. Dihydroartemisinin-piperaquine, though more effective against parasitemia, does not improve birth outcomes when used alone or in combination with SP. Interventions targeting first-trimester infections, blood-stage parasites, and vaccines that prime defences in primigravidae would be optimal for controlling malaria in pregnancy.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"99 ","pages":"Article 102726"},"PeriodicalIF":5.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of ion channels in immune regulation of psoriasis 离子通道在银屑病免疫调节中的作用。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-11-05 DOI: 10.1016/j.coi.2025.102688

Hideaki Uchida , Xuesong Wu , Yan Zhou , Jie Zheng , Heike Wulff , Samuel T Hwang

引用次数: 0

Regulatory T cell approaches for graft-versus-host disease prevention 调节性T细胞方法预防移植物抗宿主病

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-10-30 DOI: 10.1016/j.coi.2025.102685

Cameron S Bader , Everett H Meyer , Robert S Negrin

{"title":"Regulatory T cell approaches for graft-versus-host disease prevention","authors":"Cameron S Bader , Everett H Meyer , Robert S Negrin","doi":"10.1016/j.coi.2025.102685","DOIUrl":"10.1016/j.coi.2025.102685","url":null,"abstract":"<div><div>Regulatory T cells (Tregs) are a rare subset of T cells that are potent regulators of the immune system. As a result, the use of Tregs to prevent undesired immune activation and to re-establish immune balance is an attractive cellular therapy approach. In hematopoietic cell transplantation (HCT), there has been significant interest in using Tregs to prevent graft-versus-host disease (GVHD), which occurs when donor alloreactive T cells recognize recipient HLA- or other minor transplantation antigens as non-self. There is a critical unmet need for novel strategies to prevent GVHD since as many as 50% of patients will develop clinically significant GVHD with current therapies. Evidence from preclinical murine models and early-phase human studies suggests that an additional benefit to Treg cellular therapy in HCT is the apparent maintenance of pathogenic immunity and graft-versus-tumor effects, which are required to prevent leukemia relapse. While the major limiting factor for Treg-based therapies has been the rarity of these cells, novel methods to improve Treg isolation and expansion have demonstrated feasibility for implementation of these strategies in the clinic. Moreover, genetic engineering of Tregs has been shown to be a promising strategy to improve their specificity, longevity, and function. Clinical trials have established that such approaches are feasible and can be effective in both human leukocyte antigen (HLA)-matched and haplo-matched settings. In this review, we describe proposed mechanisms for Treg control of alloreactivity, modern methods for Treg isolation and expansion, the history of Treg clinical trials for GVHD prevention, and the horizon for Treg cellular therapy.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"98 ","pages":"Article 102685"},"PeriodicalIF":5.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0