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Current Opinion in Immunology最新文献

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Host-encoded antivirulence defenses: host physiologies teach pathogens to play nice 宿主编码的抗病毒防御系统：宿主生理机能教病原体学会和睦相处。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-09 DOI: 10.1016/j.coi.2024.102472
Janelle S Ayres
{"title":"Host-encoded antivirulence defenses: host physiologies teach pathogens to play nice","authors":"Janelle S Ayres","doi":"10.1016/j.coi.2024.102472","DOIUrl":"10.1016/j.coi.2024.102472","url":null,"abstract":"<div><div>Successful treatment of infectious diseases requires a multiprong approach involving strategies that limit pathogen burdens and that limit disease. Traditionally, disease defense is thought to be a direct function of pathogen killing, and thus, our current methods for treating infections have largely relied on pathogen eradication, leading to drug resistance. Strategies that target the virulence of the pathogen, called antivirulence, have been proposed to be a necessary strategy to integrate into our infectious disease toolbox to promote disease defense and alleviate the burden of drug resistance. Traditional antivirulence strategies have largely focused on developing compounds that directly target microbial virulence factors or products to impair their ability to initiate and sustain infection. As virulence is linked to pathogen fitness, simply targeting a virulence factor may not be sufficient to overcome the ability of pathogens evolving resistance. In this review, I discuss co-operative defenses that hosts have evolved to promote antivirulence mechanisms that suppress pathogen virulence without having a negative impact on pathogen fitness. I also discuss the different definitions antivirulence has been assigned over the years and suggest a more holistic one. Co-operative defenses remain an underexplored resource in medicine, and by learning from how hosts have evolved to promote antivirulence, we have the potential to develop disease defense interventions without the risk of pathogens developing drug resistance.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102472"},"PeriodicalIF":6.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolism and macrophages in the tumor microenvironment 肿瘤微环境中的新陈代谢和巨噬细胞
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-04 DOI: 10.1016/j.coi.2024.102491
Hannah Yang , Chan Kim , Weiping Zou
{"title":"Metabolism and macrophages in the tumor microenvironment","authors":"Hannah Yang ,&nbsp;Chan Kim ,&nbsp;Weiping Zou","doi":"10.1016/j.coi.2024.102491","DOIUrl":"10.1016/j.coi.2024.102491","url":null,"abstract":"<div><div>Tumor-associated macrophages (TAMs) constitute the primary subset of immune cells within the tumor microenvironment (TME). Exhibiting both phenotypic and functional heterogeneity, TAMs play distinct roles in tumor initiation, progression, and responses to therapy in patients with cancer. In response to various immune and metabolic cues within the TME, TAMs dynamically alter their metabolic profiles to adapt. Changes in glucose, amino acid, and lipid metabolism in TAMs, as well as their interaction with oncometabolites, not only sustain their energy demands but also influence their impact on tumor immune responses. Understanding the molecular mechanisms underlying the metabolic reprogramming of TAMs and their orchestration of metabolic processes can offer insights for the development of novel cancer immunotherapies targeting TAMs. Here, we discuss how metabolism reprograms macrophages in the TME and review clinical trials aiming to normalize metabolic alterations in TAMs and alleviate TAM-mediated immune suppression and protumor activity.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102491"},"PeriodicalIF":6.6,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carbohydrate metabolism in supporting and regulating neutrophil effector functions 支持和调节中性粒细胞效应功能的碳水化合物代谢。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-03 DOI: 10.1016/j.coi.2024.102497
Jorgo Lika , Jing Fan
{"title":"Carbohydrate metabolism in supporting and regulating neutrophil effector functions","authors":"Jorgo Lika ,&nbsp;Jing Fan","doi":"10.1016/j.coi.2024.102497","DOIUrl":"10.1016/j.coi.2024.102497","url":null,"abstract":"<div><div>Neutrophils, the first responders of the innate immune system, can turn on a range of effector functions upon activation. Emerging research shows activated neutrophils undergo highly dynamic metabolic rewiring. This metabolic rewiring provides energy and reducing power to fuel effector functions and modulate signaling molecules to regulate neutrophil functions. Here, we review the current understanding of the specific metabolic requirements and regulators of neutrophil migration, neutrophil extracellular traps release, and pathogen killing. Particularly, we discuss how major carbohydrate metabolic pathways, including glycolysis, glycogen cycling, pentose phosphate pathway, and TCA cycle, are rewired upon neutrophil activation to support these functions. Continued investigation into the metabolic regulators of neutrophil functions can lead to therapeutic opportunities in various diseases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102497"},"PeriodicalIF":6.6,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunometabolic regulation of germinal centers and its implications for aging 生殖中心的免疫代谢调节及其对衰老的影响。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-01 DOI: 10.1016/j.coi.2024.102485
Daehong Kim , Jaemin Kim , Hyeonuk Yeo , Yeonseok Chung
{"title":"Immunometabolic regulation of germinal centers and its implications for aging","authors":"Daehong Kim ,&nbsp;Jaemin Kim ,&nbsp;Hyeonuk Yeo ,&nbsp;Yeonseok Chung","doi":"10.1016/j.coi.2024.102485","DOIUrl":"10.1016/j.coi.2024.102485","url":null,"abstract":"<div><div>Aging, metabolism, and immunity have long been considered distinct domains. Aging is primarily associated with the gradual decline of physiological functions, metabolism regulates energy production and maintains cellular processes, and the immune system manages innate and adaptive responses against pathogens and vaccines. However, recent studies have revealed that these three systems are intricately interconnected, collectively influencing an individual’s response to stress and disease. This review explores the interplay between immunometabolism, T follicular helper cells, B cells, and aging, focusing on how these interactions impact immune function in the elderly.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102485"},"PeriodicalIF":6.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of inflammation by Interleukin-10 in the intestinal and respiratory mucosa 白细胞介素-10对肠道和呼吸道粘膜炎症的调节作用
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-01 DOI: 10.1016/j.coi.2024.102495
William J Branchett , Margarida Saraiva , Anne O’Garra
{"title":"Regulation of inflammation by Interleukin-10 in the intestinal and respiratory mucosa","authors":"William J Branchett ,&nbsp;Margarida Saraiva ,&nbsp;Anne O’Garra","doi":"10.1016/j.coi.2024.102495","DOIUrl":"10.1016/j.coi.2024.102495","url":null,"abstract":"<div><div>Intricate immune regulation is required at mucosal surfaces to allow tolerance to microbiota and harmless allergens and to prevent overexuberant inflammatory responses to pathogens. The cytokine Interleukin-10 (IL-10) is a key mediator of mucosal immune regulation. While IL-10 can be produced by virtually all cells of the immune system, many of its <em>in vivo</em> functions depend upon its production by regulatory or effector T cell populations and its signalling to macrophages, dendritic cells and specific T cell subsets. In this review, we discuss our current understanding of the role of IL-10 in regulation of immune responses, with a focus on its context-specific roles in intestinal homeostasis, respiratory infection and asthma. We highlight the importance of appropriate production and function of IL-10 for balancing pathogen clearance, control of microbiota and host tissue damage, and that precise modulation of IL-10 functions <em>in vivo</em> could present therapeutic opportunities.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102495"},"PeriodicalIF":6.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fuelling B cells: dynamic regulation of B cell metabolism 为 B 细胞提供燃料：B 细胞新陈代谢的动态调节。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-01 DOI: 10.1016/j.coi.2024.102484
Julia C. Johnstone , Yavuz F. Yazicioglu , Alexander J. Clarke
{"title":"Fuelling B cells: dynamic regulation of B cell metabolism","authors":"Julia C. Johnstone ,&nbsp;Yavuz F. Yazicioglu ,&nbsp;Alexander J. Clarke","doi":"10.1016/j.coi.2024.102484","DOIUrl":"10.1016/j.coi.2024.102484","url":null,"abstract":"<div><div>B cells experience extreme alterations in their metabolism throughout their life cycle, from naïve B cells, which have minimal activity, to germinal centre (GC) B cells, which proliferate at the fastest rate of all cells, to long-lived plasma cells with very high levels of protein production that can persist for decades. The underpinning of these transitions remains incompletely understood, and a key question is how utilisation of fuel source supports B cell metabolism. For example, GC B cells, unlike almost all rapidly proliferating cells, mainly use fatty acid oxidation rather than glycolysis. However, following differentiation to plasma cells, their metabolism switches towards a high rate of glucose consumption to aid antibody production. In this review, we discuss the key metabolic pathways in B cells, linking them to cellular signalling events and placing them in the context of disease and therapeutic potential.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102484"},"PeriodicalIF":6.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms regulating T helper 2 cell differentiation and function 调节 T 辅助细胞 2 分化和功能的分子机制。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-01 DOI: 10.1016/j.coi.2024.102483
Aydan CH Szeto , Ana CF Ferreira , Andrew NJ McKenzie
{"title":"Molecular mechanisms regulating T helper 2 cell differentiation and function","authors":"Aydan CH Szeto ,&nbsp;Ana CF Ferreira ,&nbsp;Andrew NJ McKenzie","doi":"10.1016/j.coi.2024.102483","DOIUrl":"10.1016/j.coi.2024.102483","url":null,"abstract":"<div><div>T helper 2 (T<sub>H</sub>2) cells orchestrate type 2 immunity during protective antihelminth immunity and help restore tissue homoeostasis. Their misdirected activities against innocuous substances also underlie atopic diseases, such as asthma and allergy. Recent technological advances are uncovering novel insights into the molecular mechanisms governing T<sub>H</sub>2 cell differentiation and function.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102483"},"PeriodicalIF":6.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of allergen immunotherapy and biologics in allergic diseases 过敏原免疫疗法和生物制剂在过敏性疾病中的作用。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-10-01 DOI: 10.1016/j.coi.2024.102494
Xiaoying Zhou , Elisabeth M Simonin , Youn S Jung , Stephen J Galli , Kari C Nadeau
{"title":"Role of allergen immunotherapy and biologics in allergic diseases","authors":"Xiaoying Zhou ,&nbsp;Elisabeth M Simonin ,&nbsp;Youn S Jung ,&nbsp;Stephen J Galli ,&nbsp;Kari C Nadeau","doi":"10.1016/j.coi.2024.102494","DOIUrl":"10.1016/j.coi.2024.102494","url":null,"abstract":"<div><div>The rise in the prevalence of allergic diseases has become a global health burden. Allergic diseases are a group of immune-mediated disorders characterized by IgE-mediated conditions resulting from a type 2 helper T cell (Th2)-skewed immune response. This review aims to comprehensively summarize recent research on the roles of allergen immunotherapy (AIT) and biologics in allergic diseases. Specifically, we review the mechanisms of AIT and biologics in modulating innate and adaptive immunity involved in allergic disease pathogenesis, as well as their safety and efficacy in the treatment of allergic diseases. We also discuss current new AIT strategies such as recombinant allergen-based vaccines and allergen extract nanoencapsulation. Further research is needed to understand immune tolerance mechanisms beyond the Th2 pathway and to characterize immunological changes in responders and nonresponders to AIT or biologics. This additional research may uncover new targets for monitoring treatment responses and developing personalized treatment strategies for allergic diseases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102494"},"PeriodicalIF":6.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The path ahead for understanding Toll-like receptors–driven systemic autoimmunity 了解 Toll 样受体驱动的系统性自身免疫的未来之路
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-30 DOI: 10.1016/j.coi.2024.102482
Jessica A Hamerman , Gregory M Barton
{"title":"The path ahead for understanding Toll-like receptors–driven systemic autoimmunity","authors":"Jessica A Hamerman ,&nbsp;Gregory M Barton","doi":"10.1016/j.coi.2024.102482","DOIUrl":"10.1016/j.coi.2024.102482","url":null,"abstract":"<div><div>Five mammalian Toll-like receptors (TLR 3, 7, 8, 9, and 13) recognize nucleic acids (NA) and induce signals that control the function of multiple immune cell types and initiate both innate and adaptive immune responses. While these receptors enable recognition of diverse microbial threats, in some instances, they respond inappropriately to self-NA released from host cells and drive the development of autoimmune diseases. Specifically, activation of TLR7 and TLR8 by self-RNA and TLR9 by self-DNA has been linked to development of a collection of systemic autoimmune or autoinflammatory disorders, including systemic lupus erythematosus, systemic juvenile idiopathic arthritis, and macrophage activation syndrome. Here, we discuss recent progress in understanding how these receptors contribute to such diverse clinical phenotypes. We highlight how comparative studies between mice and humans have not only been beneficial in identifying key pathways relevant for disease but also reveal gaps in our understanding of disease mechanisms. We identify several challenges that we hope the field will tackle in the years ahead.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102482"},"PeriodicalIF":6.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eating for immunity: how diet shapes our defenses 吃出免疫力：饮食如何塑造我们的防御能力
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-30 DOI: 10.1016/j.coi.2024.102486
Freya Q Zhang, Jing Chen, Hao Fan
{"title":"Eating for immunity: how diet shapes our defenses","authors":"Freya Q Zhang,&nbsp;Jing Chen,&nbsp;Hao Fan","doi":"10.1016/j.coi.2024.102486","DOIUrl":"10.1016/j.coi.2024.102486","url":null,"abstract":"<div><div>Emerging studies on the diet-immune axis have uncovered novel dietary immune regulators and identified crucial targets and pathways mediating the crosstalk between specific dietary components and diverse immune cell populations. Here, we discuss the recent discovery and mechanisms by which diet-derived components, such as vitamins, amino acids, fatty acids, and antioxidants, could impact immune cell metabolism, alter signaling pathways, and reprogram the overall cellular responses. We also note crucial considerations that need to be tackled to make these findings clinically relevant, acknowledging that our current understanding often relies on simplified models that may not adequately represent the intricate network of factors influencing the diet-immune axis at the whole organism level. Overall, our growing understanding of how diet shapes our defenses underscores the importance of lifestyle choices and illuminates the potential to fine-tune immune responses through targeted nutritional strategies, thereby fortifying the immune system and bolstering our defenses against diseases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102486"},"PeriodicalIF":6.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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