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Inflammasomes and their role in PANoptosomes 炎症体及其在泛光体中的作用
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-27 DOI: 10.1016/j.coi.2024.102489
Vinod Nadella, Thirumala-Devi Kanneganti
{"title":"Inflammasomes and their role in PANoptosomes","authors":"Vinod Nadella,&nbsp;Thirumala-Devi Kanneganti","doi":"10.1016/j.coi.2024.102489","DOIUrl":"10.1016/j.coi.2024.102489","url":null,"abstract":"<div><div>Inflammasomes are multiprotein signaling structures in the innate immune system that drive cell death and inflammatory responses. These protein complexes generally comprise an innate immune sensor, the adaptor protein ASC, and the inflammatory protease caspase-1. Inflammasomes are formed when a cytosolic sensor, also known as a pattern recognition receptor, senses its cognate ligand, which can include microbial components, endogenous damage/danger signals, or environmental stimuli. Inflammasome assembly leads to autoproteolytic cleavage and activation of caspase-1. This activation, in turn, induces proteolytic maturation and release of the proinflammatory cytokines interleukin (IL)-1β and IL-18, and the activation of the pore-forming molecule gasdermin D to induce cell death, known as pyroptosis. Recent studies have identified inflammasomes as integral components of larger cell death complexes, known as PANoptosomes. These PANoptosomes regulate PANoptosis, an innate immune cell death pathway initiated by innate immune sensors and driven by caspases and receptor-interacting serine/threonine protein kinases. PANoptosome assembly and activation leads to cell lysis, inflammation, and the release of proinflammatory cytokines, damage-associated molecular patterns, and alarmins. In this review, we discuss the current understanding of different inflammasomes and their role in PANoptosomes.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102489"},"PeriodicalIF":6.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B cell memory of Immunoglobulin E (IgE) antibody responses in allergy 过敏症中免疫球蛋白 E (IgE) 抗体反应的 B 细胞记忆
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-27 DOI: 10.1016/j.coi.2024.102488
Weslley Fernandes-Braga, Maria A Curotto de Lafaille
{"title":"B cell memory of Immunoglobulin E (IgE) antibody responses in allergy","authors":"Weslley Fernandes-Braga,&nbsp;Maria A Curotto de Lafaille","doi":"10.1016/j.coi.2024.102488","DOIUrl":"10.1016/j.coi.2024.102488","url":null,"abstract":"<div><div>Immunoglobulin E (IgE)-mediated allergic diseases are driven by high-affinity allergen-specific IgE antibodies. IgE antibodies bind to Fc epsilon receptors on mast cells, prompting their degranulation and initiating inflammatory reactions upon allergen crosslinking. While most IgE-producing plasma cells have short lifespans, and IgE memory B cells are exceedingly rare, studies have indicated that non-IgE-expressing type 2–polarized IgG memory B cells serve as a reservoir of IgE memory in allergies. This review explores the B cell populations underlying IgE-mediated allergies, including the cellular and molecular processes that drive IgE class switching from non-IgE memory B cells. It highlights emerging evidence from human studies identifying type 2 IgG memory B cells as the source of pathogenic IgE in allergic responses.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102488"},"PeriodicalIF":6.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial sensing in allergic disease 过敏性疾病中的上皮传感
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-25 DOI: 10.1016/j.coi.2024.102490
Michael V Mandanas , Nora A Barrett
{"title":"Epithelial sensing in allergic disease","authors":"Michael V Mandanas ,&nbsp;Nora A Barrett","doi":"10.1016/j.coi.2024.102490","DOIUrl":"10.1016/j.coi.2024.102490","url":null,"abstract":"<div><div>Epithelial cells provide a first line of immune defense by maintaining barrier function, orchestrating mucociliary clearance, secreting antimicrobial molecules, and generating sentinel signals to both activate innate immune cells and shape adaptive immunity. Although epithelial alarmins play a particularly important role in the initiation of type 2 inflammation in response to allergens, the mechanisms by which epithelial cells sense the environment and regulate the generation and release of alarmins have been poorly understood. Recent studies have identified new sensors and signaling pathways used by barrier epithelial cells to elicit type 2 inflammation, including a novel pathway for the release of interleukin-33 from the nucleus that depends on apoptotic signaling. These recent findings have implications in the development of allergic diseases, from atopic eczema to food allergy, rhinitis, and asthma.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102490"},"PeriodicalIF":6.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of intestinal bacteria in promoting tolerance to food 肠道细菌在促进食物耐受性方面的作用
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-25 DOI: 10.1016/j.coi.2024.102492
Edward Ionescu , Cathryn R Nagler
{"title":"The role of intestinal bacteria in promoting tolerance to food","authors":"Edward Ionescu ,&nbsp;Cathryn R Nagler","doi":"10.1016/j.coi.2024.102492","DOIUrl":"10.1016/j.coi.2024.102492","url":null,"abstract":"<div><div>The global prevalence of atopic diseases, including food allergy, is increasing and correlates with shifts in the commensal microbiota triggered by modern lifestyle factors. Current research focuses on the immunological mechanisms and microbial cues that regulate mucosal immunity and prevent allergic responses to food. We review the identification and characterization of novel antigen-presenting cell subsets that may be critical for the establishment and maintenance of tolerance to both food and intestinal bacteria. Microbially derived products, particularly from the <em>Lachnospiraceae</em> family of Clostridia, regulate intestinal homeostasis through a variety of mechanisms. Here, we highlight recent work on Clostridial metabolites and products that mediate protection against allergic responses to food.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102492"},"PeriodicalIF":6.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multilevel approaches to immunization equity 实现免疫公平的多层次方法
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-24 DOI: 10.1016/j.coi.2024.102496
Joshua TB Williams , Sean T O’Leary
{"title":"Multilevel approaches to immunization equity","authors":"Joshua TB Williams ,&nbsp;Sean T O’Leary","doi":"10.1016/j.coi.2024.102496","DOIUrl":"10.1016/j.coi.2024.102496","url":null,"abstract":"<div><div>Over the last 2 years, immunization disparities have surged due to a pandemic, violent conflicts, economic crises, and their disrupting effects on health care systems. This review provides a multilevel framework for understanding vaccination disparities and provides examples of work addressing disparities risk factors and building immunization equity. Readers will review the World Health Organization’s 2023 priorities for vaccination equity, learn about vaccination campaigns in conflict zones like Ukraine, identify key components to a successful COVID-19 response in Ghana, and understand Brazilian efforts to minimize stigma and champion community members to build trust in mpox vaccines and health services. These efforts will improve equity and foster flourishing among vulnerable populations.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102496"},"PeriodicalIF":6.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial barrier dysfunction, type 2 immune response, and the development of chronic inflammatory diseases 上皮屏障功能障碍、2 型免疫反应和慢性炎症性疾病的发展
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-24 DOI: 10.1016/j.coi.2024.102493
Ismail Ogulur, Yagiz Pat, Duygu Yazici, Sena Ardicli, Ozge Ardicli, Yasutaka Mitamura, Mübeccel Akdis, Cezmi A Akdis
{"title":"Epithelial barrier dysfunction, type 2 immune response, and the development of chronic inflammatory diseases","authors":"Ismail Ogulur,&nbsp;Yagiz Pat,&nbsp;Duygu Yazici,&nbsp;Sena Ardicli,&nbsp;Ozge Ardicli,&nbsp;Yasutaka Mitamura,&nbsp;Mübeccel Akdis,&nbsp;Cezmi A Akdis","doi":"10.1016/j.coi.2024.102493","DOIUrl":"10.1016/j.coi.2024.102493","url":null,"abstract":"<div><div>The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, humans have been increasingly exposed to substances toxic for epithelial cells, including air pollutants, laundry and dishwashers, household chemicals, toothpaste, food additives, microplastics, and nanoparticles, introduced into our daily lives as part of industrialization, urbanization, and modernization. These substances disrupt the epithelial barriers and lead to microbial dysbiosis and cause immune response to allergens, opportunistic pathogens, bacterial toxins, and autoantigens followed by chronic inflammation due to epigenetic mechanisms. Recent evidence from studies on the mechanisms of epithelial barrier damage has demonstrated that even trace amounts of toxic substances can damage epithelial barriers and induce tissue inflammation. Further research in this field is essential for our understanding of the causal substances and molecular mechanisms involved in the initiation of leaky epithelial barriers that cascade into chronic inflammatory diseases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102493"},"PeriodicalIF":6.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic footprint and logic through the T cell life cycle T 细胞生命周期中的代谢足迹和逻辑。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-21 DOI: 10.1016/j.coi.2024.102487
Tingting Fan, Rushil Shah, Ruoning Wang
{"title":"Metabolic footprint and logic through the T cell life cycle","authors":"Tingting Fan,&nbsp;Rushil Shah,&nbsp;Ruoning Wang","doi":"10.1016/j.coi.2024.102487","DOIUrl":"10.1016/j.coi.2024.102487","url":null,"abstract":"<div><div>A simple definition of life is a system that can self-replicate (proliferation) and self-sustain (metabolism). At the cellular level, metabolism has evolved to drive proliferation, which requires energy and building blocks to duplicate cellular biomass before division. T lymphocytes (or T cells) are required for adaptive immune responses, protecting us against invading and malignant agents capable of hyper-replication. To gain a competitive advantage over these agents, activated T cells can duplicate their biomass and divide into two daughter cells in as short as 2–6 hours, considered the fastest cell division among all cell types in vertebrates. Thus, the primary task of cellular metabolism has evolved to commit available resources to drive T cell hyperproliferation. Beyond that, the T cell life cycle involves an ordered series of fate-determining events that drive cells to transition between discrete cell states. At the life stages not involved in hyperproliferation, T cells engage metabolic programs that are more flexible to sustain viability and maintenance and sometimes are fine-tuned to support specific cellular activities. Here, we focus on the central carbon metabolism, which is most relevant to cell proliferation. We provide examples of how the changes in the central carbon metabolism may or may not change the fate of T cells and further explore a few conceptual frameworks, such as metabolic flexibility, the Goldilocks Principle, overflow metabolism, and effector-signaling metabolites, in the context of T cell fate transitions.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102487"},"PeriodicalIF":6.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000773/pdfft?md5=53eec91d31cb362d95c62f0974622792&pid=1-s2.0-S0952791524000773-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking Toll-like receptor signalling 对 Toll 样受体信号的再思考
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-16 DOI: 10.1016/j.coi.2024.102460
Clare E Bryant
{"title":"Rethinking Toll-like receptor signalling","authors":"Clare E Bryant","doi":"10.1016/j.coi.2024.102460","DOIUrl":"10.1016/j.coi.2024.102460","url":null,"abstract":"<div><p>Since the discovery of Toll and Toll-like receptors (TLRs) in the 90s, an extensive body of research has been performed to determine how Pattern Recognition Receptors (PRRs) recognise ‘ligands’ and signal. The families of PRRs now include membrane and cytosolic proteins, which broadly signal by forming large protein platforms or supramolecular organising centres (SMOCs). The concept of SMOC-driven signalling has led to the development of a set of assumptions, particularly for TLRs, based on experimental data, to explain the physiological consequences of PRR activation. Recent research suggests that at least some of these assumptions should be reconsidered, especially as many of these receptors are important therapeutic targets for drug development, so understanding the mechanisms by which they signal is critical.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102460"},"PeriodicalIF":6.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000505/pdfft?md5=06675d4a32ef2587f4ce04c1ff7422c0&pid=1-s2.0-S0952791524000505-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome modulation of antigen presentation in tolerance and inflammation 微生物组在耐受和炎症中对抗原递呈的调节作用
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-14 DOI: 10.1016/j.coi.2024.102471
Yiming He , Gayatree Mohapatra , Sahana Asokan , Samuel Philip Nobs , Eran Elinav
{"title":"Microbiome modulation of antigen presentation in tolerance and inflammation","authors":"Yiming He ,&nbsp;Gayatree Mohapatra ,&nbsp;Sahana Asokan ,&nbsp;Samuel Philip Nobs ,&nbsp;Eran Elinav","doi":"10.1016/j.coi.2024.102471","DOIUrl":"10.1016/j.coi.2024.102471","url":null,"abstract":"<div><p>The microbiome regulates mammalian immune responses from early life to adulthood. Antigen presentation, orchestrating these responses, integrates commensal and pathogenic signals. However, the temporal and spatial specificity of microbiome impacts on antigen presentation and downstream tolerance versus inflammation remain incompletely understood. Herein, we review the influences of antigen presentation of microbiome-related epitopes on immunity; impacts of microbiome-based modulation of antigen presentation on innate and adaptive immune responses; and their ramifications on homeostasis and immune-related disease, ranging from auto-inflammation to tumorigenesis. We highlight mechanisms driving these influences, such as ‘molecular mimicry’, in which microbiome auto-antigen presentation aberrantly triggers an immune response driving autoimmunity or influences conferred by microbiome-derived metabolites on antigen-presenting cells in inflammatory bowel disease. We discuss unknowns, controversies, and challenges associated with the study of microbiome regulation of antigen presentation while demonstrating how increasing knowledge may contribute to the development of microbiome-based therapeutics modulating immune responses in a variety of clinical contexts.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102471"},"PeriodicalIF":6.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T follicular helper cells in food allergy 食物过敏中的 T 滤泡辅助细胞
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-14 DOI: 10.1016/j.coi.2024.102461
Jennifer S Chen , Donguk Lee , Uthaman Gowthaman
{"title":"T follicular helper cells in food allergy","authors":"Jennifer S Chen ,&nbsp;Donguk Lee ,&nbsp;Uthaman Gowthaman","doi":"10.1016/j.coi.2024.102461","DOIUrl":"10.1016/j.coi.2024.102461","url":null,"abstract":"<div><p>T follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has delineated the specific phenotypes of Tfh cells that induce antibodies to food while also clarifying the divergent Tfh cell requirement for different food-specific antibody isotypes. Furthermore, Tfh and antibody responses to food can occur at multiple barrier sites — namely, skin, airway, and gut. Depending on the context of food antigen exposure, the immune response to food at these sites can be protective, as in the case of tolerance or immunotherapy, or pathogenic, as in the case of allergy. This review will highlight recent advances in our understanding of how Tfh cells promote antibodies to food as well as future avenues for continued discovery.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102461"},"PeriodicalIF":6.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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