Current Opinion in Immunology最新文献_第3页

Pulmonary transfusion reactions as an immunological spectrum disorder 肺输血反应作为一种免疫谱系障碍

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-11-06 DOI: 10.1016/j.coi.2025.102689

Jonas Lowack , Alexander PJ Vlaar , Robert B Klanderman , Anna-Linda Peters

{"title":"Pulmonary transfusion reactions as an immunological spectrum disorder","authors":"Jonas Lowack , Alexander PJ Vlaar , Robert B Klanderman , Anna-Linda Peters","doi":"10.1016/j.coi.2025.102689","DOIUrl":"10.1016/j.coi.2025.102689","url":null,"abstract":"<div><div>Transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) are leading causes of transfusion-related morbidity and mortality. Despite distinct diagnostic criteria, both syndromes present similarly with respiratory distress and pulmonary edema. In recent research, they increasingly appear to share pathophysiological and immunological features. In this review, we discuss current evidence supporting a spectrum model of pulmonary transfusion reactions, spanning hydrostatic to permeability edema. We highlight key immunological mechanisms in TRALI, including Fc-receptor or complement engagement, and cytokine responses, and explore emerging evidence of immune involvement in TACO. To differentiate, the anti-inflammatory cytokine interleukin (IL)-10 and pro-inflammatory IL-6 emerge as potential biomarkers with diagnostic and therapeutic implications. The underdiagnosis of reverse TRALI and TRALI/TACO overlap further highlights the need for additional mechanistic insight and improved diagnostics. Future work should focus on biomarker-guided phenotyping to improve clinical differentiation and treatment strategies for transfusion-related respiratory complications as a spectrum disorder.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"98 ","pages":"Article 102689"},"PeriodicalIF":5.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The power of genetics in decoding Sjögren’s disease: current status and future development 基因解码Sjögren疾病的力量：现状和未来发展。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-11-11 DOI: 10.1016/j.coi.2025.102690

Marcin Radziszewski , Kandice L Tessneer , Christopher J Lessard

{"title":"The power of genetics in decoding Sjögren’s disease: current status and future development","authors":"Marcin Radziszewski , Kandice L Tessneer , Christopher J Lessard","doi":"10.1016/j.coi.2025.102690","DOIUrl":"10.1016/j.coi.2025.102690","url":null,"abstract":"<div><div>Sjögren’s disease (SjD) is the second most common systemic autoimmune disease in the United States. SjD patients are predominantly women 30–50 years of age and exhibit heterogeneous clinical manifestations, including symptoms of extensive dryness, chronic fatigue, and joint pain, and various major organ involvement. Late onset, clinical heterogeneity, and limited mechanistic understanding of its etiology frequently lead to delayed or misdiagnosis. Although the etiology of SjD is unclear, candidate gene studies and population-based genome-wide association studies suggest that SjD results from an interplay between genetics and environment. Defining the genetic susceptibility of SjD remains an important research focus to improve the understanding of SjD etiology and the development of diagnostic and treatment options. Unfortunately, the genetic understanding of SjD lags far behind that of other related autoimmune diseases. This review provides a brief history of key milestones in the field of SjD genetics and highlights several areas of future research that will bolster the discovery power of ongoing genetic studies and define the underlying mechanisms that drive disease etiology.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"98 ","pages":"Article 102690"},"PeriodicalIF":5.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward indole postbiotics precision therapy via AI-powered drug delivery technologies 通过人工智能给药技术实现吲哚后生物精准治疗。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-11-11 DOI: 10.1016/j.coi.2025.102692

Puccetti Matteo , Pariano Marilena , Wojtylo Paulina Anna , Ricci Maurizio , Stefano Giovagnoli

引用次数: 0

Sarcoidosis of the nervous system: a rare but serious manifestation 神经系统结节病：一种罕见但严重的症状。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-12-08 DOI: 10.1016/j.coi.2025.102704

Patompong Ungprasert , Brandon P Moss

引用次数: 0

The role of linked recognition and B cell precursor frequency in alloimmunization to transfused RBCs 联认和B细胞前体频率在输血红细胞异体免疫中的作用。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.coi.2025.102705

Elizabeth L Frost , Arijita Jash , Angelo D’Alessandro , Krystalyn E Hudson , James C Zimring

{"title":"The role of linked recognition and B cell precursor frequency in alloimmunization to transfused RBCs","authors":"Elizabeth L Frost , Arijita Jash , Angelo D’Alessandro , Krystalyn E Hudson , James C Zimring","doi":"10.1016/j.coi.2025.102705","DOIUrl":"10.1016/j.coi.2025.102705","url":null,"abstract":"<div><div>Despite multiple alloantigenic differences in every allotransfusion, only 3–6% of transfusion recipients develop a detectable alloantibody even with multiple transfusions. Moreover, patients typically become alloimmunized only to some of the alloantigens to which they are exposed. In recent decades, precursor frequency of antigen-specific T and B cells has been demonstrated to be a key determinant of adaptive immunity. Given the small differences between donor and recipient alloantigens (typically a single amino acid), precursor frequencies for T and B cells are predicted to be extremely low for a given alloantigen. In this review, it is argued based upon existing evidence in the literature and new data presented herein that linked recognition occurs with red blood cell (RBC) alloantigens resulting in a dramatically increased precursor frequency for CD4<sup>+</sup> T cell help with no increase in B cell precursor frequency. The hypothesis is forwarded that B cell precursor frequency is a limiting factor in RBC alloimmunization.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"98 ","pages":"Article 102705"},"PeriodicalIF":5.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is psoriatic arthritis a dissemination of cutaneous psoriatic TRM cells? Role of tissue-resident memory T cells (TRM) in psoriatic disease 银屑病关节炎是皮肤银屑病TRM细胞的扩散吗？组织常驻记忆T细胞（TRM）在银屑病中的作用

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.coi.2025.102702

Siba P Raychaudhuri , Smriti K Raychaudhuri

引用次数: 0

Diet-derived microbial metabolites as regulators of immune function 饮食来源的微生物代谢物作为免疫功能的调节因子。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-12-22 DOI: 10.1016/j.coi.2025.102713

Francesco Siracusa , Andres Machicote , Samuel Huber , Nicola Gagliani

引用次数: 0

Mapping the B-cell axis in Sjögren’s disease: repertoire, microenvironment, and potential routes to precision treatment 绘制Sjögren疾病中的b细胞轴：库、微环境和精确治疗的潜在途径

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1016/j.coi.2025.102712

Loukas Chatzis , Dimitris Anastasios Palamidas , Thomas Dörner

{"title":"Mapping the B-cell axis in Sjögren’s disease: repertoire, microenvironment, and potential routes to precision treatment","authors":"Loukas Chatzis , Dimitris Anastasios Palamidas , Thomas Dörner","doi":"10.1016/j.coi.2025.102712","DOIUrl":"10.1016/j.coi.2025.102712","url":null,"abstract":"<div><div>Sjögren’s disease (SjD) is a chronic autoimmune disorder in which sustained B-cell activation drives glandular injury and systemic complications. Epithelial stress and interferon tone amplify B-cell activating factor (BAFF)-dependent survival, skewing selection toward autoreactive clones in both glands and blood. In addition, single-cell B-cell receptor analyses have uncovered interferon-high endotypes with tissue-imprinted oligoclonality and biased isotype and light-chain usage. Within salivary glands, ectopic germinal centers and FcRL4⁺ B cells act as local ‘training sites,’ integrating Tfh/Tph help, CXCL13 cues, and BAFF/APRIL-NF-κB signaling to sustain plasmablast differentiation. Extrafollicular trajectories — double-negative and age-associated B cells — expand in IFN/TLR7 and IL-21 milieus, while regulatory B-cell restraint is diminished. Emerging data also implicate glycolysis and mTORC1-GLUT1 metabolism in sustaining B-cell hyperactivation. Chronic B-cell receptor signaling and clonal evolution provide a bridge to lymphoma risk. In this review, we outline how these converging pathways define molecular endotypes and propose a precision framework linking them to targeted therapy in SjD.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"98 ","pages":"Article 102712"},"PeriodicalIF":5.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we cure autoimmunity? 我们能治愈自身免疫吗？

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-11-10 DOI: 10.1016/j.coi.2025.102684

Nicolle Sweeney , Yemil Atisha-Fregoso , Rita Pozovskiy , Lauren Higdon , Mark Anderson , Betty Diamond , William M Ridgway

{"title":"Can we cure autoimmunity?","authors":"Nicolle Sweeney , Yemil Atisha-Fregoso , Rita Pozovskiy , Lauren Higdon , Mark Anderson , Betty Diamond , William M Ridgway","doi":"10.1016/j.coi.2025.102684","DOIUrl":"10.1016/j.coi.2025.102684","url":null,"abstract":"<div><div>Autoimmune diseases have, until recently, been treated with relatively broad immunosuppressive regimens. Newer, more focused monoclonal antibody therapies directed to specific targets, for example, anti-TNF or anti-B cell therapies, can produce significant immunosuppression. ‘Remission’ of autoimmune disease that requires ongoing immunosuppression is not an ideal solution. We define a ‘cure’ for autoimmunity as: <em>resolution of disease without ongoing immunosuppressive therapy</em>. Herein, we discuss the possibilities of such a cure, the mechanisms behind such approaches, and obstacles in the setting of representative systemic (systemic lupus erythematosus, or SLE) and organ-specific (type 1 diabetes, T1D) autoimmune diseases. ‘Cure’ of autoimmunity is a remarkably difficult goal and, as illustrated here, will require detailed scientific understanding of each autoimmune disease, even beyond the remarkable advances achieved to date. The basic distinction between autoimmune diseases, in which the target organ is largely destroyed at clinical onset (e.g. T1D), and systemic diseases affecting multiple organs strongly affects how progress can be made towards a cure. In the case of systemic disease, obtaining exact further knowledge of the role of immune cell subsets (e.g. short-lived plasma cells in SLE) is critical. In organ-specific autoimmunity, such as in T1D, improved preclinical detection and characterization of the preclinical immune pathology will be essential.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"98 ","pages":"Article 102684"},"PeriodicalIF":5.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting tryptophan metabolism in cancer: complexity, context, and spatial heterogeneity 癌症中的色氨酸代谢：复杂性、背景和空间异质性。

IF 5.8 2区医学

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-12-09 DOI: 10.1016/j.coi.2025.102706

Teng Teng Xu , Camille Guyot , Peter J Murray

{"title":"Revisiting tryptophan metabolism in cancer: complexity, context, and spatial heterogeneity","authors":"Teng Teng Xu , Camille Guyot , Peter J Murray","doi":"10.1016/j.coi.2025.102706","DOIUrl":"10.1016/j.coi.2025.102706","url":null,"abstract":"<div><div>Tryptophan (TRP) metabolism has long been associated with cancer immunity, primarily through the kynurenine pathway mediated by indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase (TDO2). Both enzymes can deplete TRP within cells and in local microenvironments, triggering dysfunction of T cells with anti-tumor functions. This view fostered the development of IDO1/TDO2 inhibitors, which ultimately failed in clinical trials. However, we now know that TRP metabolism in tumors is far more complex than anticipated. Recent work highlights the dual, context-dependent roles of TRP-depleting enzymes. Importantly, advances in spatial profiling have uncovered that TRP-metabolizing enzymes are not uniformly expressed but instead form distinct metabolic niches within tumors. These niches shape local TRP availability, metabolite gradients, downstream metabolic signaling, and immune responses in ways that cannot be captured by bulk or single-cell approaches alone. This review synthesizes emerging insights into the diverse and spatially defined functions of TRP metabolism in cancer and discusses how integrating spatial omics may guide next-generation therapeutic strategies beyond IDO1 inhibition.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"98 ","pages":"Article 102706"},"PeriodicalIF":5.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0