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Current Opinion in Immunology最新文献

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Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans 强大的显微镜技术解码了驱动人体免疫疗法反应的空间组织细胞网络
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-14 DOI: 10.1016/j.coi.2024.102463
Jonathan H Chen , Liad Elmelech , Alexander L Tang , Nir Hacohen
{"title":"Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans","authors":"Jonathan H Chen ,&nbsp;Liad Elmelech ,&nbsp;Alexander L Tang ,&nbsp;Nir Hacohen","doi":"10.1016/j.coi.2024.102463","DOIUrl":"10.1016/j.coi.2024.102463","url":null,"abstract":"<div><p>In tumors, immune cells organize into networks of different sizes and composition, including complex tertiary lymphoid structures and recently identified networks centered around the chemokines CXCL9/10/11 and CCL19. New commercially available highly multiplexed microscopy using cyclical RNA <em>in situ</em> hybridization and antibody-based approaches have the potential to establish the organization of the immune response in human tissue and serve as a foundation for future immunology research.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102463"},"PeriodicalIF":6.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking signal input, cell state, and spatial context to inflammatory responses 将信号输入、细胞状态和空间环境与炎症反应联系起来
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-11 DOI: 10.1016/j.coi.2024.102462
Rachel A Gottschalk , Ronald N Germain
{"title":"Linking signal input, cell state, and spatial context to inflammatory responses","authors":"Rachel A Gottschalk ,&nbsp;Ronald N Germain","doi":"10.1016/j.coi.2024.102462","DOIUrl":"10.1016/j.coi.2024.102462","url":null,"abstract":"<div><p>Signal integration is central to a causal understanding of appropriately scaled inflammatory responses. Here, we discuss recent progress in our understanding of the stimulus–response linkages downstream of pro-inflammatory inputs, with special attention to (1) the impact of cell state on the specificity of evoked gene expression and (2) the critical role of the spatial context of stimulus exposure. Advances in these directions are emerging from new tools for inferring cell–cell interactions and the activities of cytokines and transcription factors in complex microenvironments, enabling analysis of signal integration in tissue settings<em>.</em> Building on data-driven elucidation of factors driving inflammatory outcomes, mechanistic modeling can then contribute to a quantitative understanding of regulatory events that balance protective versus pathological inflammation.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102462"},"PeriodicalIF":6.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene: environment interactions in immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 infection 严重急性呼吸系统综合征冠状病毒 2 感染的免疫和炎症反应中基因与环境的相互作用。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-06 DOI: 10.1016/j.coi.2024.102459
Yunxiang Yang, Alessia Azzuolo, Nassima Fodil, Philippe Gros
{"title":"Gene: environment interactions in immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 infection","authors":"Yunxiang Yang,&nbsp;Alessia Azzuolo,&nbsp;Nassima Fodil,&nbsp;Philippe Gros","doi":"10.1016/j.coi.2024.102459","DOIUrl":"10.1016/j.coi.2024.102459","url":null,"abstract":"<div><p>Despite its devastating human cost, the rapid spread and global establishment of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic had the benefit of providing unique insights into the intricate interplay between genetic, environmental, and socioeconomic factors, which collectively impact susceptibility to infection with SARS-CoV-2. Preceding the implementation of broad vaccination programs and assuming the absence of significant acquired immunity, examining the innate vulnerability to the virus becomes essential. There is indeed considerable heterogeneity observed at both the population and individual levels for various SARS-CoV-2 infection phenotypes, including emergence, progression, and survival from the coronavirus disease 2019 (COVID-19) syndrome. Particularly intriguing is the seemingly milder course of COVID-19 disease reported for the African continent early during the pandemic. This was characterized by significantly lower mortality rates in SARS-CoV-2 patients compared with the European and American continents and globally. We will discuss some of the demographic and socioeconomic factors that may have contributed to these observations. We review the mapped COVID-19 genetic architecture, including the remarkable association of type I interferon as a single protective mechanism and a major determinant of susceptibility. Furthermore, we speculate on potential ‘environmental’ modulators of penetrance and expressivity of intrinsic vulnerability factors, with a focus on the microbiome and associated metabolomes. Additionally, this review explores the potential immunomodulatory contribution of helminth parasites to the human host immune and inflammatory responses to respiratory viral infections.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"90 ","pages":"Article 102459"},"PeriodicalIF":6.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000499/pdfft?md5=fb32fa09490ad1683df372ef85988b46&pid=1-s2.0-S0952791524000499-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Friendly fire: recognition of self by the innate immune system 友谊之火：先天免疫系统识别自我
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-03 DOI: 10.1016/j.coi.2024.102457
Veit Hornung , Moritz M Gaidt
{"title":"Friendly fire: recognition of self by the innate immune system","authors":"Veit Hornung ,&nbsp;Moritz M Gaidt","doi":"10.1016/j.coi.2024.102457","DOIUrl":"10.1016/j.coi.2024.102457","url":null,"abstract":"<div><p>The innate immune system employs two different strategies to detect pathogens: first, it recognizes microbial components as ligands of pattern recognition receptors (pattern-triggered immunity [PTI]), and second, it detects the activities of pathogen-encoded effectors (effector-triggered immunity [ETI]). Recently, these pathogen-centric concepts were expanded to include sensing of self-derived signals during cellular distress or damage (damage-triggered immunity [DTI]). This extension relied on broadening the PTI model to include damage-associated molecular patterns (DAMPs). However, applying the pattern recognition framework of PTI to DTI overlooks the critical role of sterile activation of ETI pathways. We argue that both PTI and ETI pathways are prone to erroneous detection of self, which is largely attributable to ‘friendly fire’ rather than protective immune activation. This erroneous activation is inherent to the trade-off between sensitivity and specificity of immune sensing and might be tolerated because its detrimental effects emerge late in life, a phenomenon known as antagonistic pleiotropy.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"90 ","pages":"Article 102457"},"PeriodicalIF":6.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmune recognition of allergens 神经免疫识别过敏原
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-29 DOI: 10.1016/j.coi.2024.102458
Isaac M Chiu , Caroline L Sokol
{"title":"Neuroimmune recognition of allergens","authors":"Isaac M Chiu ,&nbsp;Caroline L Sokol","doi":"10.1016/j.coi.2024.102458","DOIUrl":"10.1016/j.coi.2024.102458","url":null,"abstract":"<div><p>Interactions between the nervous system and the immune system play crucial roles in initiating and directing the type 2 immune response. Sensory neurons can initiate innate and adaptive type 2 immunity through their ability to detect allergens and promote dendritic cell and mast cell responses. Neurons also indirectly promote type 2 inflammation through suppression of type 1 immune responses. Type 2 cytokines promote neuronal function by directly activating or sensitizing neurons. This positive neuroimmune feedback loop may not only enhance allergic inflammation but also promote the system-wide responses of aversion, anaphylaxis, and allergen polysensitization that are characteristic of allergic immunity.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"90 ","pages":"Article 102458"},"PeriodicalIF":6.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining the niche for stem-like CD8+ T cell formation and function 确定干样 CD8+ T 细胞形成和功能的生态位
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-01 DOI: 10.1016/j.coi.2024.102454
Benjamin J Broomfield , Joanna R Groom
{"title":"Defining the niche for stem-like CD8+ T cell formation and function","authors":"Benjamin J Broomfield ,&nbsp;Joanna R Groom","doi":"10.1016/j.coi.2024.102454","DOIUrl":"10.1016/j.coi.2024.102454","url":null,"abstract":"<div><p>TCF-1<sup>+</sup> CD8<sup>+</sup> T cell populations have emerged as critical determinants for long-lived immunological memory. This cell population has stem-like properties and is implicated in improved disease outcomes by driving sustained killing of infected cells and maintaining the immune-cancer equilibrium. During an immune response, several factors, including antigen deposition and affinity, the inflammatory milieu, and T cell priming dynamics, aggregate to skew CD8<sup>+</sup> T cell differentiation. Although these mechanisms are altered between acute and chronic disease settings, phenotypically similar stem-like TCF-1<sup>+</sup> CD8<sup>+</sup> T cell states are formed in each of these settings. Here, we characterize the specialized microenvironments within lymph nodes and the tumor microenvironment, which foster the generation or re-activation of stem-like TCF-1<sup>+</sup> CD8<sup>+</sup> T cell populations. We highlight the potential for targeting the stem-like CD8<sup>+</sup> T cell niche to enhance vaccination and cancer immunotherapy and to track the trajectory of stem-like CD8<sup>+</sup> T cells as biomarkers of therapeutic efficacy.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"89 ","pages":"Article 102454"},"PeriodicalIF":6.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles of bacterial innate immunity against viruses 细菌对病毒的先天免疫原理。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-01 DOI: 10.1016/j.coi.2024.102445
Michael T Laub , Athanasios Typas
{"title":"Principles of bacterial innate immunity against viruses","authors":"Michael T Laub ,&nbsp;Athanasios Typas","doi":"10.1016/j.coi.2024.102445","DOIUrl":"10.1016/j.coi.2024.102445","url":null,"abstract":"<div><p>All organisms must defend themselves against viral predators. This includes bacteria, which harbor immunity factors such as restriction-modification systems and CRISPR-Cas systems. More recently, a plethora of additional defense systems have been identified, revealing a richer, more sophisticated immune system than previously appreciated. Some of these newly identified defense systems have distant homologs in mammals, suggesting an ancient evolutionary origin of some facets of mammalian immunity. An even broader conservation exists at the level of how these immunity systems operate. Here, we focus at this level, reviewing key principles and high-level attributes of innate immunity in bacteria that are shared with mammalian immunity, while also noting key differences, with a particular emphasis on how cells sense viral infection.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"89 ","pages":"Article 102445"},"PeriodicalIF":6.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000359/pdfft?md5=33658de57204a932cd10c0d4f96607a6&pid=1-s2.0-S0952791524000359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory T cells in the context: deciphering the dynamic interplay with the tissue environment 环境中的调节性 T 细胞：解读与组织环境的动态相互作用
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-01 DOI: 10.1016/j.coi.2024.102453
Xiao Huang, Alexander Y Rudensky
{"title":"Regulatory T cells in the context: deciphering the dynamic interplay with the tissue environment","authors":"Xiao Huang,&nbsp;Alexander Y Rudensky","doi":"10.1016/j.coi.2024.102453","DOIUrl":"10.1016/j.coi.2024.102453","url":null,"abstract":"<div><p>The delicate balance between protective immunity against pathogens and the prevention of autoimmunity requires finely tuned generation and function of regulatory CD4<sup>+</sup> T (Treg) cells. Here, we review recent progress in the understanding of a complex set of cues, which converge on Treg cells in lymphoid and nonlymphoid organs and in tumors and how these cues modulate Treg functions. We highlight the versatility of Treg cells underlying their ability to dynamically adapt to local microenvironments and perform a wide range of functions that extend beyond the archetypal role of Treg cells in moderating adverse effects of immune response-associated inflammation and in suppressing autoimmunity.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"89 ","pages":"Article 102453"},"PeriodicalIF":6.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota and B-1 B cell repertoire development in mice 微生物群与小鼠 B-1 B 细胞群的发育
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-01 DOI: 10.1016/j.coi.2024.102452
James Stewart New, Rodney Glenn King, Jeremy B Foote, John F Kearney
{"title":"Microbiota and B-1 B cell repertoire development in mice","authors":"James Stewart New,&nbsp;Rodney Glenn King,&nbsp;Jeremy B Foote,&nbsp;John F Kearney","doi":"10.1016/j.coi.2024.102452","DOIUrl":"10.1016/j.coi.2024.102452","url":null,"abstract":"<div><p>Microbiota-derived antigens play a critical role in the development of both the mucosal and systemic B cell repertoires; however, how glycan epitopes promote B cell repertoire selection is only recently being understood. The production of glycan-derived antigens by individual microbes within a host can be dynamic and influenced by interactions within other members of microbial communities, the composition of diet, and host-derived contents, including those of the mucosal immune system. The size and complexity of the emerging neonatal B cell repertoire are paralleled by the acquisition of a diverse microbiota from maternal and environmental sources, which is now appreciated to exert long-lasting influences on the nascent B cell repertoire.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"89 ","pages":"Article 102452"},"PeriodicalIF":6.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Necroptosis in immunity, tissue homeostasis, and cancer 免疫、组织稳态和癌症中的坏死过程
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-01 DOI: 10.1016/j.coi.2024.102455
Jinwen Yin , Yuqiang Yu , Xinyue Huang , Francis K-M Chan
{"title":"Necroptosis in immunity, tissue homeostasis, and cancer","authors":"Jinwen Yin ,&nbsp;Yuqiang Yu ,&nbsp;Xinyue Huang ,&nbsp;Francis K-M Chan","doi":"10.1016/j.coi.2024.102455","DOIUrl":"10.1016/j.coi.2024.102455","url":null,"abstract":"<div><p>Immune and tissue homeostasis is achieved through balancing signals that regulate cell survival, proliferation, and cell death. Recent studies indicate that certain cell death programs can stimulate inflammation and are often referred as ‘immunogenic cell death’ (ICD). ICD is a double-edged sword that can confer protection against pathogen infection but also cause tissue damage. Necroptosis is a key ICD module that has been shown to participate in host defense against pathogen infection, tissue homeostasis, and cancer response to immunotherapy. Here, we will review recent findings on the regulation of necroptosis signaling and its role in pathogen infection, tissue homeostasis, and cancer.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"89 ","pages":"Article 102455"},"PeriodicalIF":6.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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