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Current Opinion in Immunology最新文献

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IFNε, IFNω and IFNλ: interferons defending the mucosa IFNε、IFNω和IFNλ：保护粘膜的干扰素。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-01 DOI: 10.1016/j.coi.2024.102456
Jasmine J M Chuah , Nicole K Campbell
{"title":"IFNε, IFNω and IFNλ: interferons defending the mucosa","authors":"Jasmine J M Chuah ,&nbsp;Nicole K Campbell","doi":"10.1016/j.coi.2024.102456","DOIUrl":"10.1016/j.coi.2024.102456","url":null,"abstract":"<div><p>The unconventional type I interferons IFNε and IFNω and type III interferon IFNλ are gradually emerging as tissue-specific cytokines in defence of mucosal tissues. This review provides an overview of the distinct features and functions that define these IFNs as protective factors in the respiratory, gastrointestinal and reproductive tracts, highlighting their immunoregulatory roles against pathogens while maintaining tolerance against commensal microbes. In particular, we discuss recent advances in our understanding of the constitutively expressed IFNε and its role in protecting against mucosal infections, inflammation and cancers. We identify an emerging theme for this unique cytokine as a key contributor to the ‘first line of defence’ against pathogens and maintenance of mucosal tissue homeostasis, primarily through its regulation of immune cell populations.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"89 ","pages":"Article 102456"},"PeriodicalIF":6.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammasome-independent pyroptosis 独立于炎症体的脓毒血症
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-06-01 DOI: 10.1016/j.coi.2024.102432
Xing Liu , Judy Lieberman
{"title":"Inflammasome-independent pyroptosis","authors":"Xing Liu ,&nbsp;Judy Lieberman","doi":"10.1016/j.coi.2024.102432","DOIUrl":"10.1016/j.coi.2024.102432","url":null,"abstract":"<div><p>Gasdermins are membrane pore–forming proteins that cause pyroptosis, an inflammatory cell death in which cells burst and release cytokines, chemokines, and other host alarm signals, such as ATP and HMGB1, which recruit and activate immune cells at sites of infection and danger. There are five gasdermins in humans — gasdermins A to E. Pyroptosis was first described in myeloid cells and mucosal epithelia, which express gasdermin D and activate it when cytosolic sensors of invasive infection or tissue damage assemble into large macromolecular structures, called inflammasomes. Inflammasomes recruit and activate inflammatory caspases (caspase 1, 4, 5, and 11), which cut gasdermin D to remove an inhibitory C-terminal domain, allowing the N-terminal domain to bind to membrane acidic lipids and oligomerize into pores. Recent studies have identified inflammasome-independent proteolytic pathways that activate gasdermin D and the other gasdermins. Here, we review inflammasome-independent pyroptosis pathways and what is known about their role in normal physiology and disease.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"88 ","pages":"Article 102432"},"PeriodicalIF":7.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into the mechanisms regulating plasma cell survival and longevity 浆细胞存活和寿命调节机制的新见解。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-06-01 DOI: 10.1016/j.coi.2024.102442
Mélanie Khamyath , Houda Melhem , Karl Balabanian , Marion Espéli
{"title":"New insights into the mechanisms regulating plasma cell survival and longevity","authors":"Mélanie Khamyath ,&nbsp;Houda Melhem ,&nbsp;Karl Balabanian ,&nbsp;Marion Espéli","doi":"10.1016/j.coi.2024.102442","DOIUrl":"10.1016/j.coi.2024.102442","url":null,"abstract":"<div><p>Plasma cells correspond to the last stage of B cell differentiation and are professional antibody-secreting cells. While most persist for only few days, some may survive for weeks to years in dedicated survival niches. The determination of plasma cell survival rate seems to rely both on intrinsic and extrinsic factors. Although often opposed, the deterministic and environmental models for plasma cell longevity are certainly overlapping. Understanding the contribution and the regulation of these different factors is paramount to develop better vaccines but also to target malignant plasma cells. Here, we review recent literature highlighting new findings pertaining to plasma cell survival rate, intrinsic regulation of plasma cell persistence and function, as well as the plasma cell/niche dialogue. Moreover, the now well-recognised heterogeneity observed among plasma cells is also discussed.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"88 ","pages":"Article 102442"},"PeriodicalIF":6.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000323/pdfft?md5=a026170615a2045d2f16a17aa5928c6c&pid=1-s2.0-S0952791524000323-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The tumor-driven antibody-mediated immune response in cancer 癌症中由肿瘤驱动的抗体介导的免疫反应。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-06-01 DOI: 10.1016/j.coi.2024.102431
{"title":"The tumor-driven antibody-mediated immune response in cancer","authors":"","doi":"10.1016/j.coi.2024.102431","DOIUrl":"10.1016/j.coi.2024.102431","url":null,"abstract":"<div><p><span>Immune cells<span><span><span><span> in the tumor microenvironment play a crucial role in </span>cancer prognosis and response to </span>immunotherapy. Recent studies highlight the significance of tumor-infiltrating B cells and </span>tertiary lymphoid structures<span> as markers of favorable prognosis and patient-positive response to immune checkpoint<span> blockers in some types of cancer. Although the presence of germinal center B cells and plasma cells in the tumor microenvironment has been established, determining their tumor reactivity remains challenging. The few known tumor targets range from </span></span></span></span>viral proteins<span><span> to self and altered self-proteins. The emergence of self-reactive antibodies in patients with cancer, involves the opposing forces of antigen-driven affinity increase and peripheral tolerance mechanisms. Here, B cell </span>tumor antigen<span> specificity and affinity maturation in tumor-directed immune responses in cancer are discussed.</span></span></p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"88 ","pages":"Article 102431"},"PeriodicalIF":6.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances and challenges in investigating B-cells via single-cell transcriptomics 通过单细胞转录组学研究 B 细胞的进展与挑战。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-06-01 DOI: 10.1016/j.coi.2024.102443
Oliver P Skinner, Saba Asad, Ashraful Haque
{"title":"Advances and challenges in investigating B-cells via single-cell transcriptomics","authors":"Oliver P Skinner,&nbsp;Saba Asad,&nbsp;Ashraful Haque","doi":"10.1016/j.coi.2024.102443","DOIUrl":"10.1016/j.coi.2024.102443","url":null,"abstract":"<div><p>Single-cell RNA sequencing (scRNAseq) and Variable, Diversity, Joining (VDJ) profiling have improved our understanding of B-cells. Recent scRNAseq-based approaches have led to the discovery of intermediate B-cell states, including preplasma cells and pregerminal centre B-cells, as well as unveiling protective roles for B-cells within tertiary lymphoid structures in respiratory infections and cancers. These studies have improved our understanding of transcriptional and epigenetic control of B-cell development and of atypical and memory B-cell differentiation. Advancements in temporal profiling in parallel with transcriptomic and VDJ sequencing have consolidated our understanding of the trajectory of B-cell clones over the course of infection and vaccination. Challenges remain in studying B-cell states across tissues in humans, in relating spatial location with B-cell phenotype and function, in examining antibody isotype switching events, and in unequivocal determination of clonal relationships. Nevertheless, ongoing multiomic assessments and studies of cellular interactions within tissues promise new avenues for improving humoral immunity and combatting autoimmune conditions.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"88 ","pages":"Article 102443"},"PeriodicalIF":6.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000335/pdfft?md5=72065bcd7dee0f2e13e5af03df176bbb&pid=1-s2.0-S0952791524000335-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yin and yang of interferons: lessons from the coronavirus disease 2019 (COVID-19) pandemic 干扰素的阴与阳：2019 年冠状病毒病（COVID-19）大流行的教训
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102423
Sara Svensson Akusjärvi , Ivan Zanoni
{"title":"Yin and yang of interferons: lessons from the coronavirus disease 2019 (COVID-19) pandemic","authors":"Sara Svensson Akusjärvi ,&nbsp;Ivan Zanoni","doi":"10.1016/j.coi.2024.102423","DOIUrl":"https://doi.org/10.1016/j.coi.2024.102423","url":null,"abstract":"<div><p>The host immune response against severe acute respiratory syndrome coronavirus 2 includes the induction of a group of natural antiviral cytokines called interferons (IFNs). Although originally recognized for their ability to potently counteract infections, the mechanistic functions of IFNs in patients with varying severities of coronavirus disease 2019 (COVID-19) have highlighted a more complex scenario. Cellular and molecular analyses have revealed that timing, location, and subtypes of IFNs produced during severe acute respiratory syndrome coronavirus 2 infection play a major role in determining disease progression and severity. In this review, we summarize what the COVID-19 pandemic has taught us about the protective and detrimental roles of IFNs during the inflammatory response elicited against a new respiratory virus across different ages and its longitudinal consequences in driving the development of long COVID-19.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102423"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141078419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptive immune receptor germline gene variation 适应性免疫受体种系基因变异。
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102429
Martin M Corcoran, Gunilla B Karlsson Hedestam
{"title":"Adaptive immune receptor germline gene variation","authors":"Martin M Corcoran,&nbsp;Gunilla B Karlsson Hedestam","doi":"10.1016/j.coi.2024.102429","DOIUrl":"10.1016/j.coi.2024.102429","url":null,"abstract":"<div><p>Recognition of antigens by T cell receptors (TCRs) and B cell receptors (BCRs) is a key step in lymphocyte activation. T and B cells mediate adaptive immune responses, which protect us against infections and provide immunological memory, and also, in some instances, drive pathogenic responses in autoimmune diseases. TCRs and BCRs are encoded within loci that are known to be genetically diverse. However, the extent and functional impact of this variation, both in humans and model animals used in immunological research, remain largely unknown. Experimental and genetic evidence has demonstrated that the complementarity determining regions 1 and 2 (HCDR1 and HCDR2), encoded by the variable (V) region of TCRs and BCRs, also often make critical contacts with the targeted antigen. Thus, knowledge about allelic variation in the genes encoding TCRs and BCRs is critically important for understanding adaptive immune responses in outbred populations and to define responder and non-responder phenotypes.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102429"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000190/pdfft?md5=c7ab7b467052a99abd025c9b3125d157&pid=1-s2.0-S0952791524000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In search of a function for human type III interferons: insights from inherited and acquired deficits 寻找人类 III 型干扰素的功能：从遗传性和获得性缺陷中获得启示
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102427
Qian Zhang , Kai Kisand , Yi Feng , Darawan Rinchai , Emmanuelle Jouanguy , Aurélie Cobat , Jean-Laurent Casanova , Shen-Ying Zhang
{"title":"In search of a function for human type III interferons: insights from inherited and acquired deficits","authors":"Qian Zhang ,&nbsp;Kai Kisand ,&nbsp;Yi Feng ,&nbsp;Darawan Rinchai ,&nbsp;Emmanuelle Jouanguy ,&nbsp;Aurélie Cobat ,&nbsp;Jean-Laurent Casanova ,&nbsp;Shen-Ying Zhang","doi":"10.1016/j.coi.2024.102427","DOIUrl":"https://doi.org/10.1016/j.coi.2024.102427","url":null,"abstract":"<div><p>The essential and redundant functions of human type I and II interferons (IFNs) have been delineated over the last three decades by studies of patients with inborn errors of immunity or their autoimmune phenocopies, but much less is known about type III IFNs. Patients with cells that do not respond to type III IFNs due to inherited IL10RB deficiency display no overt viral disease, and their inflammatory disease phenotypes can be explained by defective signaling via other interleukine10RB-dependent pathways. Moreover, patients with inherited deficiencies of interferon-stimulated gene factor 3 (ISGF-3) (STAT1, STAT2, IRF9) present viral diseases also seen in patients with inherited deficiencies of the type I IFN receptor (IFNAR1/2). Finally, patients with autoantibodies neutralizing type III IFNs have no obvious predisposition to viral disease. Current findings thus suggest that type III IFNs are largely redundant in humans. The essential functions of human type III IFNs, particularly in antiviral defenses, remain to be discovered.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102427"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type III interferons in innate and adaptive immunity in the respiratory tract 呼吸道先天性和适应性免疫中的 III 型干扰素。
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102430
Artemios Piperakis, Ioanna E Galani, Evangelos Andreakos
{"title":"Type III interferons in innate and adaptive immunity in the respiratory tract","authors":"Artemios Piperakis,&nbsp;Ioanna E Galani,&nbsp;Evangelos Andreakos","doi":"10.1016/j.coi.2024.102430","DOIUrl":"10.1016/j.coi.2024.102430","url":null,"abstract":"<div><p>Lambda interferons (IFNλs), also termed type III interferons (IFNs) or interleukins-28/29, have been in the shadow of type I IFNs for a long time. Their common induction mechanisms and signalling cascades with type I IFNs have made difficult the unwinding of their unique nonredundant functions. However, this is now changing with mounting evidence supporting a major role of IFNλs as a specialized antiviral defense system in the body, mediating protection at mucosal barrier surfaces while limiting immunopathology.</p><p>Here, we review the latest progress on the complex activities of IFNλs in the respiratory tract, focusing on their multiple effects in IFNλ receptor-expressing cells, the modulation of innate and adaptive immune responses in the context of infections and respiratory diseases, and their similarities and differences with type I IFNs. We also discuss their potential in therapeutic applications and the most recent developments in that direction.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102430"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function 帮我帮你：T 滤泡辅助细胞分化、特性和功能的新概念
IF 7 2区 医学
Current Opinion in Immunology Pub Date : 2024-04-01 DOI: 10.1016/j.coi.2024.102421
Sebastian A Wellford, Pamela L Schwartzberg
{"title":"Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function","authors":"Sebastian A Wellford,&nbsp;Pamela L Schwartzberg","doi":"10.1016/j.coi.2024.102421","DOIUrl":"https://doi.org/10.1016/j.coi.2024.102421","url":null,"abstract":"<div><p>Effective high-affinity, long-term humoral immunity requires T cell help provided by a subset of differentiated CD4<sup>+</sup> T cells known as T follicular helper (Tfh) cells. Classically, Tfh cells provide contact-dependent help for the generation of germinal centers (GCs) in secondary lymphoid organs (SLOs). Recent studies have expanded the conventional definition of Tfh cells, revealing new functions, new descriptions of Tfh subsets, new factors regulating Tfh differentiation, and new roles outside of SLO GCs. Together, these data suggest that one Tfh is not equivalent to another, helping redefine our understanding of Tfh cells and their biology.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"87 ","pages":"Article 102421"},"PeriodicalIF":7.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000116/pdfft?md5=ac2f8094f3295a719b55b7d7c17c5549&pid=1-s2.0-S0952791524000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140901828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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