{"title":"Insights into platelet post-transfusional human leukocyte antigen I immunization","authors":"Gabriel Rojas-Jiménez, Blandine Maître","doi":"10.1016/j.coi.2025.102607","DOIUrl":null,"url":null,"abstract":"<div><div>Although human leukocyte antigen (HLA) class I alloimmunization is asymptomatic, it nevertheless introduces a degree of complexity in the context of transplantation or allogeneic transfusion. In practice, it is evidenced by the presence of anti-HLA-I alloantibodies in patient circulation, which can lead to graft rejection or, of interest in this work, platelet transfusion refractoriness. Exposure of HLA-I antigens during pregnancy or after a transfusion does not lead systematically to the production of alloantibodies. We discuss here recent studies that illustrate the nature of the intrinsic and extrinsic factors involved in regulating humoral response following platelet transfusion. We highlight the importance of the factors related to the ‘donor/blood product/recipient triad’. Understanding their relative importance may help us to develop a stewardship of strategies to prevent the production of antibodies with potential to interfere with transfusions or transplants. We also underscore new directions to orient research in the field.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102607"},"PeriodicalIF":5.8000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952791525000834","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Although human leukocyte antigen (HLA) class I alloimmunization is asymptomatic, it nevertheless introduces a degree of complexity in the context of transplantation or allogeneic transfusion. In practice, it is evidenced by the presence of anti-HLA-I alloantibodies in patient circulation, which can lead to graft rejection or, of interest in this work, platelet transfusion refractoriness. Exposure of HLA-I antigens during pregnancy or after a transfusion does not lead systematically to the production of alloantibodies. We discuss here recent studies that illustrate the nature of the intrinsic and extrinsic factors involved in regulating humoral response following platelet transfusion. We highlight the importance of the factors related to the ‘donor/blood product/recipient triad’. Understanding their relative importance may help us to develop a stewardship of strategies to prevent the production of antibodies with potential to interfere with transfusions or transplants. We also underscore new directions to orient research in the field.
期刊介绍:
Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.
In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students.
Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.