Insights into platelet post-transfusional human leukocyte antigen I immunization

IF 5.8 2区 医学 Q1 IMMUNOLOGY
Gabriel Rojas-Jiménez, Blandine Maître
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引用次数: 0

Abstract

Although human leukocyte antigen (HLA) class I alloimmunization is asymptomatic, it nevertheless introduces a degree of complexity in the context of transplantation or allogeneic transfusion. In practice, it is evidenced by the presence of anti-HLA-I alloantibodies in patient circulation, which can lead to graft rejection or, of interest in this work, platelet transfusion refractoriness. Exposure of HLA-I antigens during pregnancy or after a transfusion does not lead systematically to the production of alloantibodies. We discuss here recent studies that illustrate the nature of the intrinsic and extrinsic factors involved in regulating humoral response following platelet transfusion. We highlight the importance of the factors related to the ‘donor/blood product/recipient triad’. Understanding their relative importance may help us to develop a stewardship of strategies to prevent the production of antibodies with potential to interfere with transfusions or transplants. We also underscore new directions to orient research in the field.
血小板输注后人白细胞抗原I免疫的研究进展
尽管人类白细胞抗原(HLA) I类同种异体免疫是无症状的,但它在移植或同种异体输血的背景下引入了一定程度的复杂性。在实践中,患者循环中存在抗hla - 1同种抗体证明了这一点,这可能导致移植物排斥反应,或者本研究感兴趣的是,血小板输注难耐。在怀孕期间或输血后暴露于hla - 1抗原不会系统性地导致同种抗体的产生。我们在这里讨论最近的研究,说明参与调节血小板输注后体液反应的内在和外在因素的性质。我们强调与“献血者/血液制品/接受者三位一体”相关因素的重要性。了解它们的相对重要性可能有助于我们制定一种管理策略,以防止产生可能干扰输血或移植的抗体。我们还强调了该领域研究的新方向。
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来源期刊
CiteScore
13.30
自引率
1.40%
发文量
94
审稿时长
67 days
期刊介绍: Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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