Current Opinion in Immunology最新文献_第10页

In search of the cell biology for self- versus non-self- recognition 寻找自我识别与非自我识别的细胞生物学

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102334

Sebastien Apcher , Borek Vojtesek , Robin Fahraeus

引用次数: 0

Visualising tapasin- and TAPBPR-assisted editing of major histocompatibility complex class-I immunopeptidomes 可视化tapasin和TAPBPR辅助编辑主要组织相容性复合体I类免疫肽

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102340

Andy van Hateren , Tim Elliott

引用次数: 0

Recent progress in type 1 classical dendritic cell cross-presentation - cytosolic, vacuolar, or both? 1型经典树突状细胞交叉呈递的最新进展——胞质、液泡还是两者兼有？

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102350

Ray A Ohara, Kenneth M Murphy

{"title":"Recent progress in type 1 classical dendritic cell cross-presentation - cytosolic, vacuolar, or both?","authors":"Ray A Ohara, Kenneth M Murphy","doi":"10.1016/j.coi.2023.102350","DOIUrl":"10.1016/j.coi.2023.102350","url":null,"abstract":"<div><p>Type 1 classical dendritic cells (cDC1s) have emerged as the major antigen-presenting cell performing cross-presentation (XP) <em>in vivo</em>, but the antigen-processing pathway in this cell remains obscure. Two competing models for <em>in vivo</em><span> XP of cell-associated antigens by cDC1 include a vacuolar pathway and cytosolic pathway. A vacuolar pathway relies on directing antigens captured in vesicles toward a class I major histocompatibility complex<span> loading compartment independently of cytosolic entry. Alternate proposals invoke phagosomal rupture, either constitutive or triggered by spleen tyrosine kinase (SYK) signaling in response to C-type lectin domain family 9 member A (CLEC9A) engagement, that releases antigens into the cytosol for proteasomal degradation. The Beige and Chediak–Higashi (BEACH) protein WD repeat- and FYVE domain-containing protein 4 (WDFY4) is strictly required for XP of cell-associated antigens </span></span><em>in vivo</em>. However, the cellular mechanism for WDFY4 activity remains unknown and its requirement in XP <em>in vivo</em> is currently indifferent regarding the vacuolar versus cytosolic pathways. Here, we review the current status of these models and discuss the need for future investigation.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9943800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Major histocompatibility complex class II in the tumor microenvironment: functions of nonprofessional antigen-presenting cells 肿瘤微环境中的主要组织相容性复合体II类：非专业抗原呈递细胞的功能。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102330

Anne M Macy , Lauren M Herrmann , Anngela C Adams , K Taraszka Hastings

引用次数: 0

TAP-ing into the cross-presentation secrets of dendritic cells 深入了解树突状细胞的交叉呈递秘密

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102327

Kristel Joy Yee Mon , J. Magarian Blander

引用次数: 0

Transcriptomics of Epstein–Barr virus aids to the classification of T-cell evasion in nasopharyngeal carcinoma EB病毒的转录组学有助于鼻咽癌T细胞逃避的分类

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102335

Shweta Mahajan , Michiel Bongaerts , Jose Hardillo , Anna Tsang , Kwok W Lo , Dian Kortleve , Brigette Ma , Reno Debets

{"title":"Transcriptomics of Epstein–Barr virus aids to the classification of T-cell evasion in nasopharyngeal carcinoma","authors":"Shweta Mahajan , Michiel Bongaerts , Jose Hardillo , Anna Tsang , Kwok W Lo , Dian Kortleve , Brigette Ma , Reno Debets","doi":"10.1016/j.coi.2023.102335","DOIUrl":"10.1016/j.coi.2023.102335","url":null,"abstract":"<div><p>Epstein–Barr virus (EBV) contributes to oncogenesis and immune evasion in nasopharyngeal carcinoma (NPC). At present, an aggregated, higher-level view on the impact of EBV genes toward the immune microenvironment of NPC is lacking. To this end, we have interrogated tumor-derived RNA sequences of 106 treatment-naive NPC patients for 98 EBV transcripts, and captured the presence of 10 different immune cell populations as well as 23 different modes of T-cell evasion. We discovered 3 clusters of EBV genes that each associate with distinct immunophenotypes of NPC. Cluster 1 associated with gene sets related to immune cell recruitment, such as those encoding for chemoattractants and their receptors. Cluster 2 associated with antigen processing and presentation, such as interferon-related genes, whereas cluster 3 associated with presence of M1-like macrophages, absence of CD4+ T cells, and oncogenic pathways, such as the nuclear factor kappa light-chain enhancer of activated B-cell pathway. We discuss these 3 EBV clusters regarding their potential for stratification for T-cell immunity in NPC together with the next steps needed to validate such therapeutic value.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9945988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of mouse dendritic cell subsets in priming naive CD4 T cells 小鼠树突状细胞亚群在启动幼稚CD4 T细胞中的作用。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102352

Naoya Tatsumi , Yosuke Kumamoto

引用次数: 2

Eat, prey, love: Pathogen-mediated subversion of lysosomal biology 吃、捕食、爱：病原体介导的溶酶体生物学颠覆

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102344

Lauren E Bird , Laura E Edgington-Mitchell , Hayley J Newton

引用次数: 0

‘Persistent germinal center responses: slow-growing trees bear the best fruits’ “持续的生发中心反应：生长缓慢的树木结出最好的果实”

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102332

Hanover C Matz , Katherine M McIntire , Ali H Ellebedy

引用次数: 2

PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis 泛视体信号传导和感染的治疗意义：ZBP1激活炎症小体和泛视症的中心作用。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-08-01 DOI: 10.1016/j.coi.2023.102348

Rajendra Karki , Thirumala-Devi Kanneganti

{"title":"PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis","authors":"Rajendra Karki , Thirumala-Devi Kanneganti","doi":"10.1016/j.coi.2023.102348","DOIUrl":"10.1016/j.coi.2023.102348","url":null,"abstract":"<div><p>The innate immune response provides the first line of defense against infection and disease. Regulated cell death (RCD) is a key component of innate immune activation, and RCD must be tightly controlled to clear pathogens while preventing excess inflammation. Recent studies have highlighted a central role for the innate immune sensor Z-DNA-binding protein 1 (ZBP1) as an activator of a form of inflammatory RCD called PANoptosis, which is regulated by a multifaceted cell death complex called the PANoptosome. In response to influenza A virus infection, ZBP1 activates the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome, which then acts as an integral component of the ZBP1-PANoptosome to drive inflammatory cell death, PANoptosis. In this context, the NLRP3 inflammasome is critical for caspase-1 activation and proinflammatory cytokine interleukin (IL)-1β and IL-18 maturation, but dispensable for cell death due to functional redundancies between PANoptosome molecules. Similarly, ZBP1 is also central to the absent in melanoma 2 (AIM2)-PANoptosome; this PANoptosome forms in response to <em>Francisella novicida</em> and herpes simplex virus 1 infection and incorporates the AIM2 inflammasome as an integral component. In this review, we will discuss the critical roles of ZBP1 in mediating innate immune responses through inflammasomes, PANoptosomes, and PANoptosis during infection. An improved understanding of the molecular mechanisms of innate immunity and cell death will be essential for the development of targeted modalities that can improve patient outcomes by mitigating severe disease.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7