Current Opinion in Immunology最新文献_第10页

Granulocytes subsets and their divergent functions in host resistance to Mycobacterium tuberculosis — a ‘tipping-point’ model of disease exacerbation 颗粒细胞亚群及其在宿主对结核分枝杆菌耐药性中的不同功能——疾病恶化的“临界点”模型。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102365

Katrin D Mayer-Barber

引用次数: 1

Viral-vectored respiratory mucosal vaccine strategies 病毒载体呼吸道粘膜疫苗策略。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102370

Mangalakumari Jeyanathan, Sam Afkhami, Alisha Kang, Zhou Xing

引用次数: 0

Outer membrane vesicle-based intranasal vaccines 基于外膜囊泡的鼻内疫苗。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102376

Peter Van der Ley, Virgil EJC Schijns

{"title":"Outer membrane vesicle-based intranasal vaccines","authors":"Peter Van der Ley, Virgil EJC Schijns","doi":"10.1016/j.coi.2023.102376","DOIUrl":"10.1016/j.coi.2023.102376","url":null,"abstract":"<div>Delivery of vaccines via the mucosal route is regarded as the most effective mode of immunization to counteract infectious diseases that enter via mucosal tissues, including oral, nasal, pulmonary, intestinal, and urogenital surfaces. Mucosal vaccines not only induce local immune effector elements, such as secretory Immunoglobulin A (IgA) reaching the luminal site of the mucosa, but also systemic immunity. Moreover, mucosal vaccines may trigger immunity in distant mucosal tissues because of the homing of primed antigen-specific immune cells toward local and distant mucosal tissue via the common mucosal immune system.While most licensed intramuscular vaccines induce only systemic immunity, next-generation mucosal vaccines may outperform parenteral vaccination strategies by also eliciting protective mucosal immune responses that block infection and/or transmission. Especially the nasal route of vaccination, targeting the nasal-associated lymphoid tissue, is attractive for local and distant mucosal immunization. In numerous studies, bacterial outer membrane vesicles (OMVs) have proved attractive as vaccine platform for homologous bacterial strains, but also as antigen delivery platform for heterologous antigens of nonbacterial diseases, including viruses, parasites, and cancer. Their application has also been extended to mucosal delivery. Here, we will summarize the characteristics and clinical potential of (engineered) OMVs as vaccine platform for mucosal, especially intranasal delivery.</div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"84 ","pages":"Article 102376"},"PeriodicalIF":7.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10406290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An easy pill to swallow: oral recombinant vaccines for the 21st century 一粒容易下咽的药丸：21世纪的口服重组疫苗。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102374

Molly R Braun, Becca A Flitter, William Sun, Sean N Tucker

{"title":"An easy pill to swallow: oral recombinant vaccines for the 21st century","authors":"Molly R Braun, Becca A Flitter, William Sun, Sean N Tucker","doi":"10.1016/j.coi.2023.102374","DOIUrl":"10.1016/j.coi.2023.102374","url":null,"abstract":"<div>Oral vaccines have a distinctive advantage of stimulating immune responses in the mucosa, where numerous pathogens gain entry and cause disease. Although various efforts have been attempted to create recombinant mucosal vaccines that provoke strong immunogenicity, the outcomes in clinical trials have been weak or inconsistent. Therefore, next-generation mucosal vaccines are needed that are more immunogenic. Here, we discuss oral vaccines with an emphasis on a next-generation mucosal vaccine that utilizes a nonreplicating human recombinant adenovirus type-5 (rAd5) vector. Numerous positive clinical results investigating oral rAd5 vaccines are reviewed, with a summary of the immunogenicity and efficacy results for specific vaccine indications of influenza, norovirus, and SARS-CoV-2. The determination of correlates of protection for oral vaccination and the potential impact this novel vaccine formulation may have on disease transmission are also discussed. In summary, successful oral vaccination can be accomplished and would have major public health benefits if approved.</div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"84 ","pages":"Article 102374"},"PeriodicalIF":7.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines 从小儿麻痹症疫苗的成功经验中吸取的经验教训没有在新冠肺炎疫苗的开发和实施中吸取或应用。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102386

Charles S Pavia , Maria M Plummer

{"title":"Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines","authors":"Charles S Pavia , Maria M Plummer","doi":"10.1016/j.coi.2023.102386","DOIUrl":"10.1016/j.coi.2023.102386","url":null,"abstract":"<div>The eradication of polio during the latter half of the 20th century can be considered one of the greatest medical triumphs in history. This achievement can be attributed to the development of vaccines that received the public's almost unwavering acceptance of them, especially by parents who had been waiting/hoping for a medical breakthrough that would ensure that their children would not succumb to the devastating effects of infantile paralysis. Sixty years later, the worldwide population was now confronted with an equally devastating disease — Covid-19 — which by the 2020–2021 time period had reached pandemic levels not seen since the flu outbreak of 1918. Unlike polio, however, several vaccines against Covid-19 were rapidly developed and deployed due to advances in microbiologic and immunologic technology. But also, unlike the polio vaccine experience, there was not universal acceptance of the Covid-19 vaccines and this has led to continuation of the pandemic into 2023 (albeit at a reduced level). In addition, acceptance of the Covid-19 vaccines has been confronted with the uncertainty that they do not apparently prevent transmission in asymptomatic people, and the mutation rate of the virus requires periodic re-evaluation and possible upgrading of the vaccines. This review will focus on the various factors that have led to these contrasting attitudes toward these two different vaccines and how resistance and hesitancy to vaccine use can be overcome by implementing various measures, after introducing the key roles that the sciences of microbiology and immunology have played in vaccine development over the past 250+ years.</div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"84 ","pages":"Article 102386"},"PeriodicalIF":7.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10184720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ubiquitination and cell-autonomous immunity 泛素化和细胞自主免疫。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102368

João Mello-Vieira , Tobias Bopp , Ivan Dikic

引用次数: 1

Tissue-specific macrophage immunometabolism 组织特异性巨噬细胞免疫代谢。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102369

Hadar Ben-Arosh, Roi Avraham

{"title":"Tissue-specific macrophage immunometabolism","authors":"Hadar Ben-Arosh, Roi Avraham","doi":"10.1016/j.coi.2023.102369","DOIUrl":"10.1016/j.coi.2023.102369","url":null,"abstract":"<div>Macrophages are phagocytic cells distributed across tissues that sustain homeostasis by constantly probing their local environment. Upon perturbations, macrophages rewire their energy metabolism to execute their immune programs. Intensive research in the field of immunometabolism highlights cell-intrinsic immunometabolites such as succinate and itaconate as immunomodulatory signals. A role for cell-extrinsic stimuli now emerges with evidence for signals that shape macrophages' metabolism in a tissue-specific manner. In this review, we will cover macrophage immunometabolism in the gut, a complex metabolic and immunologically active tissue. During homeostasis, gut macrophages are constantly exposed to pro-inflammatory ligands from the microbiota, and in contrast, are balanced by microbiota-derived anti-inflammatory metabolites. Given their extensive metabolic changes during activation, spatial analyses of the tissue will allow the characterization of metabolic niches of macrophage in the gut. Identifying metabolic perturbations of macrophage subsets during chronic inflammation and infection can direct future tissue-specific metabolotherapies.</div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"84 ","pages":"Article 102369"},"PeriodicalIF":7.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9848909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation SARS-CoV-2的炎症激活及其参与新冠肺炎恶化。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102387

Tamara S Rodrigues, Dario S Zamboni

引用次数: 0

Turning foes into permissive hosts: manipulation of macrophage polarization by intracellular bacteria 将敌人变成允许的宿主：细胞内细菌对巨噬细胞极化的操纵。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102367

Trung HM Pham , Denise M Monack

{"title":"Turning foes into permissive hosts: manipulation of macrophage polarization by intracellular bacteria","authors":"Trung HM Pham , Denise M Monack","doi":"10.1016/j.coi.2023.102367","DOIUrl":"10.1016/j.coi.2023.102367","url":null,"abstract":"<div>Macrophages function as tissue-immune sentinels and mediate key antimicrobial responses against bacterial pathogens. Yet, they can also act as a cellular niche for intracellular bacteria, such as Salmonella enterica, to persist in infected tissues. Macrophages exhibit heterogeneous activation or polarization, states that are linked to differential antibacterial responses and bacteria permissiveness. Remarkably, recent studies demonstrate that Salmonella and other intracellular bacteria inject virulence effectors into the cellular cytoplasm to skew the macrophage polarization state and reprogram these immune cells into a permissive niche. Here, we review mechanisms of macrophage reprogramming by Salmonella and highlight manipulation of macrophage polarization as a shared bacterial pathogenesis strategy. In addition, we discuss how the interplay of bacterial effector mechanisms, microenvironmental signals, and ontogeny may shape macrophage cell states and functions. Finally, we propose ideas of how further research will advance our understanding of macrophage functional diversity and immunobiology.</div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"84 ","pages":"Article 102367"},"PeriodicalIF":7.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9776206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules 抗原处理机制在细胞内Toll样受体分子的调节和运输中的作用。

IF 7 2区医学

Current Opinion in Immunology Pub Date : 2023-10-01 DOI: 10.1016/j.coi.2023.102375

Moïse de Lavergne, Lucie Maisonneuve, Katrina Podsypanina, Bénédicte Manoury

引用次数: 0