Drivers and shapers of macrophages specification in the developing brain

IF 6.6 2区 医学 Q1 IMMUNOLOGY
Simone Brioschi , Claudia Z Han , Marco Colonna
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引用次数: 0

Abstract

The brain harbors two major macrophage populations: microglia reside within the brain parenchyma, while border-associated macrophages (BAMs) are situated at central nervous system (CNS) interfaces. BAMs can be further classified into distinct subsets based on their localization: perivascular macrophages surround blood vessels, meningeal macrophages reside in the leptomeninges, dura macrophages in the dura mater, and choroid plexus macrophages are confined to the choroid plexus. The environmental factors and molecular mechanisms driving the specification of these macrophage populations are still being elucidated. Deciphering the communication pathways between CNS macrophages and their tissue niches during development, homeostasis, and pathologic conditions offers significant potential for treating a wide range of brain disorders, from neurodevelopmental and neuroinflammatory diseases to neurovascular and neurodegenerative conditions. With this short review, we will address the current understanding and knowledge gaps in the field, as well as the future directions for the upcoming years.
脑发育过程中巨噬细胞规范的驱动者和塑造者
大脑中有两种主要的巨噬细胞群:小胶质细胞位于脑实质内,而边界相关巨噬细胞位于中枢神经系统(CNS)界面。根据其定位,可以进一步将巨噬细胞分为不同的亚群:血管周围巨噬细胞包围血管,脑膜巨噬细胞位于脑膜,硬脑膜巨噬细胞位于硬脑膜,脉络膜丛巨噬细胞局限于脉络膜丛。驱动这些巨噬细胞群体的环境因素和分子机制仍在阐明。破译中枢神经系统巨噬细胞及其组织龛在发育、体内平衡和病理状态期间的通讯途径,为治疗从神经发育和神经炎症疾病到神经血管和神经退行性疾病等广泛的脑部疾病提供了巨大的潜力。通过这篇简短的综述,我们将解决该领域目前的理解和知识差距,以及未来几年的未来方向。
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来源期刊
CiteScore
13.30
自引率
1.40%
发文量
94
审稿时长
67 days
期刊介绍: Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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