Intracellular complement in monocytes and macrophages: emerging roles

IF 5.8 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-08-06 DOI:10.1016/j.coi.2025.102629

Valentin Baverel , Carmen Garrido , Evelyne Kohli

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Abstract

Macrophages and the complement system are fundamental components of innate immunity, emerging early in evolutionary history. The well-established functions of complement in relation to macrophages contribute to both innate and adaptive immunity and are mediated by extracellular components acting systemically or locally within tissues.

A novel compartment, termed intracellular complement or the ‘complosome’, was first identified in 2013 within CD4+ T cells, marking the onset of an active research field. Intracellular complement has been associated with responses to both infectious and noninfectious stimuli, akin to extracellular complement, while also exhibiting significant autocrine functions in cell metabolism and homeostasis.

This review focuses on intracellular complement within monocytes/macrophages. After a brief overview of the complement system and its canonical roles in these cells, we define intracellular complement and discuss current knowledge regarding its expression and functions in monocytes/macrophages, as well as its potential links to human diseases.

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单核细胞和巨噬细胞的细胞内补体：新角色

巨噬细胞和补体系统是先天免疫的基本组成部分，出现在进化史的早期。补体与巨噬细胞相关的完善功能有助于先天免疫和适应性免疫，并由组织内系统或局部作用的细胞外成分介导。2013年，在CD4+ T细胞中首次发现了一种称为细胞内补体或“合体”的新型隔室，标志着一个活跃研究领域的开始。细胞内补体与对感染性和非感染性刺激的反应有关，类似于细胞外补体，同时在细胞代谢和体内平衡中也表现出显著的自分泌功能。本文综述了单核/巨噬细胞内的细胞内补体。在简要概述了补体系统及其在这些细胞中的典型作用之后，我们定义了细胞内补体，并讨论了目前关于其在单核/巨噬细胞中的表达和功能的知识，以及它与人类疾病的潜在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.