Necroptosis in immunity, tissue homeostasis, and cancer

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-08-01 DOI:10.1016/j.coi.2024.102455

Jinwen Yin , Yuqiang Yu , Xinyue Huang , Francis K-M Chan

引用次数: 0

Abstract

Immune and tissue homeostasis is achieved through balancing signals that regulate cell survival, proliferation, and cell death. Recent studies indicate that certain cell death programs can stimulate inflammation and are often referred as ‘immunogenic cell death’ (ICD). ICD is a double-edged sword that can confer protection against pathogen infection but also cause tissue damage. Necroptosis is a key ICD module that has been shown to participate in host defense against pathogen infection, tissue homeostasis, and cancer response to immunotherapy. Here, we will review recent findings on the regulation of necroptosis signaling and its role in pathogen infection, tissue homeostasis, and cancer.

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免疫、组织稳态和癌症中的坏死过程

免疫和组织平衡是通过调节细胞存活、增殖和死亡的平衡信号来实现的。最近的研究表明，某些细胞死亡程序会刺激炎症，通常被称为 "免疫原性细胞死亡"（ICD）。免疫性细胞死亡是一把双刃剑，既能抵御病原体感染，又能造成组织损伤。坏死是一种关键的 ICD 模块，已被证明参与宿主对病原体感染的防御、组织稳态和癌症对免疫疗法的反应。在此，我们将回顾有关坏死信号传导调控及其在病原体感染、组织稳态和癌症中作用的最新研究成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.