IFNε、IFNω和IFNλ：保护粘膜的干扰素。

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-08-01 DOI:10.1016/j.coi.2024.102456

Jasmine J M Chuah , Nicole K Campbell

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引用次数: 0

摘要

非常规 I 型干扰素 IFNε 和 IFNω 以及 III 型干扰素 IFNλ 正逐渐成为防御粘膜组织的组织特异性细胞因子。本综述概述了这些 IFN 作为呼吸道、胃肠道和生殖道保护因子的独特特征和功能，强调了它们在维持对共生微生物的耐受性的同时对病原体的免疫调节作用。特别是，我们讨论了最近在了解组成型表达的 IFNε 及其在防止粘膜感染、炎症和癌症方面的作用方面取得的进展。我们发现，这种独特的细胞因子是抵御病原体和维持粘膜组织稳态的 "第一道防线 "的关键因素，主要通过调节免疫细胞群来发挥作用。

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IFNε, IFNω and IFNλ: interferons defending the mucosa

The unconventional type I interferons IFNε and IFNω and type III interferon IFNλ are gradually emerging as tissue-specific cytokines in defence of mucosal tissues. This review provides an overview of the distinct features and functions that define these IFNs as protective factors in the respiratory, gastrointestinal and reproductive tracts, highlighting their immunoregulatory roles against pathogens while maintaining tolerance against commensal microbes. In particular, we discuss recent advances in our understanding of the constitutively expressed IFNε and its role in protecting against mucosal infections, inflammation and cancers. We identify an emerging theme for this unique cytokine as a key contributor to the ‘first line of defence’ against pathogens and maintenance of mucosal tissue homeostasis, primarily through its regulation of immune cell populations.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.