Current Microbiology最新文献

{"title":"Identifying the Alkaline Tolerance-Related Genes Through Transcriptome Analysis of Halomonas alkalicola CICC 11012 s.","authors":"Lei Zhai, Shuaicheng Mu, Ruina Liu, Rui Liu, Geer Lin, Qi Han, Su Yao","doi":"10.1007/s00284-025-04178-1","DOIUrl":"10.1007/s00284-025-04178-1","url":null,"abstract":"<p><p>Halomonas alkalicola CICC 11012 s is the strongest alkaliphile in the genus Halomonas. So far, studies have focused on the genome level and functional validation of a single gene, providing an overview and partial analysis of the adaptive mechanisms. As such, the comprehensive adaptations of alkaliphiles to extremely alkaline stress remain largely unclear. Therefore, in this study, the transcriptome profiling of H. alkalicola under neutral and alkaline conditions was compared to explore its global adaptation mechanisms towards pH homeostasis. In addition, the different up-regulated genes of this strain grown at pH 11.0 were compared with those grown at pH 7.0. The results revealed that the up-regulated genes were mainly distributed in six categories, including glycosyl transferase, fimbrial assembly protein, TonB-dependent transport system, C₄-dicarboxylate TRAP transport system, transposase, and toxin-antitoxin system. This result indicated that H. alkalicola developed various adaptive strategies to survive under extremely alkaline pressure, from modifying their cell wall structure to enhancing their membrane transport activities and intracellular metabolism homeostasis. Furthermore, the function of the gene cluster tonB-exbB-exbB2-exbD under extreme alkaline stress was verified by the CRISPR-Cas9 gene-editing system, indicating that the TonB-dependent transport system significantly affected the growth of the strain under extreme alkaline stresses.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 7","pages":"287"},"PeriodicalIF":2.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Occupations in Different Populations Based on Skin Microbial Characteristics.","authors":"Kewen Zhang, Jun Zhang, Daijing Yu, Tian Wang, Liwei Zhang, Xudong Zhao, Lijuan Su, Jiangwei Yan","doi":"10.1007/s00284-025-04263-5","DOIUrl":"10.1007/s00284-025-04263-5","url":null,"abstract":"<p><p>The composition and diversity of the skin microbiome are affected by several factors, including the working environment, which plays an active role in shaping microbial communities in human skin. Previous studies have shown that residual microbial communities on personal items can be used to identify their owners. However, few studies have used the skin microbiome to identify occupations in different populations or evaluate whether the skin microbiome can be used as a tool for forensic investigations. Here, we collected palm and cuff swabs from three occupational groups-cooks, medical staff, and students-and performed next-generation sequencing targeting the 16S rRNA gene to characterise the microbial communities associated with each profession. We found that different occupational environments resulted in different skin microbial community compositions. Actinobacteria and Firmicutes were the dominant phyla in the student samples. Compared with the other two occupations, cooks had the highest relative abundances of Bacteroides and Cyanobacteria. Additionally, cuff samples from medical staff had the highest relative abundances of Proteobacteria. Principal co-ordinate analysis results indicated that the samples were roughly divided into three clusters according to their occupation. Furthermore, linear discriminant analysis effect size results showed that cooks, medical staff, and students had their own unique biomarkers, cooks exhibited seven shared biomarkers between palm and cuff samples, medical staff showed 2, while students demonstrated the highest congruence which was 13 shared biomarkers. This suggested that some palm skin microbial communities could be transferred to the cuffs through contact friction. Thus, there were also microbial communities present in cuff samples that could be used to identify the owner's occupations, suggesting that skin microorganisms left on personal items via daily contact could also be used to provide information about an individual's occupation. Finally, we constructed a random forest model based on the composition and relative abundance of the microbiota to infer the subject's occupation, achieving an accuracy of 76.92% for the palm testing dataset and 73.33% for the cuff testing dataset; all of the cuff sample datasets showed an accuracy of 70.97%. These findings suggested that an individual's occupation can be inferred not only from the skin microbiota but also from the microbiota left on the cuffs of the individual's clothes. Further studies are needed; however, these results demonstrate the potential of the skin microbiota as a forensic tool for predicting population occupations.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 7","pages":"288"},"PeriodicalIF":2.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic and Structural Insights into Chandipura Virus: A Comparative in Silico Analysis of Indian and West African Strains and Potential Host Receptor Interactions.","authors":"Megha Gupta, Disharee Mallick, Dilip Kumar, Rajesh Kumar","doi":"10.1007/s00284-025-04258-2","DOIUrl":"10.1007/s00284-025-04258-2","url":null,"abstract":"<p><p>Chandipura virus (CHPV), a member of the Rhabdoviridae family, is an emerging pathogen responsible for encephalitis outbreaks, particularly among children under 15 years of age. Predominantly transmitted by sandflies, CHPV has caused multiple outbreaks in India, whereas strains from West African countries, including Kenya, Senegal, and Nigeria, have not been linked to human infections. The CHPV glycoprotein (G protein), a crucial spike protein, plays a key role in viral entry into host cells. In this study, we performed an in silico analysis to identify the potential mechanism of viral entry into host cells through interactions with the G protein. We also conducted bioinformatics analyses to examine the global distribution of CHPV strains and performed comparative structural and sequence-level analyses of the CHPV G protein. The phylogenetic analysis revealed a clear division of the CHPV G protein into two distinct clades. Despite this divergence, genome-wide analysis revealed high sequence conservation across the CHPV strains. Additionally, we identified potential interactions between the CHPV G protein and human receptors such as Lipoprotein Receptor-related Protein 1 (LRP1), facilitated by conserved lysine residues in the CHPV G protein in a calcium-dependent manner. The conservation of interacting residues across all strains raises concerns about the zoonotic potential of CHPV, particularly in regions where the virus is circulating in sandfly populations but has not yet caused any reported human infection. Our findings offer valuable insights into the genetic and structural similarities of CHPV strains, emphasizing the CHPV potential to spread beyond its current geographic boundaries and possibly cause human infections.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 6","pages":"286"},"PeriodicalIF":2.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal Endophytes: An Insight into Diversity, Stress Tolerance, Biocontrol and Plant Growth-Promoting Potentials.","authors":"Purusottam Majhi, Umakant Pradhan, Anunay Toppo, A K Shukla","doi":"10.1007/s00284-025-04266-2","DOIUrl":"10.1007/s00284-025-04266-2","url":null,"abstract":"<p><p>Food and human health are closely related to each other. A healthy diet contributes to excellent health. However, chemical-based agricultural products delivered the poisons in our tray, which cause fatal illnesses like cancer. Overuse of chemical-based fertilizer, herbicides, insecticides, pesticides, etc. is responsible for decreasing soil health status and the development of resistant variants of phytopathogens. Endophytes may overcome such issues effectively without showing any harmful effects. Endophytes are microorganisms that invade intercellular or intracellular parts of host plants without causing any apparent symptoms of infection. Endophytes are broad groups of microorganisms; they may be algae, fungi, bacteria, or ascomycetes. Among them, endophytic fungi are a major group of endophytes that reside inside the host plant body. Types and biodiversity of fungal endophytes make them a potent biological agent for sustainable agricultural management because of their vast geographical distribution. Historically fungal endophytes are broadly categorized into two groups as clavicipitaceous and non-clavicipitaceous based on phylogeny and life history traits. Based on various criteria such as in planta biodiversity, colonization, transmission and fitness to the host, non-clavicipitaceous fungi classified into three distinct classes. They promote plant growth and development by overcoming biotic and abiotic stress and by accelerating systematic inducing resistance (SIR) in plants. They harbor a variety of bioactive compounds like., alkaloids, terpenoids, phenolic acid, steroids, tannins, and saponins that act as antifungal, antibacterial, anticancer, antioxidant, and insecticidal agents. These bioactive compounds have a great potential role in sustainable agricultural management. This review highlights the potential role of fungal endophytes in the field of sustainable agricultural practices to overcome biotic and abiotic stress along with plant growth-promoting activities rather than the use of chemicals in agro-ecosystems.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 6","pages":"283"},"PeriodicalIF":2.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity of Bacterial Communities in Seleniferous Soils and Their Impact on Plant Growth and Selenium Toxicity.","authors":"Deepali Deepali, N Tejoprakash, M Sudhakara Reddy","doi":"10.1007/s00284-025-04245-7","DOIUrl":"10.1007/s00284-025-04245-7","url":null,"abstract":"<p><p>The present study aimed to investigate the diversity of bacterial communities in seleniferous soils using Illumina Mi-Seq Next-Generation Sequencing. This study also compared seleniferous soils (SE) with non-seleniferous (NS) soils to evaluate Selenium (Se) impact on microbial communities and soil properties. Metagenomic analysis identified Proteobacteria as the predominant phylum in both environments, with SE soils exhibiting a higher dominance (48%) than NS soils (31%). The most dominant operational taxonomic unit (OTU) across both soil types belonged to the genus Bacillus. Se altered microbial community composition, increasing the abundance of the Bacillaceae family (30%) and Pseudomonadaceae family (25%) compared to NS soil. Bacillus was the dominant genus in the SE environment indicating its tolerance to selenium. Diversity indices indicated that control soils had higher species richness, while SE soils exhibited a more stressed microbial structure. A consortium of bacterial isolates (Proteus terrae Se3, Halopseudomonas formosensis Se5, and Corynebacterium glutamicum Se38) was inoculated in maize plants cultivated in natural seleniferous soils. Plants inoculated with bacterial consortium grew more healthy and had greater biomass in their roots, shoots, and seeds. Bacterial inoculation results in lesser selenium accumulation in the roots, shoots and seeds of maize plants compared to non-inoculated plants. These results suggest that bacterial species from seleniferous soils may be employed as biofertilizers to enhance plant growth and help plants tolerate Se toxicity in seleniferous soils.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 6","pages":"285"},"PeriodicalIF":2.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and De Novo Genome Assembly for New Rhizobium Ruizarguesonis Rhizobial Strain Vst36-3 Involved in Symbiosis with Pisum and Vicia Plants.","authors":"Alexandra V Dolgikh, Elizaveta A Salnikova, Alina M Dymo, Elizaveta S Kantsurova, Tatyana S Aksenova, Oleg S Yuzikhin, Oksana N Kurchak, Olga P Onishchuk, Elena A Dolgikh","doi":"10.1007/s00284-025-04265-3","DOIUrl":"10.1007/s00284-025-04265-3","url":null,"abstract":"<p><p>Pea and vetch are the important legume crops used as food, forage, and green manure in agriculture. Several new rhizobial isolates were obtained from vetch Vicia sativa root nodules. For one of them, Vst36-3, the nodulation test showed various specificity in relation to plant hosts from the Fabeae tribe, such as pea and vetch. It is in contrast to typical strains of the Rhizobium leguminosarum species complex (Rlc), which formed effective nodules as in pea and vetch. Here, whole genome sequencing was performed followed by de novo genome assembly for Vst36-3 strain. As a result of de novo genome assembly, seven contigs were generated using Oxford Nanopore Technology long reads and subsequently Illumina short reads. Phylogenetic analysis allowed us to identify this strain as Rhizobium ruizarguesonis Vst36-3. Analysis of the Sym plasmid containing the nod and nif genes revealed that R. ruizarguesonis Vst36-3 has a complete suite of essential genes for the development of symbiosis. Nevertheless, this new strain forms ineffective nodules in pea. This makes Rhizobium ruizarguesonis Vst36-3 attractive for the search and investigation of new factors of host specificity in future.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 6","pages":"284"},"PeriodicalIF":2.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Potential of Marine Sponge-Associated Bacillus velezensis and Stutzerimonas stutzeri from the Indian Coast: A Genome Mining and Metabolite Profiling Approach.","authors":"Heena U Devkar, Kartik Juyal, Narsinh L Thakur, Parvinder Kaur, Keyur Parmar, Radhakrishnanand Pullapanthula, Shridhar Narayanan","doi":"10.1007/s00284-025-04262-6","DOIUrl":"10.1007/s00284-025-04262-6","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) is one of the leading health crises worldwide that demands new antimicrobials to enter the clinical pipeline. Marine sponges are a rich source of promising bioactive compounds. Due to their sessile nature and filter-feeding lifestyle, sponges are prone to attack by competitors, predators, and pathogens. To combat these threats, they produce a diverse array of bioactive compounds. Notably, the microbial communities residing within the sponges make many of these beneficial compounds. Twenty-one bacterial isolates from various marine sponges from the Indian coast were selected for this study. The bacterial isolates were fermented to obtain crude extracts, which were then screened against critical bacterial pathogens. Based on the MIC (minimum inhibitory concentration) results, two isolates, Bacillus velezensis NIO_002 and Stutzerimonas stutzeri NIO_003 showing good activity, were characterized by morphological, biochemical, and molecular methods. Genome mining predicted multiple antibiotic biosynthetic gene clusters, most of which showed a high degree of similarity to known gene clusters, and some with low or no similarity which may be indicative of novel gene clusters. LC-MS (liquid chromatography-mass spectrometry) data revealed the putative presence of certain antibacterial compounds previously reported in the literature. To our knowledge, this is the first study to report the antimicrobial activity of marine sponge-associated Bacillus velezensis and Stutzerimonas stutzeri strains characterized by whole genome sequencing, thereby indicating the novelty of our strains. This study emphasizes the potential of our bacterial isolates for further development as a source of promising antibiotics to address the escalating challenge of drug-resistant pathogens.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 6","pages":"280"},"PeriodicalIF":2.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coordinated Transcriptional Increases in Cell Wall Synthesis Genes in Neisseria gonorrhoeae Lacking the Lytic Transglycosylase, ltgA.","authors":"Candra O Broadie, Alaa I Telchy, Antonio T Baines, Joseph P Dillard, Robert A Nicholas, Daniel Williams","doi":"10.1007/s00284-025-04261-7","DOIUrl":"10.1007/s00284-025-04261-7","url":null,"abstract":"<p><p>Lytic transglycosylase A in Neisseria gonorrhoeae cleaves the β-1,4-glycosidic bond between peptidoglycan (PG) monomers to liberate 1,6-anhydro-PG fragments that are either recycled or released as cytotoxic fragments. To gain further insight into the effect of LtgA on cellular processes in Neisseria gonorrhoeae, we performed a proteomic analysis comparing wild-type and an isogenic ltgA null mutant strain. Proteins were separated by two-dimensional gel electrophoresis and identified by MALDI-TOF mass spectrometry, which revealed several proteins that were increased in their level of expression upon loss of LtgA. The most notable changes corresponded to enzymes related to aminosugar and pyrimidine metabolism. Quantitative real-time RT-PCR of mRNA from a ltgA null strain confirmed increased transcription of genes encoding enzymes involved in UDP-N-acetylglucosamine (UDP-GlcNAc) synthesis, a major precursor in PG and lipooligosaccharide (LOS) synthesis, during normal growth conditions and following exposure to penicillin. We also found that the ltgA mutant strains were more susceptible to β-lactam antibiotics, vancomycin, and the human-cathelicidin antibacterial peptide, LL-37, than their corresponding wild-type parental strains. Our results suggest that increased expression of enzymes responsible for production UDP-GlcNAc is an adaptive response due to inactivation of ltgA and/or exposure to penicillin.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 6","pages":"278"},"PeriodicalIF":2.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Genomic Landscape of Understudied Salmonella enterica Serovars from Poultry and Human: Implications for Food Safety.","authors":"Valdinete P Benevides, Mauro M S Saraiva, Viviane A Ferreira, Michelli Inácio G Funnicelli, Lucas B Rodrigues Alves, Adriana M Almeida, Henrik Christensen, John E Olsen, Angelo Berchieri Junior","doi":"10.1007/s00284-025-04234-w","DOIUrl":"10.1007/s00284-025-04234-w","url":null,"abstract":"<p><p>Despite the bacteria of the genus Salmonella are pathogens of zoonotic importance, the factors associated with some serovars genetic diversity remain unclear. We investigated genotypic profiles of antimicrobial resistance, plasmid replicons, and virulence factors in 301 S. enterica genomes from human and animal sources, supplemented by ten sequenced genomes from fecal samples of laying hens in Brazil. Many antimicrobial resistance genes have been detected across various Salmonella serovars; with a limited number of unique resistance genes predicted in poultry isolates compared to human isolates. Specifically, among the 52 antimicrobial resistance genes identified, 48% were shared between poultry and human isolates, while 21.1% were exclusive to poultry isolates and 30.7% were exclusive to human isolates. Chromosomal mutations in the gyrA and parC genes were also predicted. To the best of our knowledge, this is the first work to report S. Braenderup carrying the SPI-10. SGI-1 was detected in a few isolates of S. Schwarzengrund from poultry and the CS54 island was solely noticed in genomes referring to the serovars S. Saintpaul and S. Braenderup. Among the serovars analyzed, S. Saintpaul showed the lowest plasmid diversity. A total of 161 (161/271) virulence genes were common to all serovars, the remaining genes were exclusively identified within specific serovars, revealing a distinct distribution pattern within the S. enterica population. Overall, our study brings to light the genetic potential of Salmonella serovars frequently neglected in poultry production, which threatens public health, particularly due to multidrug-resistant profiles against active principles used to treat human infections.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 6","pages":"279"},"PeriodicalIF":2.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Methyl-Accepting Chemotaxis Protein MCP-5685 Associated with Indole Synthesis in Pantoea ananatis YJ76 Influences its Plant Growth-Promoting Potential and Adaptability to Stress Conditions.","authors":"Haotian Zhang, Xinyi Zhou, Xueying Wang, Jing Zheng, Yongjun Feng","doi":"10.1007/s00284-025-04252-8","DOIUrl":"10.1007/s00284-025-04252-8","url":null,"abstract":"<p><p>Pantoea ananatis YJ76 is a predominant endophytic diazotrophic bacterium isolated from rice, which can produce indole as a signal to improve stress resistance, colonization, and growth-promoting effect on the host. Methyl-accepting chemotaxis proteins (MCPs) are the main chemoreceptor in bacteria and participate in regulating various cellular activities. By constructing an mTn5 transposon mutant library of YJ76, we screened out a mutant with decreased indole production. And its ability to resist stresses and starvation, as well as colonizing and growth-promoting effect on host rice plants, was inhibited. Using the hiTAIL-PCR technique combined the genome re-sequencing, the mutation site was identified as the mcp-5685 gene with a length of 1545 bp. Bioinformatics analysis and chemotaxis experiments showed that the MCP encoded by mcp-5685 had L-serine chemotaxis functions, revealing the mechanism of the gene encoding protein to drive L-serine uptake, a key component for tryptophan synthesis, and thus promote indole synthesis in the regulatory pathways for indole synthesis. Starting from the upstream regulation direction of indole synthesis, this study breaks through the previous researching limitation of focusing only on the downstream physiological function regulation of indole and provides new ideas for studying the indole signal.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 6","pages":"281"},"PeriodicalIF":2.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}