Current Microbiology最新文献

{"title":"Photobiostimulation of Saccharomyces cerevisiae with Nano Cobalt Ferrite: A Sustainable Approach to Bioethanol Production from Banana Peels.","authors":"Samar Saeed, Mona Maghraby, Ashraf Y Elnaggar, Shams H Abdel-Hafez, Yasser A Attia","doi":"10.1007/s00284-025-04099-z","DOIUrl":"https://doi.org/10.1007/s00284-025-04099-z","url":null,"abstract":"<p><p>This study presents a pioneering investigation into the effects of cobalt ferrite nanoparticles (CoFe₂O₄ NPs) on the fermentation efficiency of Saccharomyces cerevisiae and the production of bioethanol from banana peel biomass. The findings reveal a notable difference between the control sample, which produced only 11.16% bioethanol, and the enhanced yield achieved with the addition of 100 ppm CoFe₂O₄ nanoparticles, which reached an impressive 52.16%. This substantial increase underscores the potential of nanomaterials to catalyze fermentation processes, likely due to their unique physicochemical properties that enhance metabolic activity in yeast cells. Additionally, the study explored the impact of visible light irradiation on bioethanol production. Light exposure alone resulted in a 15.44% increase in ethanol yield compared to the control sample without nanoparticles. This emphasizes the role of light in enhancing fermentation dynamics, potentially by providing additional energy for metabolic reactions. When CoFe₂O₄ nanoparticles were activated by visible light, their stimulating effects on ethanol production were further intensified, leading to a remarkable ethanol yield of 63.01%. These results indicate a synergistic relationship between the nanoparticles and light, where the photoactivation of the nanomaterials not only boosts their catalytic properties but also enhances the overall metabolic activity of Saccharomyces cerevisiae. This suggests a promising approach for developing more efficient fermentation processes, potentially increasing bioethanol yields while utilizing waste materials. Overall, the integration of nanotechnology with renewable biomass resources offers a viable pathway toward more sustainable energy solutions.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"117"},"PeriodicalIF":2.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rhizospheric Alkali-Halotolerant Bacillus sp. KhSb-159 Enhanced Growth Parameters of the Mung Bean Crop.","authors":"Nishtha R Vaghela, Sangeeta D Gohel","doi":"10.1007/s00284-025-04087-3","DOIUrl":"https://doi.org/10.1007/s00284-025-04087-3","url":null,"abstract":"<p><p>Plant growth-promoting rhizobacteria (PGPR) play a crucial role in enhancing plant growth through various direct and indirect mechanisms. In this investigation, we isolated a potential PGPR, Bacillus sp. KhSb-159, from the rhizosphere of Sorghum bicolor L. located at Kharaghoda, Little Rann of Kutch (LRK), Gujarat (India). The isolated Bacillus sp. KhSb-159 displayed distinctive characteristics, forming circular, sticky, opaque, moderate-sized colonies with brown pigmentation. Interestingly, this strain exhibited growth at an alkaline pH of 9, even in the presence of 1 M NaCl (w/v). Further analysis revealed its capacity to produce indole acetic acid (IAA), ammonia, siderophores, and the ability to solubilize phosphate. In addition, KhSb-159 showed extracellular enzyme secretion, including amylase, protease, and cellulase. Bacillus sp. strain KhSb-159 demonstrated its potential to enhance the growth of mung bean crops which is a significant agricultural application. The treated seeds exhibited improvements in various growth parameters such as shoot length, root length, plant biomass, number of leaves, number of roots, fresh weight of shoot, dry weight of shoot, fresh weight of root, dry weight of root, fresh weight of leaves, and dry weight of leaves. Overall, Bacillus sp. strain KhSb-159 would be a good choice for bioformulation in sustainable agriculture due to its diverse range of abilities. This study has implications for the advancement of eco-friendly farming methods and offers insightful information about using rhizobacterial strains to maximize plant growth.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"114"},"PeriodicalIF":2.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and Molecular Characterization of Extended-Spectrum β-Lactamase, Plasmid-Mediated- AmpC, and Carbapenemase-Producing Enterobacteriaceae Isolated from Companion and Production Animals in Brazil.","authors":"Larissa M Chicoski, Arthur R da Costa, Maísa F Menck-Costa, Francisco E Pereira Rocha, Raffaella M Mainardi, Alais M Dall Agnol, Ulisses P Pereira","doi":"10.1007/s00284-025-04104-5","DOIUrl":"https://doi.org/10.1007/s00284-025-04104-5","url":null,"abstract":"<p><p>The crisis of bacterial resistance is an emerging One Health challenge, driven by the overuse of antimicrobials in medical and agricultural settings. This study aimed to investigate extended-spectrum β-lactamase (ESBL), Ampicillinase (AmpC), and carbapenemase production, and the presence of genes encoding these enzymes in Escherichia coli, Klebsiella spp., and Proteus spp., major contributors to infections and resistance isolates from animals. From 2016 to 2021, 130 multidrug-resistant (MDR) or extensively drug-resistant (XDR) isolates were recovered from the secretions, excretions, and organs of companion and production animals with active infections. Antibacterial sensitivity tests, along with phenotypic and genotypic detection of resistance enzymes, were performed. To the best of our knowledge, this is the first study in Brazil to estimate the prevalence of XDR Enterobacteriales isolated from companion and production animals, which accounted for 13.8% of the strains. Statistically significant differences (P < 0.05) in resistant bacteria between different classes and within the same class of antibacterial bacteria were found. The statistical probability between genotypic detection of ESBL (OR = 3.1) and phenotypic tests for AmpC (OR = 2.3) was also established. Approximately 32.3%, 17.6%, and 16.8% of the strains had positive phenotypic tests for ESBL, AmpC, and carbapenemases, respectively. Genetic analysis revealed the presence of bla_CTX-M (60.0%), bla_AmpC (9.18%), bla_KPC-2 (0.76%), and bla_NDM (1.52%). AmpC genes were identified in 8.46% of the samples, with bla_CMY being the most frequent (6.92%), followed by bla_DHA (0.77%), and bla_FOX (0.77%). The sequenced amplicons were deposited in NCBI. This study reveals critical data on Enterobacteriaceae with antibacterial resistance genes isolated from animals and may pose a significant threat to One health.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"112"},"PeriodicalIF":2.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antibiotic-Sensitive Bacillus Strain as a Potential Probiotic for Enhanced Growth in Penaeus vannamei.","authors":"Yiwen Gu, Ke Xu, Zhuoran Chen, Yanxu Lu, Shuguang Fang, Kun Hu, Xin Ju, Liangzhi Li, Zhi Chen","doi":"10.1007/s00284-025-04092-6","DOIUrl":"https://doi.org/10.1007/s00284-025-04092-6","url":null,"abstract":"<p><p>The safety of probiotics in aquaculture, particularly concerning the transfer of antibiotic resistance genes (ARGs), has become a significant concern. This study aims to isolate antibiotic-sensitive Bacillus strains from the gut of Penaeus vannamei and evaluate the potential for practical application in shrimp farming. The strain was tested for antibiotic sensitivity to 10 commonly used antibiotics, and the minimum inhibitory concentration (MIC) values were determined. Morphological analysis and 16S rRNA sequencing confirmed its identity. The probiotic properties, antibacterial activity, and feeding effects on P. vannamei were also assessed. The results showed that Bacillus sp. J3 and Lysinibacillus sp. R4 were generally sensitive to antibiotics but resistant to sulfapyridine and ciprofloxacin. Both strains exhibited acid and bile salt resistance in vitro and performed well in extracellular hydrolase tests. J3 demonstrated co-coagulation effects against Aeromonas veronii, Vibrio parahaemolyticus, and Vibrio alginolyticus, with coagulation rates over 35%, while R4 showed the highest co-coagulation rate (47%) against V. alginolyticus. Both strains exhibited strong antibacterial activity, with inhibition zones ranging from 20 to 22.5 mm. Preliminary shrimp farming tests showed that R4 improved shrimp growth and survival rates compared to the control, and its combination with Bacillus coagulans resulted in even greater efficacy. These findings suggest that Lysinibacillus sp. R4 holds promise as a probiotic for enhancing P. vannamei growth, and future research could explore the use of multiple probiotic combinations in aquaculture.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"115"},"PeriodicalIF":2.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production Optimization and Potential Bioactivities of Biosurfactant from PET Surface-Dwelling Oligotrophic Bacillus sp. EIKU23.","authors":"Atif Aziz Chowdhury, Nilendu Basak, Taniya Roy, Sayantani Paul, Ajar Nath Yadav, Sk Imran Ali, Ekramul Islam","doi":"10.1007/s00284-025-04088-2","DOIUrl":"https://doi.org/10.1007/s00284-025-04088-2","url":null,"abstract":"<p><p>The growing demand for efficient biosurfactants in various industrial sectors has driven the search for sustainable alternatives, enhanced production methods, and low-cost substrates. This study aimed to optimize the production, characterize, and assess the bioactivities of biosurfactants produced by an oligotrophic PET plastic-associated Bacillus sp. EIKU23. The bacterium yielded the highest amount of biosurfactant after 6 days of incubation in Luria broth medium (pH 7.0) at 30 °C without any additives. FTIR and NMR analyses confirmed the lipopeptide nature of the biosurfactant, which exhibited a negative charge. The biosurfactant remained stable at 4 °C-80 °C and pH 7.0-8.0 for at least 7 days. It exhibited antioxidant properties comparable to the ascorbic acid standard, with efficacy ranging from 23.61% to 89.96% in different antioxidant assays. It showed antibacterial activity against both Gram-positive and Gram-negative potential pathogens. The biosurfactant induced substantial DNA leakage at a concentration of 10 mg/mL and eradicated approximately 48.4% of pre-formed Staphylococcus aureus biofilm and showed anti-attachment behaviour to a polystyrene surface. Additionally, the biosurfactant precipitated up to 98.7% uranium from an aqueous solution, demonstrating its potential for bioremediation. These findings suggest that the biosurfactant produced by Bacillus sp. EIKU23 is multifunctional with promising applications in bioremediation, antibacterial activity, antibiofilm formation, and antioxidant defense, offering a novel solution for sustainable industrial practices and plastic waste management.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"113"},"PeriodicalIF":2.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpressing Endopeptidase Inhibitor IseA Enhances Biomass and Biochemical Production of Bacillus licheniformis.","authors":"Yongjia Zhang, Penghui He, Shiying Hu, Ruibin Zhang, Asfandyar, Shouwen Chen","doi":"10.1007/s00284-025-04096-2","DOIUrl":"https://doi.org/10.1007/s00284-025-04096-2","url":null,"abstract":"<p><p>Cell autolysis could lead to a decrease in both cell viability and the production of biochemicals, presenting one of the significant challenges during fermentation. Bacillus licheniformis, a gram-positive bacterium widely used in the production of various biologic products, also confronts the limitation caused by cell autolysis. In this study, we investigated the impact of peptidoglycan hydrolases (LytC, LytD, LytE, CwlC), endopeptidase inhibitor IseA, and prophage gene xpf on cell growth and biochemical synthesis in B. licheniformis DW2. The results showed that the deletion of xpf and overexpression of iseA could significantly increase cell survival. Then, xpf was deleted on iseA overexpressed strain P_P43UTR12iseA to construct engineered strain P_P43UTR12iseAΔxpf, which further enhanced viable cells. The results of cell autolysis showed that P_P43UTR12iseA could reduce cell autolysis significantly compared to the wild-type, but P_P43UTR12iseAΔxpf did not further decrease cell autolysis. Furthermore, the production of bacitracin was 792.23 U/mL in the iseA overexpressed strain, which increased by 13.82% compared with the wild-type, but P_P43UTR12iseAΔxpf did not further increase bacitracin production. Through detecting intracellular metabolites, we observed that iseA overexpression did not affect intracellular metabolism, but the precursors of bacitracin synthesis in P_P43UTR12iseAΔxpf were lower than that of wild-type and P_P43UTR12iseA. Finally, we found that the overexpression of iseA could also significantly improve the production of γ-PGA. In general, the overexpression of iseA could enhance the biomass and cell survival by reducing cell lysis without affecting the intracellular metabolites, which provided a potential strategy to improve production of biochemical.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"116"},"PeriodicalIF":2.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of Enterococcus hirae From Fresh White Yak Milk in Ledu District, Qinghai Province, China: A Comparative Genomic Analysis.","authors":"Huimin Lv, Jiaqi Sun, Yuanyuan Guo, Guoxuan Hang, Qiong Wu, Zhihong Sun, Heping Zhang","doi":"10.1007/s00284-024-04044-6","DOIUrl":"https://doi.org/10.1007/s00284-024-04044-6","url":null,"abstract":"<p><p>Yak milk is a widely consumed dairy product rich in lactic acid bacteria. Although Enterococcus hirae (E. hirae) is commonly found in dairy products and other foods, there is limited information available on its genetic makeup in yak milk. In the present study, 10 E. hirae strains isolated and identified from fresh white yak milk samples, along with 442 E. hirae strains obtained from the NCBI database (totaling 452 strains), were subjected to comparative genomic analysis. The findings of this study revealed that E. hirae has an open pan-genomic structure that allows for its high adaptability and environmental plasticity. Notably, E. hirae isolates from fresh white yak milk had smaller genomes, encoded more functional genes, and had fewer copies of genes encoding carbohydrate-active enzymes involved in the degradation of oligosaccharide metabolism and autolysin synthesis (CE1, GH73, GH23, and GT4 families) than those from animal and human isolates (P < 0.05). Additionally, fresh white yak milk isolates carried only three intrinsic bacteriocins and lacked virulence factors, CRISPR-Cas systems, and resistance genes linked to pathogenicity, which may be attributed to their specialization in the milk-derived environment. This study provides new insights into the genetic and functional gene diversity of E. hirae and how it adapts to milk-derived habitats.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"111"},"PeriodicalIF":2.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paeonol Inhibits the Replication of Bovine Herpesvirus Type 1 In Vitro Through Regulating the PI3K/AKT Pathway.","authors":"Xueying Yuan, Hongrui Wang, Zhicheng Zhao, Chuang Li, Xingyuan Wang, Yu Liu, Yulong Zhou, Zhanbo Zhu, Zecai Zhang","doi":"10.1007/s00284-025-04085-5","DOIUrl":"https://doi.org/10.1007/s00284-025-04085-5","url":null,"abstract":"<p><p>The bovine herpesvirus type I (BHV-1) is a significant pathogen that poses a threat to the healthy development of the cattle industry and has a global prevalence. Paeonol is a phenolic constituent extracted from the dried root bark of peony in the buttercup family. Although paeonol has anti-inflammatory and antioxidant effects, its antiviral capacity remains unclear. Here, we conducted a cytotoxicity assay to screen the safe concentration of the paeonol using bovine turbinate (BT) cells as a model. Antiviral studies showed that paeonol inhibited BHV-1 gB gene and VP8 protein expression, and reduced cytopathic effect and viral titer. Furthermore, paeonol also demonstrated a potent effect on BHV-1 replication with an EC₅₀ of 18.54 μg/mL and a Selectivity Index (SI) of 28.64. Mechanistic analysis revealed that the PI3K/AKT pathway might be involved in the antiviral mechanism of paeonol. Molecular docking combined with western blot assay further confirmed that paeonol was able to bind stably to the active sites of PI3K and AKT proteins, and significantly inhibited the activation of PI3K/AKT pathway. Interestingly, 740Y-P (a PI3K/AKT pathway agonist) significantly attenuated the anti-BHV-1 effect of paeonol. The above experiments are the first to confirm the inhibitory effect of paeonol on BHV-1 replication, which not only adds evidence to the biological function of paeonol as an antiviral agent, but also lays the foundation for the prevention and control of this disease and the development of feed additives.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"110"},"PeriodicalIF":2.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced Systemic Resistance-Mediated Defense Against Alternaria Blight Disease in Lentil by Pesticide Degrading Plant Growth-Promoting Rhizobacteria.","authors":"Tina Roy, Anuradha Bandopadhyay, Sukanta Majumdar, Shariful Alam, Nirmalendu Das","doi":"10.1007/s00284-025-04083-7","DOIUrl":"https://doi.org/10.1007/s00284-025-04083-7","url":null,"abstract":"<p><p>Enzymatic and antioxidative responses are key defense mechanisms in plants following pathogen invasion, collectively known as induced systemic resistance (ISR). Alternaria sp., a well-known soil-borne pathogen, causes blight diseases in various crops. This study investigates the defence response in lentil plants through the treatment-induced application of two multipotent pesticide degrading plant growth-promoting rhizobacteria (PGPR), Bacillus cereus and Bacillus safensis, to mitigate the destructive effects of Alternaria. Both bacterial strains were applied in different carrier-based bioformulations via soil drenching. We assessed the modulation of defense-related enzymes by various combinational treatments with the Alternaria pathogen. The in vitro production of antimicrobial compounds was analyzed using GC-MS to confirm their pathogen-suppressive capabilities. Field trials showed a positive correlation between treatments and improvements in yield and growth index (GI). The highest (180%) enzymatic induction of phenylalanine ammonia lyase (PAL) followed by catalase (CAT)(100%) and polyphenol oxidase (PPO) (54%), was observed in treatments with B. cereus alone or in combination with B. safensis, in presence of Alternaria, in respect to the control. In vitro analysis revealed the production of antimicrobial compounds, including benzoic acid derivatives, cyclotetrasiloxanes, hexacosane, chlorpyrifos, and phthalates, which may contribute to pathogen suppression. Our findings demonstrate that these biocontrol agents (BCAs) not only stimulate the plant's enzymatic defense system but also enhance growth, seed yield and produce several antimicrobial compounds in vitro. Thus, pesticide-tolerant PGPR, used in this study, exhibit both disease control and plant growth-promoting properties, offering promising applications in sustainable agriculture.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"109"},"PeriodicalIF":2.3,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Fermented Milk On Gut Microbiota And Human Health: A Comprehensive Review.","authors":"Mohamed H Abd El-Salam, Safinaz El-Shibiny, Fayza Mohamed Assem, Gharieb S El-Sayyad, Yasmeen A Hasanien, Dounia Elfadil, Tarek Nour Soliman","doi":"10.1007/s00284-025-04061-z","DOIUrl":"https://doi.org/10.1007/s00284-025-04061-z","url":null,"abstract":"<p><p>The beneficial impact of gut microbiota on human health has encouraged studies on factors modulating it. Among the different factors, diet plays a vital role in this area. Many studies on animals and humans have been concerned with the effects of fermented milk products on gut microbiota and how they relate to health benefits. Yoghurt, kefir, Koumiss, and fermented kinds of milk made using different probiotic strains were tested for their capability to modulate gut microbiota. It is apparent that the microflora present in fermented milk, specifically probiotics, are capable of enduring the gastrointestinal tract's adverse conditions primarily through transit microorganisms. Meanwhile, they can alter the gut microbiota in several ways that benefit human health. The present article gives a comprehensive overview of the modulation of gut microbiota by consumption of fermented milk, particularly those containing probiotics, and their impact on human health.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 3","pages":"107"},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}