Current Microbiology最新文献

{"title":"Ultrasensitive Detection and Its Potential Applications in the Diagnosis of Brucellosis.","authors":"Lina He, Heiya Na, Yaoxin Zhang, Pei Gong, Huanmin Zhou, Fang Wan","doi":"10.1007/s00284-026-04941-y","DOIUrl":"https://doi.org/10.1007/s00284-026-04941-y","url":null,"abstract":"<p><p>Brucellosis is a major zoonotic disease caused by Brucella spp., notably B. melitensis, B. abortus, B. canis, and B. suis. It continues to impose a significant public health and economic burden in endemic regions, including parts of Asia, Africa, the Middle East, and Latin America. The clinical presentation of the disease is often nonspecific, and early, accurate diagnosis is further complicated by the susceptibility of conventional serological assays to cross-reactivity. This narrative review covers literature published between 2000 and 2025 regarding the detection of Brucella, indexed in PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI). The review focuses on the limitations of traditional diagnostic methods and the performance characteristics and latest developments of emerging ultrasensitive detection technologies, including nucleic acid amplification (LAMP, RPA, SRCA), droplet digital PCR, CRISPR-Cas-based integrated systems, nanomaterial-enhanced assays, and protein/antigen-based biosensors. Their potential for integration into the One Health framework for zoonotic disease surveillance is also discussed.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature- and species-specific infection could modify stream insect communities.","authors":"Sarah A Taig, Galen Holt, Georgia K Dwyer, Rebecca E Lester","doi":"10.1007/s00284-026-04897-z","DOIUrl":"https://doi.org/10.1007/s00284-026-04897-z","url":null,"abstract":"<p><p>To maintain diverse communities under changing environmental conditions, species must be able to concentrate density feedback within species compared to between species. Density feedback can occur via multiple mechanisms, including predator partitioning, and is often mediated by the physical environment. If species respond differently to the environment (e.g. susceptibility to predators changes under different conditions) then environmental fluctuations can provide the necessary separation of density feedback to promote coexistence. Additionally, directional change in environmental conditions (as with climate change) can yield overall shifts in community composition. We assess possible pathways that a fungal-like parasite (Saprolegnia spp.) could modify these effects in a community of Hydrobiosidae caddisflies. We exposed caddisfly egg masses from four species to four controlled temperature regimes in the laboratory and determined mortality from infection. Saprolegnia spp. infection in caddisfly egg masses is species specific, a signature for predator partitioning which can influence coexistence. The caddisfly species also differ in how temperature alters their infection rates, with dramatic shifts in relative infection rates depending on the duration and timing of periods of high temperature. Our findings suggest that Saprolegnia spp. infection could limit dominant species, shift community composition, and help stabilise coexistence under fluctuating temperatures. While we show key conditions of coexistence are met, quantifying the effect of these temperature-mediated infection rates would require measuring the extent to which they modify density-dependent feedback.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactivation and Management of Endogenous Latent Herpesviruses in the Spaceflight Environment.","authors":"Biying Zhang, Peijun Han, Yong Liu","doi":"10.1007/s00284-026-04935-w","DOIUrl":"10.1007/s00284-026-04935-w","url":null,"abstract":"<p><p>The microgravity, radiation, and high-stress environment of space present unique challenges to astronauts' physical and mental health. In this environment, interactions between the host and pathogens are altered, thereby increasing astronauts' risk of endogenous viral infections. Notably, viral shedding detected during spaceflight does not necessarily indicate clinically significant disease, and the distinction between molecular reactivation, productive viral replication, and symptomatic infection must be carefully considered. This review aims to ensure mission success and enhance space biocapacity and biodefence by summarizing case studies and reactivation mechanisms of endogenous latent herpesviruses, the latest prevention and control strategies, and the challenges posed by host variability and antiviral efficacy in the space environment.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterizations of Carbapenem Resistance and Colistin Heteroresistance in Multidrug-Resistant Acinetobacter baumannii.","authors":"Nazanin Omidi, Ebrahim Kouhsari, Behrooz Sadeghi Kalani, Vahab Hassan Kaviar, Saeed Khoshnood, Hassan Valadbeigi, Mohammad Hossein Haddadi, Farzaneh Khodaei, Abbas Maleki","doi":"10.1007/s00284-026-04930-1","DOIUrl":"https://doi.org/10.1007/s00284-026-04930-1","url":null,"abstract":"<p><p>A. baumannii is a critical nosocomial pathogen with increasing antibiotic resistance. Colistin heteroresistance (CHR), which cannot be detected by standard methods, threatens the effectiveness of this definitive treatment. This study aimed to characterize carbapenem resistance, detect CHR, and investigate its molecular mechanisms. One hundred forty seven A. baumannii isolates were characterized. Carbapenemase genes were detected by PCR, and antibiotic susceptibility was determined by disc diffusion and broth microdilution. Heteroresistance (HR) was detected using population analysis profiling (PAP). The expression of efflux pump (adeB, adeG) and porin (ompA, carO) genes in HR isolates quantified by Real-time PCR analysis. The predominant carbapenemase genes were bla_OXA-51 (97%), bla_OXA-23 (88%), and bla_OXA-24-40 (72%). PAP revealed a prevalence of 8.5% (3/35) of CHR among carbapenem-resistant and colistin-susceptible isolates. Real-time PCR revealed a highly significant (p < 0.001) increase in expression of adeB and adeG (approximately 4-fold) and a concomitant decrease in expression of ompA and carO in these isolates, suggesting a synergistic adaptation mechanism. This study highlights the need for proactive monitoring of CHR for clinical surveillance and management to prevent the emergence of full-scale resistance. Therapeutically, the development of efflux pump inhibitors and molecular diagnostics could be crucial to maintain colistin efficacy and improve treatment outcomes.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of the Apoptotic Modulatory Pathway During Eimeriosis by Cassia alata Extract.","authors":"Rabab E Elshershaby, Mohamed A Dkhil, Yasser Dar, Felwa A Thagfan, Rewaida Abdel-Gaber, Ibrahim B Helal, Lamiaa Bakr","doi":"10.1007/s00284-026-04924-z","DOIUrl":"https://doi.org/10.1007/s00284-026-04924-z","url":null,"abstract":"<p><p>Coccidiosis, induced by Eimeria species, is a parasitic disease that impacts the intestines of animals, resulting in gastrointestinal damage, poor health, and significant economic losses in the livestock and poultry sectors. The use of traditional anticoccidial drugs presents challenges such as toxicity, drug resistance, and food contamination, prompting the search for safer alternatives. Cassia alata, a plant recognized for its anti-inflammatory and antioxidant properties, has a potential natural treatment for coccidiosis. This study involved infection of mice with Eimeria papillata to assess the efficacy of C. alata leaf extract (CALE). A methanolic extract of C. alata was analyzed via gas chromatography-mass spectrometry (GC-MS) and tested its efficacy in 35 mice across seven groups, including controls and those treated with various dosages (125, 250, or 500 mg/kg BW) or amprolium. The study evaluated treatment success by quantifying fecal oocyst shedding, examining jejunal histology, measuring glutathione peroxidase (GPx) activity, and analyzing Caspase 3 protein and gene expression to assess host cell apoptosis. The results indicated that CALE had 14 phytochemical compounds. CALE led to significant morphometric reduction in the parasitic stages, compared to untreated infected mice. The 500 mg/kg BW dose of CALE was particularly effective in lowering fecal oocyst output. Additionally, GPx levels increased in mice treated with CALE and amprolium, while, caspase-3 immunoreactivity and gene expression were significantly reduced in CALE-treated mice. This study suggests that C. alata extract could effectively modulate apoptotic pathways, offering a promising natural solution for managing eimeriosis and enhancing host health.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy in Ocular Fungal Infections: Advances and Emerging Strategies.","authors":"Agimanailiu Khapuinamai, Joveeta Joseph","doi":"10.1007/s00284-026-04893-3","DOIUrl":"https://doi.org/10.1007/s00284-026-04893-3","url":null,"abstract":"<p><p>Ocular fungal infections, represent a significant global health burden, particularly in tropical and subtropical regions. Conventional antifungal therapies often suffer from poor ocular bioavailability, delayed diagnosis, toxicity, and limited efficacy, especially in immunocompromised individuals. Given the critical role of host immunity in determining disease outcomes, immunomodulation has emerged as a promising adjunctive strategy to enhance antifungal defense while mitigating immunopathology. This review highlights the complex interplay between innate and adaptive immune responses in ocular fungal infections and explores emerging immunotherapeutic approaches such as host defense peptides, cytokine therapies (e.g., IFN-γ, IL-6, IL-17, IL-33), cellular therapies (e.g., MSCs, CAR-T cells, dendritic cells), and extracellular vesicle-based interventions. Despite existing challenges including the complexity of ocular immunopathology and the logistical hurdles of clinical trials Immunomodulatory therapies have the potential to shift the current treatment paradigm for ocular fungal infections, advancing from traditional pathogen-targeted approaches to more precise, host-directed interventions.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parabiotics as Next-Generation Microbiome Therapeutics: Insights into Mechanisms, Evidence, and Therapeutic Potential.","authors":"Aditi Singh, Shreetama Bhattacharjee, Yashvardhan Singh, Irena Kostova","doi":"10.1007/s00284-026-04942-x","DOIUrl":"https://doi.org/10.1007/s00284-026-04942-x","url":null,"abstract":"<p><p>Parabiotics (also termed paraprobiotics) are defined as non-viable microbial cells or their components, including peptidoglycans, teichoic acids, surface proteins, that confer health benefits without requiring viability which distinguishes them from traditional probiotics. Their non-viable nature eliminates risks such as microbial translocation, bacteremia, and sepsis, making them suitable for vulnerable populations including immunocompromised, critically ill, paediatric and elderly individuals. In addition, parabiotic exhibit improved thermal stability, extended shelf life, and easier incorporation into functional foods, nutraceuticals, and pharmaceutical formulations without cold-chain requirements. Mechanistically, parabiotics retain immunomodulatory, anti-inflammatory and have barrier-enhancing activities through interactions with host pattern recognition receptors, including Toll-like receptors, modulation of cytokine responses, and reinforcement of gut epithelial integrity. Preclinical and clinical studies support their therapeutic potential such as in case of heat-killed Lactobacillus acidophilus LB (L. acidophilus) has shown efficiency in managing acute paediatric diarrhoea, while heat-inactivated Lacticaseibacillus paracasei PS23 (Lcb. paracasei) has demonstrated improvements in muscle strength and inflammatory markers, including reduced C-reactive protein and interleukin-6 and increased interlukin-10 in elderly individuals. Similarly, inactivated Lactiplantibacillus plantarum (Lpb. plantarum) and Bifidobacterium strains have been associated with benefits in irritable bowel syndrome, atopic dermatitis, respiratory infections, visceral fat reduction, and antibiotic-associated dysbiosis. Synergistic combinations with prebiotics, postbiotics and related bioactives further enhance therapeutic outcomes in inflammatory, metabolic and infectious conditions. Advances in metagenomics, next-generation sequencing, proteomics, metabolomics, CRISPR-Cas systems, and synthetic biology are accelerating strain characterization, functional evaluation, and scalable production. Despite ongoing challenges in standardization and regulated harmonization, parabiotics represent a safe and effective approach for microbiome-targeted interventions. This review synthesizes current evidence on their therapeutic applications, technological advancements, and translational potential, highlighting their role in precision health and next-generation functional nutrition.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Terbinafine Response and Minimum Inhibitory Concentration-Squalene Epoxidase Mutation Correlation in Tinea Cruris and Corporis: A Cross-Sectional Study.","authors":"Anita Kumari, Shukla Das, Praveen Kumar Singh, Gargi Rai, Swati Sharma, Bineeta Kashyap, Deepika Pandhi, Arshad Jawed, Sajad Ahmad Dar","doi":"10.1007/s00284-026-04934-x","DOIUrl":"https://doi.org/10.1007/s00284-026-04934-x","url":null,"abstract":"<p><p>Chronic and recalcitrant dermatophytosis has become an increasing therapeutic challenge, particularly in India, where widespread antifungal misuse and environmental factors contribute to persistent infections. This study investigated the clinical patterns, antifungal susceptibility, and molecular mechanisms underlying terbinafine resistance in patients with tinea corporis and tinea cruris. A total of 105 clinically diagnosed and KOH-positive patients were enrolled. The majority were male (60%) with a mean age of 34 years and an average disease duration of 13 months. Most cases involved multiple sites, with the groin, thighs, and buttocks most frequently affected. Phenotypic and molecular identification revealed Trichophyton mentagrophytes/interdigitale complex (Tm/TiC) as the predominant pathogen (97%), followed by rare isolates of Trichophyton rubrum (2%) and Trichophyton indotineae (1%). Antifungal susceptibility testing (CLSI M38-A2) showed high MIC values for fluconazole (MIC₅₀/₉₀: 64 µg/ml), terbinafine (MIC₅₀: 0.5 µg/ml, MIC₉₀: 16 µg/ml), and griseofulvin (MIC₅₀: 2 µg/ml, MIC₉₀: 8 µg/ml), while itraconazole exhibited the best in vitro activity (MIC₅₀: 0.25 µg/ml, MIC₉₀: 0.5 µg/ml). Notably, 33% of isolates demonstrated high terbinafine MICs (≥ 1 µg/ml). SQLE gene sequencing identified mutations, particularly F397L, strongly associated with elevated terbinafine MICs and prior drug exposure. These findings highlight the alarming rise of terbinafine resistance among dermatophytes and underscore the role of inappropriate antifungal use in driving resistance. Regular antifungal susceptibility testing, careful drug selection based on prior exposure, and strict patient compliance are essential for improving outcomes. Until clinical breakpoints are established, treatment should be continued until both clinical and mycological cure are achieved.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Plants and the Gastrointestinal Microbiota in Chronic Diseases Modulation: A Structured Mechanistic and Translational Review.","authors":"Esther Ugo Alum, Daniel Ejim Uti, Okechukwu Paul-Chima Ugwu, Michael Ben Okon, Waheeb Sami Aggad, Hailah M Almohaimeed, Neeraj Bainsal, Sandeep Kumar Shukla, Kranti Kiran Reddy Ealla","doi":"10.1007/s00284-026-04940-z","DOIUrl":"https://doi.org/10.1007/s00284-026-04940-z","url":null,"abstract":"<p><p>The gut microbiome supports digestion, immunity, and metabolism; its imbalance (dysbiosis) drives inflammation and metabolic dysfunction, contributing to chronic diseases such as diabetes, cardiovascular disease, inflammatory bowel disease, and autoimmune disorders. Medicinal plants provide a wide range of phytochemicals (such as polyphenols, flavonoids, alkaloids, saponins), which reach the colon and undergo two-sided interactions with microbes in the gut, acting as potential microbiome modulators and substrates of biotransformation into bioactive metabolites. This structured narrative review synthesises evidence from peer-reviewed studies indexed in PubMed, Scopus, and Web of Science over the last 10 years on the role of medicinal plants in microbiome-mediated chronic disease modulation. This literature is organised into three mechanistic axes: (i) perturbations, defined here as measurable shifts in microbial diversity or taxonomic composition relative to a baseline or healthy reference state, together with beneficial taxa enrichment; (ii) alterations in microbial metabolite output, especially short-chain fatty acids (SCFAs) and other immunometabolic mediators; and (iii) downstream host metabolic and immune signalling. Rather than broad descriptive summaries, the literature is organised using an axis-based mechanistic framework, highlighting key translational constraints such as botanical heterogeneity, dose/formulation variability, and inconsistent microbiome endpoint standardisation, that must be addressed to strengthen human evidence and clinical relevance. Illustrative microbiome-mediated processes involve botanicals such as turmeric (curcumin), ginseng (ginsenosides), and green tea (catechins), though evidence strength varies by study design. Future progress requires standardised phytochemical characterisation, microbiome-stratified trials, and integration of multi-omics with artificial intelligence analytics to enhance mechanistic insight, identify responders, and enable personalised plant-based microbiome therapies.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-1 and Vaccine: Analysis of gp41 Target Sequences.","authors":"Dimonte Salvatore, Scutari Rossana, Salpini Romina, Aquaro Stefano, Svicher Valentina, Pellegrino Michele","doi":"10.1007/s00284-026-04936-9","DOIUrl":"https://doi.org/10.1007/s00284-026-04936-9","url":null,"abstract":"<p><p>Despite extensive efforts by scientists, academic institutions, and pharmaceutical companies, a safe and effective HIV/AIDS vaccine remains elusive. Most HIV-1 envelope peptide vaccine strategies have concentrated on Gp120, gp140, or gp160. HIV-1 Env trimer binding to the CD4-receptor initiates structural changes promoting the envelope's transition from a closed to an open state via an intermediate step. Broadly neutralizing antibodies target the state-1 Env conformation, while less effective antibodies typically recognize open states. However, due to virus variability, an optimal vaccine has not yet been successfully developed. In this study, focusing on the pivotal role of Gp41 in various vaccine strategies, a very large sequence dataset was utilized. These sequences were obtained from drug-naïve individuals or those undergoing antiretroviral therapy (ART). Gp41 amino acid variability was characterized genetically using a starting pool dataset of 24,505 full-length Env sequences from HIV-1 Subtype-B infected individuals. The dataset underwent hydropathy analysis, genetic distance evaluation, non-synonymous/synonymous substitution rate estimation, Shannon-Entropy calculation, and N-linked glycosylation (NLG) analysis. Similar variability between viral sequences retrieved from drug-naïve and antiretroviral-treated individuals was observed. In our dataset, ART selection pressures observed at gp41 level are minimal: 7 positions with dN/dS > 1, significant increases in entropy values, and a comparable value of glycosylation sites were highlighted. This study reinforces the importance of identifying specific single sensitizing mutations in HIV control. Gp41 remains an important vaccine target for understanding virus-host immunological interactions. Further analyses may reveal specific mechanisms related to host antiviral responses and viral regions with strong masking activity.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"83 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}