Current Microbiology最新文献

{"title":"Investigating the Efficacy of Amoxicillin-Broccoli Combination in Combating Multidrug-Resistant Staphylococcus aureus Infection.","authors":"Habiba Mosaad, Engy Elekhnawy, Walaa A Negm, Salwa S Younis, Mona El-Aasr","doi":"10.1007/s00284-025-04316-9","DOIUrl":"https://doi.org/10.1007/s00284-025-04316-9","url":null,"abstract":"<p><p>In light of the propagation of resistance amongst bacteria, many infections are currently difficult to treat, with extremely high death and morbidity rates. Thus, we investigated the effect of using a combination of amoxicillin and broccoli ethanolic extract against Staphylococcus aureus infections. Broccoli or Brassica oleracea active metabolites' were to be identified and quantified using high-performance liquid chromatography (HPLC). The major detected compounds were chlorogenic acid and gallic acid. In vitro, the combination of amoxicillin with broccoli revealed fractional inhibitory concentration index of the amoxicillin-broccoli combination was less than 0.5 in 50% of the isolates, which indicates a synergetic potential. The in vivo study revealed a notable lessening in the bacterial count present in the examined tissues in the employed systemic infection model. The studied tissues were kidney, liver, and spleen. Moreover, the histological characteristics were found to have a remarkable enhancement in the combination-treated group. Thus, future clinical reports have to be employed to explicate the usefulness of such a combination in the clinical practice.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 8","pages":"338"},"PeriodicalIF":2.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ribosome Engineering for Enhanced Butenyl-Spinosyn Production in Saccharopolyspora pogona.","authors":"Chao Guo, Yuchun Liu, Bo Lv, Xinying Li, Qingrong Wang, Wei Han, Chao Wang","doi":"10.1007/s00284-025-04317-8","DOIUrl":"https://doi.org/10.1007/s00284-025-04317-8","url":null,"abstract":"<p><p>Ribosome engineering, a strategy that utilizes antibiotic resistance mutations to modulate ribosomal function, has emerged as a powerful approach for enhancing microbial metabolite production. In this study, ribosome engineering was applied to Saccharopolyspora pogona ASAGF2-G4 under streptomycin selection to improve butenyl-spinosyn production. Screening for streptomycin-resistant mutants at concentrations ranging from 2 to 20 µg/mL resulted in the isolation of 58 mutants, of which 27.6% exhibited increased butenyl-spinosyn production. Among these, 22 mutants harbored six distinct mutations in the rpsL gene, resulting in five amino acid substitutions in the ribosomal protein S12: Lys43 to Arg, Lys43 to Thr, Lys43 to Asn, Lys88 to Glu, and Lys88 to Arg. The highest frequency of rpsL mutant isolation was observed at a streptomycin concentration of 15 µg/mL. Phenotypic characterization revealed altered growth dynamics, pH shifts, and glucose utilization among the mutants, with the K88R and K43R variants exhibiting significantly increased butenyl-spinosyn production-1.78-fold and 1.64-fold higher than that of the parental strain, respectively. Quantitative PCR analysis showed significant upregulation of translation-related genes (rpsL and frr), growth-related genes (whiA and bldD), and key butenyl-spinosyn biosynthetic genes (busA, busF, and busI) in the K88R mutant, suggesting that the K88R substitution enhances target compound biosynthesis by modulating ribosomal function and associated metabolic networks. Future research should explore combinatorial approaches, including the development of multi-antibiotic-resistant mutants and elevated expression of ribosomal genes, to maximize butenyl-spinosyn yields. This study underscores the potential of ribosome engineering as a platform for improving butenyl-spinosyn production and provides a foundation for subsequent industrial-scale applications.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 8","pages":"337"},"PeriodicalIF":2.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Sensory Qualities and Microbial Community Structure in the Fermented Grains by Low-Temperature Daqu from Different Regions of China.","authors":"Fanshu Xiang, Wenchao Cai, Qiangchuan Hou, Zhongjun Liu, Liang Li, Xiaoyuan Dong, Chunhui Shan, Zhuang Guo","doi":"10.1007/s00284-025-04315-w","DOIUrl":"https://doi.org/10.1007/s00284-025-04315-w","url":null,"abstract":"<p><p>Low-temperature Daqu (LTD) serves as the starter for the fermented grains (FG) of Light-amora Baijiu, yet its impact on FG remains unclear. This study assessed the differences in sensory attributes and microbial community structures of the FG fermented by LTD from two regions through electronic sensing and MiSeq high-throughput sequencing. The results showed significant differences in odor and taste between the two FG groups (P < 0.05). The dominant bacteria in both FG groups were mainly Lactobacillus (74.05%), and dominant fungi were Saccharomycopsis (44.30%) and Saccharomyces (37.84%). The microbial differences in the both groups may be manifested in the low abundance of microbial communities. The fermentation environment of LTD and FG is very different, resulting in their microbial community structure and bacterial gene function being significantly different. LTD had more anaerobes with higher expression of transport and metabolic genes for amino acid and lipid functions, whereas FG contained more facultative anaerobes with higher expression of carbohydrate transport and metabolic genes. Notably, 71.77% of endemic bacteria were found in FG but absent in LTD. Overall, our results indicated that different LTD had a greater impact on the sensory and low-abundance microflora of FG, enhancing our understanding of its role in fermentation processes.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 8","pages":"336"},"PeriodicalIF":2.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Infection Caused by Mycobacterium fortuitum Following Aortic Valve Transplantation-Employing Combined Molecular Techniques for Accurate Species Identification.","authors":"Max Roberto Batista de Araújo, Débora Marques da Silveira E Santos, Jailan da Silva Sousa, Gerson Fernandes do Prado, Diogo Luiz de Carvalho Castro, Moacir Soares Dias Júnior, Hugo Felix Perini, Cíntia Minafra, Siomar de Castro Soares, Evandro Bento Rodrigues, Luan Freitas Lana, Letícia Aparecida Caldeira Gonçalves, Bruno Silva Andrade, Talita Gomes, Vasco Azevedo","doi":"10.1007/s00284-025-04313-y","DOIUrl":"https://doi.org/10.1007/s00284-025-04313-y","url":null,"abstract":"<p><p>Mycobacterium fortuitum, a nontuberculous mycobacterium (NTM), is known for causing opportunistic infections, particularly in immunocompromised individuals. Identification of NTM species requires precise diagnostic techniques. Here, we present a study of a systemic infection by M. fortuitum in an elderly patient, identified through MALDI-TOF MS and confirmed by gene sequencing. An 88-year-old Italian man developed an abscess at his pacemaker site, leading to acute infectious endocarditis caused by Staphylococcus capitis. During hospitalization, he experienced multiple complications, including jugular vein thrombosis, pulmonary thromboembolism, and gastrointestinal bleeding. Despite treatment with vancomycin, he developed bacteremia, allowing the isolation of M. fortuitum from blood culture. The strain was identified using MALDI-TOF MS and confirmed by Sanger sequencing of the 16S rRNA and hsp65 genes. Phylogenetic analysis supported the identification. The patient, after treatment with carbapenems and aminoglycosides, returned to Italy without further clinical complications. This case underscores the necessity of precise diagnostic tools for managing NTM infections. The combined application of MALDI-TOF MS and gene sequencing enabled accurate species identification, which is essential for guiding effective treatment of systemic M. fortuitum infections, especially in complex clinical scenarios involving immunosuppression.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 8","pages":"335"},"PeriodicalIF":2.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Vaccine Candidate Expressing JUNV GP1-GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display.","authors":"Carla Tomatis, Mara C A M Aguiar, Nancy Charo, Silvia Aquila, Pablo D Thomas, Paula N Arrías, Matías L Pidre, Víctor Romanowski, Laura Riera, Julia Brignone, Andrea Maiza, Eugenio Antonio Carrera Silva, María Florencia Ferrer, Ricardo Martín Gómez","doi":"10.1007/s00284-025-04320-z","DOIUrl":"https://doi.org/10.1007/s00284-025-04320-z","url":null,"abstract":"<p><p>With the aim of developing a new vaccine candidate using a recombinant baculovirus (rBV) expressing the Junín virus (JUNV) GP1 and GP2 proteins on its surface, a pBacPAK9 vector containing the BV-GP64 signal peptide, the JUNV GP1-GP2 and the transmembrane domain of the vesicular stomatitis virus G (VSV-G) protein were synthesized. This plasmid was co-transfected with the bApGOZA bacmid into Sf9 cells. The rBV was recovered from the supernatant. Protein expression was confirmed with a human serum by Western blot and with an anti-GPC monoclonal antibody by IFI staining and virometry. In an ELISA test, mice immunized with rBV exhibited specific antibody levels that also showed neutralizing properties in a plaque reduction test compared to controls. Guinea pigs immunized with rBV and challenged with JUNV showed partial protection compared to the Candid#1 vaccine. We have developed an rBV surface display platform to validate a potential JUNV vaccine candidate.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 8","pages":"334"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oryzobacter faecalis sp. nov., an Antibiotics-Resistant Actinobacterium of the Family Intrasporangiaceae Isolated from Pig Faeces.","authors":"Xinyan He, Miaohuan Xiong, Bin Liu, Qiuxiang Yan","doi":"10.1007/s00284-025-04309-8","DOIUrl":"https://doi.org/10.1007/s00284-025-04309-8","url":null,"abstract":"<p><p>A Gram-stain-positive, aerobic, rod-shaped, and non-motile bacterium, designated strain R7^T, was isolated from pig faeces. Strain R7^T grew at 15-37 °C (optimum 30 °C), pH 6-8 (optimum pH 7), and salinity of 0-5.0% (w/v; optimum 1.0%). Strain R7^T was resistant to cefradine, ampicillin, gentamicin, and spectinomycin. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain R7^T belonged to genus Oryzobacter, and showed 98.9% similarity with Oryzobacter terrae PSGM2-16^T. The average nucleotide identity and digital DNA-DNA hybridization values between strain R7^T and O. terrae PSGM2-16^T were 84.5% and 27.6%, respectively. The predominant fatty acids of strain R7^T were iso-C_16:0, C_17:1ω8c, iso-C_14:0, C_17:0, and iso-C_15:0. The predominant ubiquinone was MK-8(H₄). The major polar lipids of strain R7^T were phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylinositol, aminophosphoglycolipid, one unidentified phospholipid, and two unidentified polar lipids. The diagnostic diamino acid of the cell-wall peptidoglycan was meso-diaminopimelic acid. Based on the phenotypic, genotypic and phylogenetic evidence, strain R7^T represents a novel species in the genus Oryzobacter, for which the name Oryzobacter faecalis sp. nov. is proposed. The type strain is R7^T (=GDMCC 1.4961^T = KCTC 59403^T = KACC 23902^T).</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 8","pages":"333"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moraxella marmotae sp. nov. Isolated from the Respiratory Tract of Marmota himalayana.","authors":"Jinlv Liu, Yaqi Wang, Juan Zhou, Qiang Hou, Jiajia Ma, Danna Pu, Ji Pu, Feifei Wang, Jing Yang, Shan Lu","doi":"10.1007/s00284-025-04307-w","DOIUrl":"https://doi.org/10.1007/s00284-025-04307-w","url":null,"abstract":"<p><p>Two novel Gram-stain-negative, Oxidase-positive, catalase-negative, aerobic, non-motile and coccus-shaped bacterial strains (ZJ142^T and ZJ171) were isolated from the respiratory tract of marmots collected from Yushu Tibetan Autonomous Prefecture (Altitude: 3600 m; N: 33°13'57'', E: 97°1'11'') in Qinghai Province. The 16S rRNA genes of strains ZJ142^T and ZJ171 are most similar to Moraxella porci DSM 25326^T (99.04%). The phylogenetic tree based on the 16S rRNA gene and phylogenomic tree based on 700 single-copy core genes indicated that strains ZJ142^T and ZJ171 formed a distinct clade within the genus Moraxella. Two novel strains exhibiting Orthologous Average Nucleotide Identity values (ANI) ≤ 77.0% and digital DNA-DNA hybridization values (dDDH) ≤ 25.4% within the genus Moraxella affirmed their distinctiveness. The dDDH and ANI between strains ZJ142^T and ZJ171 were 73.3% and 97.1%, respectively. Compared to other species in the genus Moraxella, both strains have similar colony morphology and growth conditions, and are capable of hydrolyzing esculin. Based on the phenotypic, phylogenetic, and physiological results, the two strains were classified as a novel species of the genus Moraxella, for which we proposed the name Moraxella marmotae sp. nov. (type strain ZJ142^T = GDMCC 1.3113^T = JCM 35324^T). In type strain ZJ142^T, we predicted biosynthetic gene clusters of lipooligosaccharide (LOS), pili and nitrate reductase and other virulence genes. Considering the respiratory source of our isolates and the best known pathogen in genus Moraxella, Moraxella catarrhalis, a well-known human respiratory pathogen, Moraxella marmotae sp. nov. may be a potential pathogen.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 8","pages":"332"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the Prokaryotic Microbial Community Structures and their Ecological Potentials in Manjanggul Cave, a Lava Tube on Jeju Island.","authors":"Minji Kim, So-Jeong Kim, In-Tae Cha, Soo-Je Park","doi":"10.1007/s00284-025-04318-7","DOIUrl":"https://doi.org/10.1007/s00284-025-04318-7","url":null,"abstract":"<p><p>This study investigated the prokaryotic microbiota-comprising both archaea and bacteria-of Manjanggul Cave, a UNESCO World Heritage lava tube on Jeju Island, South Korea. Despite their geological significance, the archaeal and bacterial community structures within Jeju Island's diverse cave systems have remained largely unexplored, primarily due to access restrictions. Here, we used high-throughput sequencing of archaeal and bacterial 16S rRNA genes, as well as biostatistics, to elucidate the structure and diversity of these communities within Manjanggul Cave. The findings revealed that the bacterial community was dominated by Proteobacteria, while Crenarchaeota (classified by silva) was the predominant archaeal phylum. Notably, the ammonia-oxidizing archaeal genus Nitrososphaera was highly abundant, whereas ammonia-oxidizing bacteria (genera Nitrosococcus and Nitrosomonas) were detected at extremely low levels. The nitrite-oxidizing bacterial genus Nitrospira was consistently abundant across all samples, suggesting that Nitrososphaera/Nitrospira may play crucial roles in aerobic nitrification within the cave ecosystem. Intriguingly, a high proportion of haloarchaea was also observed, which may be attributed to the unique geological characteristics of Jeju Island, indicating a distinct microbial ecosystem within Manjanggul Cave. In conclusion, this study provides molecular evidence for the mixing of indigenous cave-associated prokaryotic communities with external microbial populations, suggesting potential alterations in the composition of both communities within Manjanggul Cave. These findings underscore the importance of research to understand the impact of human activities on cave microbial ecosystems, and the need for conservation strategies to preserve these unique environments.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 8","pages":"331"},"PeriodicalIF":2.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, Screening, Identification of Cellulolytic Bacteria and Optimization of Factors Affecting FPUase Synthesis for Bagasse Hydrolysis.","authors":"Le Duy Khuong, Van Minh Nguyen, Roan Thi Do, Huong Thi Thanh Doan, Don Nguyen, Sang Van Vu, Hong Thi Nguyen, Ichiro Kamei, Chu Luong Tri","doi":"10.1007/s00284-025-04298-8","DOIUrl":"10.1007/s00284-025-04298-8","url":null,"abstract":"<p><p>The screening of FPUase-synthesizing bacteria and optimization of hydrolysis conditions for alkaline pre-treated bagasse are key focuses of current research. This study systematically screened cellulose‑degrading bacteria from soil, mud, and cow liver samples, identifying HL04 as a robust FPUase‑producing strain. Based on 16S rRNA ribosome sequence, HL04 was identified as Bacillus safensis, a newly discovered microorganism capable of synthesizing FPUase. FPUase production conditions were optimized through single‑factor experiments analyzing fermentation time, substrate concentration, pH, and temperature. Using the Box-Behnken Design (BBD) under the response surface methodology (RSM), the study refined these factors to enhance FPUase production. The resulting second-degree polynomial model demonstrated high validity (R² = 0.9913), and statistically significant interactions (P < 0.05). Optimal conditions-12 g/L of substrate concentration, pH 7, and a fermentation temperature of 40 °C-yielded the highest FPUase activity of 61.5 U/L.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 7","pages":"330"},"PeriodicalIF":2.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local Genomic Epidemiology of Acinetobacter baumannii Circulating in Hospital and Non-hospital Environments in Kano, Northwest Nigeria.","authors":"I Yusuf, H B Idris, E Skiebe, G Wilharm","doi":"10.1007/s00284-025-04304-z","DOIUrl":"10.1007/s00284-025-04304-z","url":null,"abstract":"<p><p>Acinetobacter baumannii is a pathogenic bacterium of public health significance, capable of rapidly spreading within and between environments. The local epidemiology and transmission pattern of A. baumannii strains circulating in hospitals and non-hospital environments is rarely studied, and hence this is investigated in Kano, Nigeria. A cross-sectional study design was used to collect 172 samples from clinical, hospital, and non-hospital samples. Acinetobacter baumannii isolates were identified and confirmed using microbiological and molecular techniques. Variants of bla_OXA-51 were determined through amplicon sequencing, while whole genome sequencing was performed on 22 isolates to determine their allelic variants/sequence types (ST), resistance/virulence genes, insertion sequences, plasmids, single-nucleotide polymorphism (SNPs) and investigate phylogenetic relationships between the isolates. Twenty-seven A. baumannii were isolated from door handle and toilet floors of student hostels (14), soil and sullage samples (3 each), bed, chair, and drawer of hospital environments (9), and 1 from the urine of a patient. All these isolates belong to only 2 variants of bla_OXA51-like genes, 16 (48.8%) are bla_OXA-66 and 11 (33.3%) are bla_OXA-180. About 70% of the isolates were susceptible to many antibiotics, and 8 resistance genes encoding aminoglycoside, tetracycline, and sulphonamide resistance were acquired by only strains harbouring bla_OXA-66, and between 37 and 39 virulence genes were harboured by all the variants. Intrinsic bla_ADC-25 encoding resistance to β-lactams was found in all A. baumannii strains. The 2 variants had Pasteur scheme MLST allelic profiles ST2 and 267, which are not commonly reported in Nigeria. Few isolates from hospital and non-hospital sources form a cluster with SNPs number distances within the two clusters in the range of 85-100, suggesting a close relationship. The 2 variants circulate in both environments, suggesting transmission in both directions. Detection of ST267 (bla_OXA-180 variant) in a clinical sample indicates an environment-to-human transmission.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 7","pages":"329"},"PeriodicalIF":2.3,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}