Current Biology最新文献

{"title":"Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions restricts epithelial permeability in Drosophila.","authors":"Thea Jacobs, Jone Isasti Sanchez, Steven Reger, Stefan Luschnig","doi":"10.1016/j.cub.2025.01.043","DOIUrl":"https://doi.org/10.1016/j.cub.2025.01.043","url":null,"abstract":"<p><p>Cell contacts in epithelia are remodeled to regulate paracellular permeability and to control the passage of migrating cells, but how barrier function is modulated while preserving epithelial integrity is not clear. In the follicular epithelium of Drosophila ovaries, tricellular junctions (TCJs) open transiently in a process termed patency to allow passage of externally produced yolk proteins for uptake by the oocyte. Here, we show that modulation of actomyosin contractility at cell vertices controls TCJ permeability. Before patency, circumferential actomyosin bundles are anchored at apical follicle cell vertices, where tension-sensing junctional proteins, Rho-associated kinase (Rok), and active myosin II accumulate and maintain vertices closed. TCJ opening is initiated by redistribution of myosin II from circumferential bundles to the medial zone, accompanied by decreasing tension on vertices. This transition requires activation of Cofilin-dependent filamentous actin (F-actin) disassembly by the phosphatase Slingshot and myosin II inactivation by myosin light-chain phosphatase and is counteracted by Rok. Accordingly, constitutive activation of myosin or of Rho signaling prevents vertex opening, whereas reduced myosin II or Rok activity causes excessive vertex opening. Thus, the opening of intercellular gaps in the follicular epithelium relies on relaxation of actomyosin contractility rather than active actomyosin-based pulling forces. Conversely, F-actin assembly is required for closing intercellular gaps after patency. Our findings are consistent with a force transduction model in which TCJ integrity is maintained by vertex-anchored contractile actomyosin. We propose that the cell-type-specific organization of actomyosin at cell vertices determines the mode of contractility-dependent regulation of epithelial permeability.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A leaf-mimicking moth uses nanostructures to create 3D leaf shape appearance.","authors":"Jennifer L Kelley, Anna-Lee Jessop, Mahdi K Karahroudi, Gerd E Schröder-Turk, Bodo D Wilts","doi":"10.1016/j.cub.2025.01.029","DOIUrl":"10.1016/j.cub.2025.01.029","url":null,"abstract":"<p><p>Nature provides many astonishing examples of visual deception, from fish that resemble leaves to spiders and butterfly pupae that look like bird droppings or moth larvae that bear a striking resemblance to the head and neck of a tree snake.¹^,² Most types of camouflage rely on preventing object detection, but this strategy of resemblance, known as masquerade, operates by fooling the viewer into misidentifying the animal as an inedible or unprofitable object rather than as predator or prey.³ As masquerade hinders object identification, the masquerader must have coloration that recreates the visual features of the object being mimicked. Here, we report a leaf-mimicking nocturnal moth, Eudocima aurantia (Noctuidae), that mimics not only leaf coloration but also a leaf's surface highlights and appearance. The three-dimensional (3D) leaf-like appearance, which is accentuated by the apparent presence of a 3D midrib, is achieved with a featureless planar wing featuring uniformly oriented scales that combine structural and pigmentary coloration. Remarkably, these specialized nanostructures occur in those regions of the wing surface that correspond to the convex parts of a leaf. These structures and pigments combine scattering, absorption, and additive color mixing to produce a leaf-like brown coloration. E. aurantia has exploited the inherent mirror-like properties of thin-film reflectors to produce directional reflections that are usually associated with highlights on smooth, curved surfaces. Specular reflections provide a strong indicator of surface curvature to visual systems,⁴ suggesting that 3D shape mimicry is an integral part of the visual deception.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive evolution of CENP-T modulates centromere binding.","authors":"Damian Dudka, Alexandra L Nguyen, Katelyn G Boese, Océane Marescal, R Brian Akins, Ben E Black, Iain M Cheeseman, Michael A Lampson","doi":"10.1016/j.cub.2025.01.017","DOIUrl":"10.1016/j.cub.2025.01.017","url":null,"abstract":"<p><p>Centromeric DNA and proteins evolve rapidly despite conserved function in mediating kinetochore-microtubule attachments during cell division. This paradox is explained by selfish DNA sequences preferentially binding centromeric proteins to disrupt attachments and bias their segregation into the egg (drive) during female meiosis. Adaptive centromeric protein evolution is predicted to prevent preferential binding to these sequences and suppress drive. Here, we test this prediction by defining the impact of adaptive evolution of the DNA-binding histone fold domain of CENP-T, a major link between centromeric DNA and microtubules. We reversed adaptive changes by creating chimeric variants of mouse CENP-T with the histone fold domain from closely related species, expressed exogenously in mouse oocytes or in a transgenic mouse model. We show that adaptive evolution of mouse CENP-T reduced centromere binding, which supports robust female gametogenesis. However, this innovation is independent of the centromeric DNA sequence, as shown by comparing the binding of divergent CENP-T variants to distinct centromere satellite arrays in mouse oocytes and in somatic cells from other species. Overall, our findings support a model in which selfish sequences drive to fixation, disrupting attachments of all centromeres to the spindle. DNA sequence-specific innovations are not needed to mitigate fitness costs in this model, so centromeric proteins adapt by modulating their binding to all centromeres in the aftermath of drive.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blow fly larvae socially integrate termite nests through morphological and chemical mimicry.","authors":"Sämi Schär, Gerard Talavera, Leonardo Dapporto, Claudia Bruschini, Vlad Dincă, Cristian Beza-Beza, Brian M Wiegmann, Ahmed Taheri, Thomas Pape, Roger Vila","doi":"10.1016/j.cub.2025.01.007","DOIUrl":"10.1016/j.cub.2025.01.007","url":null,"abstract":"<p><p>Nests of ecosystem-dominant eusocial insects like ants and termites offer stable, nutrient-rich, and protected habitats that may be exploited by other organisms. Several arthropod lineages managed to breach nest defenses and become inquilines, mutualists, predators, parasitoids, or social parasites.¹^,²^,³^,⁴ However, achieving social integration requires extreme morphological, behavioral, and physiological adaptations.⁵ Among flies, only scuttle flies (Phoridae) are well-known social parasites,² although interactions with termites (predation, scavenging, and putative parasitism) have also been mentioned in anecdotal reports for blow flies (Rhiniinae⁶^,⁷^,⁸^,⁹^,¹⁰ and Bengaliinae¹¹^,¹²^,¹³) and flesh flies (Miltogramminae¹⁴^,¹⁵^,¹⁶). Here, we report a fly larva found to be socially integrated within nests of the termite Anacanthotermes ochraceus (Burmeister) in Morocco. Behavioral, chemical, and morphological analyses show that colony integration, including communication and grooming, is achieved through unique adaptations. The chemical profiles of the fly larvae perfectly match those of the termites at the colony level. Notably, the posterior part of the larvae mimics a termite's head, and the long papillae that imitate the termites' antennae surround the entire body. Based on phylogenomics, we show that the larvae belong to the blow fly genus Rhyncomya (Calliphoridae: Rhiniinae). Our results support the hypothesis that the enigmatic blow fly subfamily Prosthetosomatinae (only known from larvae observed in termite nests¹⁷^,¹⁸^,¹⁹^,²⁰) is Rhiniinae. Thus, we demonstrate that the diverse schizophoran flies evolved social integration independently from the 150-million-year-diverged Phoridae radiation. This discovery sheds light on the repeated evolution of termitophily within the order Diptera. VIDEO ABSTRACT.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Play-like behavior exhibited by the vinegar fly Drosophila melanogaster.","authors":"Tilman Triphan, Clara H Ferreira, Wolf Huetteroth","doi":"10.1016/j.cub.2025.01.025","DOIUrl":"10.1016/j.cub.2025.01.025","url":null,"abstract":"<p><p>Anecdotal accounts about animals repeatedly exposing themselves to sources of passive movement by engaging with swings, slides, or carousels are generally assumed to be \"play.\" Criteria for play-like behavior require the activity to be (1) of no immediate relevance for survival; (2) voluntary, intentional, and rewarding; (3) non-ethotypical; (4) repeated, yet unstereotyped; and (5) free from stress.¹^,² Play-like behavior following these rules is pervasive across the vertebrate subphylum²; recent studies in rats even identified and characterized the involved brain regions.³^,⁴ In invertebrates, sparse reports have so far addressed either social play in parasitoid wasps or spiders,⁵^,⁶ object play in bumblebees,⁷ or are anecdotal.¹ Contrary to social play or object play, which are thought to train social interaction or muscle/motor skills, respectively, a convincing hypothesis of the adaptive value of voluntary passive movement play-like behavior is currently lacking in any organism. Like other animals, flies are highly sensitive to the direction of gravitational pull,⁸ hence such intentional passive motion could be sufficient to induce proprioceptive stimulation externally.⁹ Here, we identify voluntary spinning on a carousel as idiosyncratic play-like behavior in the vinegar fly Drosophila melanogaster: while some flies show spontaneous avoidance, others actively seek stimulation, engaging in repeated, prolonged visits to the carousel. We propose that animals voluntarily expose themselves to external forces, thus intentionally receiving exafferent stimulation. This deliberate, yet indirect, proprioceptive stimulation provides an efficient way to improve self-perception via internal model training and shaping multisensory integration. Importantly, this theoretical framework can now be tested empirically in flies. VIDEO ABSTRACT.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population genomics of Marchantia polymorpha subsp. ruderalis reveals evidence of climate adaptation.","authors":"Shuangyang Wu, Katharina Jandrasits, Kelly Swarts, Johannes Roetzer, Svetlana Akimcheva, Masaki Shimamura, Tetsuya Hisanaga, Frédéric Berger, Liam Dolan","doi":"10.1016/j.cub.2025.01.008","DOIUrl":"10.1016/j.cub.2025.01.008","url":null,"abstract":"<p><p>Sexual reproduction results in the development of haploid and diploid cell states during the life cycle. In bryophytes, the dominant multicellular haploid phase produces motile sperm that swim through water to the egg to effect fertilization from which a relatively small diploid phase develops. In angiosperms, the reduced multicellular haploid phase produces non-motile sperm that is delivered to the egg through a pollen tube to effect fertilization from which the dominant diploid phase develops. These different life cycle characteristics are likely to impact the distribution of genetic variation among populations. However, little is known about the distribution of genetic variation among wild populations of bryophytes. To investigate how genetic variation is distributed among populations of a bryophyte and to establish the foundation for population genetics research in bryophytes, we described the genetic diversity of collections of Marchantia polymorpha subsp. ruderalis, a cosmopolitan ruderal liverwort. We identified 78 genetically unique (non-clonal) from a total of 209 sequenced accessions collected from 37 sites in Europe and Japan. There was no detectable population structure among European populations but significant genetic differentiation between Japanese and European populations. By associating genetic variation across the genome with global climate data, we showed that temperature and precipitation influence the frequency of potentially adaptive alleles. This collection establishes the core of an experimental platform that exploits natural genetic variation to answer diverse questions in biology.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate-induced shifts in crocodile body temperature impact behavior and performance.","authors":"Kaitlin E Barham, Céline H Frère, Ross G Dwyer, Cameron J Baker, Hamish A Campbell, Terri R Irwin, Craig E Franklin","doi":"10.1016/j.cub.2025.01.033","DOIUrl":"https://doi.org/10.1016/j.cub.2025.01.033","url":null,"abstract":"<p><p>The increase of energy in the climate system caused by anthropogenic climate change is expected to disrupt predictable weather patterns and result in greater temperature extremes.¹^,² As a result of these climate shifts, El-Niño Southern Oscillation (ENSO), which drives predictable periods of hot/dry and cool/wet across the Pacific, is expected to increase in variability and magnitude.³ These changes will significantly impact ectotherms, whose performance across a range of behaviors is dependent on local environmental temperatures.⁴ As such, we must understand the way individuals experience climate conditions and how changes in their body temperature (T_b), whether through climate or modification of their thermoregulatory mechanisms,⁵ affect their performance. Laboratory studies have shown that estuarine crocodile (Crocodylus porosus) diving and swimming performance is reduced above 32°C-33°C,⁶^,⁷^,⁸ temperatures commonly exceeded across their natural range. By monitoring T_b and diving activity in 203 free-ranging estuarine crocodiles over 15 years, we show that the T_b of crocodiles has increased alongside rising air temperatures since 2008, reflecting the climatic shifts caused by the ENSO cycle. As ambient temperatures rose, crocodiles experienced more days close to critical thermal limits (32°C-33°C), at which temperatures the duration of dives was reduced and the prevalence of active cooling behavior was elevated. This study demonstrates that crocodiles are susceptible to multi-year fluctuations in ambient temperature, which requires them to undertake concomitant changes in behavior. They are already close to their physiological thermal limit, but the impact of future predicted rises in temperature remains unknown.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversification of social complexity following a major evolutionary transition in bees.","authors":"Ohad Peled, Gili Greenbaum, Guy Bloch","doi":"10.1016/j.cub.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.cub.2025.01.009","url":null,"abstract":"<p><p>How social complexity evolved remains a long-standing enigma. In most animal groups, social complexity is typically classified into a few discrete classes. This approach is oversimplified and constrains our inference of social evolution to a narrow trajectory consisting of transitions between classes. Such categorical classifications also limit quantitative studies on the molecular and environmental drivers of social complexity. The recent accumulation of relevant quantitative data has set the stage to overcome these limitations. Here, we propose a data-driven, high-dimensional approach for studying the full diversity of social phenotypes. We curated and analyzed a comprehensive dataset encompassing 17 social traits across 80 species and studied the evolution of social complexity in bees. We found that honey bees, stingless bees, and bumble bees underwent a major evolutionary transition ∼80 mya, inconsistent with the stepwise progression of the social ladder conceptual framework. This major evolutionary transition was followed by a phase of substantial phenotypic diversification of social complexity. Other bee lineages display a continuum of social complexity, ranging from solitary to simple societies, but do not reach the levels of social complexity seen in honey bees, stingless bees, and bumble bees. Bee evolution, therefore, provides a remarkable demonstration of a macroevolutionary process in which a major transition removed biological constraints and opened novel evolutionary opportunities, driving the exploration of the landscape of social phenotypes. Our approach can be extended to incorporate additional data types and readily applied to illuminate the evolution of social complexity in other animal groups.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-exposure to stress reduces loss of community and genetic diversity following severe environmental disturbance.","authors":"Charles C Y Xu, Vincent Fugère, Naíla Barbosa da Costa, Beatrix E Beisner, Graham Bell, Melania E Cristescu, Gregor F Fussmann, Andrew Gonzalez, B Jesse Shapiro, Rowan D H Barrett","doi":"10.1016/j.cub.2025.01.037","DOIUrl":"https://doi.org/10.1016/j.cub.2025.01.037","url":null,"abstract":"<p><p>Environmental stress caused by anthropogenic impacts is increasing worldwide. Understanding the ecological and evolutionary consequences for biodiversity will be crucial for our ability to respond effectively. Historical exposure to environmental stress is expected to select for resistant species, shifting community composition toward more stress-tolerant taxa. Concurrent with this species sorting process, genotypes within resistant taxa that have the highest relative fitness under severe stress are expected to increase in frequency, leading to evolutionary adaptation. However, empirical demonstrations of these dual ecological and evolutionary processes in natural communities are rare. Here, we provide evidence for simultaneous species sorting and evolutionary adaptation across multiple species within a natural freshwater bacterial community. Using a two-phase stressor experimental design (acidification pre-exposure followed by severe acidification) in aquatic mesocosms, we show that pre-exposed communities were more resistant than naive communities to taxonomic loss when faced with severe acid stress. However, after sustained severe acidification, taxonomic richness of both pre-exposed and naive communities eventually converged. All communities experiencing severe acidification became dominated by an acidophilic bacterium, Acidiphilium rubrum, but this species retained greater genetic diversity and followed distinct evolutionary trajectories in pre-exposed relative to naive communities. These patterns were shared across other acidophilic species, providing repeated evidence for the impact of pre-exposure on evolutionary outcomes despite the convergence of community profiles. Our results underscore the need to consider both ecological and evolutionary processes to accurately predict the responses of natural communities to environmental change.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative flavoring behavior in Goffin's cockatoos.","authors":"Jeroen Stephan Zewald, Alice Marie Isabel Auersperg","doi":"10.1016/j.cub.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.cub.2025.01.002","url":null,"abstract":"<p><p>Dunking behavior can be a foraging innovation in non-human animals in which food is dipped in a medium prior to consumption.¹ Five functions of this behavior have previously been suggested (soaking, cleaning, flavoring, drowning, and transporting liquid).²^,³^,⁴^,⁵^,⁶^,⁷^,⁸ Although experimental reports exist,¹^,⁵^,⁹^,¹⁰^,¹¹ most dunking observations are anecdotal,¹² making it hard to infer its function. Previously, we reported innovative dunking behavior in a group of Goffin's cockatoos (Cacatua goffiniana) with the apparent function of soaking dry food.¹³ Here, we report cockatoos dunking in soy yogurt with the likely function of flavoring their food, something thus far only observationally reported in Japanese macaques.³^,¹⁴ In an experimental setup with two types of soy yogurt and water, 9 out of 18 cockatoos dragged food through yogurt, with an overall preference for blueberry-flavored yogurt over neutral yogurt, which could not be explained by color preference alone. Furthermore, the cockatoos showed an overall preference for the combination of yogurt and noodles in a separate food preference task. This combination of quantitative and qualitative results indicates that the cockatoos use yogurt to flavor their food, preferring this combination rather than the yogurt flavor alone. Considering that not all cockatoos dunk their food in yogurt, and little overlap in individuals dunking in a previous study,¹³ this suggests a second food preparation innovation in this species. Our results thus provide experimental evidence of innovative food flavoring behavior outside the primate lineage, which may supplement our present understanding of the emergence of rare forms of food preparation behaviors in animals. VIDEO ABSTRACT.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}