Current Biology最新文献_第10页

Mitochondria mechanosensing: The powerhouse fueling cellular force signaling. 线粒体机械感应：细胞力信号的动力来源。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-07 DOI: 10.1016/j.cub.2025.07.084

Jorge Oliver-De La Cruz, Pere Roca-Cusachs

引用次数: 0

Evolutionary consequences of extreme climate events. 极端气候事件的进化后果。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 DOI: 10.1016/j.cub.2025.07.046

Simon Baeckens, Colin M Donihue

引用次数: 0

A top-down control of stress-induced REM sleep shortening. 压力诱发的快速眼动睡眠缩短的自上而下控制。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-06 DOI: 10.1016/j.cub.2025.07.039

Mathilde Chouvaeff, Alice Descamps, Sophie Bagur, Léo Macé, Karim Benchenane, Thierry Gallopin

{"title":"A top-down control of stress-induced REM sleep shortening.","authors":"Mathilde Chouvaeff, Alice Descamps, Sophie Bagur, Léo Macé, Karim Benchenane, Thierry Gallopin","doi":"10.1016/j.cub.2025.07.039","DOIUrl":"10.1016/j.cub.2025.07.039","url":null,"abstract":"The cerebral structures orchestrating the daily cycles of wake, rapid eye movement (REM), and non-rapid eye movement (NREM) sleep have been identified in remarkable detail. However, the mechanisms by which they dynamically adapt to environmental challenges remain to be fully understood. Here, we show that the prefrontal cortex (PFC), a key hub in stress regulation, modulates sleep architecture through direct projections to the ventrolateral preoptic nucleus (VLPO), a major sleep center. We characterize the detailed sleep architecture in mice after social defeat stress (SDS) and discover, for the first time, a persistent shortening of REM sleep bouts during the light phase, which outlasts the normalization of overall NREM sleep, REM sleep, and wakefulness proportions. This shift, marked by an increase in short REM sleep episodes and a reduction in long ones, is reminiscent of the fragmentation of REM sleep bouts often described in stress-related conditions. Chemogenetic inhibition of PFC to VLPO projections has no effect under baseline conditions but prevents the SDS-induced shortening of REM sleep bouts. Interestingly, optogenetic activation of this pathway is sufficient to shorten REM sleep episodes, despite the absence of the stressor, and promotes rapid transitions into NREM sleep. Finally, using ex vivo optogenetics, we demonstrate that activation of PFC terminals induces monosynaptic currents in VLPO sleep-promoting neurons. Therefore, the PFC-VLPO pathway provides top-down regulation specifically recruited under stress to shorten REM sleep episodes and increase transitions into NREM sleep while preserving total NREM sleep duration.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4151-4164.e4"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

dArc1 controls sugar reward valuation in Drosophila melanogaster. dArc1控制黑腹果蝇的糖奖励评估。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-08 DOI: 10.1016/j.cub.2025.07.048

Sven Bervoets, Miles Solomon Jacob, Anita V Devineni, Brennan Dale Mahoney, Kaelan R Sullivan, Andrew R Butts, Hayeon Sung, Jenifer Einstein, Mark M Metzstein, Monica Dus, Jason D Shepherd, Sophie Jeanne Cécile Caron

{"title":"dArc1 controls sugar reward valuation in Drosophila melanogaster.","authors":"Sven Bervoets, Miles Solomon Jacob, Anita V Devineni, Brennan Dale Mahoney, Kaelan R Sullivan, Andrew R Butts, Hayeon Sung, Jenifer Einstein, Mark M Metzstein, Monica Dus, Jason D Shepherd, Sophie Jeanne Cécile Caron","doi":"10.1016/j.cub.2025.07.048","DOIUrl":"10.1016/j.cub.2025.07.048","url":null,"abstract":"The Arc genes-which include Drosophila Arc1 and Arc2 (dArc)-evolved from Ty3 retrotransposons and encode proteins that form virus-like capsids. These capsids enable a novel form of intercellular communication by transferring RNAs between cells. However, the specific neuronal circuits and brain processes controlled by Arc signaling remain unidentified. Here, we show that loss of both dArc genes in Drosophila melanogaster enhances associative learning in an appetitive conditioning paradigm, where flies associate an odor with sugar rewards. This increased learning performance arises from an increased valuation of sugar rewards: unlike wild-type flies, dArc-/- flies form abnormally strong associations even when the sugar reward is small or has no caloric value. We found that the γ5-dopaminergic neurons of the protocerebral anterior medial (PAM) cluster, which encode the positive valence of sugar rewards, show heightened activity in response to sucrose in dArc-/- flies. We further show that the learning phenotype of dArc-/- flies depends on the formation of capsids, underscoring a direct role for capsid-mediated Arc signaling in sugar valuation. Our findings establish dArc genes as critical regulators of reward valuation in D. melanogaster, acting through a non-cell-autonomous mechanism that relies on capsid-mediated communication between cells.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4188-4198.e7"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cooperative behavior: Superefficient weaver ants. 合作行为：超级高效的织蚁。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 DOI: 10.1016/j.cub.2025.07.076

David L Hu

引用次数: 0

Pollinators: Honey bees shift tolerance to attacks with seasonal decline in flower availability. 传粉者：蜜蜂对攻击的耐受性随着花朵数量的季节性下降而变化。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 DOI: 10.1016/j.cub.2025.07.067

Roger Schürch

引用次数: 0

Symbiosis: A SWEET deal for nodules. 共生：结核的甜蜜交易。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 DOI: 10.1016/j.cub.2025.07.069

Michael Udvardi, Celine Mens

引用次数: 0

The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration. KASH蛋白UNC-83通过调控激酶1活性来控制发育阶段特异性核迁移。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 DOI: 10.1016/j.cub.2025.08.025

Selin Gümüşderelioğlu, Natalie Sahabandu, Daniel Elnatan, Ellen F Gregory, Kyoko Chiba, Shinsuke Niwa, G W Gant Luxton, Richard J McKenney, Daniel A Starr

{"title":"The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration.","authors":"Selin Gümüşderelioğlu, Natalie Sahabandu, Daniel Elnatan, Ellen F Gregory, Kyoko Chiba, Shinsuke Niwa, G W Gant Luxton, Richard J McKenney, Daniel A Starr","doi":"10.1016/j.cub.2025.08.025","DOIUrl":"10.1016/j.cub.2025.08.025","url":null,"abstract":"Nuclear migration plays a fundamental role in development, requiring precise spatiotemporal control of bidirectional movement through dynein and kinesin motors. Here, we uncover a differential isoform-dependent mechanism for developmental regulation of nuclear migration directionality. The nuclear envelope Klarsicht/ANC-1/Syne homology (KASH) protein UNC-83 in Caenorhabditis elegans exists in multiple isoforms that differentially control motor activity to achieve tissue-specific nuclear positioning. The shorter UNC-83c isoform promotes kinesin-1-dependent nuclear movement in embryonic hyp7 precursors, while longer UNC-83a/b isoforms facilitate dynein-mediated nuclear migration in larval P cells. We demonstrate that the UNC-83a-specific N-terminal domain functions as a kinesin-1 inhibitory module by directly binding the kinesin heavy chain (UNC-116). This interaction prevents kinesin-1 activation and reduces the protein's affinity for kinesin light chain (KLC-2), allowing for dynein-mediated transport. By contrast, UNC-83c exhibits high-affinity binding to KLC-2, promoting kinesin-1 activation for plus-end-directed movement. AlphaFold structural predictions reveal that UNC-83 contains five spectrin-like repeats, with two located within the inhibitory N-terminal domain. Genetic analysis demonstrates that these spectrin-like repeats are essential for dynein-dependent P cell nuclear migration but dispensable for kinesin-1-dependent hyp7 migration. This isoform-specific inhibition, combined with differential affinity for KLC-2, establishes a mechanism for achieving directional control of nuclear positioning during development. Together, these interdisciplinary studies reveal how alternative isoforms of cargo adaptors can generate developmental stage-specific regulation of motor activity.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pangenome biology and evolution in harmful algal-bloom-forming pelagophytes. 有害藻华形成的浮游植物泛基因组生物学和进化。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-18 DOI: 10.1016/j.cub.2025.07.055

Shannon J Sibbald, Maggie Lawton, Charlotte Maclean, Andrew J Roger, John M Archibald

{"title":"Pangenome biology and evolution in harmful algal-bloom-forming pelagophytes.","authors":"Shannon J Sibbald, Maggie Lawton, Charlotte Maclean, Andrew J Roger, John M Archibald","doi":"10.1016/j.cub.2025.07.055","DOIUrl":"10.1016/j.cub.2025.07.055","url":null,"abstract":"In prokaryotes, lateral gene transfer (LGT) is a key mechanism leading to intraspecies variability in gene content and the phenomenon of pangenomes. In microbial eukaryotes, however, the extent to which LGT-driven pangenomes exist is unclear. Pelagophytes are ecologically important marine algae that include Aureococcus anophagefferens-a species notorious for causing harmful algal blooms. To investigate genome evolution across Pelagophyceae and within Ac. anophagefferens, we used long-read sequencing to produce high-quality genome assemblies for five strains of Ac. anophagefferens (52-54 megabase pairs [Mbp]), a telomere-to-telomere assembly for Pelagomonas calceolata (32 Mbp), and the first reference genome for Aureoumbra lagunensis (41 Mbp). Using comparative genomics and phylogenetics, we show remarkable strain-level genetic variation in Ac. anophagefferens, with a pangenome (23,356 orthogroups) that is 81.1% core and 18.9% accessory. Although gene content variation within Ac. anophagefferens does not appear to be largely driven by recent prokaryotic LGTs (2.6% of accessory orthogroups), 368 orthogroups were acquired from bacteria in a common ancestor of all analyzed strains and are not found in P. calceolata or Au. lagunensis. A total of 1,077 recent LGTs from prokaryotes and viruses were identified within Pelagophyceae overall, constituting 3.5%-4.0% of the orthogroups in each species. This includes genes likely contributing to the ecological success of pelagophytes globally and in long-lasting harmful blooms.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4215-4228.e6"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An independent coding scheme for idiothetic distance in the hippocampus. 海马体独特距离的独立编码方案。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-13 DOI: 10.1016/j.cub.2025.07.050

Mathilde Nordlund, Nicolas Levernier, Massimiliano Trippa, Romain Bourboulou, Geoffrey Marti, Rémi Monasson, Hervé Rouault, Jérôme Epsztein, Julie Koenig-Gambini

{"title":"An independent coding scheme for idiothetic distance in the hippocampus.","authors":"Mathilde Nordlund, Nicolas Levernier, Massimiliano Trippa, Romain Bourboulou, Geoffrey Marti, Rémi Monasson, Hervé Rouault, Jérôme Epsztein, Julie Koenig-Gambini","doi":"10.1016/j.cub.2025.07.050","DOIUrl":"10.1016/j.cub.2025.07.050","url":null,"abstract":"Self-location and navigation are crucial to daily life, and their disruption is particularly disabling. The hippocampus is central to this process as well as episodic memory. Hippocampal place cells are spatially selective, increasing their activity in specific locations. When external landmarks are scarce, place cells use self-motion (idiothetic) information to track location based on distance traveled (distance coding). Distance coding may be particularly relevant to episodic memory. However, the determinants of distance coding are poorly understood. Here, we used virtual reality, electrophysiological recordings in mice, and local cue manipulations to isolate and characterize hippocampal distance coding. In cue-poor conditions, a global distance coding scheme dominated hippocampal activity with high distance indices in all place cells, including both superficial and deep CA1 pyramidal cells. The mapping of distance onto a low-dimensional manifold and rigid distance relationships between place fields are compatible with attractor dynamics similar to those observed for grid cells. Inactivation of the medial septum (MS), which disrupts grid cells, significantly reduced both distance coding and rigid distance dynamics, suggesting an alteration (but not complete abolition) of the underlying attractor. By contrast, place cell coding was also influenced by local visual cues in cue-rich environments, notably deep CA1 pyramidal cells, and this persisted under MS inactivation. We propose that grid cells and associated rigid attractor dynamics predominantly contribute to hippocampal distance coding.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4199-4214.e8"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0