Current Biology最新文献_第10页

Animal behavior: Chimpanzee play and the evolutionary roots of cooperation. 动物行为：黑猩猩的游戏和合作的进化根源。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 DOI: 10.1016/j.cub.2024.11.061

Kathelijne Koops

引用次数: 0

A recurrent neural circuit in Drosophila temporally sharpens visual inputs. 果蝇的循环神经回路暂时地使视觉输入变得清晰。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2024-12-19 DOI: 10.1016/j.cub.2024.11.064

Michelle M Pang, Feng Chen, Marjorie Xie, Shaul Druckmann, Thomas R Clandinin, Helen H Yang

{"title":"A recurrent neural circuit in Drosophila temporally sharpens visual inputs.","authors":"Michelle M Pang, Feng Chen, Marjorie Xie, Shaul Druckmann, Thomas R Clandinin, Helen H Yang","doi":"10.1016/j.cub.2024.11.064","DOIUrl":"10.1016/j.cub.2024.11.064","url":null,"abstract":"A critical goal of vision is to detect changes in light intensity, even when these changes are blurred by the spatial resolution of the eye and the motion of the animal. Here, we describe a recurrent neural circuit in Drosophila that compensates for blur and thereby selectively enhances the perceived contrast of moving edges. Using in vivo, two-photon voltage imaging, we measured the temporal response properties of L1 and L2, two cell types that receive direct synaptic input from photoreceptors. These neurons have biphasic responses to brief flashes of light, a hallmark of cells that encode changes in stimulus intensity. However, the second phase was often much larger in area than the first, creating an unusual temporal filter. Genetic dissection revealed that recurrent neural circuitry strongly shapes the second phase of the response, informing the structure of a dynamical model. By applying this model to moving natural images, we demonstrate that rather than veridically representing stimulus changes, this temporal processing strategy systematically enhances them, amplifying and sharpening responses. Comparing the measured responses of L2 to model predictions across both artificial and natural stimuli revealed that L2 tunes its properties as the model predicts to temporally sharpen visual inputs. Since this strategy is tunable to behavioral context, generalizable to any time-varying sensory input, and implementable with a common circuit motif, we propose that it could be broadly used to selectively enhance sharp and salient changes.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"333-346.e6"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxytocin-mediated social preference and socially reinforced reward learning in the miniature fish Danionella cerebrum. 催产素介导的社会偏好和社会强化的奖励学习在微型鱼丹尼拉的大脑中。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2024-12-27 DOI: 10.1016/j.cub.2024.11.037

Ariadne Penalva-Tena, Jacob Bedke, Adam Gaudin, Joshua P Barrios, Erin P L Bertram, Adam D Douglass

{"title":"Oxytocin-mediated social preference and socially reinforced reward learning in the miniature fish Danionella cerebrum.","authors":"Ariadne Penalva-Tena, Jacob Bedke, Adam Gaudin, Joshua P Barrios, Erin P L Bertram, Adam D Douglass","doi":"10.1016/j.cub.2024.11.037","DOIUrl":"10.1016/j.cub.2024.11.037","url":null,"abstract":"Integrative studies of diverse neuronal networks that govern social behavior are hindered by a lack of methods to record neural activity comprehensively across the entire brain. The recent development of the miniature fish Danionella cerebrum as a model organism offers one potential solution, as the small size and optical transparency of these animals make it possible to visualize circuit activity throughout the nervous system.1,2,3,4 Here, we establish the feasibility of using Danionella as a model for social behavior and socially reinforced learning by showing that adult fish exhibit strong affiliative tendencies and that social interactions can serve as the reinforcer in an appetitive conditioning paradigm. Fish exhibited an acute ability to identify conspecifics and distinguish them from closely related species, which was mediated by both visual and particularly olfactory cues. These behaviors were abolished by pharmacological and genetic interference with oxytocin signaling, demonstrating the conservation of key neural mechanisms observed in other vertebrates.5,6,7,8,9,10,11 Our work validates Danionella as a tool for understanding the social brain in general and its modulation by neuropeptide signaling in particular.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"363-372.e3"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria mechanosensing: The powerhouse fueling cellular force signaling. 线粒体机械感应：细胞力信号的动力来源。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 DOI: 10.1016/j.cub.2024.12.006

Jorge Oliver-De La Cruz, Pere Roca-Cusachs

引用次数: 0

Social behavior: A tiny fish with prodigious skills. 社会行为：一条有着惊人技能的小鱼。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 DOI: 10.1016/j.cub.2024.12.009

Florian Engert

引用次数: 0

Associative learning of non-nestmate cues improves enemy recognition in ants. 非筑巢线索的联想学习提高了蚂蚁对敌人的识别能力。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2024-12-31 DOI: 10.1016/j.cub.2024.11.054

Mélanie Bey, Rebecca Endermann, Christina Raudies, Jonas Steinle, Volker Nehring

{"title":"Associative learning of non-nestmate cues improves enemy recognition in ants.","authors":"Mélanie Bey, Rebecca Endermann, Christina Raudies, Jonas Steinle, Volker Nehring","doi":"10.1016/j.cub.2024.11.054","DOIUrl":"10.1016/j.cub.2024.11.054","url":null,"abstract":"Recognition protects biological systems at all scales, from cells to societies. Social insects recognize their nestmates by colony-specific olfactory labels that individuals store as neural templates in their memory. Throughout an ant's life, learning continuously shapes the nestmate recognition template to keep up with the constant changes in colony labels.1,2,3,4 Most explanations for template update rely on non-associative learning.5 Indeed, we know that ants become habituated to their colony's label: their reaction to the omnipresent chemical cues typical of their own nest fades.3,6,7,8 However, non-associative habituation cannot explain the enormous variation in nestmate recognition behavior. For example, some ant species are more aggressive toward neighboring colonies than toward unfamiliar colonies (nasty neighbor effect9,10,11,12). Social insects can learn associatively, for example, by associating an odor cue with a food reward.13 A recent model proposes that associative learning of non-nestmate odors leads to variation in the recognition templates among individuals, which then improves recognition at the group level.14 Here, we test whether associative learning of non-nestmate colony odors is possible.11 Our results show that associative learning plays a crucial role in the formation of both nestmate and non-nestmate recognition templates and that the aggression received by an ant acts as an unconditioned stimulus that the ant likely associates with the odor label of its enemy. This type of template learning can help explain different patterns of variation in nestmate recognition, from nasty neighbor effects to task- and age-specific variation in aggression.15,16.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"407-412.e3"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probabilistically constrained vector summation of motion direction in the mouse superior colliculus.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-16 DOI: 10.1016/j.cub.2024.12.029

Chuiwen Li, Victor J DePiero, Hui Chen, Seiji Tanabe, Jianhua Cang

{"title":"Probabilistically constrained vector summation of motion direction in the mouse superior colliculus.","authors":"Chuiwen Li, Victor J DePiero, Hui Chen, Seiji Tanabe, Jianhua Cang","doi":"10.1016/j.cub.2024.12.029","DOIUrl":"https://doi.org/10.1016/j.cub.2024.12.029","url":null,"abstract":"Visual motion is a crucial cue for the brain to track objects and take appropriate actions, enabling effective interactions with the environment. Here, we study how the superior colliculus (SC) integrates motion information using asymmetric plaids composed of drifting gratings of different directions and speeds. With both in vivo electrophysiology and two-photon calcium imaging, we find that mouse SC neurons integrate motion direction by performing vector summation of the component gratings. The computation is constrained probabilistically by the possible physical motions consistent with each grating. Excitatory and inhibitory SC neurons respond similarly to the plaid stimuli. Finally, the probabilistically constrained vector summation also guides optokinetic eye movements. Such a computation is fundamentally different from that in the visual cortex, where motion integration follows the intersection of the constraints. Our studies thus demonstrate a novel neural computation in motion processing and raise intriguing questions regarding its neuronal implementation and functional significance.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-16 DOI: 10.1016/j.cub.2024.12.031

Kurt M Fraser, Val Collins, Amy R Wolff, David J Ottenheimer, Kaisa N Bornhoft, Fiona Pat, Bridget J Chen, Patricia H Janak, Benjamin T Saunders

{"title":"Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system.","authors":"Kurt M Fraser, Val Collins, Amy R Wolff, David J Ottenheimer, Kaisa N Bornhoft, Fiona Pat, Bridget J Chen, Patricia H Janak, Benjamin T Saunders","doi":"10.1016/j.cub.2024.12.031","DOIUrl":"10.1016/j.cub.2024.12.031","url":null,"abstract":"Adaptive behavior in a dynamic environmental context often requires rapid revaluation of stimuli that deviates from well-learned associations. The divergence between stable value-encoding and appropriate behavioral output remains a critical component of theories of dopamine's function in learning, motivation, and motor control. Yet, how dopamine neurons are involved in the revaluation of cues when the world changes, to alter our behavior, remains unclear. Here, we make use of a complementary set of in vivo approaches to clarify the contributions of the mesolimbic dopamine system to the dynamic reorganization of reward- seeking behavior. Male and female rats were trained to discriminate when a conditioned stimulus would be followed by a sucrose reward by exploiting the prior, non-overlapping presentation of a another discrete cue-an occasion setter. Only when the occasion setter's presentation preceded the conditioned stimulus did the conditioned stimulus predict sucrose delivery, dissociating the average value of the conditioned stimulus from its immediate value, on a trial-to-trial basis. Activity of ventral tegmental area dopamine neurons was essential for rats to successfully update behavioral response to the occasion setter. Moreover, dopamine release in the nucleus accumbens following the conditioned stimulus only occurred when the occasion setter indicated it would predict reward and did not reflect its average expected value. Downstream of dopamine release, we found that neurons in the nucleus accumbens dynamically tracked the value of the conditioned stimulus. Together, these results help refine notions of dopamine function, revealing a prominent contribution of the mesolimbic dopamine system to the rapid revaluation of motivation.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apparent timescaling of fossil diversification rates is caused by sampling bias.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-15 DOI: 10.1016/j.cub.2024.12.038

Bouwe R Reijenga, Roger A Close

{"title":"Apparent timescaling of fossil diversification rates is caused by sampling bias.","authors":"Bouwe R Reijenga, Roger A Close","doi":"10.1016/j.cub.2024.12.038","DOIUrl":"https://doi.org/10.1016/j.cub.2024.12.038","url":null,"abstract":"Negative scaling relationships between both speciation and extinction rates, on the one hand, and the age or duration of organismal groups on the other, are pervasive and recovered in both molecular phylogenetic and fossil time series.1,2,3,4 The agreement between molecular and fossil data hints at a universal cause and potentially at incongruence between micro- and macroevolution. However, the existence of negative rate scaling in fossil time series has not undergone the same level of scrutiny as in molecular data. Here, we analyze the marine animal fossil record across the last ∼538.8 Ma of the Phanerozoic to investigate the presence and strength of negative rate scaling. We find that negative rate scaling arises under commonly applied age range-based per capita rates, which do not control for sampling bias, but are severely reduced or absent when metrics are used that do correct for sampling. We further show by simulation that even moderately incomplete sampling of species occurrences through time may induce rate scaling. We thus conclude that there are no significant scaling relationships present in these fossil clades and that any apparent trend is caused by sampling artefacts and taxonomic practices. If rate scaling in molecular phylogenies is genuine, the absence of such a relationship in the fossil record will provide a valuable benchmark and constraint on what processes can cause it.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRMP/UNC-33 maintains neuronal microtubule arrays by promoting individual microtubule rescue.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-11 DOI: 10.1016/j.cub.2024.12.030

Xing Liang, Regina Agulto, Kelsie Eichel, Caitlin Ann Taylor, Victor Alexander Paat, Huichao Deng, Kassandra Ori-McKenney, Kang Shen

{"title":"CRMP/UNC-33 maintains neuronal microtubule arrays by promoting individual microtubule rescue.","authors":"Xing Liang, Regina Agulto, Kelsie Eichel, Caitlin Ann Taylor, Victor Alexander Paat, Huichao Deng, Kassandra Ori-McKenney, Kang Shen","doi":"10.1016/j.cub.2024.12.030","DOIUrl":"10.1016/j.cub.2024.12.030","url":null,"abstract":"Microtubules (MTs) are intrinsically dynamic polymers. In neurons, staggered individual microtubules form stable, polarized acentrosomal MT arrays spanning the axon and dendrite to support long-distance intracellular transport. How the stability and polarity of these arrays are maintained when individual MTs remain highly dynamic is still an open question. Here, we visualize MT arrays in vivo in C. elegans neurons with single MT resolution. We find that the CRMP family homolog UNC-33 is essential for the stability and polarity of MT arrays in neurites. In unc-33 mutants, MTs exhibit dramatically reduced rescue after catastrophe, develop gaps in coverage, and lose their polarity, leading to trafficking defects. UNC-33 is stably anchored on the cortical cytoskeleton and forms patch-like structures along the dendritic shaft. These discrete and stable UNC-33 patches concentrate free tubulins and correlate with MT rescue sites. In vitro, purified UNC-33 preferentially associates with MT tips and increases MT rescue frequency. Together, we propose that UNC-33 functions as a microtubule-associated protein (MAP) to promote individual MT rescue locally. Through this activity, UNC-33 prevents the loss of individual MTs, thereby maintaining the coverage and polarity of MT arrays throughout the lifetime of neurons.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0