Current Biology最新文献_第9页

Intrinsic timing of brood care in shell-dwelling cichlids. 壳栖慈鲷育雏的内在时序。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 Epub Date: 2025-01-15 DOI: 10.1016/j.cub.2024.12.020

Ash V Parker, Manuel Stemmer, Swantje Grätsch, Alessandro Dorigo, Oriolson Rodriguez Ramirez, Abdelrahman Adel, Alex Jordan, Herwig Baier

{"title":"Intrinsic timing of brood care in shell-dwelling cichlids.","authors":"Ash V Parker, Manuel Stemmer, Swantje Grätsch, Alessandro Dorigo, Oriolson Rodriguez Ramirez, Abdelrahman Adel, Alex Jordan, Herwig Baier","doi":"10.1016/j.cub.2024.12.020","DOIUrl":"10.1016/j.cub.2024.12.020","url":null,"abstract":"Brood care relies on interactions between parents and offspring. Emergence of nestlings from their nest has been hypothesized to rely on the readout by the parent of the maturational state of the young. Theoretical considerations predict a conflict: parents should push for early emergence, if possible, to reduce care demands and maximize the number of reproductive cycles, whereas offspring should delay leaving to maximize resource allocation and protection by the parents. We tested this prediction in Lamprologus ocellatus, a shell-dwelling cichlid from Lake Tanganyika. We developed a laboratory paradigm to investigate the factors influencing emergence from the shell and found that mothers ensure their young stay inside the nest until 9 days after egg laying. Emergence coincides with an inversion of larval phototactic tendency from dark-seeking to light-seeking behavior on day 9. When we experimentally created a timing conflict by introducing older larvae to a foster mother, the mother resisted the (subjectively) premature emergence of her adopted fry. Removing the mother did not alter the larval intrinsic schedule, provided fresh water was supplied inside the shell. These findings suggest that, in L. ocellatus brood care, maternal and offspring behavior is normally synchronized by independent timing mechanisms. Our findings highlight the intricate coordination of parental and offspring behavior, offering insights into the evolutionary pressures shaping brood care in cichlids and challenging the traditional view of parent-offspring conflict over emergence timing.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"672-680.e4"},"PeriodicalIF":8.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laura Eme.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 DOI: 10.1016/j.cub.2024.12.057

Laura Eme

引用次数: 0

Balancing limited resources in actin network competition. 动态网络竞争中有限资源的平衡。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 Epub Date: 2025-01-09 DOI: 10.1016/j.cub.2024.11.067

Christophe Guérin, Anne-Betty N'Diaye, Laurène Gressin, Alex Mogilner, Manuel Théry, Laurent Blanchoin, Alexandra Colin

{"title":"Balancing limited resources in actin network competition.","authors":"Christophe Guérin, Anne-Betty N'Diaye, Laurène Gressin, Alex Mogilner, Manuel Théry, Laurent Blanchoin, Alexandra Colin","doi":"10.1016/j.cub.2024.11.067","DOIUrl":"10.1016/j.cub.2024.11.067","url":null,"abstract":"In cells, multiple actin networks coexist in a dynamic manner. These networks compete for a common pool of actin monomers and actin-binding proteins. Interestingly, all of these networks manage to coexist despite the strong competition for resources. Moreover, the coexistence of networks with various strengths is key to cell adaptation to external changes. However, a comprehensive view of how these networks coexist in this competitive environment, where resources are limited, is still lacking. To address this question, we used a reconstituted system, in closed microwells, consisting of beads propelled by actin polymerization or micropatterns functionalized with lipids capable of initiating polymerization close to a membrane. This system enabled us to build dynamic actin architectures, competing for a limited pool of proteins, over a period of hours. We demonstrated the importance of protein turnover for the coexistence of actin networks, showing that it ensures resource distribution between weak and strong networks. However, when competition becomes too intense, turnover alone is insufficient, leading to a selection process that favors the strongest networks. Consequently, we emphasize the importance of competition strength, which is defined by the turnover rate, the amount of available protein, and the number of competing structures. More generally, this work illustrates how turnover allows biological populations with various competition strengths to coexist despite resource constraints.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"500-513.e5"},"PeriodicalIF":8.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple plastid losses within photosynthetic stramenopiles revealed by comprehensive phylogenomics. 综合系统基因组学揭示的光合叠层中多个质体损失。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 Epub Date: 2025-01-09 DOI: 10.1016/j.cub.2024.11.065

Kristina X Terpis, Eric D Salomaki, Dovilė Barcytė, Tomáš Pánek, Heroen Verbruggen, Martin Kolisko, J Craig Bailey, Marek Eliáš, Christopher E Lane

{"title":"Multiple plastid losses within photosynthetic stramenopiles revealed by comprehensive phylogenomics.","authors":"Kristina X Terpis, Eric D Salomaki, Dovilė Barcytė, Tomáš Pánek, Heroen Verbruggen, Martin Kolisko, J Craig Bailey, Marek Eliáš, Christopher E Lane","doi":"10.1016/j.cub.2024.11.065","DOIUrl":"10.1016/j.cub.2024.11.065","url":null,"abstract":"Ochrophyta is a vast and morphologically diverse group of algae with complex plastids, including familiar taxa with fundamental ecological importance (diatoms or kelp) and a wealth of lesser-known and obscure organisms. The sheer diversity of ochrophytes poses a challenge for reconstructing their phylogeny, with major gaps in sampling and an unsettled placement of particular taxa yet to be tackled. We sequenced transcriptomes from 25 strategically selected representatives and used these data to build the most taxonomically comprehensive ochrophyte-centered phylogenomic supermatrix to date. We employed a combination of approaches to reconstruct and critically evaluate the relationships among ochrophytes. While generally congruent with previous analyses, the updated ochrophyte phylogenomic tree resolved the position of several taxa with previously uncertain placement and supported a redefinition of the classes Picophagea and Synchromophyceae. Our results indicated that the heterotrophic, plastid-lacking heliozoan Actinophrys sol is not a sister lineage of ochrophytes, as proposed recently, but rather phylogenetically nested among them, implying that it lacks a plastid due to loss. In addition, we found the heterotrophic ochrophyte Picophagus flagellatus to lack all hallmark plastid genes yet to exhibit mitochondrial proteins that seem to be genetic footprints of a lost plastid organelle. We thus document, for the first time, plastid loss in two separate ochrophyte lineages. Furthermore, by exploring eDNA data, we enrich the ochrophyte phylogenetic tree by identifying five novel uncultured class-level lineages. Altogether, our study provides a new framework for reconstructing trait evolution in ochrophytes and demonstrates that plastid loss is more common than previously thought.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"483-499.e8"},"PeriodicalIF":8.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos. 细胞周期振荡器和纺锤体长度决定果蝇胚胎染色体分离的速度。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 Epub Date: 2025-01-09 DOI: 10.1016/j.cub.2024.11.046

Yitong Xu, Anna Chao, Melissa Rinaldin, Alison Kickuth, Jan Brugués, Stefano Di Talia

{"title":"The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos.","authors":"Yitong Xu, Anna Chao, Melissa Rinaldin, Alison Kickuth, Jan Brugués, Stefano Di Talia","doi":"10.1016/j.cub.2024.11.046","DOIUrl":"10.1016/j.cub.2024.11.046","url":null,"abstract":"Anaphase is tightly controlled spatiotemporally to ensure proper separation of chromosomes.1,2,3 The mitotic spindle, the self-organized microtubule structure driving chromosome segregation, scales in size with the available cytoplasm.4,5,6,7 Yet, the relationship between spindle size and chromosome movement remains poorly understood. Here, we address this relationship during the cleavage divisions of the Drosophila blastoderm. We show that the speed of chromosome separation gradually decreases during the four nuclear divisions of the blastoderm. This reduction in speed is accompanied by a similar reduction in spindle length, ensuring that these two quantities are tightly linked. Using a combination of genetic and quantitative imaging approaches, we find that two processes contribute to controlling the speed at which chromosomes move in anaphase: the activity of molecular motors important for microtubule depolymerization and sliding and the cell cycle oscillator. Specifically, we found that the levels of multiple kinesin-like proteins important for microtubule depolymerization, as well as kinesin-5, contribute to setting the speed of chromosome separation. This observation is further supported by the scaling of poleward flux rate with the length of the spindle. Perturbations of the cell cycle oscillator using heterozygous mutants of mitotic kinases and phosphatases revealed that the duration of anaphase increases during the blastoderm cycles and is the major regulator of chromosome velocity. Thus, our work suggests a link between the biochemical rate of mitotic exit and the forces exerted by the spindle. Collectively, we propose that the cell cycle oscillator and spindle length set the speed of chromosome separation in anaphase.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"655-664.e3"},"PeriodicalIF":8.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of future input explains lateral connectivity in primary visual cortex. 对未来输入的预测解释了初级视觉皮层的侧连通性。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 Epub Date: 2025-01-10 DOI: 10.1016/j.cub.2024.11.073

Sebastian Klavinskis-Whiting, Emil Fristed, Yosef Singer, M Florencia Iacaruso, Andrew J King, Nicol S Harper

引用次数: 0

Long-term human influence on the demography and genetic diversity of the hyperdominant Bertholletia excelsa in the Amazon Basin.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 Epub Date: 2025-01-24 DOI: 10.1016/j.cub.2024.12.023

Hua Wang, Victor Caetano-Andrade, Nicole Boivin, Charles R Clement, Wellyngton Espindola Ayala, Ramiro Dario Melinski, Francislaide da Silva Costa, Detlef Weigel, Patrick Roberts

{"title":"Long-term human influence on the demography and genetic diversity of the hyperdominant Bertholletia excelsa in the Amazon Basin.","authors":"Hua Wang, Victor Caetano-Andrade, Nicole Boivin, Charles R Clement, Wellyngton Espindola Ayala, Ramiro Dario Melinski, Francislaide da Silva Costa, Detlef Weigel, Patrick Roberts","doi":"10.1016/j.cub.2024.12.023","DOIUrl":"10.1016/j.cub.2024.12.023","url":null,"abstract":"The Amazon rainforest is characterized by a limited number of hyperdominant trees that play an oversized role in its ecosystems, nutrient cycle, and rainfall production. Some of these, such as the Brazil nut, appear to have been intensively exploited and dispersed by Indigenous populations since their earliest arrival in this part of South America around 13,000 years ago. However, the genetic diversity-and geographic structure-of these species remains poorly understood, as does their exact relationship with past human land use. We use a new genome assembly for Brazil nut to analyze 270 individuals sampled at areas with varying intensities of archaeological evidence. We demonstrate that overall low genetic diversity, with a notable decrease since the Late Pleistocene, is accompanied by significant geographic structure, where evidence for improved gene flow and regeneration by long-term traditional human management is linked to increased genetic diversity. We argue that historical perspectives on the genetic diversity of key tree species, such as the Brazil nut, can support the development of more active management strategies today.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"629-639.e4"},"PeriodicalIF":8.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential recruitment of F-BAR proteins controls cytoskeletal crosstalk at the yeast bud neck. F-BAR蛋白的连续募集控制着酵母芽颈部的细胞骨架串扰。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 Epub Date: 2025-01-10 DOI: 10.1016/j.cub.2024.12.011

Joseph O Magliozzi, Lucas A Runyan, Priyanka Dutta, Gregory J Hoeprich, Bruce L Goode

{"title":"Sequential recruitment of F-BAR proteins controls cytoskeletal crosstalk at the yeast bud neck.","authors":"Joseph O Magliozzi, Lucas A Runyan, Priyanka Dutta, Gregory J Hoeprich, Bruce L Goode","doi":"10.1016/j.cub.2024.12.011","DOIUrl":"10.1016/j.cub.2024.12.011","url":null,"abstract":"In vivo functions of the septin and actin cytoskeletons are closely intertwined, yet the mechanisms underlying septin-actin crosstalk have remained poorly understood. Here, we show that the yeast-bud-neck-associated Fes/CIP4 homology Bar-amphiphysin-Rvs (F-BAR) protein suppressor of yeast profilin 1 (Syp1)/FCHo uses its intrinsically disordered region (IDR) to directly bind and bundle filamentous actin (F-actin) and to physically link septins and F-actin. Interestingly, the only other F-BAR protein found at the neck during bud development, Hof1, has related activities and also potently inhibits the bud-neck-associated formin Bnr1. However, we find that Syp1 enhances rather than inhibits Bnr1-mediated actin assembly and fully overcomes Hof1-mediated inhibition of Bnr1. Further, during bud development, Syp1 and Hof1 show reciprocal patterns of arrival and departure from the bud neck, and in vitro Syp1 and Hof1 compete for septin binding. Together, our observations suggest that as the bud grows, the relative levels of these two F-BAR proteins at the bud neck invert, driving changes in septin organization, septin-actin linkage, and formin activity. More broadly, our findings expand the functional roles of Syp1/FCHo family proteins and our understanding of the working relationships among F-BAR proteins in cytoskeletal regulation.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"574-590.e10"},"PeriodicalIF":8.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosome segregation: Scaling speed with time and space.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 DOI: 10.1016/j.cub.2024.11.072

Akihiro Tanaka, Yuta Shimamoto

引用次数: 0

The mycomembrane.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-02-03 DOI: 10.1016/j.cub.2024.11.002

Elizabeth M Hart, Thomas G Bernhardt

引用次数: 0