Current Biology最新文献

{"title":"Bats resolve conflicting sensory information for individual recognition.","authors":"Mirjam Knörnschild, Martina Nagy, Danilo Russo","doi":"10.1016/j.cub.2025.02.060","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.060","url":null,"abstract":"<p><p>Recognizing conspecifics individually is paramount in shaping animal societies,¹^,²^,³^,⁴^,⁵^,⁶^,⁷^,⁸ and vocal signals can play an important role in this process.⁹^,¹⁰^,¹¹^,¹² Humans¹³ and some other species¹⁴^,¹⁵^,¹⁶^,¹⁷^,¹⁸ identify individuals by integrating information from different sensory modalities. This ability can facilitate stable relationships, kin recognition, and cooperative interactions.⁵^,⁶^,⁷^,⁸ Studies of individual recognition in wild animals remain rare.¹⁹^,²⁰^,²¹ Here, we present experimental evidence that wild greater sac-winged bats, Saccopteryx bilineata, a species with stable social groups, high roost fidelity, and a preference for well-lit day-roosts,²²^,²³ recognize individual group members. In many species,²⁴^,²⁵^,²⁶^,²⁷^,²⁸^,²⁹ including bats,³⁰^,³¹^,³²^,³³^,³⁴ individuals produce distress calls when physically constrained by a predator. We show that distress calls of S. bilineata encode individual signatures. Further, we conducted playback experiments at the day-roosts to test for individual recognition. We used a violation-of-expectation paradigm in which the subject is presented with information for individual identification aligning or conflicting with one another.¹⁷ When individual recognition occurs, the subject may show heightened attention to conflicting information¹⁷^,¹⁹^,²¹ or the plausible association.¹⁸^,³⁵^,³⁶ Remarkably, roosting bats only approached the source of a distress call under plausible conditions-when the supposed caller was absent from the roost. When confronted with an impossibility-the supposed caller was in the roost and its voice simultaneously came from elsewhere-bats ignored the playback entirely. This striking ability to detect and reject such inconsistencies reveals a high level of cognitive sophistication, as these bats reconcile what they see or smell with what they hear to assess the reality of a situation.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly accurate Batesian mimicry of wasps dates back to the Early Oligocene and was driven by non-passerine birds.","authors":"Klára Daňková, Jiří Hadrava, Jakub Straka, Michael Mikát, Alice Exnerová, Pavel Hulva, Valentin Nidergas, Martina Pecharová, André Nel, Jakub Prokop","doi":"10.1016/j.cub.2025.02.069","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.069","url":null,"abstract":"<p><p>Batesian mimicry is a widespread strategy that reduces the risk of predation of a harmless mimic by imitating a harmful model.¹ Batesian mimics often vary greatly in how accurately they resemble their models.² However, disentangling the causes of evolutionary changes in mimetic accuracy, or lack of them, is challenging. The fossil record provides a powerful tool, although it is constrained by the quality of preservation. In particular, fossil records of accurate mimics are exceptionally rare. Here, we describe the first evidence of highly accurate wasp mimicry, in a fossil belonging to diverse group of Batesian mimics: hoverflies (Diptera, Syrphidae). The hoverfly Spilomyia kvaceki sp. nov., from the Early Oligocene (33 mya) deposits in Děčín-Bechlejovice, Czech Republic, exhibits well-preserved color pattern that closely resembles extant wasp mimics. Whether modern wasp genera could have served as its model remains uncertain. However, there is an abundant fossil record of stem-group social wasps (Palaeovespa spp.)³^,⁴^,⁵^,⁶^,⁷ that we propose as suitable models. Notably, two Palaeovespa specimens were found in the same locality as S. kvaceki,⁸ supporting their co-occurrence. Currently, passerine birds (Passeriformes) are considered the main selecting agent of mimicry of wasps.⁹ However, passerines were rare in Europe during the Early Oligocene.¹⁰ Thus, the agents selecting the earliest known highly accurate mimics of wasps were most likely non-passerines of Coraciimorphae and Apodiformes clades.¹⁰^,¹¹^,¹²^,¹³ In conclusion, the highly accurate mimicry of wasps originated during or at least persisted through the era of non-passerine dominance in the guild of diurnal flying insectivorous predators in the Northern Hemisphere.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice.","authors":"Mathilde C C Guillaumin, Christian D Harding, Lukas B Krone, Tomoko Yamagata, Martin C Kahn, Cristina Blanco-Duque, Gareth T Banks, Peter Achermann, Cecilia Diniz Behn, Patrick M Nolan, Stuart N Peirson, Vladyslav V Vyazovskiy","doi":"10.1016/j.cub.2025.02.053","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.053","url":null,"abstract":"<p><p>Growing evidence suggests that brain activity during sleep, as well as sleep regulation, are tightly linked with synaptic function and network excitability at the local and global levels. We previously reported that a mutation in synaptobrevin 2 (Vamp2) in restless (rlss) mice results in a marked increase of wakefulness and suppression of sleep, in particular REM sleep (REMS), as well as increased consolidation of sleep and wakefulness. In this study, using finer-scale in vivo electrophysiology recordings, we report that spontaneous cortical activity in rlss mice during NREM sleep (NREMS) is characterized by an occurrence of abnormally prolonged periods of complete neuronal silence (OFF-periods), often lasting several seconds, similar to the burst suppression pattern typically seen under deep anesthesia. Increased incidence of prolonged network OFF-periods was not specific to NREMS but also present in REMS and wake in rlss mice. Slow-wave activity (SWA) was generally increased in rlss mice relative to controls, while higher frequencies, including theta-frequency activity, were decreased, further resulting in diminished differences between vigilance states. The relative increase in SWA after sleep deprivation was attenuated in rlss mice, suggesting either that rlss mice experience persistently elevated sleep pressure or, alternatively, that the intrusion of sleep-like patterns of activity into the wake state attenuates the accumulation of sleep drive. We propose that a deficit in global synaptic neurotransmitter release leads to \"state inertia,\" reflected in an abnormal propensity of brain networks to enter and remain in a persistent \"default state\" resembling coma or deep anesthesia.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burrowing facilitated the survival of mammals in harsh and fluctuating climates.","authors":"Stefan Pinkert, Victoria Reuber, Lena-Marie Krug, Lea Heidrich, Finn Rehling, Roland Brandl, Nina Farwig","doi":"10.1016/j.cub.2025.02.064","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.064","url":null,"abstract":"<p><p>Species' ability to cope with climatic instability varies greatly, influenced by factors such as dispersal, physiological adaptations, and phylogenetic conservatism. Here, we investigate how burrowing behavior, a key component of species' endurance strategies and ecosystem functioning, shaped the contemporary patterns of species richness and range size as well as the diversification of mammalian lineages. Analyzing 4,407 terrestrial mammal species, excluding bats, combined with novel trait data on 3,096 species, we reveal contrasting responses to climatic factors between burrowing and non-burrowing species. Burrowing lineages are disproportionately species-rich at lower temperatures and productivity. Both range size and species richness steeply increase with climate seasonality in burrowing species as opposed to non-burrowing species. The proportion of burrowing species increases with latitude, with regions above 20°, especially those exhibiting greater Pleistocene temperature changes, being almost exclusively composed of burrowing species. Trait conservatism, higher net diversification rates, and Eocene peak diversification provide the evolutionary context for these contemporary patterns, underscoring the role of burrowing for mammalian radiations into temperate climates. Moreover, the lower extinction rate of burrowing species and peak diversification at the Cretaceous-Paleogene (K-Pg) boundary support the longstanding hypothesis that burrowing behavior promoted survival during the \"impact winter\" that marks the replacement of non-avian dinosaurs by mammals. Our study highlights the potential of readily available trait information for understanding the ecological and evolutionary processes that shape species distributions through space and time. The careful integration of divergent environmental constraints bears vast improvements for forecasts of species' responses to climatic changes and global models of biodiversity patterns.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The activation of INF2 by Piezo1/Ca²⁺ is required for mesenchymal-to-amoeboid transition in confined environments.","authors":"Neelakshi Kar, Alexa P Caruso, Nicos Prokopiou, Alleah Abrenica, Jeremy S Logue","doi":"10.1016/j.cub.2025.02.066","DOIUrl":"10.1016/j.cub.2025.02.066","url":null,"abstract":"<p><p>To invade tissues, cells may undergo a mesenchymal-to-amoeboid transition (MAT). However, the mechanisms regulating this transition are poorly defined. In melanoma cells, we demonstrate that intracellular [Ca²⁺] increases with the degree of confinement in a Piezo1-dependent fashion. Moreover, Piezo1/Ca²⁺ is found to drive amoeboid and not mesenchymal migration in confined environments. Consistent with a model in which Piezo1 senses tension at the plasma membrane, the percentage of cells using amoeboid migration is further increased in undulating microchannels. Surprisingly, amoeboid migration was not promoted by myosin light-chain kinase (MLCK), which is sensitive to intracellular [Ca²⁺]. Instead, we report that Piezo1/Ca²⁺ activates inverted formin-2 (INF2) to induce widespread actin cytoskeletal remodeling. Strikingly, the activation of INF2 promotes de-adhesion, which in turn facilitates migration across micropatterned surfaces. Thus, we reveal a novel Piezo1/Ca²⁺/INF2 signaling cascade that regulates MAT, enabling cancer cells to adapt their migration mode in response to varying mechanochemical environments.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevational constraints on flight efficiency shape global gradients in avian wing morphology.","authors":"Jingyi Yang, Chenyue Yang, Hung-Wei Lin, Alexander C Lees, Joseph A Tobias","doi":"10.1016/j.cub.2025.02.068","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.068","url":null,"abstract":"<p><p>Wings with an elongated shape or larger surface area are associated with increased flight efficiency in a wide range of animals from insects to birds.¹^,²^,³^,⁴ Inter- and intra-specific variation in these attributes of wing shape is determined by a range of factors-including foraging ecology, migration, and climatic seasonality⁵^,⁶^,⁷^,⁸-all of which may drive latitudinal gradients in wing morphology.⁹^,¹⁰ A separate hypothesis predicts that wing shape should also follow an elevational gradient⁵^,¹¹ because air density declines with altitude,¹² altering the aerodynamics of flight and driving the evolution of more efficient wings in high-elevation species to compensate for reduced lift.¹³^,¹⁴^,¹⁵ Although previous analyses have shown a tendency for longer or larger wings at higher elevations, at least locally,¹⁶^,¹⁷^,¹⁸^,¹⁹^,²⁰ it is difficult to rule out a range of alternative explanations since we currently lack a global synthesis of elevational gradients in wing shape for any taxonomic group. In this study, we use phylogenetic models to explore elevational effects on metrics of wing morphology linked to aerodynamic function in 9,982 bird species while simultaneously controlling for multiple climatic factors and ecological attributes of species. We found that relative wing elongation (hand-wing index) and wing area increase with elevation, even when accounting for latitude, temperature seasonality, body mass, habitat, aerial lifestyle, and altitudinal migration. These results confirm a pervasive elevational gradient in avian wing morphology and suggest that aerodynamic constraints linked to air density, perhaps coupled with oxygen deficiency, contribute to global patterns of trait evolution in flying animals.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of pre-dawn arousal in Drosophila by a pair of trissinergic descending neurons of the visual and circadian networks.","authors":"Ruihan Jiang, Yue Tian, Xin Yuan, Fang Guo","doi":"10.1016/j.cub.2025.02.056","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.056","url":null,"abstract":"<p><p>Circadian neurons form a complex neural network that generates circadian oscillations. How the circadian neural network transmits circadian signals to other brain regions, thereby regulating the activity patterns in fruit flies, is not well known. Using the FlyWire database, we identified a cluster of descending neurons, DNp27, which is densely connected with key circadian neurons and the visual circuit, projecting extensively across the brain. DNp27 receives excitatory inputs from the circadian neurons DN3s at night and photo-inhibitory signals predominantly during the day, resulting in calcium oscillations that peak in the early morning and dip at dusk. Experimental manipulation of DNp27 revealed its role in activity regulation: artificial activation of DNp27 decreased flies' activity, while ablation or silencing led to an advance in the morning anticipatory peak. Similar alterations in the morning peak were observed following pan-neuronal knockdown of either Trissin or TrissinR, suggesting the involvement of this neuropeptide signaling pathway in DNp27 function. Moreover, neural circuitry and connectivity analyses indicate that DNp27 may regulate circadian neurons via extra-clock electrical oscillators (xCEOs). Lastly, we found that DNp27 modulates arousal thresholds by inhibiting light-responsive activity in the central brain, thereby promoting sleep stability, particularly in the pre-dawn period. Together, these findings suggest that DNp27 plays a crucial role in maintaining stable sleep patterns.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal symbiont transmission via envenomation in the parasitoid wasp Spalangia cameroni.","authors":"Benjamin Weiss, Sarit Rohkin Shalom, Anna Dolgova, Li Szhen Teh, Martin Kaltenpoth, Colin Dale, Elad Chiel","doi":"10.1016/j.cub.2025.02.035","DOIUrl":"10.1016/j.cub.2025.02.035","url":null,"abstract":"<p><p>Microbial symbionts of multicellular hosts originate from free-living ancestors and often persist through vertical transmission, but their mechanisms of establishment are not well understood. Here, we studied acquisition and transmission routes in a nascent symbiosis involving the bacterium Sodalis praecaptivus subsp. spalangiae (Sodalis SC) and the parasitoid wasp Spalangia cameroni. Using fluorescence in situ hybridization, transmission electron microscopy, and experimental infections, we found that oocytes are devoid of Sodalis SC, but the female venom gland is densely colonized. Sodalis SC is injected with the venom into the fly host, subsequently acquired by larval progeny during feeding, invades through the larval gut epithelium into multiple host organs, and eventually localizes in the venom gland. Adult wasps can also acquire Sodalis SC by artificial feeding, but, in this case, the bacterium is not transmitted vertically. Additionally, Sodalis SC is localized in the testes of some males, transmitted paternally at low frequency, and females that inherit Sodalis SC paternally can subsequently transmit it via the venom. To assess the specificity of the symbiosis, we performed experiments with the closely related free-living species Sodalis praecaptivus subsp. praecaptivus (Sodalis PP), known to initiate symbiosis with other insects. Sodalis PP is readily acquired when supplied artificially to wasp larvae but not transmitted to wasp progeny, because it fails to proliferate in the parasitized host. Our results indicate that non-ovarian transmission routes of intracellular symbionts may be more common than currently appreciated and provide a scenario for the early steps in establishing persistent symbiotic associations in insects.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An accumbal microcircuit for the transition from acute to chronic pain.","authors":"Yu-Mei Yu, Sun-Hui Xia, Zheng Xu, Wei-Nan Zhao, Lingzhen Song, Xiangyu Pan, Chao-Chao Zhong, Di Wang, Yi-Hong Gao, Jun-Xia Yang, Peng Wu, Hongxing Zhang, Shuming An, Jun-Li Cao, Hai-Lei Ding","doi":"10.1016/j.cub.2025.02.055","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.055","url":null,"abstract":"<p><p>Persistent nociceptive inputs arising from peripheral tissues or/and nerve injuries cause maladaptive changes in neurons or neural circuits in the central nervous system, which further confer acute injury into chronic pain transitions (pain chronification) even after the injury is resolved. However, the critical brain regions and their neural mechanisms involved in this transition have not yet been elucidated. Here, we reveal an accumbal microcircuit that is essential for pain chronification. Notably, the increase of neuronal activity in the nucleus accumbens shell (NAcS) in the acute phase (<7 days) and in core (NAcC) in the chronic phase (14-21 days) was detected in a neuropathic pain mouse model. Importantly, we demonstrated that the NAcS neuronal activation in the acute phase of injury was necessary and sufficient for the development of chronic neuropathic pain. This process was mediated by the accumbal dopamine D2 receptor-expressing neuronal microcircuit from NAcS to NAcC. Thus, our findings reveal an accumbal microcircuit mechanism for pain chronification and suggest that the early intervention targeting this microcircuit may provide a therapeutic approach to pain chronification.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global to local influences on temporal expectation in marmosets and humans.","authors":"Tudor Dragoi, Hiroki Sugihara, Nhat Minh Le, Elie Adam, Jitendra Sharma, Guoping Feng, Robert Desimone, Mriganka Sur","doi":"10.1016/j.cub.2025.01.052","DOIUrl":"10.1016/j.cub.2025.01.052","url":null,"abstract":"<p><p>Marmosets are emerging rapidly as experimental models for studying the neural bases of cognition and, importantly, for modeling disorders of human cognition, but many aspects of their mental attributes remain to be characterized. When judging elapsed time, humans implicitly use prior information to predict upcoming events and reduce perceptual and decision-making uncertainty. An influential model of temporal expectation is the hazard rate model, which posits the likelihood of an event occurring in the future, provided it has not occurred already. Here, we report that marmosets trained on a reaction time task acquire the hazard rate model of expectation, consistent with the global task structure. The model emerges progressively with learning but unexpectedly continues to be modified by local contingencies, as demonstrated by a serial effect of trial duration on responses. The combined effects of global and local task structure are well described by a multiple regression model and computationally by Bayesian updating of the hazard function. Parallel experiments in human subjects similarly demonstrate global followed by local influences on reaction times and temporal expectation. Thus, in both marmosets and humans, task history and local structure continuously update task-specific responses, surprisingly at the expense of optimal responses after the competent acquisition of an internal model.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1095-1106.e7"},"PeriodicalIF":8.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}