Current Biology最新文献_第8页

Prefrontal tDCS fails to modulate memory retrieval in younger and older adults. 在年轻人和老年人中，前额叶tDCS无法调节记忆提取。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-06 Epub Date: 2024-12-06 DOI: 10.1016/j.cub.2024.10.080

Tesnim Arar, Gabriella V Hirsch, Taylor A Chamberlain, Miranda Malone, Cheyenne D Wakeland-Hart, Martynas Snarskis, Diane S Lauderdale, L Philip Schumm, David A Gallo

{"title":"Prefrontal tDCS fails to modulate memory retrieval in younger and older adults.","authors":"Tesnim Arar, Gabriella V Hirsch, Taylor A Chamberlain, Miranda Malone, Cheyenne D Wakeland-Hart, Martynas Snarskis, Diane S Lauderdale, L Philip Schumm, David A Gallo","doi":"10.1016/j.cub.2024.10.080","DOIUrl":"10.1016/j.cub.2024.10.080","url":null,"abstract":"Previous research shows that a single session of anodal transcranial direct current stimulation (tDCS) to the left dorsolateral prefrontal cortex (dlPFC) can improve the accuracy of episodic memory retrieval, but stimulation effects are not always found and may be moderated by time of day. Here, we report the results from a rigorous clinical trial (NCT03723850) designed to replicate these tDCS findings in younger adults and extend them to cognitively normal older adults. We conducted the largest double-blind, between-subjects tDCS study on memory retrieval in younger and older adults to date. 150 younger adults and 91 older adults received anodal tDCS or sham stimulation to the left dlPFC prior to episodic memory retrieval and working memory tasks. We also manipulated when tDCS was administered (time of day: morning vs. afternoon), task difficulty (easy vs. hard), and stimulus format (verbal vs. visual/pictorial) to test the extent that these variables are important for identifying tDCS effects. Contrary to our preregistered predictions, we did not find any effect of tDCS or time of day on younger or older adults' episodic or working memory performance. This outcome was not due to insensitivity of our cognitive tasks, given that we found expected effects of task difficulty and age-related effects on our memory measures. Based on these and prior tDCS results, we conclude that a single dose of tDCS using the typical and often recommended parameters does not reliably improve episodic memory retrieval in either age group.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"50-58.e4"},"PeriodicalIF":8.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modularity buffers the spread of spatial perturbations in macroalgal networks. 模块化缓冲了大藻网络中空间扰动的传播。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-06 Epub Date: 2024-12-19 DOI: 10.1016/j.cub.2024.11.038

Caterina Mintrone, Luca Rindi, Iacopo Bertocci, Elena Maggi, Lisandro Benedetti-Cecchi

{"title":"Modularity buffers the spread of spatial perturbations in macroalgal networks.","authors":"Caterina Mintrone, Luca Rindi, Iacopo Bertocci, Elena Maggi, Lisandro Benedetti-Cecchi","doi":"10.1016/j.cub.2024.11.038","DOIUrl":"10.1016/j.cub.2024.11.038","url":null,"abstract":"Theory predicts that spatial modular networks contain the propagation of local disturbances, but field experimental tests of this hypothesis are lacking. We combined a field experiment with a metacommunity model to assess the role of modularity in buffering the spatial spread of algal turfs in three replicated canopy-dominated macroalgal networks. Experimental networks included three modules where plots with intact canopy cover (nodes) were connected through canopy-thinned corridors. The local perturbation consisted of removal of the canopy and understory species from four nodes within a single module to enable the establishment of algal turfs, which could then spread vegetatively to other untouched nodes through the canopy-thinned links. Results show that algal turfs invade mainly untouched nodes in the perturbed module, in agreement with the hypothesis that modularity can effectively constrain the spread of a spatial perturbation. The metacommunity model supports the empirical findings, illustrating greater resistance to perturbations of modular than random macroalgal canopy networks and making alternative explanations for the observed results unlikely. Evidence that the buffering effect of modularity can operate in natural environmental conditions has important implications for designing more robust networks of protected areas and less-fragile human-dominated fragmented landscapes.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"154-162.e4"},"PeriodicalIF":8.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Days-old zebrafish rapidly learn to recognize threatening agents through noradrenergic and forebrain circuits. 几天大的斑马鱼通过去肾上腺素能和前脑回路迅速学会识别威胁性物质。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-06 Epub Date: 2024-12-23 DOI: 10.1016/j.cub.2024.11.057

Dhruv Zocchi, Millen Nguyen, Emmanuel Marquez-Legorreta, Igor Siwanowicz, Chanpreet Singh, David A Prober, Elizabeth M C Hillman, Misha B Ahrens

{"title":"Days-old zebrafish rapidly learn to recognize threatening agents through noradrenergic and forebrain circuits.","authors":"Dhruv Zocchi, Millen Nguyen, Emmanuel Marquez-Legorreta, Igor Siwanowicz, Chanpreet Singh, David A Prober, Elizabeth M C Hillman, Misha B Ahrens","doi":"10.1016/j.cub.2024.11.057","DOIUrl":"10.1016/j.cub.2024.11.057","url":null,"abstract":"Animals need to rapidly learn to recognize and avoid predators. This ability may be especially important for young animals due to their increased vulnerability. It is unknown whether, and how, nascent vertebrates are capable of such rapid learning. Here, we used a robotic predator-prey interaction assay to show that 1 week after fertilization-a developmental stage where they have approximately 1% the number of neurons of adults-zebrafish larvae rapidly and robustly learn to recognize a stationary object as a threat after the object pursues the fish for ∼1 min. Larvae continue to avoid the threatening object after it stops moving and can learn to distinguish threatening from non-threatening objects of a different color. Whole-brain functional imaging revealed the multi-timescale activity of noradrenergic neurons and forebrain circuits that encoded the threat. Chemogenetic ablation of those populations prevented the learning. Thus, a noradrenergic and forebrain multiregional network underlies the ability of young vertebrates to rapidly learn to recognize potential predators within their first week of life.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"163-176.e4"},"PeriodicalIF":8.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Origin of visual experience-dependent theta oscillations. 依赖于视觉经验的θ波振荡的起源。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-06 Epub Date: 2024-12-09 DOI: 10.1016/j.cub.2024.11.015

Michael P Zimmerman, Samuel T Kissinger, Paige Edens, Renee C Towers, Sanghamitra Nareddula, Yididiya Y Nadew, Christopher J Quinn, Alexander A Chubykin

{"title":"Origin of visual experience-dependent theta oscillations.","authors":"Michael P Zimmerman, Samuel T Kissinger, Paige Edens, Renee C Towers, Sanghamitra Nareddula, Yididiya Y Nadew, Christopher J Quinn, Alexander A Chubykin","doi":"10.1016/j.cub.2024.11.015","DOIUrl":"10.1016/j.cub.2024.11.015","url":null,"abstract":"Visual experience gives rise to persistent theta oscillations in the mouse primary visual cortex (V1) that are specific to the familiar stimulus. Our recent work demonstrated the presence of these oscillations in higher visual areas (HVAs), where they are synchronized with V1 in a context-dependent manner. However, it remains unclear where these unique oscillatory dynamics originate. To investigate this, we conducted paired extracellular electrophysiological recordings in two visual thalamic nuclei (dorsal lateral geniculate nucleus [dLGN] and lateral posterior nucleus [LP]), the retrosplenial cortex (RSC), and the hippocampus (HPC). Oscillatory activity was not found in either of the thalamic nuclei, but a sparse ensemble of oscillating neurons was observed in both the RSC and HPC, similar to V1. To infer functional connectivity changes between the brain regions, we performed directed information analysis, which indicated a trend toward decreased connectivity in all V1-paired regions, with a consistent increase in V1 → V1 connections, suggesting that the oscillations appear to initiate independently within V1. Lastly, complete NMDA lesioning of the HPC did not abolish theta oscillations in V1 that emerge with familiarity. Altogether, these results suggest that (1) theta oscillations do not originate in the thalamus; (2) RSC exhibits theta oscillations, which may follow V1 given the temporal delay present; and (3) the HPC had a sparse group of neurons, with theta oscillations matching V1; however, lesioning suggests that these oscillations emerge independent of each other. Overall, our findings pave the way for future studies to determine the mechanisms by which diverse inputs and outputs shape this memory-related oscillatory activity in the brain.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"87-99.e6"},"PeriodicalIF":8.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolite-level regulation of enzymatic activity controls awakening of cyanobacteria from metabolic dormancy. 酶活性的代谢物水平调节控制蓝藻从代谢休眠的觉醒。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-06 Epub Date: 2024-12-02 DOI: 10.1016/j.cub.2024.11.011

Sofía Doello, Jakob Sauerwein, Nathan von Manteuffel, Markus Burkhardt, Niels Neumann, Jens Appel, Johanna Rapp, Pauline Just, Hannes Link, Kirstin Gutekunst, Karl Forchhammer

{"title":"Metabolite-level regulation of enzymatic activity controls awakening of cyanobacteria from metabolic dormancy.","authors":"Sofía Doello, Jakob Sauerwein, Nathan von Manteuffel, Markus Burkhardt, Niels Neumann, Jens Appel, Johanna Rapp, Pauline Just, Hannes Link, Kirstin Gutekunst, Karl Forchhammer","doi":"10.1016/j.cub.2024.11.011","DOIUrl":"10.1016/j.cub.2024.11.011","url":null,"abstract":"Transitioning into and out of dormancy is a crucial survival strategy for many organisms. In unicellular cyanobacteria, surviving nitrogen-starved conditions involves tuning down their metabolism and reactivating it once nitrogen becomes available. Glucose-6-phosphate dehydrogenase (G6PDH), the enzyme that catalyzes the first step of the oxidative pentose phosphate (OPP) pathway, plays a key role in this process. G6PDH is produced at the onset of nitrogen starvation but remains inactive in dormant cells, only to be rapidly reactivated when nitrogen is restored. In this study, we investigated the mechanisms underlying this enzymatic regulation and found that G6PDH inactivation is primarily due to the accumulation of inhibitory metabolites. Moreover, our findings demonstrate that metabolite-level regulation is the driving force behind the resuscitation program. This study highlights the critical importance of metabolite-level regulation in ensuring rapid and precise enzymatic control, enabling microorganisms to swiftly adapt to environmental changes and undergo developmental transitions.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"77-86.e4"},"PeriodicalIF":8.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos. 细胞周期振荡器和纺锤体长度决定果蝇胚胎染色体分离的速度。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-04 DOI: 10.1016/j.cub.2024.11.046

Yitong Xu, Anna Chao, Melissa Rinaldin, Alison Kickuth, Jan Brugués, Stefano Di Talia

{"title":"The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos.","authors":"Yitong Xu, Anna Chao, Melissa Rinaldin, Alison Kickuth, Jan Brugués, Stefano Di Talia","doi":"10.1016/j.cub.2024.11.046","DOIUrl":"10.1016/j.cub.2024.11.046","url":null,"abstract":"Anaphase is tightly controlled spatiotemporally to ensure proper separation of chromosomes.1,2,3 The mitotic spindle, the self-organized microtubule structure driving chromosome segregation, scales in size with the available cytoplasm.4,5,6,7 Yet, the relationship between spindle size and chromosome movement remains poorly understood. Here, we address this relationship during the cleavage divisions of the Drosophila blastoderm. We show that the speed of chromosome separation gradually decreases during the four nuclear divisions of the blastoderm. This reduction in speed is accompanied by a similar reduction in spindle length, ensuring that these two quantities are tightly linked. Using a combination of genetic and quantitative imaging approaches, we find that two processes contribute to controlling the speed at which chromosomes move in anaphase: the activity of molecular motors important for microtubule depolymerization and sliding and the cell cycle oscillator. Specifically, we found that the levels of multiple kinesin-like proteins important for microtubule depolymerization, as well as kinesin-5, contribute to setting the speed of chromosome separation. This observation is further supported by the scaling of poleward flux rate with the length of the spindle. Perturbations of the cell cycle oscillator using heterozygous mutants of mitotic kinases and phosphatases revealed that the duration of anaphase increases during the blastoderm cycles and is the major regulator of chromosome velocity. Thus, our work suggests a link between the biochemical rate of mitotic exit and the forces exerted by the spindle. Collectively, we propose that the cell cycle oscillator and spindle length set the speed of chromosome separation in anaphase.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gustatory cortex neurons perform reliability-dependent integration of multisensory flavor inputs. 味觉皮层神经元执行多感官风味输入的可靠性依赖整合。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-04 DOI: 10.1016/j.cub.2024.12.015

Isabella B Allar, Alex Hua, Benjamin A Rowland, Joost X Maier

{"title":"Gustatory cortex neurons perform reliability-dependent integration of multisensory flavor inputs.","authors":"Isabella B Allar, Alex Hua, Benjamin A Rowland, Joost X Maier","doi":"10.1016/j.cub.2024.12.015","DOIUrl":"https://doi.org/10.1016/j.cub.2024.12.015","url":null,"abstract":"Flavor is the quintessential multisensory experience, combining gustatory, retronasal olfactory, and texture qualities to inform food perception and consumption behavior. However, the computations that govern multisensory integration of flavor components and their underlying neural mechanisms remain elusive. Here, we use rats as a model system to test the hypothesis that taste and smell components of flavor are integrated in a reliability-dependent manner to inform hedonic judgments and that this computation is performed by neurons in the primary taste cortex. Using a series of two-bottle preference tests, we demonstrate that hedonic judgments of taste + smell mixtures are a weighted average of the component judgments, and that the weight of the components depends on their relative reliability. Using extracellular recordings of single-neuron spiking and local field potential activity in combination with decoding analysis, we reveal a correlate of this computation in gustatory cortex (GC). GC neurons weigh bimodal taste and smell inputs based on their reliability, with more reliable inputs contributing more strongly to taste + smell mixture responses. Input reliability was associated with less variable responses and stronger network-level synchronization in the gamma band. Together, our findings establish a quantitative framework for understanding hedonic multisensory flavor judgments and identify the neural computations that underlie them.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity of a descending neuron associated with visually elicited flight saccades in Drosophila. 在果蝇中，与视觉诱发的飞行扫视有关的下降神经元的活动。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-03 DOI: 10.1016/j.cub.2024.12.001

Elhanan Buchsbaum, Bettina Schnell

{"title":"Activity of a descending neuron associated with visually elicited flight saccades in Drosophila.","authors":"Elhanan Buchsbaum, Bettina Schnell","doi":"10.1016/j.cub.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.cub.2024.12.001","url":null,"abstract":"Approaching threats are perceived through visual looming, a rapid expansion of an image on the retina. Visual looming triggers defensive responses such as freezing, flight, turning, or take-off in a wide variety of organisms, from mice to fish to insects.1,2,3,4 In response to looming, flies perform rapid evasive turns known as saccades.5 Saccades can also be initiated spontaneously to change direction during flight.6,7,8,9 Two types of descending neurons (DNs), DNaX and DNb01, were previously shown to exhibit activity correlated with both spontaneous and looming-elicited saccades in Drosophila.10,11 As they do not receive direct input from the visual system, it has remained unclear how visually elicited flight turns are controlled by the nervous system. DNp03 receives input from looming-sensitive visual projection neurons and provides output to wing motor neurons12,13 and is therefore a promising candidate for controlling flight saccades. Using whole-cell patch-clamp recordings from DNp03 in head-fixed flying Drosophila, we showed that DNp03 responds to ipsilateral visual looming in a behavioral-state-dependent manner. We further explored how DNp03 activity relates to the variable behavioral output. Sustained DNp03 activity, persisting after the visual stimulus, was the strongest predictor of saccade execution. However, DNp03 activity alone cannot fully explain the variability in behavioral responses. Combined with optogenetic activation experiments during free flight, these results suggest an important but not exclusive role for DNp03 in controlling saccades, advancing our understanding of how visual information is transformed into motor commands for rapid evasive maneuvers in flying insects.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential recruitment of F-BAR proteins controls cytoskeletal crosstalk at the yeast bud neck. F-BAR蛋白的连续募集控制着酵母芽颈部的细胞骨架串扰。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-03 DOI: 10.1016/j.cub.2024.12.011

Joseph O Magliozzi, Lucas A Runyan, Priyanka Dutta, Gregory J Hoeprich, Bruce L Goode

{"title":"Sequential recruitment of F-BAR proteins controls cytoskeletal crosstalk at the yeast bud neck.","authors":"Joseph O Magliozzi, Lucas A Runyan, Priyanka Dutta, Gregory J Hoeprich, Bruce L Goode","doi":"10.1016/j.cub.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.cub.2024.12.011","url":null,"abstract":"In vivo functions of the septin and actin cytoskeletons are closely intertwined, yet the mechanisms underlying septin-actin crosstalk have remained poorly understood. Here, we show that the yeast-bud-neck-associated Fes/CIP4 homology Bar-amphiphysin-Rvs (F-BAR) protein suppressor of yeast profilin 1 (Syp1)/FCHo uses its intrinsically disordered region (IDR) to directly bind and bundle filamentous actin (F-actin) and to physically link septins and F-actin. Interestingly, the only other F-BAR protein found at the neck during bud development, Hof1, has related activities and also potently inhibits the bud-neck-associated formin Bnr1. However, we find that Syp1 enhances rather than inhibits Bnr1-mediated actin assembly and fully overcomes Hof1-mediated inhibition of Bnr1. Further, during bud development, Syp1 and Hof1 show reciprocal patterns of arrival and departure from the bud neck, and in vitro Syp1 and Hof1 compete for septin binding. Together, our observations suggest that as the bud grows, the relative levels of these two F-BAR proteins at the bud neck invert, driving changes in septin organization, septin-actin linkage, and formin activity. More broadly, our findings expand the functional roles of Syp1/FCHo family proteins and our understanding of the working relationships among F-BAR proteins in cytoskeletal regulation.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates. 前庭和本体感觉信号在小脑结节/小舌的融合增强了灵长类动物自我运动的编码。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-03 DOI: 10.1016/j.cub.2024.11.063

Robyn L Mildren, Lex J Gómez, Kathleen E Cullen

{"title":"Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates.","authors":"Robyn L Mildren, Lex J Gómez, Kathleen E Cullen","doi":"10.1016/j.cub.2024.11.063","DOIUrl":"https://doi.org/10.1016/j.cub.2024.11.063","url":null,"abstract":"The integration of different sensory streams is required to dynamically estimate how our head and body are oriented and moving relative to gravity. This process is essential to continuously maintain stable postural control, autonomic regulation, and self-motion perception. The nodulus/uvula (NU) in the posterior cerebellar vermis is known to integrate canal and otolith vestibular input to signal angular and linear head motion in relation to gravity. However, estimating body orientation and motion requires integrating proprioceptive cues with vestibular signals. Lesion studies demonstrate that the NU is crucial for maintaining postural control, suggesting it could play an important role in combining multimodal sensory input. Using high-density extracellular recordings in rhesus monkeys, we found that the majority of vestibular-sensitive Purkinje cells also encoded dynamic neck proprioceptive input. Furthermore, Purkinje cells generally aligned their directional tuning to vestibular and proprioceptive stimulation such that self-motion encoding was enhanced. The heterogeneous response dynamics among Purkinje cells enabled their population activity to generate head or body motion encoding in the downstream nuclei neurons on which they converge. Strikingly, when we then experimentally altered the orientation of the head relative to the body, Purkinje cells modulated their responses to vestibular stimulation to account for the change in body motion in space. These findings reveal that the NU integrates proprioceptive and vestibular input synergistically to maintain robust postural control.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0