Current Biology最新文献

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 DOI: 10.1016/j.cub.2024.11.062

Andrew M M Matheson, Nicholas J Chua, Maria Antonietta Tosches

引用次数: 0

Improved cost-effectiveness of species monitoring programs through data integration. 通过数据整合提高物种监测项目的成本效益。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2025-01-06 DOI: 10.1016/j.cub.2024.11.051

Ardiantiono, Nicolas J Deere, David J I Seaman, U Mamat Rahmat, Eka Ramadiyanta, Muhammad I Lubis, Ahtu Trihangga, Ahmad Yasin, Gunawan Alza, Dessy P Sari, Muhammad Daud, Ridha Abdullah, Rina Mutia, Dewi Melvern, Tarmizi, Jatna Supriatna, Matthew J Struebig

{"title":"Improved cost-effectiveness of species monitoring programs through data integration.","authors":"Ardiantiono, Nicolas J Deere, David J I Seaman, U Mamat Rahmat, Eka Ramadiyanta, Muhammad I Lubis, Ahtu Trihangga, Ahmad Yasin, Gunawan Alza, Dessy P Sari, Muhammad Daud, Ridha Abdullah, Rina Mutia, Dewi Melvern, Tarmizi, Jatna Supriatna, Matthew J Struebig","doi":"10.1016/j.cub.2024.11.051","DOIUrl":"https://doi.org/10.1016/j.cub.2024.11.051","url":null,"abstract":"Conservation initiatives strive for reliable and cost-effective species monitoring.1,2,3 However, resource constraints mean management decisions are overly reliant on data derived from single methodologies, resulting in taxonomic or geographic biases.4 We introduce a data integration framework to optimize species monitoring in terms of spatial representation, the reliability of biodiversity metrics, and the cost of implementation, focusing on tigers and their principal prey (sambar deer and wild pigs). We combined information from unstructured ranger patrols, systematic sign transects, and camera traps in Sumatra's largest remaining tropical forest and used integrated community occupancy models to analyze this multifaceted dataset in a unified way. Data integration improved the precision of species occupancy estimates by 14%-42%, enhanced the accuracy of species inferences, expanded the spatial scope of inference to the landscape level, and cut operational costs up to 51-fold. Our framework demonstrates the underappreciated value of integrating unstructured observations with monitoring data derived from traditional wildlife surveys.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"35 2","pages":"391-397.e3"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tubulin sequence divergence is associated with the use of distinct microtubule regulators. 微管蛋白序列分化与不同微管调节剂的使用有关。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2024-12-17 DOI: 10.1016/j.cub.2024.11.022

Andrew S Kennard, Katrina B Velle, Ravi Ranjan, Danae Schulz, Lillian K Fritz-Laylin

{"title":"Tubulin sequence divergence is associated with the use of distinct microtubule regulators.","authors":"Andrew S Kennard, Katrina B Velle, Ravi Ranjan, Danae Schulz, Lillian K Fritz-Laylin","doi":"10.1016/j.cub.2024.11.022","DOIUrl":"10.1016/j.cub.2024.11.022","url":null,"abstract":"Diverse eukaryotic cells assemble microtubule networks that vary in structure and composition. While we understand how cells build microtubule networks with specialized functions, we do not know how microtubule networks diversify across deep evolutionary timescales. This problem has remained unresolved because most organisms use shared pools of tubulins for multiple networks, making it difficult to trace the evolution of any single network. In contrast, the amoeboflagellate Naegleria expresses distinct tubulin genes to build distinct microtubule networks: while Naegleria builds flagella from conserved tubulins during differentiation, it uses divergent tubulins to build its mitotic spindle. This genetic separation makes for an internally controlled system to study independent microtubule networks in a single organismal and genomic context. To explore the evolution of these microtubule networks, we identified conserved microtubule-binding proteins and used transcriptional profiling of mitosis and differentiation to determine which are upregulated during the assembly of each network. Surprisingly, most microtubule-binding proteins are upregulated during only one process, suggesting that Naegleria uses distinct component pools to specialize its microtubule networks. Furthermore, the divergent residues of mitotic tubulins tend to fall within the binding sites of differentiation-specific microtubule regulators, suggesting that interactions between microtubules and their binding proteins constrain tubulin sequence diversification. We therefore propose a model for cytoskeletal evolution in which pools of microtubule network components constrain and guide the diversification of the entire network, so that the evolution of tubulin is inextricably linked to that of its binding partners.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"233-248.e8"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell shape modulates mitotic spindle positioning forces via intracellular hydrodynamics. 细胞形状通过细胞内流体动力学调节有丝分裂纺锤体定位力。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2025-01-03 DOI: 10.1016/j.cub.2024.11.055

Jing Xie, Javad Najafi, Aude Nommick, Luc Lederer, Jeremy Salle, Serge Dmitrieff, Benjamin Lacroix, Julien Dumont, Nicolas Minc

{"title":"Cell shape modulates mitotic spindle positioning forces via intracellular hydrodynamics.","authors":"Jing Xie, Javad Najafi, Aude Nommick, Luc Lederer, Jeremy Salle, Serge Dmitrieff, Benjamin Lacroix, Julien Dumont, Nicolas Minc","doi":"10.1016/j.cub.2024.11.055","DOIUrl":"10.1016/j.cub.2024.11.055","url":null,"abstract":"The regulation of mitotic spindle positioning and orientation is central to the morphogenesis of developing embryos and tissues.1,2,3,4,5 In many multicellular contexts, cell geometry has been shown to have a major influence on spindle positioning, with spindles that commonly align along the longest cell shape axis.6,7,8,9,10,11,12,13,14 To date, however, we still lack an understanding of how the nature and amplitude of intracellular forces that position, orient, or hold mitotic spindles depend on cell geometry. Here, we used in vivo magnetic tweezers to directly measure the forces that maintain the mitotic spindle in the center of sea urchin cells that adopt different shapes during early embryo development. We found that spindles are held by viscoelastic forces that progressively increase in amplitude as cells become more elongated during early development. By coupling direct cell shape manipulations in microfabricated chambers with in vivo force measurements, we establish how spindle-associated forces increase in dose dependence with cell shape anisotropy. Cytoplasm flow analysis and hydrodynamic simulations suggest that this geometry-dependent mechanical enhancement results from a stronger hydrodynamic coupling between the spindle and cell boundaries, which dampens cytoplasm flows and spindle mobility as cells become more elongated. These findings establish how cell shape affects spindle-associated forces and suggest a novel mechanism for shape sensing and division positioning mediated by intracellular hydrodynamics with functional implications for early embryo morphogenesis.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"413-421.e6"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual identification of conspecifics shapes social behavior in mice. 同种动物的视觉识别塑造了小鼠的社会行为。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2024-12-19 DOI: 10.1016/j.cub.2024.11.041

Devon Greer, Tianhao Lei, Anna Kryshtal, Zachary F Jessen, Gregory William Schwartz

引用次数: 0

Ectopic reconstitution of a spine-apparatus-like structure provides insight into mechanisms underlying its formation. 脊柱样结构的异位重构提供了对其形成机制的深入了解。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2024-12-02 DOI: 10.1016/j.cub.2024.11.010

Hanieh Falahati, Yumei Wu, Mumu Fang, Pietro De Camilli

{"title":"Ectopic reconstitution of a spine-apparatus-like structure provides insight into mechanisms underlying its formation.","authors":"Hanieh Falahati, Yumei Wu, Mumu Fang, Pietro De Camilli","doi":"10.1016/j.cub.2024.11.010","DOIUrl":"10.1016/j.cub.2024.11.010","url":null,"abstract":"The endoplasmic reticulum (ER) is a continuous cellular endomembrane network that displays focal specializations. Most notable examples of such specializations include the spine apparatus of neuronal dendrites and the cisternal organelle of axonal initial segments. Both organelles exhibit stacks of smooth ER sheets with a narrow lumen, interconnected by a dense protein matrix. The actin-binding protein synaptopodin is required for their formation, but the underlying mechanisms remain unknown. Here, we report that the spine apparatus and synaptopodin are conserved from flies to mammals and that a highly conserved region of this protein is necessary, but not sufficient, for its association with ER. We reveal a dual role of synaptopodin in generating actin bundles and in linking them to the ER. Expression of a synaptopodin construct constitutively anchored to the ER in non-neuronal cells is sufficient to generate stacked ER cisterns resembling the spine apparatus. Cisterns within these stacks are molecularly distinct from the surrounding ER and are connected to each other by an actin-based matrix that contains proteins also found at the spine apparatus of neuronal spines. Our findings shed light on mechanisms governing the biogenesis of this peculiar structure and represent a step toward understanding the elusive properties of this organelle.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"265-276.e4"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wildfires: Burning our way to a 'hot house Earth'? 野火：燃烧我们通往“热屋地球”的道路？

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 DOI: 10.1016/j.cub.2024.11.060

David M J S Bowman, Calum X Cunningham

引用次数: 0

Carbon dioxide shapes parasite-host interactions in a human-infective nematode. 在感染人类的线虫中，二氧化碳塑造了寄生虫与宿主的相互作用。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 Epub Date: 2024-12-23 DOI: 10.1016/j.cub.2024.11.036

Navonil Banerjee, Spencer S Gang, Michelle L Castelletto, Breanna Walsh, Felicitas Ruiz, Elissa A Hallem

{"title":"Carbon dioxide shapes parasite-host interactions in a human-infective nematode.","authors":"Navonil Banerjee, Spencer S Gang, Michelle L Castelletto, Breanna Walsh, Felicitas Ruiz, Elissa A Hallem","doi":"10.1016/j.cub.2024.11.036","DOIUrl":"10.1016/j.cub.2024.11.036","url":null,"abstract":"Skin-penetrating nematodes infect nearly one billion people worldwide. The developmentally arrested infective larvae (iL3s) seek out hosts, invade hosts via skin penetration, and resume development inside the host in a process called activation. Activated infective larvae (iL3as) traverse the host body, ending up as parasitic adults in the small intestine. Skin-penetrating nematodes respond to many chemosensory cues, but how chemosensation contributes to host seeking and intra-host navigation-two crucial steps of the parasite-host interaction-remains poorly understood. Here, we investigate the role of carbon dioxide (CO2) in promoting host seeking and intra-host navigation in the human-infective threadworm Strongyloides stercoralis. We show that S. stercoralis exhibits life-stage-specific behavioral preferences for CO2: iL3s are repelled, non-infective larvae and adults are neutral, and iL3as are attracted. CO2 repulsion in iL3s may prime them for host seeking by stimulating dispersal from host feces, while CO2 attraction in iL3as may direct worms toward high-CO2 areas of the body, such as the lungs and intestine. We also identify sensory neurons that detect CO2; these neurons display CO2-evoked calcium activity, promote behavioral responses to CO2, and express the receptor guanylate cyclase Ss-GCY-9. Finally, we develop an approach for generating stable knockout lines in S. stercoralis and use this approach to show that Ss-gcy-9 is required for CO2-evoked behavioral responses in both iL3s and iL3as. Our results highlight chemosensory mechanisms that shape the interaction between parasitic nematodes and their human hosts and may aid in the design of novel anthelmintics that target the CO2-sensing pathway.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"277-286.e6"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agrochemicals: Insect declines in a warming world. 农用化学品：全球变暖导致昆虫数量减少。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 DOI: 10.1016/j.cub.2024.11.048

Felipe Martelli, Philip Batterham

引用次数: 0

Socially contagious urination in chimpanzees. 黑猩猩的社会传染性排尿。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-01-20 DOI: 10.1016/j.cub.2024.11.052

Ena Onishi, James Brooks, Sota Inoue, Shinya Yamamoto

{"title":"Socially contagious urination in chimpanzees.","authors":"Ena Onishi, James Brooks, Sota Inoue, Shinya Yamamoto","doi":"10.1016/j.cub.2024.11.052","DOIUrl":"https://doi.org/10.1016/j.cub.2024.11.052","url":null,"abstract":"The decision to urinate involves a complex combination of both physiological and social considerations1,2,3. However, the social dimensions of urination remain largely unexplored. More specifically, aligning urination in time (i.e. synchrony) and the triggering of urination by observing similar behavior in others (i.e. social contagion) are thought to occur in humans across different cultures (Figure S1A), and possibly also in non-human animals. However, neither has been scientifically quantified in any species. Contagious urination, like other forms of behavioral and emotional state matching4, may have important implications in establishing and maintaining social cohesion, in addition to potential roles in preparation for collective departure5 (i.e. voiding before long-distance travel) and territorial scent-marking6 (i.e. coordination of chemosensory signals). Here, we report socially contagious urination in chimpanzees, one of our closest relatives, as measured through all-occurrence recording of 20 captive chimpanzees across >600 hours. Our results suggest that socially contagious urination may be an overlooked, and potentially widespread, facet of social behavior.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"35 2","pages":"R58-R59"},"PeriodicalIF":8.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0