Current Biology最新文献_第2页

Visual loom caused by self-movement or object-movement elicits distinct responses in mouse superior colliculus. 由自我运动或物体运动引起的视觉织网在小鼠上丘中引起不同的反应。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-07-31 DOI: 10.1016/j.cub.2025.07.013

Stefano Zucca, Auguste Schulz, Pedro J Gonçalves, Jakob H Macke, Aman B Saleem, Samuel G Solomon

{"title":"Visual loom caused by self-movement or object-movement elicits distinct responses in mouse superior colliculus.","authors":"Stefano Zucca, Auguste Schulz, Pedro J Gonçalves, Jakob H Macke, Aman B Saleem, Samuel G Solomon","doi":"10.1016/j.cub.2025.07.013","DOIUrl":"10.1016/j.cub.2025.07.013","url":null,"abstract":"The meaning of a visual image depends on context-a mouse sees an expanding visual stimulus when approaching a dark refuge or when a cat approaches them, and distinguishing between the two is a matter of life and death. The superior colliculus (SC) is an evolutionarily ancient hub essential for survival behaviors like approach and avoidance of threats.1,2 We therefore combined virtual reality and neural recordings to ask whether matching visual stimuli to self-motion alters behavior and neural activity in SC. We first measured locomotion behavior and neural activity while animals approached an object in virtual reality or while the same object loomed at them. In both contexts, vision dominated activity in the superficial layers of SC (SCs), whereas locomotion had more influence on activity in the intermediate layers (SCim). In addition, animals instinctively slowed their locomotion when nearing the object or when the object neared them. To directly test animals' ability to distinguish self from object motion, we replayed the visual images generated during object approach. Locomotion behavior often changed during replay, showing animals can determine whether visual motion is matched to their self-movement. Further, decoders trained on locomotion behavior or on population activity in SC, particularly in SCim, were able to reliably discriminate self-movement and object movement contexts. We conclude that both mouse behavior and SC activity distinguish the context of visual motion and can thus discriminate motion arising from an animal's own movement and that of an external agent.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4241-4250.e4"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Representational drift gates critical-period plasticity in mouse visual cortex. 小鼠视觉皮层表征漂移门关键期可塑性。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-05 DOI: 10.1016/j.cub.2025.07.026

Thomas C Brown, Aaron W McGee

引用次数: 0

Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of apoptotic and bacterial extracellular vesicles. 磷脂酰乙醇胺是一种吞噬配体，参与细胞凋亡和细菌细胞外囊泡的结合和清除。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-11 DOI: 10.1016/j.cub.2025.07.043

Ava A Kavianpour, Sina Ghasempour, Kirsten J Meyer, Trieu Le, Ruiqi Cai, Pedro Elias Marques, Justin R Nodwell, Spencer A Freeman

{"title":"Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of apoptotic and bacterial extracellular vesicles.","authors":"Ava A Kavianpour, Sina Ghasempour, Kirsten J Meyer, Trieu Le, Ruiqi Cai, Pedro Elias Marques, Justin R Nodwell, Spencer A Freeman","doi":"10.1016/j.cub.2025.07.043","DOIUrl":"10.1016/j.cub.2025.07.043","url":null,"abstract":"The efficient recognition and removal of apoptotic cells and extracellular vesicles (EVs) by phagocytes is critical to prevent secondary necrosis and maintain tissue homeostasis. Such detection involves receptors and bridging molecules that recognize aminophospholipids-normally restricted to the inner leaflet of healthy cells-which become exposed on the surface of dead cells and the vesicles they produce.1,2,3,4,5 A majority of studies focus on phosphatidylserine (PS), for which there are well-established receptors that either bind to the lipid directly or indirectly via intermediary proteins.6,7,8 Phosphatidylethanolamine (PE) is even more prevalent than PS in the inner leaflet of mammalian cells9 and also becomes exposed by the action of scramblases during cell death,10,11 though little is known about the effects of PE once scrambled. Here, we report that PE can itself serve as a phagocytic ligand for macrophages by engaging CD300 family receptors. CD300a and CD300b specifically modulated the binding and uptake of PE particles, and this process involved immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptors and spleen tyrosine kinase (Syk). For bacteria, which contain PE but largely lack PS in their membranes, we report that PE engagement enabled the binding and uptake of spheroplasts and bacterial extracellular vesicles (BEVs) that were unsheathed by the cell wall. The inflammatory responses of macrophages to PE particles containing lipopolysaccharide (LPS) were also curtailed by CD300a expression. Based on these observations, we posit that the direct recognition of PE facilitates mechanisms of clearance that stand to have a broad impact on the immune response.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4276-4284.e5"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superefficient teamwork in weaver ants. 织蚁的高效团队合作。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-12 DOI: 10.1016/j.cub.2025.07.038

Madelyne Stewardson, Daniele Carlesso, David Labonte, Chris R Reid

{"title":"Superefficient teamwork in weaver ants.","authors":"Madelyne Stewardson, Daniele Carlesso, David Labonte, Chris R Reid","doi":"10.1016/j.cub.2025.07.038","DOIUrl":"10.1016/j.cub.2025.07.038","url":null,"abstract":"Teamwork is often assumed to enhance group performance, particularly for physical tasks. However, in both human and non-human animal teams, the effort contributed by each member may, in fact, decrease as team size grows. This counterintuitive phenomenon, known as the Ringelmann effect,1 is generally ascribed to poor coordination or differences in motivation.2,3 Weaver ants (Oecophylla smaragdina) display some of the most impressive feats of teamwork in the natural world,4,5 including self-assembly into pulling teams that fold leaves into nesting chambers.6,7 Here, we investigated whether weaver ant pulling teams suffer from the Ringelmann effect by measuring the force that weaver ant teams of varying sizes produce during nest construction. The average force contribution per individual almost doubled as team size increased, demonstrating that weaver ants not only avoid the Ringelmann effect but achieve the opposite-they are \"superefficient\" team workers.8,9,10 We propose that this superefficiency is facilitated by a division of labor within teams: \"active pullers\" work together to generate a pulling force that is stored in chains of \"passive resisters,\" which capitalize on the remarkable frictional strength of weaver ant attachment organs; weaver ant teams thereby act as a \"force ratchet.\" Our results highlight a novel mechanism of teamwork in a highly coordinated natural system and may inspire optimization algorithms for superefficient teams in distributed artificial systems, including swarm robotics. VIDEO ABSTRACT.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4270-4275.e3"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria mechanosensing: The powerhouse fueling cellular force signaling. 线粒体机械感应：细胞力信号的动力来源。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-07 DOI: 10.1016/j.cub.2025.07.084

Jorge Oliver-De La Cruz, Pere Roca-Cusachs

引用次数: 0

A top-down control of stress-induced REM sleep shortening. 压力诱发的快速眼动睡眠缩短的自上而下控制。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-06 DOI: 10.1016/j.cub.2025.07.039

Mathilde Chouvaeff, Alice Descamps, Sophie Bagur, Léo Macé, Karim Benchenane, Thierry Gallopin

{"title":"A top-down control of stress-induced REM sleep shortening.","authors":"Mathilde Chouvaeff, Alice Descamps, Sophie Bagur, Léo Macé, Karim Benchenane, Thierry Gallopin","doi":"10.1016/j.cub.2025.07.039","DOIUrl":"10.1016/j.cub.2025.07.039","url":null,"abstract":"The cerebral structures orchestrating the daily cycles of wake, rapid eye movement (REM), and non-rapid eye movement (NREM) sleep have been identified in remarkable detail. However, the mechanisms by which they dynamically adapt to environmental challenges remain to be fully understood. Here, we show that the prefrontal cortex (PFC), a key hub in stress regulation, modulates sleep architecture through direct projections to the ventrolateral preoptic nucleus (VLPO), a major sleep center. We characterize the detailed sleep architecture in mice after social defeat stress (SDS) and discover, for the first time, a persistent shortening of REM sleep bouts during the light phase, which outlasts the normalization of overall NREM sleep, REM sleep, and wakefulness proportions. This shift, marked by an increase in short REM sleep episodes and a reduction in long ones, is reminiscent of the fragmentation of REM sleep bouts often described in stress-related conditions. Chemogenetic inhibition of PFC to VLPO projections has no effect under baseline conditions but prevents the SDS-induced shortening of REM sleep bouts. Interestingly, optogenetic activation of this pathway is sufficient to shorten REM sleep episodes, despite the absence of the stressor, and promotes rapid transitions into NREM sleep. Finally, using ex vivo optogenetics, we demonstrate that activation of PFC terminals induces monosynaptic currents in VLPO sleep-promoting neurons. Therefore, the PFC-VLPO pathway provides top-down regulation specifically recruited under stress to shorten REM sleep episodes and increase transitions into NREM sleep while preserving total NREM sleep duration.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4151-4164.e4"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary consequences of extreme climate events. 极端气候事件的进化后果。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 DOI: 10.1016/j.cub.2025.07.046

Simon Baeckens, Colin M Donihue

引用次数: 0

dArc1 controls sugar reward valuation in Drosophila melanogaster. dArc1控制黑腹果蝇的糖奖励评估。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 Epub Date: 2025-08-08 DOI: 10.1016/j.cub.2025.07.048

Sven Bervoets, Miles Solomon Jacob, Anita V Devineni, Brennan Dale Mahoney, Kaelan R Sullivan, Andrew R Butts, Hayeon Sung, Jenifer Einstein, Mark M Metzstein, Monica Dus, Jason D Shepherd, Sophie Jeanne Cécile Caron

{"title":"dArc1 controls sugar reward valuation in Drosophila melanogaster.","authors":"Sven Bervoets, Miles Solomon Jacob, Anita V Devineni, Brennan Dale Mahoney, Kaelan R Sullivan, Andrew R Butts, Hayeon Sung, Jenifer Einstein, Mark M Metzstein, Monica Dus, Jason D Shepherd, Sophie Jeanne Cécile Caron","doi":"10.1016/j.cub.2025.07.048","DOIUrl":"10.1016/j.cub.2025.07.048","url":null,"abstract":"The Arc genes-which include Drosophila Arc1 and Arc2 (dArc)-evolved from Ty3 retrotransposons and encode proteins that form virus-like capsids. These capsids enable a novel form of intercellular communication by transferring RNAs between cells. However, the specific neuronal circuits and brain processes controlled by Arc signaling remain unidentified. Here, we show that loss of both dArc genes in Drosophila melanogaster enhances associative learning in an appetitive conditioning paradigm, where flies associate an odor with sugar rewards. This increased learning performance arises from an increased valuation of sugar rewards: unlike wild-type flies, dArc-/- flies form abnormally strong associations even when the sugar reward is small or has no caloric value. We found that the γ5-dopaminergic neurons of the protocerebral anterior medial (PAM) cluster, which encode the positive valence of sugar rewards, show heightened activity in response to sucrose in dArc-/- flies. We further show that the learning phenotype of dArc-/- flies depends on the formation of capsids, underscoring a direct role for capsid-mediated Arc signaling in sugar valuation. Our findings establish dArc genes as critical regulators of reward valuation in D. melanogaster, acting through a non-cell-autonomous mechanism that relies on capsid-mediated communication between cells.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4188-4198.e7"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cooperative behavior: Superefficient weaver ants. 合作行为：超级高效的织蚁。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 DOI: 10.1016/j.cub.2025.07.076

David L Hu

引用次数: 0

The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration. KASH蛋白UNC-83通过调控激酶1活性来控制发育阶段特异性核迁移。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-08 DOI: 10.1016/j.cub.2025.08.025

Selin Gümüşderelioğlu, Natalie Sahabandu, Daniel Elnatan, Ellen F Gregory, Kyoko Chiba, Shinsuke Niwa, G W Gant Luxton, Richard J McKenney, Daniel A Starr

{"title":"The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration.","authors":"Selin Gümüşderelioğlu, Natalie Sahabandu, Daniel Elnatan, Ellen F Gregory, Kyoko Chiba, Shinsuke Niwa, G W Gant Luxton, Richard J McKenney, Daniel A Starr","doi":"10.1016/j.cub.2025.08.025","DOIUrl":"https://doi.org/10.1016/j.cub.2025.08.025","url":null,"abstract":"Nuclear migration plays a fundamental role in development, requiring precise spatiotemporal control of bidirectional movement through dynein and kinesin motors. Here, we uncover a differential isoform-dependent mechanism for developmental regulation of nuclear migration directionality. The nuclear envelope Klarsicht/ANC-1/Syne homology (KASH) protein UNC-83 in Caenorhabditis elegans exists in multiple isoforms that differentially control motor activity to achieve tissue-specific nuclear positioning. The shorter UNC-83c isoform promotes kinesin-1-dependent nuclear movement in embryonic hyp7 precursors, while longer UNC-83a/b isoforms facilitate dynein-mediated nuclear migration in larval P cells. We demonstrate that the UNC-83a-specific N-terminal domain functions as a kinesin-1 inhibitory module by directly binding the kinesin heavy chain (UNC-116). This interaction prevents kinesin-1 activation and reduces the protein's affinity for kinesin light chain (KLC-2), allowing for dynein-mediated transport. By contrast, UNC-83c exhibits high-affinity binding to KLC-2, promoting kinesin-1 activation for plus-end-directed movement. AlphaFold structural predictions reveal that UNC-83 contains five spectrin-like repeats, with two located within the inhibitory N-terminal domain. Genetic analysis demonstrates that these spectrin-like repeats are essential for dynein-dependent P cell nuclear migration but dispensable for kinesin-1-dependent hyp7 migration. This isoform-specific inhibition, combined with differential affinity for KLC-2, establishes a mechanism for achieving directional control of nuclear positioning during development. Together, these interdisciplinary studies reveal how alternative isoforms of cargo adaptors can generate developmental stage-specific regulation of motor activity.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0