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Pollination chemistry: Roadmaps to reproduction or how to get lost. 授粉化学:繁殖的路线图或如何迷路。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 DOI: 10.1016/j.cub.2025.02.020
Björn Bohman
{"title":"Pollination chemistry: Roadmaps to reproduction or how to get lost.","authors":"Björn Bohman","doi":"10.1016/j.cub.2025.02.020","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.020","url":null,"abstract":"<p><p>Chemical analyses of volatile organic compounds in flowers and nectar, combined with extensive behavioural bioassays, reveal complex roles for these compounds in olfaction and gustation, providing novel insights into plant pollination and nectar robbing.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"35 7","pages":"R249-R251"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered proportions of retinal cell types and distinct visual codes in rodents occupying divergent ecological niches. 占据不同生态位的啮齿动物视网膜细胞类型和不同视觉编码的改变比例。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 Epub Date: 2025-03-04 DOI: 10.1016/j.cub.2025.02.014
Annette E Allen, Joshua Hahn, Rose Richardson, Andreea Pantiru, Josh Mouland, Aadhithyan Babu, Beatriz Baño-Otalora, Aboozar Monavarfeshani, Wenjun Yan, Christopher Williams, Jonathan Wynne, Jessica Rodgers, Nina Milosavljevic, Patrycja Orlowska-Feuer, Riccardo Storchi, Joshua R Sanes, Karthik Shekhar, Robert J Lucas
{"title":"Altered proportions of retinal cell types and distinct visual codes in rodents occupying divergent ecological niches.","authors":"Annette E Allen, Joshua Hahn, Rose Richardson, Andreea Pantiru, Josh Mouland, Aadhithyan Babu, Beatriz Baño-Otalora, Aboozar Monavarfeshani, Wenjun Yan, Christopher Williams, Jonathan Wynne, Jessica Rodgers, Nina Milosavljevic, Patrycja Orlowska-Feuer, Riccardo Storchi, Joshua R Sanes, Karthik Shekhar, Robert J Lucas","doi":"10.1016/j.cub.2025.02.014","DOIUrl":"10.1016/j.cub.2025.02.014","url":null,"abstract":"<p><p>Vertebrate retinas share a basic blueprint comprising 5 neuronal classes arranged according to a common wiring diagram. Yet, vision is aligned with species differences in behavior and ecology, raising the question of how evolution acts on this circuit to adjust its computational characteristics. We address that problem by comparing the thalamic visual code and retinal cell composition in closely related species occupying different niches: Rhabdomys pumilio, which are day-active murid rodents, and nocturnal laboratory mice (Mus musculus). Using high-density electrophysiological recordings, we compare visual responses at both single-unit and population levels in the thalamus of these two species. We find that Rhabdomys achieves a higher spatiotemporal resolution visual code through the selective expansion of information channels characterized by non-linear spatiotemporal summation. Comparative analysis of single-cell transcriptomic atlases reveals that this difference originates with the increased relative abundance of retinal bipolar and ganglion cell types supporting OFF and ON-OFF responses. These findings demonstrate that evolution may drive changes in neural computation by adjusting the proportions of shared cell types rather than inventing new types and show the power of matching high-density physiological recordings with transcriptomic cell atlases to study evolution in the brain.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1446-1458.e5"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycology: A gene to go ballistic. 真菌学:一种会爆炸的基因。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 DOI: 10.1016/j.cub.2025.02.058
Soleil E Young, Anne Pringle
{"title":"Mycology: A gene to go ballistic.","authors":"Soleil E Young, Anne Pringle","doi":"10.1016/j.cub.2025.02.058","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.058","url":null,"abstract":"<p><p>Spore launch is the ultimate job of a mushroom, but the genetics of spore development are poorly understood. A new study describes the discovery of a basidiomycete gene shaping spore formation, and it may facilitate new research on fungal dispersal.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"35 7","pages":"R254-R255"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction, inference, and generalization in orbitofrontal cortex. 眶额叶皮质的预测、推断和泛化。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 DOI: 10.1016/j.cub.2025.02.021
Fengjun Ma, Huixin Lin, Jingfeng Zhou
{"title":"Prediction, inference, and generalization in orbitofrontal cortex.","authors":"Fengjun Ma, Huixin Lin, Jingfeng Zhou","doi":"10.1016/j.cub.2025.02.021","DOIUrl":"https://doi.org/10.1016/j.cub.2025.02.021","url":null,"abstract":"<p><p>Our understanding of the orbitofrontal cortex (OFC) has significantly evolved over the past few decades. This prefrontal region has been associated with a wide range of cognitive functions, including a popular view that it primarily signals the expected value of each possible option, allowing downstream areas to use these value signals for decision-making. However, the discovery of rich, task-related information within the OFC and its essential role in inference-based behaviors has shifted our perspective and led to the proposal that the OFC holds a cognitive map used by both humans and animals for making predictions and inferences. Recent studies have further shown that these cognitive maps can be abstracted and generalized, serving both immediate and future needs. In this review, we trace the research journey leading to these evolving insights, discuss the potential neural mechanisms supporting the OFC's roles in prediction, inference, and generalization, and compare the OFC with the hippocampus, another critical region for cognitive mapping, while also exploring the interactions between these two areas.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"35 7","pages":"R266-R272"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear exclusion of condensin I in prophase coordinates mitotic chromosome reorganization to ensure complete sister chromatid resolution. 核排斥凝聚蛋白I在前期协调有丝分裂染色体重组,以确保完整的姐妹染色单体的分解。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 Epub Date: 2025-03-18 DOI: 10.1016/j.cub.2025.02.047
John K Eykelenboom, Marek Gierliński, Zuojun Yue, Tomoyuki U Tanaka
{"title":"Nuclear exclusion of condensin I in prophase coordinates mitotic chromosome reorganization to ensure complete sister chromatid resolution.","authors":"John K Eykelenboom, Marek Gierliński, Zuojun Yue, Tomoyuki U Tanaka","doi":"10.1016/j.cub.2025.02.047","DOIUrl":"10.1016/j.cub.2025.02.047","url":null,"abstract":"<p><p>During early mitosis, chromosomes transition from their unfolded interphase state to the distinct rod-shaped structures characteristic of mitosis. This process allows correct segregation of replicated sister chromatids to the opposite spindle poles during anaphase. Two protein complexes, named condensin I and condensin II, facilitate mitotic chromosome organization. Condensin II is important for achieving sister chromatid separation (resolution), while condensin I is required for chromosome condensation (folding). Although sister chromatid resolution occurs earlier than chromosome folding, it is not yet clear how these events are coordinated through time or whether this is important for correct chromosome segregation. In this study, we tested the hypothesis that temporal control is achieved through differential localization of the two condensin complexes; i.e., while condensin II localizes in the nucleus, condensin I is excluded from the nucleus in interphase and prophase. We engineered the localization of condensin I to the nucleus and monitored sister chromatid resolution and chromosome folding by real-time imaging. We found that localization of condensin I to the nucleus led to precocious chromosome folding during prophase, with similar timing to sister chromatid resolution. Furthermore, this change led to incomplete sister chromatid resolution in prometaphase/metaphase and frequent chromosome missegregation in anaphase, in which most missegregated chromosomes consisted of lagging chromosomes involving both sister chromatids. We conclude that, in a physiological context, the exclusion of condensin I from the nucleus during prophase delays chromosome folding and allows condensin II to complete sister chromatid resolution, which ensures correct chromosome segregation later in mitosis.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1562-1575.e7"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An evolutionarily ancient transcription factor drives spore morphogenesis in mushroom-forming fungi. 一种进化上古老的转录因子驱动蘑菇形成真菌的孢子形态发生。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 Epub Date: 2025-03-11 DOI: 10.1016/j.cub.2025.02.025
Zhihao Hou, Zsolt Merényi, Yashu Yang, Yan Zhang, Árpád Csernetics, Balázs Bálint, Botond Hegedüs, Csenge Földi, Hongli Wu, Zsolt Kristóffy, Edit Ábrahám, Nikolett Miklovics, Máté Virágh, Xiao-Bin Liu, Nikolett Zsibrita, Zoltán Lipinszki, Ildikó Karcagi, Wei Gao, László G Nagy
{"title":"An evolutionarily ancient transcription factor drives spore morphogenesis in mushroom-forming fungi.","authors":"Zhihao Hou, Zsolt Merényi, Yashu Yang, Yan Zhang, Árpád Csernetics, Balázs Bálint, Botond Hegedüs, Csenge Földi, Hongli Wu, Zsolt Kristóffy, Edit Ábrahám, Nikolett Miklovics, Máté Virágh, Xiao-Bin Liu, Nikolett Zsibrita, Zoltán Lipinszki, Ildikó Karcagi, Wei Gao, László G Nagy","doi":"10.1016/j.cub.2025.02.025","DOIUrl":"10.1016/j.cub.2025.02.025","url":null,"abstract":"<p><p>Sporulation is the most widespread means of reproduction and dispersal in fungi and, at the same time, an industrially important trait in crop mushrooms. In the Basidiomycota, sexual spores are produced on specialized cells known as basidia, from which they are forcibly discharged with the highest known acceleration in nature. However, the genetics of sporulation remains poorly known. Here, we identify a new, highly conserved transcription factor, sporulation-related regulator 1 (srr1), and systematically address the genetics of spore formation for the first time in the Basidiomycota. We show that Srr1 regulates postmeiotic spore morphogenesis, but not other aspects of fruiting body development or meiosis, and its role is conserved in the phylogenetically distant, but industrially important, Pleurotus spp. (oyster mushrooms). We used RNA sequencing to understand genes directly or indirectly regulated by Srr1 and identified a strongly supported binding motif for the protein. Using an inferred network of putative target genes regulated by Srr1 and comparative genomics, we identified genes lost in secondarily non-ballistosporic taxa, including a novel sporulation-specific chitinase gene. Overall, our study offers systematic insights into the genetics of spore morphogenesis in the Basidiomycota.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1470-1483.e5"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific neurons instruct sexually dimorphic neurite branching via Netrin signaling in Caenorhabditis elegans. 秀丽隐杆线虫的性别特异性神经元通过Netrin信号传导指导两性二态神经突分支。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 Epub Date: 2025-03-17 DOI: 10.1016/j.cub.2025.02.050
Dongyoung Kim, HoYong Jin, Da-Hyun Kang, Byunghyuk Kim
{"title":"Sex-specific neurons instruct sexually dimorphic neurite branching via Netrin signaling in Caenorhabditis elegans.","authors":"Dongyoung Kim, HoYong Jin, Da-Hyun Kang, Byunghyuk Kim","doi":"10.1016/j.cub.2025.02.050","DOIUrl":"10.1016/j.cub.2025.02.050","url":null,"abstract":"<p><p>Animals often exhibit sexually dimorphic behavior in mating, learning, and decision-making. These sexual dimorphisms arise due to sex differences in the structure and function of neural circuits, but how sexually dimorphic neural circuits are established remains less understood. In the nematode C. elegans, both males and hermaphrodites possess a set of sex-shared neurons with sexually dimorphic features that contribute to the observed sex differences in neural connectivity. Here, we focused on the motor neuron preanal cell body dorsal axon B (PDB) to investigate the molecular mechanism underlying sexually dimorphic neurite branching. The PDB neuron exhibits extensive neurite branches near the cell body in males but not in hermaphrodites. By manipulating the sexual identity of PDB neurons, we discovered that neurite branching is influenced by both cell-autonomous and non-autonomous factors. We found that the UNC-6/Netrin signaling is crucial for the elaborate PDB neurite branching in males. Specifically, UNC-6/Netrin, expressed in a set of male-specific neurons, induces the formation of PDB neurite branches. The cognate receptor UNC-40/deleted in colorectal cancer (DCC), located in the PDB neurites, plays a role in mediating neurite branching in response to the UNC-6/Netrin cue. Furthermore, we show that males with aberrant PDB neurite branches exhibit defects in male mating behavior, particularly in coordinating movements required for successful mating. Our findings provide insights into the establishment of sexually dimorphic neural circuits, demonstrating how an evolutionarily conserved molecular cue and its receptor can be utilized in this process.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1591-1600.e5"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial heterozygosity promotes survival under multidrug selection. 细菌杂合性促进多药选择下的生存。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 Epub Date: 2025-03-03 DOI: 10.1016/j.cub.2025.02.012
Shraddha Shitut, Thomas van Dijk, Dennis Claessen, Daniel Rozen
{"title":"Bacterial heterozygosity promotes survival under multidrug selection.","authors":"Shraddha Shitut, Thomas van Dijk, Dennis Claessen, Daniel Rozen","doi":"10.1016/j.cub.2025.02.012","DOIUrl":"10.1016/j.cub.2025.02.012","url":null,"abstract":"<p><p>Although bacterial cells typically contain a single chromosome, some species are naturally polyploid and carry multiple copies of their chromosome. Polyploid chromosomes can be identical or heterogeneous, the latter giving rise to bacterial heterozygosity. Although the benefits of heterozygosity are well studied in eukaryotes, its consequences in bacteria are less understood. Here, we examine this question in the context of antibiotic resistance to understand how bacterial genomic heterozygosity affects bacterial survival. Using a cell-wall-deficient model system in the actinomycete Kitasatospora viridifaciens, we found that heterozygous cells that contain different chromosomes expressing different antibiotic resistance markers persist across a broad range of antibiotic concentrations. Recombinant cells containing the same resistance genes on a single chromosome also survive these conditions, but these cells pay a significant fitness cost due to the constitutive expression of these genes. By contrast, heterozygous cells can mitigate these costs by flexibly adjusting the ratio of their different chromosomes, thereby allowing rapid responses in temporally and spatially variable environments. Our results provide evidence that bacterial heterozygosity can increase adaptive plasticity in bacterial cells in a similar manner to the evolutionary benefits provided by multicopy plasmids in bacteria.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1437-1445.e3"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian control in the timing of critical periods during Drosophila larval neuronal development. 果蝇幼虫神经元发育关键时期的昼夜节律控制。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 Epub Date: 2025-03-24 DOI: 10.1016/j.cub.2025.02.054
Sarah Doran, Adam A Bradlaugh, Jack Corke, Richard A Baines
{"title":"Circadian control in the timing of critical periods during Drosophila larval neuronal development.","authors":"Sarah Doran, Adam A Bradlaugh, Jack Corke, Richard A Baines","doi":"10.1016/j.cub.2025.02.054","DOIUrl":"10.1016/j.cub.2025.02.054","url":null,"abstract":"<p><p>Developing neural circuits are maximally open to modification during defined critical periods (CPs).<sup>1</sup><sup>,</sup><sup>2</sup><sup>,</sup><sup>3</sup><sup>,</sup><sup>4</sup> We previously identified a CP in the Drosophila embryo, from 17 to 19 h after egg laying (AEL), during which activity manipulation (optogenetic and/or pharmacological) permanently alters locomotor network stability.<sup>5</sup><sup>,</sup><sup>6</sup> Analysis of excitatory and inhibitory inputs to an identified motoneuron shows that CP activity manipulation preferentially enhances excitation.<sup>7</sup> This effect is permanent, persisting through to third instars (5 days post manipulation). A manifestation of this effect is a marked increase in seizure recovery time (RT) in response to an electric shock. The induced seizure results in immediate paralysis, followed by uncoordinated peristalsis until the larva recovers sufficiently to move away from its original position (i.e., the seizure endpoint).<sup>6</sup> Significantly, exposure to blue light (BL) during this same embryonic temporal window is similarly able to lead to an increased seizure RT, an effect that requires the presence of CRYPTOCHROME (CRY).<sup>8</sup> Here, we identify a series of BL-sensitive CPs, occurring at ∼24-h intervals, from embryogenesis through larval development. Exposure to BL during these CPs increases the time taken for wandering larvae to recover from electroshock-induced seizure activity. This effect is absent when CRY or the principal clock-signaling neuropeptide-pigment-dispersing factor (PDF)-is absent. Thus, we uncover a novel role for the circadian clock during the embryonic and larval stages of Drosophila neural development.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1665-1671.e3"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonlinear high-activity neuronal excitation enhances odor discrimination. 非线性高活性神经元兴奋增强气味识别。
IF 8.1 1区 生物学
Current Biology Pub Date : 2025-04-07 Epub Date: 2025-03-18 DOI: 10.1016/j.cub.2025.02.034
Julia E Manoim-Wolkovitz, Tal Camchy, Eyal Rozenfeld, Hao-Hsin Chang, Hadas Lerner, Ya-Hui Chou, Ran Darshan, Moshe Parnas
{"title":"Nonlinear high-activity neuronal excitation enhances odor discrimination.","authors":"Julia E Manoim-Wolkovitz, Tal Camchy, Eyal Rozenfeld, Hao-Hsin Chang, Hadas Lerner, Ya-Hui Chou, Ran Darshan, Moshe Parnas","doi":"10.1016/j.cub.2025.02.034","DOIUrl":"10.1016/j.cub.2025.02.034","url":null,"abstract":"<p><p>Discrimination between different signals is crucial for animals' survival. Inhibition that suppresses weak neural activity is crucial for pattern decorrelation. Our understanding of alternative mechanics that allow efficient signal classification remains incomplete. We show that Drosophila olfactory receptor neurons (ORNs) have numerous intraglomerular axo-axonal connections mediated by the G protein-coupled receptor (GPCR), muscarinic type B receptor (mAChR-B). Contrary to its usual inhibitory role, mAChR-B participates in ORN excitation. The excitatory effect of mAChR-B only occurs at high ORN firing rates. A computational model demonstrates that nonlinear intraglomerular or global excitation decorrelates the activity patterns of ORNs of different types and improves odor classification and discrimination, while acting in concert with the previously known inhibition. Indeed, knocking down mAChR-B led to increased correlation in odor-induced ORN activity, which was associated with impaired odor discrimination, as shown in behavioral experiments. Furthermore, knockdown (KD) of mAChR-B and the GABAergic GPCR, GABAB-R, has an additive behavioral effect, causing reduced odor discrimination relative to single-KD flies. Together, this study unravels a novel mechanism for neuronal pattern decorrelation, which is based on nonlinear intraglomerular excitation.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1521-1538.e5"},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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