Current Biology最新文献_第2页

Animal physiology: How do tardigrades survive intense radiation?

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 DOI: 10.1016/j.cub.2025.01.057

Bob Goldstein

引用次数: 0

Epithelial biology: Holding the corners together.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 DOI: 10.1016/j.cub.2025.02.023

Tara M Finegan

引用次数: 0

Detection and neural encoding of whisker-generated sounds in mice.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 Epub Date: 2025-02-19 DOI: 10.1016/j.cub.2025.01.061

Ben Efron, Athanasios Ntelezos, Yonatan Katz, Ilan Lampl

{"title":"Detection and neural encoding of whisker-generated sounds in mice.","authors":"Ben Efron, Athanasios Ntelezos, Yonatan Katz, Ilan Lampl","doi":"10.1016/j.cub.2025.01.061","DOIUrl":"10.1016/j.cub.2025.01.061","url":null,"abstract":"The vibrissa system of mice and other rodents enables active sensing via whisker movements and is traditionally considered a purely tactile system. Here, we ask whether whisking against objects produces audible sounds and whether mice are capable of perceiving these sounds. We found that whisking by head-fixed mice against objects produces audible sounds well within their hearing range. We recorded neural activity in the auditory cortex of mice in which we had abolished vibrissae tactile sensation and found that the firing rate of auditory neurons was strongly modulated by whisking against objects. Furthermore, the object's identity could be reliably decoded from the population's neuronal activity and closely matched the decoding patterns derived from sounds that were recorded simultaneously, suggesting that neuronal activity reflects acoustic information. Lastly, trained mice, in which vibrissae tactile sensation was abolished, were able to accurately identify objects solely based on the sounds produced during whisking. Our results suggest that, beyond its traditional role as a tactile sensory system, the vibrissa system of rodents engages both tactile and auditory modalities in a multimodal manner during active exploration.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1211-1226.e8"},"PeriodicalIF":8.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translocations spur population growth but fail to prevent genetic erosion in imperiled Florida Scrub-Jays. 迁移刺激了种群增长，但未能防止濒危的佛罗里达缩鸦的基因侵蚀。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 Epub Date: 2025-02-27 DOI: 10.1016/j.cub.2025.01.058

Tyler Linderoth, Lauren Deaner, Nancy Chen, Reed Bowman, Raoul K Boughton, Sarah W Fitzpatrick

{"title":"Translocations spur population growth but fail to prevent genetic erosion in imperiled Florida Scrub-Jays.","authors":"Tyler Linderoth, Lauren Deaner, Nancy Chen, Reed Bowman, Raoul K Boughton, Sarah W Fitzpatrick","doi":"10.1016/j.cub.2025.01.058","DOIUrl":"10.1016/j.cub.2025.01.058","url":null,"abstract":"Land and natural resource use in addition to climate change can restrict populations to degraded and fragmented habitats, catalyzing extinction through the reinforced interplay of small population size and genetic decay. Translocating individuals is a powerful strategy for overcoming direct threats from human development and reconnecting isolated populations but is not without risks.1 Habitat Management Plan analyses under section 7 of the U.S. Endangered Species Act determined that multiple subpopulations of Federally Threatened Florida Scrub-Jays (Aphelocoma coerulescens, hereafter FSJ) belonging to a metapopulation on Florida's west coast were declining demographic sinks, occupying areas where agriculture and fire suppression had degraded and fragmented the habitat.2 In order to increase the viability of the overall metapopulation, 51 FSJs from five of these small subpopulations in areas to be mined were translocated throughout 2003-2010 into a larger site of more contiguous, recently restored habitat at the core of the metapopulation, which contained a small resident population.3 Prior to translocations and for nearly two decades afterward, this core population, referred to as the M4 core region (CR) population, was extensively monitored, yielding a nearly complete pedigree. We used this pedigree, along with temporal genomic analyses and simulations, to show that translocations coupled with habitat restoration generated rapid population growth, but high reproductive skew increased inbreeding and led to genetic erosion. This mechanistic understanding of mixed conservation outcomes highlights the importance of monitoring and the potential need for genetic rescue to offset consequences of reproductive skew following translocations, regardless of demographic recovery.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1391-1399.e6"},"PeriodicalIF":8.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animal camouflage: Sculpting with light.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 DOI: 10.1016/j.cub.2025.01.067

Daniel Osorio, Hannah E Smithson, Lucas Wilkins

引用次数: 0

A new member of the dynamin superfamily modulates mitochondrial membrane branching in Trypanosoma brucei.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 Epub Date: 2025-03-12 DOI: 10.1016/j.cub.2025.02.033

Chloé Alexandra Morel, Corinne Asencio, David Moreira, Corinne Blancard, Bénédicte Salin, Etienne Gontier, Stéphane Duvezin-Caubet, Manuel Rojo, Frédéric Bringaud, Emmanuel Tetaud

{"title":"A new member of the dynamin superfamily modulates mitochondrial membrane branching in Trypanosoma brucei.","authors":"Chloé Alexandra Morel, Corinne Asencio, David Moreira, Corinne Blancard, Bénédicte Salin, Etienne Gontier, Stéphane Duvezin-Caubet, Manuel Rojo, Frédéric Bringaud, Emmanuel Tetaud","doi":"10.1016/j.cub.2025.02.033","DOIUrl":"10.1016/j.cub.2025.02.033","url":null,"abstract":"Unlike most other eukaryotes, where mitochondria continuously fuse and divide, the mitochondrion of trypanosome cells forms a single and continuously interconnected network that divides only during cytokinesis. However, the machinery governing mitochondrial remodeling and interconnection of trypanosome mitochondrion remain largely unknown. We functionally characterize a new member of the dynamin superfamily protein (DSP) from T. brucei (TbMfnL), which shares similarity with a family of homologs present in various eukaryotic and prokaryotic phyla but not in opisthokonts like mammals and budding yeast. The sequence and domain organization of TbMfnL is distinct, and it is phylogenetically very distant from the yeast and mammalian dynamin-related proteins involved in mitochondrial fusion/fission dynamics, such as optic atrophy 1 (Opa1) and mitofusin (Mfn). TbMfnL localizes to the inner mitochondrial membrane facing the matrix and, upon overexpression, induces a strong increase in the interconnection and branching of mitochondrial filaments in a GTPase-dependent manner. TbMfnL is a component of a novel membrane remodeling machinery with an unprecedented matrix-side localization that is able to modulate the degree of inter-mitochondrial connections.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1337-1352.e5"},"PeriodicalIF":8.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymmetric microtubule nucleation from Golgi stacks promotes opposite microtubule polarity in axons and dendrites.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 Epub Date: 2025-03-03 DOI: 10.1016/j.cub.2025.02.013

Akila Yagoubat, Paul T Conduit

{"title":"Asymmetric microtubule nucleation from Golgi stacks promotes opposite microtubule polarity in axons and dendrites.","authors":"Akila Yagoubat, Paul T Conduit","doi":"10.1016/j.cub.2025.02.013","DOIUrl":"10.1016/j.cub.2025.02.013","url":null,"abstract":"The neuronal microtubule cytoskeleton is highly polarized, with most microtubules growing away from the soma in axons (plus-end-out), but many microtubules growing toward the soma in dendrites (minus-end-out). This differential microtubule polarity allows directional trafficking of specific organelles, vesicles, and molecules into either axons or dendrites, but how it is established and maintained remains unclear. We showed previously that microtubules are nucleated asymmetrically from Golgi stacks within the soma of Drosophila neurons, with their plus ends growing preferentially toward and into axons and away from dendrites. Here, we show that this microtubule nucleation asymmetry correlates with a cis-to-trans orientation of specific Golgi stacks toward the axon and depends on microtubule-nucleating γ-tubulin ring complexes (γ-TuRCs) at the cis-Golgi and the plus-end-stabilizing protein CLASP at the trans-Golgi. Depleting CLASP or reducing γ-TuRC localization to the Golgi by depleting the Golgin protein GMAP (Golgi microtubule-associated protein) perturbs asymmetric microtubule nucleation and growth within the soma and results in polarity changes in proximal axons and dendrites. We propose that the plus ends of microtubules nucleated by γ-TuRCs at the cis-Golgi are stabilized by CLASP at the trans-Golgi to promote the growth of microtubules along the cis-to-trans Golgi axis. This, coupled with oriented Golgi stacks, promotes microtubule growth toward and into axons and away from dendrites, helping promote plus-end-out microtubule polarity in axons and maintain minus-end-out microtubule polarity in dendrites.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1311-1325.e4"},"PeriodicalIF":8.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cohesinopathies: Is enhancer disruption to blame?

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 DOI: 10.1016/j.cub.2025.01.046

Thomas M Guérin, Frank Uhlmann

引用次数: 0

Paleobiology: Drilling for the drivers of the Cambrian explosion.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 DOI: 10.1016/j.cub.2025.02.018

Simon A F Darroch, Michelle C Casey

引用次数: 0

Ecophysical constraints on avian adaptation and diversification.

IF 8.1 1区生物学

Current Biology Pub Date : 2025-03-24 Epub Date: 2025-03-04 DOI: 10.1016/j.cub.2025.02.015

Ferran Sayol, Bouwe R Reijenga, Joseph A Tobias, Alex L Pigot

{"title":"Ecophysical constraints on avian adaptation and diversification.","authors":"Ferran Sayol, Bouwe R Reijenga, Joseph A Tobias, Alex L Pigot","doi":"10.1016/j.cub.2025.02.015","DOIUrl":"10.1016/j.cub.2025.02.015","url":null,"abstract":"The evolution of morphological diversity is ultimately governed by physical laws and ecological contexts, which together impose a range of ecophysical constraints. Substantial progress has been made in identifying how these constraints shape the form and function of producers (plants), but similar knowledge is lacking for consumers, in part because the requisite data have not been available at sufficient scale for animals. Using morphometric measurements for all birds, we demonstrate that observed variation is restricted-both for beak shape and body shape-to triangular regions of morphospace with clearly defined boundaries and vertices (corners). By combining morphometric data with information on ecological and behavioral functions, we provide evidence that the extent of avian morphospace reflects a trade-off between three fundamental physical tasks for feeding (crush, engulf, and reach) that characterize resource acquisition and processing by the beak and three physical tasks (fly, swim, and walk) that characterize avian lifestyles or locomotion. Phylogenetic analyses suggest that trajectories of morphological evolution trend toward the vertices, with lineages evolving from a core of functional generalists toward more specialized physical tasks. We further propose that expansion beyond the current boundaries of morphospace is constrained by the shorter evolutionary lifespan of functional specialists, although patterns of speciation rate and current extinction risk provide only weak support for this hypothesis. Overall, we show that the structure of avian morphospace follows relatively simple rules defined by ecophysical constraints and trade-offs, shedding light on the processes shaping modern animal diversity and responses to environmental change.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"1326-1336.e6"},"PeriodicalIF":8.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0