Current Biology最新文献_第3页

Manvir Singh. Manvir辛格。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 DOI: 10.1016/j.cub.2025.08.012

Manvir Singh

引用次数: 0

Animal communication: When rivers roar, dippers switch channels. 动物交流：当河流咆哮时，下水者会转换河道。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 DOI: 10.1016/j.cub.2025.08.017

Hans Slabbekoorn

引用次数: 0

Diverse and flexible strategies enable successful cooperation in marmoset dyads. 多样而灵活的策略使狨猴的合作成功。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 Epub Date: 2025-08-28 DOI: 10.1016/j.cub.2025.08.005

Olivia C Meisner, Weikang Shi, Amrita Nair, Gargi Nandy, Monika P Jadi, Anirvan S Nandy, Steve W C Chang

引用次数: 0

Conservation: Sequencing and saving the Saola? 保护：排序和拯救绍拉？

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 DOI: 10.1016/j.cub.2025.07.086

Uma Ramakrishnan

引用次数: 0

Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates. 非人类灵长类动物苍白球外段兴奋驱动促进动作启动。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 Epub Date: 2025-08-14 DOI: 10.1016/j.cub.2025.07.051

Atsushi Yoshida, Okihide Hikosaka

{"title":"Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates.","authors":"Atsushi Yoshida, Okihide Hikosaka","doi":"10.1016/j.cub.2025.07.051","DOIUrl":"10.1016/j.cub.2025.07.051","url":null,"abstract":"The external segment of the globus pallidus (GPe) has been conventionally regarded as a key relay in the indirect pathway of the basal ganglia, primarily mediating movement suppression. However, recent studies in rodents suggest a more complex role, including active facilitation of actions. Here, we investigated whether the primate GPe exhibits similar functional diversity by recording single-unit activity in two macaque monkeys performing a novel sequential choice task. This task separated the process of action initiation and suppression by requiring the monkeys to either accept a \"good\" object for reward or reject a \"bad\" object using one of multiple strategies. We identified three distinct neuronal clusters based on their firing patterns. Clusters 1 and 2 were linked to action facilitation: cluster 1 increased activity for saccades to both object types, while cluster 2 was selectively active for good-object saccades and suppressed during rejections-similar to cluster 3, which showed suppression during bad-object rejection. Local pharmacological blockade of glutamate receptors within the caudal dorsal GPe prolonged saccade latencies and reduced the frequency of rejection saccades, confirming a causal role for excitatory drive in saccade facilitation. These findings expand the traditional view of the GPe beyond a purely inhibitory station, indicating that in primates, it simultaneously mediates both motor facilitation and proactive suppression. Our results emphasize the importance of characterizing circuit-specific and cell-type-specific roles of the GPe within basal ganglia networks, with implications for normal motor function and movement disorder pathophysiology under complex reward-based decision processes in non-human primates.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4321-4336.e6"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nuclear-cytoplasmic ratio controls the cell-cycle period in compartmentalized frog egg extract. 区隔化蛙卵提取液的核质比控制细胞周期。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 Epub Date: 2025-08-26 DOI: 10.1016/j.cub.2025.07.075

Liliana Piñeros, Nikita Frolov, Daniel Ruiz-Reynés, Aleyde Van Eynde, Gabriel Cavin-Meza, Rebecca Heald, Lendert Gelens

{"title":"The nuclear-cytoplasmic ratio controls the cell-cycle period in compartmentalized frog egg extract.","authors":"Liliana Piñeros, Nikita Frolov, Daniel Ruiz-Reynés, Aleyde Van Eynde, Gabriel Cavin-Meza, Rebecca Heald, Lendert Gelens","doi":"10.1016/j.cub.2025.07.075","DOIUrl":"10.1016/j.cub.2025.07.075","url":null,"abstract":"Each proliferating cell replicates its DNA and internal components before distributing this material evenly to its daughters. Although the regulation of cyclin-dependent kinases (Cdks) that dictate orderly cell-cycle progression is well characterized, how the subcellular localization of the cell-cycle machinery contributes to timing is not well understood. We investigated the influence of the nucleus by reconstituting cell-cycle oscillations in droplets of frog egg extract in the absence or presence of a nuclear compartment and monitoring dynamics by time-lapse microscopy. We found that the cell-cycle time increased in the presence of nuclei, which grew larger with each cell cycle. The correlation between increasing nuclear volume and a longer cell-cycle period was maintained across extracts and nuclei from various Xenopus species and persisted upon inhibition of DNA replication or transcription. However, inhibition of nuclear import or the kinase Wee1 impacted the relationship between the nuclear-cytoplasmic ratio and the cell-cycle period. To conceptually capture these experimental observations, we developed a computational model that incorporates cell-cycle oscillations, nuclear-cytoplasmic compartmentalization, and periodic nuclear envelope breakdown and reformation. Altogether, our results support the major role of the nuclear compartment in setting the pace of the cell cycle and provide an explanation for the increase in cell-cycle length observed at the midblastula transition when cells become smaller and the nuclear-cytoplasmic ratio increases.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4426-4441.e6"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-specific regulation of sociability by hypothalamic Agrp neurons. 下丘脑Agrp神经元对社交能力的年龄特异性调节。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 Epub Date: 2025-09-03 DOI: 10.1016/j.cub.2025.08.014

Onur Iyilikci, Lucas Kim, Marcelo R Zimmer, Jeremy Bober, Yuexuan Li, Macy Pelts, Gustavo M Santana, Marcelo O Dietrich

{"title":"Age-specific regulation of sociability by hypothalamic Agrp neurons.","authors":"Onur Iyilikci, Lucas Kim, Marcelo R Zimmer, Jeremy Bober, Yuexuan Li, Macy Pelts, Gustavo M Santana, Marcelo O Dietrich","doi":"10.1016/j.cub.2025.08.014","DOIUrl":"10.1016/j.cub.2025.08.014","url":null,"abstract":"Social isolation enhances sociability, suggesting that social behavior is maintained through a homeostatic mechanism. Further, mammalian social needs shift dramatically from infancy through adolescence into adulthood, raising the question of whether the neural mechanisms governing this homeostatic regulation evolve across developmental stages. Here, we show that agouti-related peptide (Agrp) neurons in the arcuate nucleus of the hypothalamus, which are known to drive hunger in adults, are activated by social isolation from weaning through adolescence but not in adulthood. Importantly, the activity of these neurons is critical for social behavior during adolescence: inhibiting Agrp neurons reduced isolation-induced sociability in juveniles, but not in adults, and Agrp neuron activation promoted sociability only in young mice. After isolation, reunion with siblings or other conspecifics, but not unfamiliar adult males or amicable rat pups, rapidly decreased neuronal activity in juveniles, an effect requiring intact olfaction. These findings identify Agrp neurons as a key component of the circuitry governing age-specific social homeostasis.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4522-4536.e6"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local regulation of auxin-related pathways in the shoot apical meristem plays a major role during proliferative arrest. 茎尖分生组织中生长素相关通路的局部调控在增殖阻滞过程中起重要作用。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 Epub Date: 2025-09-09 DOI: 10.1016/j.cub.2025.07.065

Irene González-Cuadra, Cristina Ferrándiz, Paz Merelo

{"title":"Local regulation of auxin-related pathways in the shoot apical meristem plays a major role during proliferative arrest.","authors":"Irene González-Cuadra, Cristina Ferrándiz, Paz Merelo","doi":"10.1016/j.cub.2025.07.065","DOIUrl":"10.1016/j.cub.2025.07.065","url":null,"abstract":"The end of flowering is determined by the proliferative arrest process (PA), which takes place after the production of a certain number of flowers and fruits and entails the cessation of all reproductive meristem activity. In this manner, PA guarantees the proper size and viability of offspring before plant death. PA regulation involves a complex interplay of genetic, hormonal, and environmental factors. But still, the molecular mechanisms that govern PA and their spatiotemporal coordination remain poorly understood. Here, we show that the repression of auxin transport and response in the shoot apical meristem (SAM), along with a local reduction of auxin biosynthesis and auxin content, promotes PA. Moreover, our results suggest that auxin and cytokinin pathways must be coordinated in the SAM during PA. Comparative analyses of auxin-related reporters in the SAM of fruitfull (ful) mutants, which fail to undergo PA, and after FUL induction in active meristems, indicate that FUL promotes meristem arrest at least in part by repressing auxin-related pathways. Altogether, our results indicate that local auxin biosynthesis in the SAM, as well as its transport and response, are key in the control of PA.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4394-4407.e3"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collective migration: Galvanotaxis in field-tested teams. 集体迁移：实地测试团队中的电流趋向性。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 DOI: 10.1016/j.cub.2025.07.082

Lucija Mijanovic, Robert H Insall

引用次数: 0

Global patterns of diversity and distribution in Aspergillus fungi are driven by human and environmental influences. 曲霉真菌的全球多样性和分布模式是由人类和环境影响驱动的。

IF 7.5 1区生物学

Current Biology Pub Date : 2025-09-22 Epub Date: 2025-08-22 DOI: 10.1016/j.cub.2025.07.081

Olivia L Riedling, Kyle T David, Antonis Rokas

{"title":"Global patterns of diversity and distribution in Aspergillus fungi are driven by human and environmental influences.","authors":"Olivia L Riedling, Kyle T David, Antonis Rokas","doi":"10.1016/j.cub.2025.07.081","DOIUrl":"10.1016/j.cub.2025.07.081","url":null,"abstract":"Aspergillus fungi are key producers of pharmaceuticals, enzymes, and food products and exhibit diverse lifestyles, from saprophytes to opportunistic pathogens. The genus is divided into 28 taxonomic sections sharing traits (e.g., natural products) and lifestyles (e.g., xerophily, pathogenicity). Understanding global patterns of Aspergillus occurrence and diversity would deepen our ecological understanding and help monitor pathogens and producers of mycotoxins and diverse natural products. To identify key environmental factors influencing their geographic distributions and estimate the impact of future climate change, we trained a random forest machine learning classifier on 19,105 terrestrial occurrence records for 27 taxonomic sections and 96 environmental variables to predict distributions of each section. We found that regions with high section diversity are concentrated in temperate forests, suggesting that areas with mild seasonal variation serve as diversity hotspots. Section range estimates revealed extensive variability, and low range overlap suggests distinct niches. The top predictors of average section richness were the index of cumulative human impact, ecosystem productivity, and forested vs. non-forested ecoregions. Our future climate analyses revealed considerable variation in section range estimates in response to changing climates. Suitable habitats for some sections are predicted to expand (e.g., section Restricti) and others to contract (e.g., section Nigri) or remain stable (e.g., section Fumigati) in the next few decades. Our findings reveal that both natural and human factors influence the macroecology of Aspergillus fungi and highlight their ecological diversity, including the diversity of their responses to changing climates, which is of relevance to pathogen and mycotoxin risk assessment.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"4453-4466.e3"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0