Current Biology最新文献_第3页

Gastrulation: Lessons from the quail embryo. 原肠形成：鹌鹑胚胎的教训。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 DOI: 10.1016/j.cub.2025.04.001

Guilherme Ventura, Diana Pinheiro

引用次数: 0

Rise and spread of a social tradition of interspecies abduction. 物种间绑架的社会传统的兴起和传播。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 DOI: 10.1016/j.cub.2025.03.056

Zoë Goldsborough, Margaret C Crofoot, Odd T Jacobson, Lisa Corewyn, Evelyn Del Rosario-Vargas, Julián León, Brendan J Barrett

{"title":"Rise and spread of a social tradition of interspecies abduction.","authors":"Zoë Goldsborough, Margaret C Crofoot, Odd T Jacobson, Lisa Corewyn, Evelyn Del Rosario-Vargas, Julián León, Brendan J Barrett","doi":"10.1016/j.cub.2025.03.056","DOIUrl":"10.1016/j.cub.2025.03.056","url":null,"abstract":"Cultural traditions lacking clear function are exceptionally common in humans, partially explained by our hyper-reliance on social learning1. In non-human animals, it is unclear whether the same ecological and social conditions drive the emergence of both seemingly adaptive and non-adaptive traditions. Here, we describe the origins and spread of a tradition of interspecies abduction in the wild. We documented carrying of eleven different infant howler monkeys (Alouatta palliata coibensis) by five immature male white-faced capuchin monkeys (Cebus capucinus imitator) over 15 months on Jicarón island, Coiba National Park, Panama. All cases occurred in one capuchin group, which has been studied since 2017 for their localized tradition of habitual stone tool-use, unique to Cebus2. We captured the origin of this 'howler abduction' tradition, starting with one subadult male innovator, and its spread to four subadult and juvenile males (Figure 1 and Supplemental information; see also interactive timeline: https://www.ab.mpg.de/671374/Capuchin-tool-use/interspecies-abduction-tradition). We argue that the same conditions which favored adaptive cultural innovations like tool-use on Jicarón also underlie this non-adaptive tradition.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"35 10","pages":"R375-R376"},"PeriodicalIF":8.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estrogen signaling in the ventromedial hypothalamus is required for the development of aggression circuitry in male mice. 雌性激素信号在雄性小鼠下丘脑腹内侧是攻击回路发育所必需的。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 DOI: 10.1016/j.cub.2025.04.076

Xi Zha, Xiao-Yao Liu, Lei Wang, Shuai-Shuai Li, Yi-Zhuo Sun, Jun-Kai Lin, Jing-Jing Yan, Meng-Tong Gao, Yan-Li Zhang, Rong-Rong Yang, Chun Xu, Xiao-Hong Xu

{"title":"Estrogen signaling in the ventromedial hypothalamus is required for the development of aggression circuitry in male mice.","authors":"Xi Zha, Xiao-Yao Liu, Lei Wang, Shuai-Shuai Li, Yi-Zhuo Sun, Jun-Kai Lin, Jing-Jing Yan, Meng-Tong Gao, Yan-Li Zhang, Rong-Rong Yang, Chun Xu, Xiao-Hong Xu","doi":"10.1016/j.cub.2025.04.076","DOIUrl":"https://doi.org/10.1016/j.cub.2025.04.076","url":null,"abstract":"Aggression in male mice depends on developmental estrogen exposure, yet the neural mechanisms underlying this phenomenon remain poorly understood. Although estrogen receptor α (Esr1) has served as a genetic marker to identify aggression-regulating neurons in the ventrolateral division of ventromedial hypothalamus (VMHvl), its functional role in organizing male-aggression circuits remains poorly understood. Here, we developed a genetic strategy to knock out Esr1 in VMHvl neurons while simultaneous tracing and manipulating Esr1-deleted cells. Developmental Esr1 knockout selectively altered synaptic inputs from aggression-regulating regions onto VMHvl neurons, with a stronger effect observed in males, revealing the posterior intralaminar thalamic nucleus (PIL) as a critical upstream region involved in male aggression. Additionally, VMHvl Esr1+ neurons in knockout males showed reduced excitability and failed to initiate attacks upon chemogenetic activation. These findings underscore the essential role of Esr1 in establishing male-specific aggression circuits, providing new insights into male-specific neural circuit development and function.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational differentiation of vertically displaced surfaces by grid cells. 网格细胞对垂直位移表面的平移分化。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 Epub Date: 2025-05-05 DOI: 10.1016/j.cub.2025.04.036

Patrick A LaChance, Shawn S Winter, Jeffrey S Taube

{"title":"Translational differentiation of vertically displaced surfaces by grid cells.","authors":"Patrick A LaChance, Shawn S Winter, Jeffrey S Taube","doi":"10.1016/j.cub.2025.04.036","DOIUrl":"10.1016/j.cub.2025.04.036","url":null,"abstract":"Navigation is commonly associated with two-dimensional (2D) representations of space. Recordings from place and grid cells in the rodent and bat brain have largely upheld this association. Recent studies have investigated how these 2D representations might extend into the three-dimensional (3D) world. One unexplored question is whether grid cells represent vertically separated horizontal surfaces as a single 3D space or distinct planar environments. To address this issue, we recorded grid cells as rats foraged in both an open-field environment and one with a transparent floor suspended directly above the open-field environment. Rats either actively locomoted up a ramp to the elevated environment, or they were passively moved between the two environments, to test how differences in path integration may affect grid cell firing. We found that grid cell firing patterns in the elevated environment were translated (but not rotated) relative to those in the floor environment and were consistent across active and passive sessions. The translation of the grid pattern on the elevated surface was consistent among co-recorded grid cells but differed between animals and between different groups of grid cells recorded from the same animal. Non-grid spatially modulated cells also rearranged their location preferences between the two surfaces. Overall, we did not observe any evidence that the two surfaces were represented with a single 3D representation but instead were treated as two distinct surfaces connected by a common orientation signal. These findings suggest that grid cell representations on visually distinct, vertically displaced horizontal surfaces are planar rather than volumetric.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"2379-2390.e5"},"PeriodicalIF":8.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying pterosaur trackmakers provides critical insights into mid-Mesozoic ground invasion. 识别翼龙的足迹为中生代中期的地面入侵提供了重要的见解。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 Epub Date: 2025-05-01 DOI: 10.1016/j.cub.2025.04.017

Robert S H Smyth, Brent H Breithaupt, Richard J Butler, Peter L Falkingham, David M Unwin

{"title":"Identifying pterosaur trackmakers provides critical insights into mid-Mesozoic ground invasion.","authors":"Robert S H Smyth, Brent H Breithaupt, Richard J Butler, Peter L Falkingham, David M Unwin","doi":"10.1016/j.cub.2025.04.017","DOIUrl":"10.1016/j.cub.2025.04.017","url":null,"abstract":"Fossilized tracks have provided unique insights into the distribution, behavior, and ecology of extinct taxa. Moreover, because they are abundant and often have distinct distributions in time and space compared with the body fossil record, they have considerable potential for testing and extending macroevolutionary hypotheses. The key to unlocking this vast potential lies in reliably linking tracks to their producers, but this remains a persistent challenge. This limitation is particularly evident among pterosaurs, the dominant flying vertebrates of the Mesozoic. Despite an extensive record of pterosaur tracks spanning more than 100 million years, the identities of trackmakers are unclear in most cases, limiting their use for addressing key questions about pterosaur ecology and evolution. In this study, we employ quantitative analyses and diagnostic features of pedal anatomy to directly link three distinct pterosaur track morphotypes to specific pterodactyloid clades: ctenochasmatoids, dsungaripterids, and neoazhdarchians. These results considerably extend the known biogeographic distribution of these clades, supporting macroevolutionary and ecological hypotheses derived from analyses of the body fossil record. The absence of pterosaur tracks prior to the Middle Jurassic supports evidence from hand and foot morphology indicating that early pterosaurs were arboreal or scansorial. Track evidence demonstrates a major radiation of derived pterodactyloid pterosaurs into terrestrial niches beginning in the Middle Jurassic. Successive clades maintained a strong presence across diverse terrestrial environments throughout the latter half of the Mesozoic, highlighting the evolutionary versatility and ecological significance of pterosaurs in terrestrial environments.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"2337-2353.e5"},"PeriodicalIF":8.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intercellular sphingolipid signaling mediates aversive learning in C. elegans. 细胞间鞘脂信号介导线虫的厌恶学习。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 Epub Date: 2025-04-18 DOI: 10.1016/j.cub.2025.03.082

Yu-Chun Wu, Isabel Beets, Bennett William Fox, Diana Fajardo Palomino, Li Chen, Chien-Po Liao, Elke Vandewyer, Liang-Yi Lin, Chun-Wei He, Li-Tzu Chen, Chih-Ta Lin, Frank C Schroeder, Chun-Liang Pan

{"title":"Intercellular sphingolipid signaling mediates aversive learning in C. elegans.","authors":"Yu-Chun Wu, Isabel Beets, Bennett William Fox, Diana Fajardo Palomino, Li Chen, Chien-Po Liao, Elke Vandewyer, Liang-Yi Lin, Chun-Wei He, Li-Tzu Chen, Chih-Ta Lin, Frank C Schroeder, Chun-Liang Pan","doi":"10.1016/j.cub.2025.03.082","DOIUrl":"10.1016/j.cub.2025.03.082","url":null,"abstract":"Physiological stress in non-neural tissues drives aversive learning for sensory cues associated with stress. However, the identities of signals derived from non-neural tissues and the mechanisms by which these signals mediate aversive learning remain elusive. Here, we show that intercellular sphingolipid signaling contributes to aversive learning under mitochondrial stress in C. elegans. We found that stress-induced aversive learning requires sphingosine kinase, SPHK-1, the enzyme that produces sphingosine-1-phosphate (S1P). Genetic and biochemical studies revealed an intercellular signaling pathway in which intestinal or hypodermal SPHK-1 signals through the neuronal G protein-coupled receptor, SPHR-1, and modulates responses of the octopaminergic RIC neuron to promote aversive learning. We further show that SPHK-1-mediated sphingolipid signaling is required for learned aversion of Chryseobacterium indologenes, a bacterial pathogen found in the natural habitats of C. elegans, which causes mitochondrial stress. Taken together, our work reveals a sphingolipid signaling pathway that communicates from intestinal or hypodermal tissues to neurons to promote aversive learning in response to mitochondrial stress and pathogen infection.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"2323-2336.e9"},"PeriodicalIF":8.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of dance and infant-directed song among the Northern Aché. 舞蹈和婴儿歌曲在北方阿契尔人中的消失。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 Epub Date: 2025-04-29 DOI: 10.1016/j.cub.2025.04.018

Manvir Singh, Kim Hill

{"title":"Loss of dance and infant-directed song among the Northern Aché.","authors":"Manvir Singh, Kim Hill","doi":"10.1016/j.cub.2025.04.018","DOIUrl":"10.1016/j.cub.2025.04.018","url":null,"abstract":"Dance and infant-directed song are often considered universal behaviors, a view that has been supported by considerable cross-cultural research.1,2 The conclusion that humans in every documented society engage in these behaviors has, in turn, influenced evolutionary theories of music, which often treat human musicality as an adaptation, with benefits stemming from moving in synchrony and/or singing to infants.3,4 Drawing on 122 months of fieldwork conducted between 1977 and 2020, we here report no evidence of either dance or infant-directed song among the Northern Aché of Paraguay. Excluding church singing introduced by missionaries, Northern Aché adults sing alone and in a very limited number of styles. Several lines of evidence suggest that dance and infant-directed song were lost following reductions in population size that curtailed cultural complexity among the ancestors of the Northern Aché. Although our observations are consistent with a universal psychological capacity for dance and infant-directed song, they indicate a critical role of cultural transmission in supporting these behaviors while demonstrating the value of testing claims of cultural universality in remote and minimally acculturated populations.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"2444-2447.e1"},"PeriodicalIF":8.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing. 通过温度感应而不是活动感应对电机电路进行稳态调节。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 Epub Date: 2025-04-12 DOI: 10.1016/j.cub.2025.03.054

Delaney J Cannon, Joseph M Santin

{"title":"Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.","authors":"Delaney J Cannon, Joseph M Santin","doi":"10.1016/j.cub.2025.03.054","DOIUrl":"10.1016/j.cub.2025.03.054","url":null,"abstract":"Homeostasis is a driving principle in physiology. To achieve homeostatic control of neural activity, neurons monitor their activity levels and then initiate corrective adjustments in excitability when activity strays from a set point. However, fluctuations in the brain microenvironment, such as temperature, pH, and other ions, represent some of the most common perturbations to neural function in animals. Therefore, it is unclear whether activity sensing is a universal strategy for different types of perturbations or whether stability may arise by sensing specific environmental cues. Here, we show that the respiratory network of amphibians mounts a fast homeostatic response to restore motor function following inactivity caused by cooling over the physiological range. This response was not initiated by inactivity but rather by temperature. Compensation involved cold activation of noradrenergic neurons via mechanisms that relied, in part, on inhibition of the Na+/K+ ATPase, causing β-adrenoceptor signaling that enhanced network excitability. Thus, acute cooling initiates a modulatory response that opposes inactivity and enhances network excitability. As the nervous system of all animals is subjected to changes in the microenvironment, some circuits may have selected regulatory systems tuned to environmental variables in place of, or in addition to, activity-dependent control mechanisms.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"2256-2265.e3"},"PeriodicalIF":8.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic basis of an adaptive polymorphism controlling butterfly silver iridescence. 控制蝴蝶银色虹彩的自适应多态性的遗传基础。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 Epub Date: 2025-04-29 DOI: 10.1016/j.cub.2025.04.042

Luca Livraghi, Joseph J Hanly, Ling S Loh, Albie Henry, Chloe M T Keck, Vaughn M Shirey, Cheng-Chia Tsai, Nanfang Yu, Steven M Van Belleghem, W Mark Roberts, Carol L Boggs, Arnaud Martin

引用次数: 0

Abundance measurements reveal the balance between lysis and lysogeny in the human gut microbiome. 丰度测量揭示了人类肠道微生物群中溶解和溶原之间的平衡。

IF 8.1 1区生物学

Current Biology Pub Date : 2025-05-19 Epub Date: 2025-04-28 DOI: 10.1016/j.cub.2025.03.073

Jamie Alcira Lopez, Saria McKeithen-Mead, Handuo Shi, Taylor H Nguyen, Kerwyn Casey Huang, Benjamin H Good

{"title":"Abundance measurements reveal the balance between lysis and lysogeny in the human gut microbiome.","authors":"Jamie Alcira Lopez, Saria McKeithen-Mead, Handuo Shi, Taylor H Nguyen, Kerwyn Casey Huang, Benjamin H Good","doi":"10.1016/j.cub.2025.03.073","DOIUrl":"10.1016/j.cub.2025.03.073","url":null,"abstract":"The human gut contains diverse communities of bacteriophage, whose interactions with the broader microbiome and potential roles in human health are only beginning to be uncovered. Here, we combine multiple types of data to quantitatively estimate gut phage population dynamics and lifestyle characteristics in human subjects. Unifying results from previous studies, we show that an average human gut contains a low ratio of phage particles to bacterial cells (∼1:100) but a much larger ratio of phage genomes to bacterial genomes (∼4:1), implying that most gut phage are effectively temperate (e.g., integrated prophage and phage-plasmids). By integrating imaging and sequencing data with a generalized model of temperate phage dynamics, we estimate that phage induction and lysis occur at a low average rate (∼0.001-0.01 per bacterium per day), imposing only a modest fitness burden on their bacterial hosts. Consistent with these estimates, we find that the phage composition of a diverse synthetic community in gnotobiotic mice can be quantitatively predicted from bacterial abundances alone while still exhibiting phage diversity comparable to native human microbiomes. These results provide a foundation for interpreting existing and future studies on links between the gut virome and human health.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"2282-2294.e11"},"PeriodicalIF":8.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0