Current Biology最新文献_第4页

Plant evolution: How duckweeds became so small. 植物进化：浮萍如何变得如此之小。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 DOI: 10.1016/j.cub.2026.09.001

Cristian Mateo-Elizalde, Evan Ernst, Rob Martienssen

引用次数: 0

Navigation map has to be learned by migration-naïve Eurasian reed warblers. 导航地图必须由migration-naïve欧亚苇莺学习。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 DOI: 10.1016/j.cub.2026.08.027

Gleb Utvenko, Polina Gorvat, Anna Akhapkina, Aleksandr Pakhomov, Nikita Chernetsov

{"title":"Navigation map has to be learned by migration-naïve Eurasian reed warblers.","authors":"Gleb Utvenko, Polina Gorvat, Anna Akhapkina, Aleksandr Pakhomov, Nikita Chernetsov","doi":"10.1016/j.cub.2026.08.027","DOIUrl":"https://doi.org/10.1016/j.cub.2026.08.027","url":null,"abstract":"It used to be thought that young migrating birds perform their first migration using an innate 'clock-and-compass' programme that specifies the timing of onset of movement and its direction and duration, but did not require information about the bird's current position1. In classic displacement experiments, young birds continued to fly in their normal migratory direction, whereas adults were able to adjust their course after displacement2. More recent evidence, however, suggests that young birds may estimate their position and adjust their behaviour when delayed or displaced, even during their maiden flight3,4. Evidence for innate magnetic map responses in hatchling sea turtles and juvenile salmonids5 suggests that birds may also inherit magnetic positional information. We have investigated this hypothesis in the Eurasian reed warbler (Acrocephalus scirpaceus), a species in which compensation for physical and virtual magnetic displacement has been demonstrated in experienced migrants6,7. We used migration-naïve birds trapped in early autumn as juveniles and kept in captivity over winter. In spring, the birds were tested first in the natural magnetic field at Rybachy in Russia, and then under a virtual magnetic displacement to Keele, UK. Under the virtual magnetic displacement, the birds did not change their orientation as expected if they possessed a magnetic map. We found no evidence that migration-naïve Eurasian reed warblers use a functional innate magnetic map under the conditions of our experiment. In this species, the first migration is guided primarily by an inherited compass programme, whereas a functional magnetic map develops through migratory experience.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"36 20","pages":"R1063-R1065"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria-ER-lipid droplet crosstalk regulates metabolic adaptation to shear stress via VMP1. 线粒体-内质网脂滴串扰通过VMP1调节对剪切胁迫的代谢适应。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-10-02 DOI: 10.1016/j.cub.2026.09.021

Maria Laura Rojas, Maribel Lara Corona, Carla Alemany, Juliane Da Graça, Nicolas Goudin, Ivan Nemazanyy, Ida Chiara Guerrera, Aurore Claude-Taupin, Etienne Morel

{"title":"Mitochondria-ER-lipid droplet crosstalk regulates metabolic adaptation to shear stress via VMP1.","authors":"Maria Laura Rojas, Maribel Lara Corona, Carla Alemany, Juliane Da Graça, Nicolas Goudin, Ivan Nemazanyy, Ida Chiara Guerrera, Aurore Claude-Taupin, Etienne Morel","doi":"10.1016/j.cub.2026.09.021","DOIUrl":"10.1016/j.cub.2026.09.021","url":null,"abstract":"Kidney tubular epithelial cells adapt to physiological urinary flow through rapid metabolic remodeling,1,2 but the mechanisms coordinating this response remain poorly understood. Shear stress promotes lipid catabolism and mitochondrial activity in these cells,3,4 but how changes in mitochondrial dynamics contribute to this metabolic adaptation remains poorly understood.5,6,7,8,9 Here, we show that physiological shear stress rapidly remodels mitochondrial morphology in kidney epithelial cells in vitro and in the zebrafish pronephros, characterized by the emergence of a distinct pool of donut-shaped mitochondria. This remodeling is accompanied by a transient stabilization of mitochondria-endoplasmic reticulum (ER) contact sites (MERCs), occurring independently of any increase in overall ER volume. Using split-TurboID proximity labeling and mass spectrometry, we detected subtle changes in the molecular environment of MERCs during shear stress, including increased proximity of proteins implicated in lipid transfer and membrane contact-site biology. We further show that shear stress promotes the formation of ER-lipid droplet (LD)-mitochondria contact sites and facilitates the local transfer of fatty acids from LDs to mitochondria. This lipid transfer requires vacuolar membrane protein 1 (VMP1), a component of membrane contact sites, whose depletion perturbs LDs and compromises metabolic adaptation to shear stress. Together, our findings identify ER-LD-mitochondria contact sites as dynamic platforms that coordinate lipid transfer and mitochondrial remodeling during the early adaptation of kidney epithelial cells to physiological shear stress, highlighting membrane contact sites as important components of the cellular response to mechanical forces.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5416-5426.e6"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex. 前列腺素E2的中枢输注揭示了小鼠岛叶皮层疾病的统一表现。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-30 DOI: 10.1016/j.cub.2026.09.011

Gretel B Kamm, Juan C Boffi, Muad Y Abd El Hay, Domitille Rajot, Ana Cukić, Martha N Havenith, Marieke Scholvinck, Nicolas Renier, Hiroki Asari, Robert Prevedel

{"title":"Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex.","authors":"Gretel B Kamm, Juan C Boffi, Muad Y Abd El Hay, Domitille Rajot, Ana Cukić, Martha N Havenith, Marieke Scholvinck, Nicolas Renier, Hiroki Asari, Robert Prevedel","doi":"10.1016/j.cub.2026.09.011","DOIUrl":"10.1016/j.cub.2026.09.011","url":null,"abstract":"During infections, vertebrates develop stereotypic symptoms such as elevated body temperature, reduced appetite, and lethargy. These changes, collectively known as sickness syndrome, are orchestrated by the brain in response to immune mediators released during systemic inflammation. While the roles of subcortical regions, including the hypothalamus and brainstem, in regulating sickness symptoms are well established, the contribution of the neocortex to the encoding and modulation of sickness remains less well understood. We examined the neuronal correlates of sickness in the neocortex of awake mice following a single intracerebroventricular (i.c.v.) injection of prostaglandin E2 (PGE2), a well-characterized sickness mediator. Behavioral analysis revealed that PGE2 elicits a rapid and robust sickness response, characterized by fever, slower locomotion, quiescence, anorexia, and eye squinting. Whole-brain Fos mapping showed that PGE2 generates a distinct neural activation pattern encompassing much of the interoceptive network. Electrophysiological recordings in awake mice revealed that neuronal population dynamics in the antero-mid insular cortex (IC) and the primary somatosensory cortex (SSp), two regions involved in body-state representation, encode sickness-related information, such as body temperature, walking velocity, grooming, and eye squinting. However, unlike SSp, ongoing neuronal activity in IC exhibited better decoding performance for a multidimensional measure of sickness than for individual sickness traits. Together, these results suggest that PGE2 induces a coordinated physiological and behavioral response akin to a sick state, which is preferentially encoded in the IC, providing a conceptual framework for studying interactions between the immune system and the brain.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5328-5344.e7"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichome acylsugar defenses are equally effective against leaf-mining and free-living insects. 毛状体的酰基糖防御对采叶昆虫和自由生活的昆虫同样有效。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-23 DOI: 10.1016/j.cub.2026.08.069

Zongyan Sun, Xiaochan Pan, Simin Bi, Yirui Zhang, Junling Dun, Dina Mahesati, Yibin Lin, Ying Fu, Yang Gao, Xiaoyan Xu, Na Chen, Jiarui Xing, Wenfeng Ye, Minbiao Ji, Ian T Baldwin, Jiancai Li

{"title":"Trichome acylsugar defenses are equally effective against leaf-mining and free-living insects.","authors":"Zongyan Sun, Xiaochan Pan, Simin Bi, Yirui Zhang, Junling Dun, Dina Mahesati, Yibin Lin, Ying Fu, Yang Gao, Xiaoyan Xu, Na Chen, Jiarui Xing, Wenfeng Ye, Minbiao Ji, Ian T Baldwin, Jiancai Li","doi":"10.1016/j.cub.2026.08.069","DOIUrl":"10.1016/j.cub.2026.08.069","url":null,"abstract":"Trichomes, epidermal projections, are crucial components of plant defense systems. Whether these epidermal defenses are effective against leafminers, which infest the internal mesophyll layers, remains unclear. Using the devastating invasive tomato pest, Phthorimaea absoluta (tomato leafminer), and the trichome-rich wild tomato, Solanum pennellii, we demonstrate that trichome-produced acylsugars effectively inhibit the growth of endophagous P. absoluta larvae feeding inside leaves. High-spatial-resolution leaf- and frass-metabolite analysis by matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) and stimulated Raman scattering microscopy revealed that trichome-synthesized acylsugars are translocated into the mesophyll tissues when larvae infest leaves. We identified an ATP-binding cassette (ABC) transporter, SpABCB5, as the mediator of this translocation and as an essential component of defense against leafminers. These data reveal that epidermal trichomes not only defend against free-living (ectophagous) herbivores through direct contact or rapid deposition of chemical defenses onto leaf surfaces but also defend against endophagous leafminers by rapidly depositing chemical defenses into internal tissues. By delivering mines against leafminers, trichomes offer new avenues for breeding crops with resistance to leafminers.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5273-5284.e5"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketamine attenuates habenula activity in response to aversive outcomes during Pavlovian learning. 氯胺酮在巴甫洛夫学习过程中对厌恶结果的反应中减弱缰核活性。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-15 DOI: 10.1016/j.cub.2026.08.044

Erdem Pulcu, Sara Costi, Pilar Artiach-Hortelano, Chloe Wigg, Sorcha Hamilton, Marieke Martens, Rebecca P Lawson, Rupert McShane, Philip Cowen, Susannah E Murphy, Catherine J Harmer

{"title":"Ketamine attenuates habenula activity in response to aversive outcomes during Pavlovian learning.","authors":"Erdem Pulcu, Sara Costi, Pilar Artiach-Hortelano, Chloe Wigg, Sorcha Hamilton, Marieke Martens, Rebecca P Lawson, Rupert McShane, Philip Cowen, Susannah E Murphy, Catherine J Harmer","doi":"10.1016/j.cub.2026.08.044","DOIUrl":"10.1016/j.cub.2026.08.044","url":null,"abstract":"Ketamine is an NMDA receptor antagonist with rapid antidepressant properties when administered at a subanesthetic dose. Preclinical models indicate that a direct injection of ketamine into the lateral habenula (Hb), a small midbrain structure with an evolutionarily preserved role in aversive learning across mammals, can rapidly relieve depression-like behavior. However, there is limited evidence to explain how ketamine acts on the function of the human Hb. In a translational computational neuroscience study, 70 healthy adult volunteers were randomized in a 1:1 ratio to receive ketamine (0.5 mg/kg) or placebo (NaCl 0.9%). We used an aversive Pavlovian conditioning paradigm combined with 7-tesla functional neuroimaging to show that ketamine attenuates Hb response during aversive stimuli expectations and outcomes 24 h post-infusion. Furthermore, we present preliminary evidence suggesting that when aversive learning occurs after ketamine infusion, reduced Hb activity during the learning process may lead to downstream effects that diminish the aversive impact of negative affective memories. These findings provide translational support for ketamine's modulation of aversive learning and Hb activity and help to refine mechanistic models of its rapid antidepressant effect.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5171-5179.e4"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eastern origin and three-millennia persistence of a founding grapevine lineage in Iberian viticulture. 东方起源和在伊比利亚葡萄栽培中持续三千年的葡萄树血统。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-10 DOI: 10.1016/j.cub.2026.08.039

Guillem Pérez-Jordà, Leonor Peña-Chocarro, Konstantina Drosou, Javier Tello, Laurent Bouby, Vincent Bonhomme, Natàlia Alonso, Javier Ibáñez, Cosimo Posth, Detlef Weigel, José Miguel Martínez-Zapater, Pablo Carbonell-Bejerano, Carolina Royo

{"title":"Eastern origin and three-millennia persistence of a founding grapevine lineage in Iberian viticulture.","authors":"Guillem Pérez-Jordà, Leonor Peña-Chocarro, Konstantina Drosou, Javier Tello, Laurent Bouby, Vincent Bonhomme, Natàlia Alonso, Javier Ibáñez, Cosimo Posth, Detlef Weigel, José Miguel Martínez-Zapater, Pablo Carbonell-Bejerano, Carolina Royo","doi":"10.1016/j.cub.2026.08.039","DOIUrl":"10.1016/j.cub.2026.08.039","url":null,"abstract":"Viticulture became central to most Mediterranean civilizations a few millennia after the grapevine (Vitis vinifera L.) was domesticated in the South Caucasus/Near East. To elucidate the origins of the grapevines that enabled this westward spread over the past 3,000 years, we analyzed 28 grapevine seeds from seven archaeological sites in the Iberian Peninsula and Sardinia. Ancient DNA recovered from the oldest seeds with domesticated-like morphology (from ∼1,000 BCE), found in southwestern Spain, revealed nuclear and chloroplast genome signatures of Eastern Mediterranean cultivars. Seeds from the same and later Iron Age Iberian sites, however, showed genomic signatures suggesting hybridization between local wild grapevines and eastern-origin cultivars. The genetic makeup of Sardinian and northeastern Spanish seeds supports that local diversification giving rise to the Central European and Iberian wine genetic lineages had already occurred in the early Iron Age. In Iberia, Roman-period seeds were first-degree related to both the earliest eastern-introduced domesticates and a Medieval seed whose genetic makeup matches the extant Iberian variety \"Pasa Valenciana.\" Another Medieval seed was inferred as an offspring of the extant \"Heben,\" indicating that this major founder of Iberian germplasm has been continuously propagated for over 1,100 years. Our results confirm previous evolutionary models indicating that Western Mediterranean viticulture began with introductions of eastern domesticated grapevines, followed by early hybridization with local Iberian wild grapevines that may have facilitated viticulture adaptation to the new environment. The aDNA unveils that these introductions gave rise to extant cultivars through only a few sexual generations and long-term reliance on clonal propagation.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5156-5170.e8"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Miniaturization of duckweeds occurred through compression of the angiosperm body plan. 浮萍的小型化是通过压缩被子植物的体表发生的。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-10-07 DOI: 10.1016/j.cub.2026.09.035

Alexander Ware, Emily Chan, Rahul Bhosale, Anthony Bishopp

{"title":"Miniaturization of duckweeds occurred through compression of the angiosperm body plan.","authors":"Alexander Ware, Emily Chan, Rahul Bhosale, Anthony Bishopp","doi":"10.1016/j.cub.2026.09.035","DOIUrl":"10.1016/j.cub.2026.09.035","url":null,"abstract":"Miniaturization, or an extreme reduction in body size, is present in both the plant and animal kingdoms. In animals, this concept has been studied across a range of systems, where it has been associated with the vestigialization or loss of structures such as the reduction of lungs in miniature frogs1 and the loss of body segments in tardigrades.2 By contrast, the morphological mechanisms underlying plant miniaturization remain poorly understood. The Araceae exhibits a striking evolutionary breadth, encompassing both the smallest flowering plants and some of the largest herbaceous species known, making it an ideal family for exploring the concept of miniaturization. Here, we focus on the rooted species of duckweeds, which measure just a few millimeters and have an aerial body plan consisting of a single, cryptically defined structure, called a frond. Transcriptional dissection of the duckweed frond revealed distinct zones, one with homology to aroid leaf blades and the other with both stems and petioles, indicating that the duckweed frond is a hybrid organ arising from the fusion of stem and leaf parts. The identities of these zones are further supported by patterns of cell division comparable to those in monocot leaves and by secondary cell wall staining consistent with stem tissue. Collectively, our data support the hypothesis that miniaturization in duckweeds has not arisen through the loss of body components,2 as seen in some animal lineages such as tardigrades, but through a restriction in cell division and the fusion of organs.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5407-5415.e4"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thirst reweights temperature preference through dual dopaminergic and endocrine modulation in Drosophila. 果蝇口渴通过双多巴胺能和内分泌调节来重新调节温度偏好。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-18 DOI: 10.1016/j.cub.2026.08.062

Meng-Hsuan Chiang, Yu-Chun Lin, Yan-Lin Chen, Peng-Shiuan Lee, Sheng-Fu Chen, Tsai-Feng Fu, Tony Wu, Chia-Lin Wu

{"title":"Thirst reweights temperature preference through dual dopaminergic and endocrine modulation in Drosophila.","authors":"Meng-Hsuan Chiang, Yu-Chun Lin, Yan-Lin Chen, Peng-Shiuan Lee, Sheng-Fu Chen, Tsai-Feng Fu, Tony Wu, Chia-Lin Wu","doi":"10.1016/j.cub.2026.08.062","DOIUrl":"10.1016/j.cub.2026.08.062","url":null,"abstract":"Internal physiological states shape behavior by modulating sensory processing, yet the underlying neural mechanisms remain largely unresolved. Here, we demonstrate that thirst biases temperature preference in Drosophila melanogaster by enhancing hot avoidance while suppressing cold avoidance. Combining quantitative behavioral assays, in vivo calcium brain imaging, and targeted neural manipulations, we identify γ mushroom body neurons (γ MBns) as a key integrative node for thermal and internal state signals. We further reveal a dual neuromodulatory mechanism in which dopaminergic protocerebral anterior medial (PAM)-γ5 neurons and protocerebral posterior lateral (PPL1)-γ1pedc neurons oppositely regulate cold and hot representations through distinct receptors, Dop1R2 and DopEcR, respectively. In water-sated flies, cold stimuli activate PAM-γ5 neurons, whose dopamine release enhances cold-evoked responses in γ MBns via Dop1R2. In parallel, hot stimuli recruit PPL1-γ1pedc neurons, which engage the steroid hormone 20-hydroxyecdysone (20E)-mediated DopEcR-dependent mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) mechanism to suppress hot-evoked responses. Thirst attenuates both pathways, which results in a reweighting of thermal representations that biases behavioral choice toward cooler environments. Together, our findings uncover a circuit and molecular framework by which internal states dynamically reconfigure sensory representations to guide adaptive decision-making.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5209-5222.e4"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opponent ventrolateral striatal circuits regulate behavioral flexibility and rigidity. 对手腹外侧纹状体回路调节行为的灵活性和刚性。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-22 DOI: 10.1016/j.cub.2026.08.068

Ben J Gonzales, Itay Shalom, David M Lipton, Hagit Turm, Jed Noble, Massimiliano Festuccia, Maya Groysman, Ami Citri

{"title":"Opponent ventrolateral striatal circuits regulate behavioral flexibility and rigidity.","authors":"Ben J Gonzales, Itay Shalom, David M Lipton, Hagit Turm, Jed Noble, Massimiliano Festuccia, Maya Groysman, Ami Citri","doi":"10.1016/j.cub.2026.08.068","DOIUrl":"10.1016/j.cub.2026.08.068","url":null,"abstract":"Basal ganglia circuits support the flexible selection of context-appropriate actions, and their dysfunction underlies pathologies defined by behavioral rigidity. Whether such rigidity reflects biased engagement of the same circuits that normally enable flexibility is unknown. To study behavior across adaptive and maladaptive contexts, we developed a deep-learning framework that classifies ethologically meaningful actions from raw video (STEREO). To associate striatal circuit function with flexible and rigid behavioral states, we integrated STEREO with population recordings and pathway-specific manipulations in freely behaving mice, identifying a striatal circuit that governs flexible and rigid selection of orofacial behaviors. Using a psychostimulant to induce pathological rigidity, we found that repeated exposure progressively collapses a rich behavioral repertoire into persistent dominance of a single orofacial action, with concurrent recruitment of ventrolateral striatal direct- and indirect-pathway neurons. Causal interrogation revealed opponent control within a shared selection mechanism: indirect-pathway activation rapidly alleviated cocaine-induced rigidity, while direct-pathway activation alone was sufficient to drive drug-mimetic stereotyped bouts. These findings demonstrate that biased recruitment of striatal direct-pathway circuits transforms flexible action selection into compulsive motor output.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5256-5272.e5"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0