Current Biology最新文献_第4页

Mechanical positional information guides the self-organized development of a polygonal network of creases in the skin of mammalian noses. 机械位置信息引导着哺乳动物鼻子皮肤上多边形皱褶网络的自组织发展。

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 Epub Date: 2024-10-22 DOI: 10.1016/j.cub.2024.09.055

Paule Dagenais, Ebrahim Jahanbakhsh, Aurélien Capitan, Hélène Jammes, Karine Reynaud, Camino De Juan Romero, Victor Borrell, Michel C Milinkovitch

{"title":"Mechanical positional information guides the self-organized development of a polygonal network of creases in the skin of mammalian noses.","authors":"Paule Dagenais, Ebrahim Jahanbakhsh, Aurélien Capitan, Hélène Jammes, Karine Reynaud, Camino De Juan Romero, Victor Borrell, Michel C Milinkovitch","doi":"10.1016/j.cub.2024.09.055","DOIUrl":"10.1016/j.cub.2024.09.055","url":null,"abstract":"The glabrous skin of the rhinarium (naked nose) of many mammalian species exhibits a polygonal pattern of grooves that retain physiological fluid, thereby keeping their nose wet and, among other effects, facilitating the collection of chemosensory molecules. Here, we perform volumetric imaging of whole-mount rhinaria from sequences of embryonic and juvenile cows, dogs, and ferrets. We demonstrate that rhinarial polygonal domains are not placode-derived skin appendages but arise through a self-organized mechanical process consisting of the constrained growth and buckling of the epidermal basal layer, followed by the formation of sharp epidermal creases exactly facing an underlying network of stiff blood vessels. Our numerical simulations show that the mechanical stress generated by excessive epidermal growth concentrates at the positions of vessels that form rigid base points, causing the epidermal layers to move outward and shape domes-akin to arches rising against stiff pillars. Remarkably, this gives rise to a larger length scale (the distance between the vessels) in the surface folding pattern than would otherwise occur in the absence of vessels. These results hint at a concept of \"mechanical positional information\" by which material properties of anatomical elements can impose local constraints on an otherwise globally self-organized mechanical pattern. In addition, our analyses of the rhinarial patterns in cow clones highlight a substantial level of stochasticity in the pre-pattern of vessels, while our numerical simulations also recapitulate the disruption of the folding pattern in cows affected by a hereditary disorder that causes hyperextensibility of the skin.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5197-5212.e4"},"PeriodicalIF":8.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconstitution of Arp2/3-nucleated actin assembly with proteins CP, V-1, and CARMIL. 用 CP、V-1 和 CARMIL 蛋白重建 Arp2/3 核肌动蛋白组装。

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 Epub Date: 2024-10-21 DOI: 10.1016/j.cub.2024.09.051

Olivia L Mooren, Patrick McConnell, James D DeBrecht, Anshuman Jaysingh, John A Cooper

{"title":"Reconstitution of Arp2/3-nucleated actin assembly with proteins CP, V-1, and CARMIL.","authors":"Olivia L Mooren, Patrick McConnell, James D DeBrecht, Anshuman Jaysingh, John A Cooper","doi":"10.1016/j.cub.2024.09.051","DOIUrl":"10.1016/j.cub.2024.09.051","url":null,"abstract":"Actin polymerization is often associated with membrane proteins containing capping-protein-interacting (CPI) motifs, such as capping protein, Arp2/3, myosin I linker (CARMIL), CD2AP, and WASHCAP/Fam21. CPI motifs bind directly to actin-capping protein (CP), and this interaction weakens the binding of CP to barbed ends of actin filaments, lessening the ability of CP to functionally cap those ends. The protein V-1/myotrophin binds to the F-actin-binding site on CP and sterically blocks CP from binding barbed ends. CPI-motif proteins also weaken the binding between V-1 and CP, which decreases the inhibitory effects of V-1, thereby freeing CP to cap barbed ends. Here, we address the question of whether CPI-motif proteins on a surface analogous to a membrane lead to net activation or inhibition of actin assembly nucleated by Arp2/3 complex. Using reconstitution with purified components, we discovered that CARMIL at the surface promotes and enhances actin assembly, countering the inhibitory effects of V-1 and thus activating CP. The reconstitution involves the presence of an Arp2/3 activator on the surface, along with Arp2/3 complex, V-1, CP, profilin, and actin monomers in solution, recreating key features of cell physiology.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5173-5186.e4"},"PeriodicalIF":8.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monogenean parasitic flatworms. 单基因寄生扁虫

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 DOI: 10.1016/j.cub.2024.10.033

Maarten P M Vanhove, Antoine Pariselle, Nikol Kmentová

引用次数: 0

Mosaic evolution of a learning and memory circuit in Heliconiini butterflies. 蝶类学习记忆回路的镶嵌式进化

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 Epub Date: 2024-10-18 DOI: 10.1016/j.cub.2024.09.069

Max S Farnworth, Theodora Loupasaki, Antoine Couto, Stephen H Montgomery

{"title":"Mosaic evolution of a learning and memory circuit in Heliconiini butterflies.","authors":"Max S Farnworth, Theodora Loupasaki, Antoine Couto, Stephen H Montgomery","doi":"10.1016/j.cub.2024.09.069","DOIUrl":"10.1016/j.cub.2024.09.069","url":null,"abstract":"How do neural circuits accommodate changes that produce cognitive variation? We explore this question by analyzing the evolutionary dynamics of an insect learning and memory circuit centered within the mushroom body. Mushroom bodies are composed of a conserved wiring logic, mainly consisting of Kenyon cells, dopaminergic neurons, and mushroom body output neurons. Despite this conserved makeup, there is huge diversity in mushroom body size and shape across insects. However, empirical data on how evolution modifies the function and architecture of this circuit are largely lacking. To address this, we leverage the recent radiation of a Neotropical tribe of butterflies, the Heliconiini (Nymphalidae), which show extensive variation in mushroom body size over comparatively short phylogenetic timescales, linked to specific changes in foraging ecology, life history, and cognition. To understand how such an extensive increase in size is accommodated through changes in lobe circuit architecture, we combined immunostainings of structural markers, neurotransmitters, and neural injections to generate new, quantitative anatomies of the Nymphalid mushroom body lobe. Our comparative analyses across Heliconiini demonstrate that some Kenyon cell sub-populations expanded at higher rates than others in Heliconius and identify an additional increase in GABA-ergic feedback neurons, which are essential for non-elemental learning and sparse coding. Taken together, our results demonstrate mosaic evolution of functionally related neural systems and cell types and identify that evolutionary malleability in an architecturally conserved parallel circuit guides adaptation in cognitive ability.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5252-5262.e5"},"PeriodicalIF":8.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk between the circatidal and circadian clocks mediates behavioral adaptation to tidal patterns. 潮汐钟和昼夜节律钟之间的相互联系介导了对潮汐模式的行为适应。

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 Epub Date: 2024-10-22 DOI: 10.1016/j.cub.2024.09.067

Erica R Kwiatkowski, Joshua J C Rosenthal, Patrick Emery

{"title":"Crosstalk between the circatidal and circadian clocks mediates behavioral adaptation to tidal patterns.","authors":"Erica R Kwiatkowski, Joshua J C Rosenthal, Patrick Emery","doi":"10.1016/j.cub.2024.09.067","DOIUrl":"10.1016/j.cub.2024.09.067","url":null,"abstract":"The ability to anticipate tides is critical for a wide range of marine organisms, but this task is complicated by the diversity of tidal patterns on Earth. Previous findings suggest that organisms whose geographic range spans multiple types of tidal cycles can produce distinct patterns of rhythmic behavior that correspond to the tidal cycles they experience. How this behavioral plasticity is achieved, however, is unclear. Here, we show that Parhyale hawaiensis adapts its rhythmic behavior to various naturally occurring tidal regimens through the plastic contribution of its circatidal and circadian clocks. After entrainment to a tidal cycle that deviated only mildly from a regular 12.4 h tidal cycle, animals exhibited strong circatidal rhythms. By contrast, following entrainment to more irregularly spaced tides or to tides that occurred every 24.8 h, a significant fraction of animals instead synchronized to the light/dark (LD) cycle and exhibited circadian behavior, while others showed rhythmic behavior with both circatidal and circadian traits. We also show that the circatidal clock, while able to entrain to various naturally occurring tidal patterns, does not entrain to an unnatural one. We propose that Parhyale hawaiensis's ecological success around the world relies in part on the plastic interactions between the circatidal and circadian clocks, which shape its rhythmic behavior appropriately according to tidal patterns.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5239-5251.e2"},"PeriodicalIF":8.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prior cocaine use diminishes encoding of latent information by orbitofrontal, but not medial, prefrontal ensembles. 之前吸食可卡因会减少眶额叶对潜在信息的编码，但不会减少内侧前额叶组合对潜在信息的编码。

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 Epub Date: 2024-10-24 DOI: 10.1016/j.cub.2024.09.064

Lauren E Mueller, Caitlin Konya, Melissa J Sharpe, Andrew M Wikenheiser, Geoffrey Schoenbaum

{"title":"Prior cocaine use diminishes encoding of latent information by orbitofrontal, but not medial, prefrontal ensembles.","authors":"Lauren E Mueller, Caitlin Konya, Melissa J Sharpe, Andrew M Wikenheiser, Geoffrey Schoenbaum","doi":"10.1016/j.cub.2024.09.064","DOIUrl":"10.1016/j.cub.2024.09.064","url":null,"abstract":"Maladaptive decision-making is a hallmark of substance use disorders (SUDs), though how drugs of abuse alter neural representations supporting adaptive behavior remains poorly understood. Past studies show that the orbitofrontal (OFC) and prelimbic (PL) cortices are important for decision-making, tracking both task-relevant and latent information. However, previous studies have focused on how drugs of abuse impact the firing rates of individual units. More work at the ensemble level is necessary to accurately characterize potential drug-induced changes. Using single-unit recordings in rats during a multidimensional decision-making task and then applying population- and ensemble-level analyses, we show that prior use of cocaine altered the strength and structure of task-relevant and latent representations in the OFC, changes relatable to suboptimal decision-making in this and perhaps other settings. These data expand our understanding of the neuropathological underpinnings of maladaptive decision-making in SUDs, potentially enabling enhanced future treatment strategies.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5223-5238.e3"},"PeriodicalIF":8.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cleavage of WOX5 by the peptidase DA1 connects cytokinin signaling and root stem cell regulation. 肽酶 DA1 对 WOX5 的裂解连接了细胞分裂素信号和根干细胞调控。

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 Epub Date: 2024-10-21 DOI: 10.1016/j.cub.2024.09.052

Guicai Cui, Yiqian Zhai, Yu Li, Leiying Zheng, Yunhai Li

{"title":"The cleavage of WOX5 by the peptidase DA1 connects cytokinin signaling and root stem cell regulation.","authors":"Guicai Cui, Yiqian Zhai, Yu Li, Leiying Zheng, Yunhai Li","doi":"10.1016/j.cub.2024.09.052","DOIUrl":"10.1016/j.cub.2024.09.052","url":null,"abstract":"The root system of a plant is essential for plant growth and development because it absorbs nutrients and water from the soil. The root stem cells are maintained and replenished by the quiescent center and are essential for the formation of the specific root structure. In Arabidopsis, the WUSCHEL-RELATED HOMEOBOX 5 (WOX5) plays a key role in regulating root stem cell fate. However, which factor can directly modulate the stability of WOX5 protein remains totally unknown. Here, we report that the peptidase DA1 (LARGE IN CHINESE) interacts with and cleaves WOX5, resulting in the destabilization of WOX5. Genetic analyses support that DA1 acts through WOX5 to regulate root stem cell function. We further demonstrate that cytokinin (CK) signaling induces the accumulation of DA1 protein, thereby decreasing the abundance of WOX5 protein in the root. Consistent with these results, the mutation in DA1 increases the layers of columella stem cells and influences CK-induced differentiation of columella stem cells. Thus, our results reveal a previously unrecognized mechanism by which the cleavage of WOX5 by DA1 connects CK signaling and root stem cell function in Arabidopsis.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5187-5196.e3"},"PeriodicalIF":8.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced pollen tube performance at high temperature contributes to thermotolerant fruit and seed production in tomato. 高温下花粉管性能的提高有助于番茄耐高温果实和种子的生产。

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 Epub Date: 2024-11-06 DOI: 10.1016/j.cub.2024.10.025

Sorel V Yimga Ouonkap, Meenakshisundaram Palaniappan, Kelsey Pryze, Emma Jong, Mohammad Foteh Ali, Benjamin Styler, Rasha Althiab Almasaud, Alexandria F Harkey, Robert W Reid, Ann E Loraine, Steven E Smith, James B Pease, Gloria K Muday, Ravishankar Palanivelu, Mark A Johnson

{"title":"Enhanced pollen tube performance at high temperature contributes to thermotolerant fruit and seed production in tomato.","authors":"Sorel V Yimga Ouonkap, Meenakshisundaram Palaniappan, Kelsey Pryze, Emma Jong, Mohammad Foteh Ali, Benjamin Styler, Rasha Althiab Almasaud, Alexandria F Harkey, Robert W Reid, Ann E Loraine, Steven E Smith, James B Pease, Gloria K Muday, Ravishankar Palanivelu, Mark A Johnson","doi":"10.1016/j.cub.2024.10.025","DOIUrl":"10.1016/j.cub.2024.10.025","url":null,"abstract":"Rising temperature extremes during critical reproductive periods threaten the yield of major grain and fruit crops. Flowering plant reproduction depends on the ability of pollen grains to generate a pollen tube, which elongates through the pistil to deliver sperm cells to female gametes for double fertilization. We used tomato as a model fruit crop to determine how high temperature affects the pollen tube growth phase, taking advantage of cultivars noted for fruit production in exceptionally hot growing seasons. We found that exposure to high temperature solely during the pollen tube growth phase limits fruit biomass and seed set more significantly in thermosensitive cultivars than in thermotolerant cultivars. Importantly, we found that pollen tubes from the thermotolerant Tamaulipas cultivar have enhanced growth in vivo and in vitro under high temperature. Analysis of the pollen tube transcriptome's response to high temperature allowed us to define two response modes (enhanced induction of stress responses and higher basal levels of growth pathways repressed by heat stress) associated with reproductive thermotolerance. Importantly, we define key components of the pollen tube stress response, identifying enhanced reactive oxygen species (ROS) homeostasis and pollen tube callose synthesis and deposition as important components of reproductive thermotolerance in Tamaulipas. Our work identifies the pollen tube growth phase as a viable target to enhance reproductive thermotolerance and delineates key pathways that are altered in crop varieties capable of fruiting under high-temperature conditions.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5319-5333.e5"},"PeriodicalIF":8.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glossiness disrupts predator localisation of moving prey. 光泽会干扰捕食者对移动猎物的定位。

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 DOI: 10.1016/j.cub.2024.09.066

Amanda M Franklin, Molly R Brown, Nikolas J Willmott

{"title":"Glossiness disrupts predator localisation of moving prey.","authors":"Amanda M Franklin, Molly R Brown, Nikolas J Willmott","doi":"10.1016/j.cub.2024.09.066","DOIUrl":"https://doi.org/10.1016/j.cub.2024.09.066","url":null,"abstract":"Movement is the \"enemy of camouflage\", but most animals must move to find resources, such as mates, food and shelter. Therefore, strategies that disrupt predator localization or speed perception of moving prey can play a crucial role in prey survival. Shiny or glossy appearances, which are characterised by having a high degree of specular (mirror-like) reflection of incident light1, can disrupt predator hunting behaviours towards moving prey2. Different mechanisms may explain this effect3,4,5, but no study has attempted to identify the mechanisms that disrupt perception of moving glossy prey by non-human predators. Here, we present moving glossy green or grey targets to jumping spiders (Maratus griseus) and precisely document predator hunting behaviours using high speed videography. Jumping spiders were less precise at tracking glossy targets compared to control targets, suggesting glossiness may disrupt localisation of moving targets. Importantly for prey, jumping spider attack jumps were substantially less accurate towards glossy prey compared to control targets. These results were independent of underlying target colour, suggesting benefits of glossiness may be generalisable to differently coloured glossy animals. Our results indicate that glossiness, when paired with motion, creates an unpredictable target that is difficult for predators to localise, offering insights into the prevalence of dynamically coloured organisms in nature.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"34 22","pages":"R1131-R1132"},"PeriodicalIF":8.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary biology: Co-option and the evolution of morphological novelty. 进化生物学：共同选择与形态新颖性的进化。

IF 8.1 1区生物学

Current Biology Pub Date : 2024-11-18 DOI: 10.1016/j.cub.2024.10.031

Amber M Ridgway, Alistair P McGregor

引用次数: 0