Current Biology最新文献_第5页

Spatial proteomics reveals carboxysome adaptation and mitochondrial proteome in Paulinella chromatophora. 空间蛋白质组学揭示了褐泡藻的羧基体适应性和线粒体蛋白质组学。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-22 DOI: 10.1016/j.cub.2026.08.063

Lawrence Rudy Cadena, Thomas Lenz, Christian Stiebeling, Kai Stühler, Gereon Poschmann, Eva C M Nowack

{"title":"Spatial proteomics reveals carboxysome adaptation and mitochondrial proteome in Paulinella chromatophora.","authors":"Lawrence Rudy Cadena, Thomas Lenz, Christian Stiebeling, Kai Stühler, Gereon Poschmann, Eva C M Nowack","doi":"10.1016/j.cub.2026.08.063","DOIUrl":"10.1016/j.cub.2026.08.063","url":null,"abstract":"The Rhizarian amoeba Paulinella chromatophora represents a unique case of primary endosymbiosis, which has acquired photosynthetic organelles (chromatophores) independently of the endosymbiosis event that gave rise to plastids. Using localization of organelle proteins by isotope tagging following differential centrifugation (LOPIT-DC)-based spatial proteomics, we generated a subcellular protein atlas of P. chromatophora, thus providing a comprehensive view of organelle biology in this lineage. Analysis of chromatophore-targeted proteins revealed that the second part of the bi-partite chromatophore transit peptide (crTP) remains permanently attached post-import. The absence of β-barrel proteins in chromatophore-associated clusters supports the hypothesis of vesicle-mediated protein import as opposed to a translocon-based mechanism. We further identified nucleus-encoded proteins predating chromatophore acquisition in the Paulinella lineage that now associate with chromatophore carboxysomes. Their predicted activities are consistent with an O2-scavenging system that could locally reduce O2 levels around the ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), thereby enhancing carbon fixation efficiency in the absence of a complete canonical photorespiratory pathway; an example of the repurposing of pre-existing eukaryotic proteins to modify a bacterial compartment. In the mitochondria, we identified both conserved membrane organization alongside highly divergent, lineage-specific proteins. Together, these results demonstrate how spatial proteomics can reveal both conserved organelle features and lineage-specific innovations in a non-model eukaryote.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5191-5208.e5"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioturbation. 生物扰动作用。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 DOI: 10.1016/j.cub.2024.06.003

Jack J Middelburg

引用次数: 0

Birds shape biogeochemistry and ecosystem function globally. 鸟类在全球范围内塑造生物地球化学和生态系统功能。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 DOI: 10.1016/j.cub.2026.06.061

Ethan S Duvall, Andrew J Abraham, André Bellvé, Christopher E Doughty, Amanda D Rodewald, Amanda L Subalusky, Alexander S Flecker

{"title":"Birds shape biogeochemistry and ecosystem function globally.","authors":"Ethan S Duvall, Andrew J Abraham, André Bellvé, Christopher E Doughty, Amanda D Rodewald, Amanda L Subalusky, Alexander S Flecker","doi":"10.1016/j.cub.2026.06.061","DOIUrl":"https://doi.org/10.1016/j.cub.2026.06.061","url":null,"abstract":"Birds inhabit nearly every environment on Earth, shaping ecosystems through diverse functions that include contributions to biogeochemical cycles. By transporting and recycling nutrients, birds influence the availability and distribution of chemical elements that regulate key ecological processes. Yet, as bird populations decline, their biogeochemical roles remain poorly synthesized, limiting our understanding of the broader consequences of biodiversity loss. Here, we systematically review the role of birds in biogeochemistry, with consequences for ecosystem function, structure, and connectivity globally. We highlight key mechanisms, ecological impacts, and future research and management priorities. We find that birds - by virtue of their broad distribution and abundance, flight-enabled mobility, nutrient-rich diets, and high metabolic demands - play distinct roles in nutrient transport. Although research has focused largely on waterbirds, growing evidence reveals birds' substantial chemical impacts on diverse environments, locally restructuring plant, microbial, and animal communities. Delivery of key limiting elements, such as nitrogen and phosphorus, can boost primary productivity and increase autotroph nutrient content, with bottom-up effects on higher trophic levels. However, bird subsidies can also promote soil acidification, contaminant accumulation, plant damage, and eutrophication. Because birds vary in their diet, size, life history, and behavior, declines in diversity can trigger uneven and cascading ecosystem effects. Human-driven changes in bird abundance, distribution, movement, and nutrition are modifying and diminishing avian-mediated biogeochemical processes across the biosphere, with potential consequences for ecosystem fertility, productivity, functional connectivity, and carbon storage. Nevertheless, opportunities remain to harness bird biogeochemistry in ecological restoration to revitalize Earth's natural nutrient networks.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"36 20","pages":"R1158-R1183"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A peripheral feedforward circuit amplifies taste signals, ensuring behavioral reliability. 外围前馈电路放大味觉信号，确保行为的可靠性。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-23 DOI: 10.1016/j.cub.2026.08.070

Bo-Mi Song, Bong-Hyun Kim, Mark Stopfer

{"title":"A peripheral feedforward circuit amplifies taste signals, ensuring behavioral reliability.","authors":"Bo-Mi Song, Bong-Hyun Kim, Mark Stopfer","doi":"10.1016/j.cub.2026.08.070","DOIUrl":"10.1016/j.cub.2026.08.070","url":null,"abstract":"Mechanisms ensuring reliable behavioral control amid complex, noisy sensory environments are often attributed to the central brain, yet computations occurring at the extreme sensory periphery remain poorly understood. Recent evidence hints at complex computations at the earliest stages of taste detection, but whether peripheral circuits of gustatory receptor neurons (GRNs) exist to perform them remains unknown. Here, using transsynaptic mapping and paired electrophysiological recordings in Drosophila, we reveal a feedforward circuit of monosynaptically connected GRNs. When driven by tastants, these GRNs significantly increase the spiking of follower GRNs, thus integrating, amplifying, and stabilizing taste signals before they reach the central nervous system. Connectivity among these GRNs is selective and directional rather than all-to-all and is mediated by the nicotinic acetylcholine alpha 5 receptor subunit. Genetic ablation of this subunit significantly impairs functional interactions between GRNs and significantly decreases the reliability of taste-driven behaviors, with the phenotypes being reversed by cell-specific rescue of receptor expression. These results demonstrate that GRNs are organized into functional circuits that stabilize taste signals and gustatory behaviors.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5285-5299.e7"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13688462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ecosystem engineering, regime shifts and the rise of animals. 生态系统工程，政权更迭和动物的崛起。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 DOI: 10.1016/j.cub.2026.08.056

Simon A F Darroch, Michelle M Casey, Matthew E Clapham, Dori L Contreras, Zachary Cover, Matthew Craffey, Alison T Cribb, Ivo A P Duijnstee, William Gearty, Brandt M Gibson, Nicholas J Gotelli, Riley Hayes, Pincelli M Hull, Daniel E Ibarra, Jaemin Lee, Cindy V Looy, Benjamin Muddiman, Alex B Shupinski, Sara Sjosten, Felisa A Smith, Alycia L Stigall, Kelly E Tingle, Catalina P Tomé, Katherine A Turk, Amelia Villaseñor, Peter J Wagner, Jennifer D Wagner, Steve C Wang, S Kathleen Lyons

{"title":"Ecosystem engineering, regime shifts and the rise of animals.","authors":"Simon A F Darroch, Michelle M Casey, Matthew E Clapham, Dori L Contreras, Zachary Cover, Matthew Craffey, Alison T Cribb, Ivo A P Duijnstee, William Gearty, Brandt M Gibson, Nicholas J Gotelli, Riley Hayes, Pincelli M Hull, Daniel E Ibarra, Jaemin Lee, Cindy V Looy, Benjamin Muddiman, Alex B Shupinski, Sara Sjosten, Felisa A Smith, Alycia L Stigall, Kelly E Tingle, Catalina P Tomé, Katherine A Turk, Amelia Villaseñor, Peter J Wagner, Jennifer D Wagner, Steve C Wang, S Kathleen Lyons","doi":"10.1016/j.cub.2026.08.056","DOIUrl":"https://doi.org/10.1016/j.cub.2026.08.056","url":null,"abstract":"The term 'ecosystem engineering' refers to biotic processes that modulate the availability of resources to other species. These processes thus modify, maintain or create habitats and impact the abundance and diversity of species within ecosystems. In turn, the study of ecosystem engineering in the fossil record is leading to a re-evaluation of the influence of organisms on the deep-time evolution of Earth-system structure and function. With this comes a growing recognition that biological forces may be key drivers of major transitions in Earth history. There are two crucial questions: first, have new ecosystem engineering processes emerged randomly throughout geologic time, or are they clustered? Second, to what extent has their emergence driven episodes of evolutionary radiation or extinction? Here, we address these questions through the lens of the Ediacaran-Cambrian transition (∼575-530 million years ago) - an interval that witnessed the rapid rise of animals, following nearly four billion years of microbial dominance. We propose that an engineering regime shift occurred in the late Ediacaran that gave rise to new rules of community assembly, new ecological niches, and altered macroevolutionary trajectories. We argue that the recognition of ecosystem engineering regime shifts may help us not only to understand other key intervals in the Phanerozoic, but also to project the future of ecosystems under human influence.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"36 20","pages":"R1145-R1157"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constitutively active presynaptic release factor Unc13A prevents homeostatic sleep rebound in Drosophila. 组成型活跃突触前释放因子Unc13A阻止果蝇体内平衡睡眠反弹。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-29 DOI: 10.1016/j.cub.2026.09.007

Sheng Huang, Debora Fusca, Veronika Moron, Marc Escher, Niraja Ramesh, David Toppe, Zhiying Zhao, Oriane Turrel, Yifan Wu, Sha Liu, Alexander M Walter, Zhihua Liu, Peter Kloppenburg, Stephan J Sigrist, Chengji Piao

{"title":"Constitutively active presynaptic release factor Unc13A prevents homeostatic sleep rebound in Drosophila.","authors":"Sheng Huang, Debora Fusca, Veronika Moron, Marc Escher, Niraja Ramesh, David Toppe, Zhiying Zhao, Oriane Turrel, Yifan Wu, Sha Liu, Alexander M Walter, Zhihua Liu, Peter Kloppenburg, Stephan J Sigrist, Chengji Piao","doi":"10.1016/j.cub.2026.09.007","DOIUrl":"10.1016/j.cub.2026.09.007","url":null,"abstract":"One of the major characteristics of sleep is homeostatic sleep rebound following sleep loss. While the molecular mechanisms of baseline sleep regulation have been intensively studied, a specific molecular understanding of sleep rebound remains elusive. Here, we show that a constitutively active form of the Munc13-family presynaptic release factor Unc13A, which lacks the inhibitory Ca2+/calmodulin interaction domain (Unc13AWRWR), dominantly suppressed homeostatic sleep rebound following acute sleep deprivation, leading to a near-complete elimination of recovery sleep (\"Reboundless\"). In contrast, baseline sleep remained largely normal. Through a genetic modifier screen, we identified partial loss of αSnap, a cofactor of N-ethylmaleimide-sensitive factor (NSF) required for disassembly and recycling of post-fusion cis-SNARE complex, as a potent suppressor of the reboundless phenotype of Unc13AWRWR. Given that Unc13A promotes the formation of the fusion-competent trans-SNARE complex, these findings implicate that sleep rebound critically depends on a delicate balance between SNARE complex assembly and recycling. Since Unc13AWRWR has been shown to promote presynaptic release probability (Pr), we speculate that active Unc13A suppresses rebound sleep likely by increasing Pr and subsequently enhancing synaptic transmission. Consistently, an elevated dependence on trans-SNARE formation and cis-SNARE recycling seems to explain the functional and behavioral phenotypes of Unc13AWRWR. Taken together, our data suggest a fundamental role of Pr mediated by Unc13A and SNARE dynamics in sleep homeostasis.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5314-5327.e4"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A vector navigation and inference architecture can construct universal cognitive maps for abstract reasoning. 向量导航和推理体系结构可以为抽象推理构建通用的认知地图。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 Epub Date: 2026-09-22 DOI: 10.1016/j.cub.2026.08.064

Andrej Bicanski

{"title":"A vector navigation and inference architecture can construct universal cognitive maps for abstract reasoning.","authors":"Andrej Bicanski","doi":"10.1016/j.cub.2026.08.064","DOIUrl":"10.1016/j.cub.2026.08.064","url":null,"abstract":"The idea of cognitive maps in the hippocampal formation has its origins in decades of spatial cognition research. However, increasing evidence points to cognitive maps also supporting non-spatial tasks. It appears that the hippocampal-entorhinal system can map any combination of systematically varying stimulus dimensions onto the same neural manifolds that support spatial representations-grid cells. Here, I propose a model that shows how extant spatial navigation architectures can iteratively construct universal cognitive maps via non-local inference. The model exhibits noise tolerance congruent with behavior, and the mapping process accommodates discontinuous stimulus spaces. It is also shown that the model can support several types of abstract reasoning, including analogy-making, subspace construction, and perspective taking. Importantly, these capabilities are supported by the same computational modules that are used to build a map. Neural-level implementations for several model components are proposed, and it is shown how the (abstract) 1D attributes that are to be combined on a map can be isolated upstream of entorhinal cortex. The combination of mechanisms at play thus suggests how spatial navigation architectures can function as domain-general substrates of cognition.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":" ","pages":"5223-5239.e6"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jiayang Li. Jiayang Li。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 DOI: 10.1016/j.cub.2026.09.041

Jiayang Li

引用次数: 0

The deep-time history of soils and plants. 土壤和植物的悠久历史。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 DOI: 10.1016/j.cub.2026.02.021

Christine Strullu-Derrien, Matthias C Rillig

{"title":"The deep-time history of soils and plants.","authors":"Christine Strullu-Derrien, Matthias C Rillig","doi":"10.1016/j.cub.2026.02.021","DOIUrl":"https://doi.org/10.1016/j.cub.2026.02.021","url":null,"abstract":"For a large community of ecosystem ecologists, plant-soil interactions have moved center stage in the understanding of both plant and soil ecology. Frequently, plants are deemed to be the main drivers of these interactions. However, soils existed before the evolution of land plants (i.e., embryophytes), and terrestrial communities were already highly diverse around 400 million years ago (Ma), reflecting an earlier origin of the organisms that populated them. But which organisms were contemporaneous at the origin of soil and in what type of environment they lived is not well established. Here, we trace the development of soil and its biotic components from the beginnings, about one billion years ago (Ga), by using the fossil record and geochemical data. We show that the first terrestrial ecosystems were probably situated near the ocean, where organisms were already adapted to high oxygen pressures and where plants were not yet present. Drawing on this, we discuss the need to rethink the primacy of plants in modern terrestrial ecosystems, considering that persistence of the soil system over deep time could help explain the enormous current biodiversity found in soil. We advocate for a shift in perspective by embracing a vision of terrestrial ecosystems with interdependent and equally important above- and below-ground system compartments. Finally, we highlight the importance of 'bending the curve' on the increasing rate of soil degradation and loss of soil health, and we discuss the outlook for the future of soils and their interactions with plants.","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":"36 20","pages":"R1122-R1129"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trace fossils. 跟踪化石。

IF 7.7 1区生物学

Current Biology Pub Date : 2026-10-19 DOI: 10.1016/j.cub.2026.09.039

Michael Benton

引用次数: 0