Advanced Functional Materials最新文献_第8页

Multiscale Characterization of Intrinsic Defects in Prussian White Cathodes: Bridging Defect Chemistry with Structure and Electrochemical Performance 普鲁士白阴极内禀缺陷的多尺度表征：桥接缺陷化学与结构和电化学性能

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-30 DOI: 10.1002/adfm.202521753

Xianda Wang, Ruixue Wu, Ziming Zhang, Xiaoxia Li, Wei‐Feng Huang, Hao Wang, Hui Ying Yang, Yang Shang

{"title":"Multiscale Characterization of Intrinsic Defects in Prussian White Cathodes: Bridging Defect Chemistry with Structure and Electrochemical Performance","authors":"Xianda Wang, Ruixue Wu, Ziming Zhang, Xiaoxia Li, Wei‐Feng Huang, Hao Wang, Hui Ying Yang, Yang Shang","doi":"10.1002/adfm.202521753","DOIUrl":"https://doi.org/10.1002/adfm.202521753","url":null,"abstract":"Prussian White (PW) is a highly promising cathode material for sodium‐ and potassium‐ion batteries. However, its typical co‐precipitation synthesis inevitably introduces intrinsic structural defects—most notably [Fe(CN)6] vacancies (VFeCN)—which critically undermine electrochemical performance. Given the thermodynamic and kinetic inevitability of these vacancies, merely suppressing their formation is insufficient. Instead, a deep understanding of their formation mechanisms, structural roles, and degradation pathways is essential for performance optimization. This review systematically deconstructs the types and origins of intrinsic vacancies in PW—including VFeCN, transition metal vacancies (VTM), and cyanide ligand vacancies (VCN)—with a particular emphasis on the conditions that govern VFeCN generation. More importantly, it establishes a multidimensional, multiscale defect characterization framework, spanning electronic structure, atomic coordination, crystal order, and mesoscale morphology. Beyond characterization, the review correlates vacancy chemistry with key electrochemical consequences. VFeCN defects reduce alkali‐ion storage sites, disrupt continuous ion transport pathways, and trigger interfacial side reactions—collectively leading to capacity fading, rate deterioration, limited cycling life, poor low‐temperature performance, and thermal instability. By bridging intrinsic defect chemistry with macroscopic electrochemical performance, this review provides a strategic roadmap for defect‐informed design of robust and high‐efficiency PW cathodes.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"93 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Axial Channel for Gel Electrolyte to Produce Efficient Fiber Dye‐Sensitized Solar Cell 凝胶电解质轴向通道制备高效纤维染料敏化太阳能电池

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-30 DOI: 10.1002/adfm.202522715

Siwei Cao, Li Yong, Jiuzhou Liu, Longmei Ma, Zhe Yang, Yichi Zhang, Jiamin Chen, Haoran Xu, Yedong Qin, Wenjing Zhao, Qingquan Han, Jiahe Qu, Jiatian Song, Peining Chen, Zhengfeng Zhu, Huisheng Peng

引用次数: 0

Triboelectric Sensing Enables Tactile Perception and Material‐Adaptive Intelligent Roughness Detection for CNC Machine Tools 摩擦电传感为CNC机床提供触觉感知和材料自适应智能粗糙度检测

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-30 DOI: 10.1002/adfm.202520285

Jianfeng Tang, Yinglong Shang, Mingxu Xu, Yong Hu, Jianhai Zhang

{"title":"Triboelectric Sensing Enables Tactile Perception and Material‐Adaptive Intelligent Roughness Detection for CNC Machine Tools","authors":"Jianfeng Tang, Yinglong Shang, Mingxu Xu, Yong Hu, Jianhai Zhang","doi":"10.1002/adfm.202520285","DOIUrl":"https://doi.org/10.1002/adfm.202520285","url":null,"abstract":"Surface roughness is the core quality indicator for high‐end manufacturing, but traditional inspection technologies are limited by efficiency, universality and environmental robustness. In this study, an intelligent tactile probe (ITTP) based on TENG is proposed to realize the high‐precision online detection of cross material and continuous roughness. Through the biomimetic multi‐layer structure design, ITTP converts the surface morphology into dynamic electrical signals and combines physical mechanism analysis and signal decomposition algorithm to remove the interference of electronic affinity and contact condition fluctuation. In addition, a further innovative hybrid classification and regression dual neural network model is developed to achieve 100% identification on a combination of six engineering materials and five levels of discrete roughness, while the MLP regression model predicted an average error of <5% for a full range of continuous roughness (0.05–12.5 µm). ITTP is successfully embedded in the Computer Numerical Control (CNC) machine tools to build a “perception‐decision‐control” closed‐loop system, promote the transformation of surface inspection from offline sampling inspection to all‐area online inspection, and provide the core support for real‐time process optimization and zero‐defect production for intelligent manufacturing.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"65 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

P2-Na0.61Ca0.03[Mg2/9Cu1/9Mn2/3]O2 as a High-Energy Oxygen Redox Cathode for Na-Ion Batteries: Investigation of Cu Substitution and Ca Doping to Enhance Cycling Stability (Adv. Funct. Mater. 39/2025) P2-Na0.61Ca0.03[Mg2/9Cu1/9Mn2/3]O2作为na离子电池的高能氧氧化还原阴极：Cu取代和Ca掺杂提高循环稳定性的研究板牙。39/2025)

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-30 DOI: 10.1002/adfm.71551

Jin-Wei Kang, Hsu-Chen Cheng, Hsiang-Jung Chen, Shao-Chu Huang, Chih-Heng Lee, Chin-Lung Kuo, Sheng-Yu Yu, Heng-Liang Wu, Chia-Ching Lin, Chun-Han Kuo, Hao-Hsiang Chang, Chih-Wei Hu, Shu-Chih Haw, Hsin-Yi Tiffany Chen, Han-Yi Chen

{"title":"P2-Na0.61Ca0.03[Mg2/9Cu1/9Mn2/3]O2 as a High-Energy Oxygen Redox Cathode for Na-Ion Batteries: Investigation of Cu Substitution and Ca Doping to Enhance Cycling Stability (Adv. Funct. Mater. 39/2025)","authors":"Jin-Wei Kang, Hsu-Chen Cheng, Hsiang-Jung Chen, Shao-Chu Huang, Chih-Heng Lee, Chin-Lung Kuo, Sheng-Yu Yu, Heng-Liang Wu, Chia-Ching Lin, Chun-Han Kuo, Hao-Hsiang Chang, Chih-Wei Hu, Shu-Chih Haw, Hsin-Yi Tiffany Chen, Han-Yi Chen","doi":"10.1002/adfm.71551","DOIUrl":"https://doi.org/10.1002/adfm.71551","url":null,"abstract":"Na-Ion BatteriesIn their Research Article (10.1002/adfm.202504642), Shu-Chih Haw, Hsin-Yi Tiffany Chen, Han-Yi Chen, and co-workers develop a novel P2-Na0.61Ca0.03[Mg2/9Cu1/9Mn2/3]O2 cathode material for Na-ion batteries. Cu substitution in transition-metal layers stabilizes O ions during oxygen redox, while Ca doping in alkaline-metal layers acts as structural “pillars” to suppress phase transformation. Na0.61Ca0.03[Mg2/9Cu1/9Mn2/3]O2 exhibits a high specific capacity (205 mAh g−1 at 0.1 C), good cyclic stability, and impressive rate capability (142 mAh g−1 at 2.5 C), demonstrating its potential for high-energy Na-ion batteries.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"35 39","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.71551","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4D-Printed Microrobots with Synergistic Integration of Magnetic Actuation, Diffractive Optical Sensing, and pH-Adaptive Morphing 磁驱动、衍射光学传感和ph -自适应变形协同集成的4d打印微型机器人

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-29 DOI: 10.1002/adfm.202518838

Jingang Wang, Jianchen Zheng, Chengzhi Zhang, Ya Duan, Yuzhao Zhang, Hongji Guo, Ye Qiu, Xiaoduo Wang, Lianqing Liu, Haibo Yu

{"title":"4D-Printed Microrobots with Synergistic Integration of Magnetic Actuation, Diffractive Optical Sensing, and pH-Adaptive Morphing","authors":"Jingang Wang, Jianchen Zheng, Chengzhi Zhang, Ya Duan, Yuzhao Zhang, Hongji Guo, Ye Qiu, Xiaoduo Wang, Lianqing Liu, Haibo Yu","doi":"10.1002/adfm.202518838","DOIUrl":"https://doi.org/10.1002/adfm.202518838","url":null,"abstract":"Soft microrobots exhibit distinct advantages in biomedical applications, with their exceptional maneuverability in confined spaces and environmental adaptability offering innovative solutions for targeted theranostics. However, current systems are inherently constrained by the physical separation of sensing and actuation modules, leading to inadequate integration and operational efficiency that hinder practical implementation. To overcome this challenge, a micro-nano 4D printing design paradigm is proposed. Through spatial programming of multi-responsive materials and biomimetic microstructural engineering, a microrobotic system is fabricated with synergistic perception-actuation capabilities. By integrating gradient magnetic field-responsive composites and pH-sensitive hydrogels, a 150-µm-scale biomimetic fish-shaped microrobot is developed, innovatively integrating three functionalities: magnetic-actuation, pH-triggered joint actuation, and diffractive optical sensing. Specifically, its tail joint enables adaptive modulation of doxorubicin release kinetics via pH-mediated mechanical deformation, while the head-mounted diffractive spectral sensor provides dynamic optical feedback of pathological microenvironment pH (5.0–6.5). Proof-of-concept experiments demonstrate the system's precise drug release control and environmental monitoring capabilities in gastric cancer cell therapy. This work provides a 4D printing design approach for next-generation intelligent therapeutic microrobots capable of environmental perception, intelligent response, and precise execution.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"327 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyridinic‐N‐Cu‐Se Interfacial Synergy Enables Stable Bifunctional Oxygen Electrocatalysis 吡啶- N - Cu - Se界面协同作用实现稳定的双功能氧电催化

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-29 DOI: 10.1002/adfm.202517329

Wenwen Chen, Wenyan Cheng, Kuixing Ding, Liming Zhao, Xingping Ge, Jing Zhang, Huanan Yu, Jingji Zhang, Yi Yang, Hongshuai Hou, Jiugang Hu, Xiaobo Ji

{"title":"Pyridinic‐N‐Cu‐Se Interfacial Synergy Enables Stable Bifunctional Oxygen Electrocatalysis","authors":"Wenwen Chen, Wenyan Cheng, Kuixing Ding, Liming Zhao, Xingping Ge, Jing Zhang, Huanan Yu, Jingji Zhang, Yi Yang, Hongshuai Hou, Jiugang Hu, Xiaobo Ji","doi":"10.1002/adfm.202517329","DOIUrl":"https://doi.org/10.1002/adfm.202517329","url":null,"abstract":"Transition metal selenides (TMSes) have garnered significant attention as bifunctional electrocatalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in rechargeable zinc‐air batteries (ZABs). However, their catalytic performance and durability remain constrained by the low‐activity interfacial environments. Herein, synergistic pyridinic‐N‐Cu‐Se interfacial configurations are designed and constructed on 3D nitrogen‐doped carbon nanosheets (Cu2‐xSe@3D‐NCNs) via a molten salt‐assisted strategy. Theoretical simulations and in situ spectroscopic analyses reveal that the pyridinic‐N‐Cu‐Se interface induces a significant downshift of the Cu d‐band center, optimizes adsorption of oxygen species, and drives dynamic surface reconstruction into amorphous oxyhydroxide species under OER conditions. These oxyhydroxides serve as the true active phase for OER, while coordination‐driven electronic modulation of Cu sites facilitates adsorption of oxygen intermediates during ORR, thereby enhancing reaction kinetics. As a result, Cu2‐xSe@3D‐NCNs exhibits excellent bifunctional activity, featuring a low potential gap (ΔE = 0.76 V), a high peak power density (103.8 mW cm−2), and extended cycling life (750 cycles) in aqueous ZABs. Furthermore, the assembled flexible ZABs demonstrate stable performance under mechanical deformation, highlighting its potential for next‐generation wearable energy storage systems. This work underscores the critical role of interfacial coordination engineering in the development of durable and efficient bifunctional electrocatalysts.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"95 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effect of High-Energy (211) Facets and (101) Twin Defects of SnO2 Nanowires for Ultrasensitive ppb-Level Formaldehyde Monitoring 高能（211）面和（101）双缺陷对SnO2纳米线超灵敏ppb级甲醛监测的协同效应

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-29 DOI: 10.1002/adfm.202512541

Ya-Ning Wang, Jia Yang, Xue-Li Hu, Yan-Yang Li, Lin Zhang, Qing-Chao Liu, Hong-Chang Yao

{"title":"Synergistic Effect of High-Energy (211) Facets and (101) Twin Defects of SnO2 Nanowires for Ultrasensitive ppb-Level Formaldehyde Monitoring","authors":"Ya-Ning Wang, Jia Yang, Xue-Li Hu, Yan-Yang Li, Lin Zhang, Qing-Chao Liu, Hong-Chang Yao","doi":"10.1002/adfm.202512541","DOIUrl":"https://doi.org/10.1002/adfm.202512541","url":null,"abstract":"SnO2 gas sensors have attracted significant interest for formaldehyde detection due to their real-time monitoring capabilities, cost-effectiveness, and portability. However, low sensitivity, poor selectivity, and limited long-term stability remain critical challenges for trace-level formaldehyde detection. Here, the synthesis of SnO2 nanowires with preferentially exposed high-energy (211) facets and abundant (101) twin defects via a solvothermal approach is reported. Gas-sensing evaluations revealed that sensors constructed from these nanowires, particularly those with maximized exposure of (211) facets and (101) twin defects, exhibited an impressive response of 15.2 toward 10 ppm formaldehyde. Notably, these sensors demonstrated exceptional selectivity for formaldehyde against interfering gases, including methanol, toluene, ammonia, formic acid, acetone, and ethanol, with a detection limit as low as 59 ppb and robust long-term stability. The enhanced formaldehyde sensing performance is attributed to two synergistic effects: i) the increased density of active sites for oxygen adsorption on the high-energy (211) crystal facets, which possess abundant atomic steps, and ii) the Schottky barrier at the twin boundaries, which broadens the depletion layer and accelerates electron transfer through its intrinsic electric field. These findings highlight the promising strategy of engineering high-energy crystal facets and twin defects to significantly elevate the gas-sensing performance of semiconductor nanomaterials.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"37 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Metabolic Rewiring Amplifies Cellular Oxidation and Reverses Immunosuppression for Combating Orthotopic Triple-Negative Breast Cancer 双代谢重布线放大细胞氧化和逆转免疫抑制对抗原位三阴性乳腺癌

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-29 DOI: 10.1002/adfm.202518702

Qiu-Yi Duan, Shi-Hao Wang, Ke-Fei Xu, Yuxin Guo, Xiaoyang Liu, Shao-Zhe Wang, Bai-Hui Shan, Hui-Heng Feng, Qiming Xu, Yang Shen, Fu-Gen Wu

{"title":"Dual Metabolic Rewiring Amplifies Cellular Oxidation and Reverses Immunosuppression for Combating Orthotopic Triple-Negative Breast Cancer","authors":"Qiu-Yi Duan, Shi-Hao Wang, Ke-Fei Xu, Yuxin Guo, Xiaoyang Liu, Shao-Zhe Wang, Bai-Hui Shan, Hui-Heng Feng, Qiming Xu, Yang Shen, Fu-Gen Wu","doi":"10.1002/adfm.202518702","DOIUrl":"https://doi.org/10.1002/adfm.202518702","url":null,"abstract":"Abnormal glucose/lactate metabolism is one of the key hallmarks of a tumor. Leveraging the excessive metabolite lactate to generate reactive oxygen species (ROS) by lactate oxidase (LOx) has become an efficient method for cancer therapy. However, the hypoxic tumor microenvironment (TME) and ROS-scavenging enzymes largely restrict the catalytic activity of LOx. Herein, we design an ROS generator composed of LOx-encapsulated and 7-ethyl-10-hydroxycamptothecin (SN-38)- and tamoxifen (TAM)-coloaded membrane fusion liposomes, which can directly release cargoes via fusion with cancer cell membranes. Through the glycolysis promotion and mitochondrial respiration inhibition by TAM, and the antioxidant enzyme downregulation by SN-38, the generator not only spares oxygen and increases intracellular lactate for LOx catalysis to yield cytotoxic H2O2, but also avoids ROS removal, realizing triple-amplified ROS production and effective cancer cell killing. In the TME of an orthotopic breast cancer model, the generator consumes lactate and produces immunostimulatory H2O2, thereby promoting the M1-like polarization of tumor-associated macrophages and suppressing regulatory T cells to remodel the immunosuppressive TME. Additionally, the generator inhibits angiogenesis and further cancer metastasis via hypoxia inducible factor-1α (HIF-1α) signaling blockage. Collectively, this work provides an inspirational example of using a glucose/lactate metabolism interference strategy to fight against orthotopic triple-negative breast cancer.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"139 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Square-Wettability Patterned, Recyclable Polyolefin Elastomer Sorbents for Efficient Chemical and Oil Spill Collection 方形润湿性图案，可回收的聚烯烃弹性体吸附剂，用于有效的化学和溢油收集

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-29 DOI: 10.1002/adfm.202519092

Youngmin Choi, Jinhyeok Kang, Changwoo Nam

{"title":"Square-Wettability Patterned, Recyclable Polyolefin Elastomer Sorbents for Efficient Chemical and Oil Spill Collection","authors":"Youngmin Choi, Jinhyeok Kang, Changwoo Nam","doi":"10.1002/adfm.202519092","DOIUrl":"https://doi.org/10.1002/adfm.202519092","url":null,"abstract":"Effective remediation of marine chemical spills remains a critical challenge due to the rapid dispersion and volatility of hazardous compounds. Conventional polypropylene (PP) sorbents exhibit limited absorption kinetics and pose risks of secondary contamination. Here, an architected polyolefin elastomer (POE) film is presented with engineered surface macro-patterns that enhance solvent uptake via polymer matrix swelling in the amorphous phase. Pattern spacing is systematically tuned to regulate sorption dynamics and film–solvent interactions. The optimized POE film achieved a chloroform uptake of 36.2 g g−1 within 10 min—surpassing commercial PP sorbents (14.2 g g−1) and unpatterned POE films (19.7 g g−1). Finite element modeling corroborated that sorption behavior is governed by film thickness and surface geometry. Additionally, functionalization with magnetic nanoparticles enabled facile recovery, while fluorescence doping facilitated nighttime detection. Importantly, the all-polyolefin composition permits complete recyclability through standard pyrolysis pathways, aligning with crude oil refining streams. This multifunctional, recyclable sorbent platform offers a promising avenue for responsive, high-performance, and sustainable environmental protection technologies.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"5 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Learning-Driven Co-Assembly of Naturally Sourced Compound Nanoparticles for Potentiated Cancer Immunotherapy 深度学习驱动的天然复合纳米颗粒协同组装用于增强癌症免疫治疗

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-09-29 DOI: 10.1002/adfm.202519567

Yiming Shan, Zimei Zhang, Huiling Zhou, Bo Hou, Fangmin Chen, Jiaxing Pan, Siyuan Ren, Miaomiao Yu, Zhiai Xu, Mingyue Zheng, Haijun Yu

{"title":"Deep Learning-Driven Co-Assembly of Naturally Sourced Compound Nanoparticles for Potentiated Cancer Immunotherapy","authors":"Yiming Shan, Zimei Zhang, Huiling Zhou, Bo Hou, Fangmin Chen, Jiaxing Pan, Siyuan Ren, Miaomiao Yu, Zhiai Xu, Mingyue Zheng, Haijun Yu","doi":"10.1002/adfm.202519567","DOIUrl":"https://doi.org/10.1002/adfm.202519567","url":null,"abstract":"Co-assembly of excipient-free nanoparticles has emerged as a promising drug delivery platform due to their high drug-loading capacity, ease of preparation, and ability to achieve combination therapeutic effects. However, the absence of systematic design strategies has hindered their broader application. In this study, a deep learning platform, Gramord, is developed to rationally design the excipient-free anti-tumor nanoparticles of nature-sourced compounds. A comprehensive database of excipient-free nanoparticles is first built and used to train Gramord for predicting self-assembly compatibility. By screening 1800 naturally-derived small molecules and their derivatives, the compound pairs capable of forming excipient-free nanoparticles are identified. Leveraging the advantage of oridonin (Ori) for inducing apoptosis of tumor cells and cepharanthine (Cep) for eliciting immunogenic cell death of tumor cells, the Ori-Cep pair for preparing the self-assemble nanoparticles (namely OCN) is subsequently selected. Using a mouse model of CT26 colorectal tumor, it is demonstrated that the systemically administrated OCN specifically accumulate at the tumor sites, and regress tumor growth by inducing anti-tumor immunogenicity and recruiting tumor-infiltrating cytotoxic T lymphocytes. This study highlights the application of artificial intelligence in designing excipient-free nanomedicine, offering a scalable and cost-effective approach to expanded therapeutic options.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"97 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0