{"title":"Ultrasound-Propelled Nanomotors Enable Activatable Near-Infrared-II Fluorescence Imaging-Guided Synergistic Oxygen-Independent and Oxygen-Dependent Sonodynamic Therapy of Atherosclerosis","authors":"Zeyu Jiang, Chuang Wei, Shanglang Cai, Qinrui Fu","doi":"10.1002/adfm.202503885","DOIUrl":"https://doi.org/10.1002/adfm.202503885","url":null,"abstract":"Sonodynamic therapy (SDT) holds great promise as a therapeutic approach for treating atherosclerotic plaque. However, the therapeutic efficacy of SDT is hindered by the restricted tissue penetration depth and insufficient generation of reactive oxygen species (ROS) associated with conventional sonosensitizers. Furthermore, determining the optimal timing for ultrasound (US) irradiation after the administration of sonosensitizers presents a significant technical challenge. Addressing these issues is crucial for enhancing the effectiveness of SDT. Herein, a hyaluronic acid-modified US-propelled Janus mesoporous SiO<sub>2</sub> partially coated gold nanorods loaded with 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) is developed, along with functionalized Ag/Ag<sub>2</sub>S nanoparticles (HA-JASAA), for near-infrared-II (NIR-II) fluorescence imaging-guided SDT of atherosclerotic plaque. Following intravenous administration of HA-JASAA, the hyaluronic acid modification enables specific targeting of proinflammatory macrophages within atherosclerotic plaques. Subsequently, upon reacting with H<sub>2</sub>O<sub>2</sub> in the atherosclerotic microenvironment, it turns on the NIR-II fluorescence signal. US irradiation is applied when the intensity of NIR-II fluorescence signal reaches its peak; AIPH loaded in HA-JASAA undergoes conversion into nitrogen propelling the HA-JASAA toward deep penetration into plaque tissue. Furthermore, under US activation, two sonosensitizers, AIPH and Ag<sub>2</sub>S, generate oxygen-independent and oxygen-dependent ROS respectively to induce apoptosis of lesional macrophages, thereby significantly inhibiting the progression of atherosclerotic plaque.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"183 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Bionic Grooving All-Cementitious-Dielectric Metastructure with Unprecedented Wide-Angle Broadband Electromagnetic Wave Absorption Properties","authors":"Xiaoran Wang, Qinghua Li, Haoxin Lai, Yu Peng, Chunying Hou, Shilang Xu","doi":"10.1002/adfm.202425949","DOIUrl":"https://doi.org/10.1002/adfm.202425949","url":null,"abstract":"The absorption performance of electromagnetic (EM) wave absorbing materials deteriorates sharply at large incident angles, particularly at angles exceeding 50°. To overcome this challenge, this study proposes a bionic grooving all-cementitious-dielectric metastructure (ACDMS), yielding more than 34.6 GHz effective absorption bandwidth (<i>EAB</i>) over 0°–60° incident angles without any absorbing agent. The effects of structural design, geometric parameters, and incident angles on the EM response and absorption performance are investigated by numerical simulations and experimental characterizations. It is found that the ACDMS enables multiple absorption mechanisms under various incident angles, including electric field redistribution, multi-axis interference, surface wave excitation, and multiple diffraction/scattering pathways. Experimental results demonstrate that at 60° incident angle, the absorption performance of the ACDMS even exceeds that at normal incidence, achieving a relative <i>EAB</i> of 163%, a -20 dB (99% absorption) bandwidth of 33.4 GHz, and a mean reflectivity of −23.4 dB in 1–40 GHz range. The RCS simulation and environmental testing across fluctuating humidity (40%–80%) and temperature (10–220 °C) exposures underscore the exceptional potential for practical applications and harsh environmental conditions. The combination of innovative absorption mechanisms, environmental adaptability and a convenient cement-based manufacturing process establishes the ACDMS as a promising candidate for next-generation EM wave absorbers.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"72 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lingting Zeng, Bin Zhao, Danyang Chen, Chao Xia, Qianjun He
{"title":"GeSe Nanosheets-Mediated Local Sonocatalytic Immunosuppression of Rheumatoid Arthritis","authors":"Lingting Zeng, Bin Zhao, Danyang Chen, Chao Xia, Qianjun He","doi":"10.1002/adfm.202420195","DOIUrl":"https://doi.org/10.1002/adfm.202420195","url":null,"abstract":"The first-line systemic administration of anti-rheumatic immunosuppressants unavoidably causes adverse effects such as the increase in the risk of infection. While the emergence of local drug delivery for rheumatoid arthritis (RA) therapy can effectively reduce systemic adverse effects, persistent RA therapy remains challenging. In this work, a local sonocatalytic immunosuppression strategy for persistent RA therapy without the use of traditional immunosuppressants is proposed, and develop GeSe nanosheets (GSN) with a high piezoelectric coefficient and a wide bandgap to realize efficient sonocatalytic H<sub>2</sub> production and lactic acid (LA) consumption within the articular cavity for combined immunosuppression, which restrains the deteriorate of RA. Mechanistically, locally generated H<sub>2</sub> inhibits the intraarticular levels of proinflammatory cytokines TNF-α, IFN-γ and receptor activator of nuclear factor-κB ligand (RANKL) by preventing the conversion of Th0 cells to Th1 cells, and consequently blocks the differentiation of macrophages into activated osteoclasts and the osteoclastic expression of LA. At the same time, sonocatalytic oxidation/consumption of LA eradicates the corrosion of LA to bone and cartilage. The proposed sonocatalytic immunosuppression strategy precedes photocatalysis owing to remarkably higher tissue penetrability of ultrasound than light and will open a window to realize efficient treatment of deep-seated immune-related diseases.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"30 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laser-Induced Ultrafine Cu-Anchored 3D CNT-rGO Carrier for Flexible and Durable Zinc-Iodine Micro-Batteries","authors":"Xiangyu Wang, Yubing Sun, Qiang Wang, Lijun Tang, Hui Wang, Tiansheng Mu, Yongchao Zhang, Xiaodong Zhu, Jian Gao","doi":"10.1002/adfm.202502268","DOIUrl":"https://doi.org/10.1002/adfm.202502268","url":null,"abstract":"Three-dimensional (3D) carbon materials are often used as carriers for anchoring iodine in zinc-iodine batteries (ZIBs). However, the physical stacking of carbon materials during the electrode assembly process, the weaker physical interactions between non-polar carbon materials and iodine species, and the scarcity of catalytic sites for iodine conversion led to a reduced catalytic activity for the iodine redox reaction, which fails to completely inhibit the shuttling of iodine species. Here, 3D ultrafine Cu-anchored CNT-rGO carriers (3D Cu@CNT-rGO) with interconnected structures are prepared using a simple laser-induced reduction strategy. The 3D microporous structure and excellent electrical conductivity of 3D Cu@CNT-rGO make it an ideal host for iodine. Ultrafine Cu nanoparticles introduce as catalysts accelerate the redox kinetics, efficiently catalyze iodine/polyiodide conversion, inhibit polyiodide shuttling, and enhance the electrochemical performance of ZIBs. The fabricated zinc-iodide micro-batteries (ZIMBs) delivers a high specific area capacity of 1.29 mAh cm<sup>−2</sup>, a high area energy density (1.55 mWh cm<sup>−2</sup>) and a high area power density (33.58 mW cm<sup>−2</sup>) as well as excellent cyclin stability (80% capacity retention after 4000 cycles). Meanwhile, ZIMBs have excellent mechanical flexibility and have great potential for application in the field of integrated, miniaturized and flexible electronic devices.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"22 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuxin Cai, Xuejia Kang, Lang Zhou, Shuai Wu, Chuanyu Wang, Siqi Wu, Chunghui Huang, Qi Wang, Ya Chang, R. Jayachandra Babu, Pengyu Chen
{"title":"Multifunctional Superparamagnetic Copper Iron Oxide Nanoparticles for Synergistic Cancer Therapy via Magnetic Hyperthermia, Oxidative Stress and Immune Reprogramming","authors":"Yuxin Cai, Xuejia Kang, Lang Zhou, Shuai Wu, Chuanyu Wang, Siqi Wu, Chunghui Huang, Qi Wang, Ya Chang, R. Jayachandra Babu, Pengyu Chen","doi":"10.1002/adfm.202425286","DOIUrl":"https://doi.org/10.1002/adfm.202425286","url":null,"abstract":"Aggressive cancers, characterized by high metastatic potential and resistance to conventional therapies, present a significant challenge in oncology. Current treatments often fail to effectively target metastasis, recurrence, and the immunosuppressive tumor microenvironment, while causing significant off-target toxicity. Here, superparamagnetic copper iron oxide nanoparticles (SCIONs) as a multifunctional platform that integrates magnetic hyperthermia therapy, immune modulation, and targeted chemotherapeutic delivery, aiming to provide a more comprehensive cancer treatment is presented. Specifically, SCIONs generate localized hyperthermia under an alternating magnetic field while delivering a copper-based anticancer agent, resulting in a synergistic anticancer effect. The hyperthermia induced by SCIONs caused ER stress and ROS production, leading to significant tumor cell death, while the copper complex further enhanced oxidative stress, ferroptosis, and apoptosis. Beyond direct cytotoxicity, SCIONs disrupted the tumor microenvironment by inhibiting cancer-associated fibroblasts, downregulating epithelial-mesenchymal transition markers, and reducing cell migration and invasion, thereby limiting metastasis. Additionally, SCION-based therapy reprogrammed the immune microenvironment by inducing immunogenic cell death and enhancing dendritic cell activation, resulting in increased CD8+ T cell infiltration and amplified antitumor immunity. This integrated approach targets primary and metastatic tumors while mitigating immunosuppression, offering a promising next-generation therapy for combating cancer with enhanced efficacy and reduced side effects.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"33 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naiming Liu, Depeng Chu, Xiaoqiong Xin, Jingyun Tian, Yujia Jiang, Nan Liang, Binxia Jia, Yucheng Liu, Shengzhong (Frank) Liu
{"title":"Unveiling the Role of Cesium in Halide Perovskite Single Crystal for Stable and Ultrasensitive X-Ray Detection","authors":"Naiming Liu, Depeng Chu, Xiaoqiong Xin, Jingyun Tian, Yujia Jiang, Nan Liang, Binxia Jia, Yucheng Liu, Shengzhong (Frank) Liu","doi":"10.1002/adfm.202504203","DOIUrl":"https://doi.org/10.1002/adfm.202504203","url":null,"abstract":"Metal halide perovskites have been demonstrated to be the promising X-ray detection materials, among which MAPbI<sub>3</sub> is expected for high-performance large-area X-ray detector integration due to its strong X-ray absorption and solution processible at low temperature for industrial-grade large-size single crystal (SC). However, the commercial viability of MAPbI<sub>3</sub> SC X-ray detectors remains challenging due to its poor intrinsic stability, large dark current, and significant ion migration. Herein, inorganic Cs<sup>+</sup> ions are designed to incorporate into the MAPbI<sub>3</sub> SC and the effects of Cs<sup>+</sup> on crystal structure, defect state, band structure, ion migration, and carrier transport in the SCs are systematically unveiled. The experimental results show that the incorporation of Cs<sup>+</sup> ion reduces defect density, inhibits ion migration, improves carrier mobility, and increases resistivity. Therefore, detectors fabricated on the SC with Cs<sup>+</sup> ions show high detection sensitivity of 49847 µC Gy<sup>−1</sup> cm<sup>−2</sup>, low detection limit of 3.1 nGy s<sup>−1</sup>, short response raise time of 150 µs, and superior long-term operating stability under continuous X-ray irradiation and bias. The rare combination of these figure of merits enables the detector to achieve high-definition X-ray imaging, confirming that this work provides a new strategy for designing stable and sensitive X-ray detectors.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"183 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High Entropy Metal Phosphide Activated Fluorinated Carbon as Electroactive Host for Extra High Cathode Capacity in Lithium–Sulfur Batteries","authors":"Rui Gao, Yating Zhang, Peng Chen, Tianying Yan, Xueping Gao","doi":"10.1002/adfm.202502090","DOIUrl":"https://doi.org/10.1002/adfm.202502090","url":null,"abstract":"Lithium–sulfur (Li–S) batteries are one of the most promising high-energy battery systems due to the high theoretical energy density (2600 Wh kg<sup>−1</sup>). However, a large proportion of electro-inert host materials are typically employed in cathode composites, which severely reduces the practical performance of Li–S batteries. In this study, a novel approach is proposed using fluorinated activated carbon (CF) as an electroactive host of sulfur for the first time, which can release extra capacity during the initial operation. Specifically, with the activation effect of in situ deposited high entropy metal phosphide (HEP) catalyst Pd<sub>0.34</sub>Sn<sub>0.15</sub>Ni<sub>0.05</sub>Co<sub>0.09</sub>Cu<sub>0.29</sub>P<sub>0.08</sub>, the extra capacity of the HEP/CF host is almost 1.5 times higher than pristine CF. Consequently, the S/HEP/CF cathode exhibits high initial discharge capacity (1059.2 mAh g<sup>−1</sup><sub>−composite</sub> at 0.1C), high rate performance (476.5 mAh g<sup>−1</sup><sub>−composite</sub> at 2C) and long-term cycling stability. Moreover, the as-prepared cathode retains high initial discharge capacity of 492.6 mAh g<sup>−1</sup><sub>−composite</sub> under harsh conditions (sulfur loading of 3.2 mg cm<sup>−2</sup> and lean electrolyte/sulfur ratio of 10 µL mg<sup>−1</sup>). This work demonstrates a new strategy for designing electroactive sulfur hosts to improve the performance of Li–S batteries.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"31 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficient Electrooxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid in a Weak Alkaline Medium Enabled by Interfacial OH− Enrichment","authors":"Peiyun Zhou, Xiang Liu, Zhuo Chen, Cheng Tang, Xikang Zhao, Jinyu Zheng, Ruixiang Ge, Haohong Duan","doi":"10.1002/adfm.202502081","DOIUrl":"https://doi.org/10.1002/adfm.202502081","url":null,"abstract":"Developing electrooxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) in a weak alkaline medium can potentially inhibit HMF degradation to humins and thus mitigate carbon loss that is encountered in strong alkaline media; however, the activity is often compromised under low OH<sup>−</sup> concentration. Herein, by incorporating chromium oxide (CrO<i><sub>x</sub></i>) as a hard Lewis acid onto CoO<i><sub>x</sub></i> surface (CoO<i><sub>x</sub></i>–CrO<i><sub>x</sub></i>), HMF electrooxidation activity is largely boosted in a 1 <span>m</span> carbonate buffer (pH 11), including higher FDCA Faradaic efficiency (from 41% to 90%), selectivity (from 33% to 92%), and yield (from 28% to 89%). The electrolysis under the weak alkaline medium can tolerate high HMF initial concentration (100 m<span>m</span>), showing higher carbon balance (97%) compared with that in strong alkali (≈70%). Experimental data reveal that CrO<i><sub>x</sub></i> accelerates OH<sup>−</sup> migration from bulk to the electrode surface and enriches OH<sup>−</sup> at the electrode–electrolyte interface, enhancing catalyst reconstruction and reaction intermediate conversion, thus promoting the activity. Furthermore, the interfacial OH<sup>−</sup> enrichment strategy is demonstrated effective for other weak alkaline medium and for other biomass-derived molecule (ethylene glycol and glycerol) electrooxidations. This work demonstrates that hard-Lewis-acid-induced OH<sup>−</sup> enrichment dynamically optimizes interfacial microenvironment, establishing a new design principle for efficient electrocatalytic systems under weak alkaline conditions.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"36 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pusen Cao, Jie Wei, Tingting Zhang, Huanyang Deng, Yilei Han, Zhenghang Chen, Yuxia Chen, Yong Guo, Chao Ma
{"title":"Multifunctional Luffa Sponge Hydrogel with High Mechanical Strength, Fatigue Resistance, and Ionic Conductivity for Monitoring Human Vital Signs","authors":"Pusen Cao, Jie Wei, Tingting Zhang, Huanyang Deng, Yilei Han, Zhenghang Chen, Yuxia Chen, Yong Guo, Chao Ma","doi":"10.1002/adfm.202501131","DOIUrl":"https://doi.org/10.1002/adfm.202501131","url":null,"abstract":"Biomass-based multifunctional hydrogels with high mechanical strength, fatigue resistance, and electrical conductivity are promising materials for the fabrication of flexible electronic devices. However, achieving mutually exclusive properties simultaneously remains challenging. Herein, a novel luffa sponge (LS) composite multi-functional hydrogel (WLSHG) is prepared. The LS is dignified to create a flexible 3D skeleton, which is then polymerized with polyacrylamide in situ using a tannic acid–ferric ions reoxidation system. Benefiting from the strong physical support of the LS skeleton and multiple interactions between molecules in the system, synergistically enhanced the mechanical properties of the hydrogel. The compressive strength and modulus of the WLSHG increased by 557% and 2000%, respectively, compared with the pristine hydrogels. And the honeycomb-like microchannels in the LS bundle facilitated efficient ion transport, resulting in an ionic conductivity of 0.124 S m<sup>−1</sup> for WLSHG. The WLSHG-based flexible strain sensor exhibited excellent sensitivity (2.03 kPa<sup>−1</sup>) and stability (>1000 cycles) over a wide pressure range. By integrating this sensor into an array and using Internet of Things and machine learning technologies, its ability is successfully demonstrated to accurately recognize human sitting position and gait patterns. This study presents a promising approach for fabricating high-performance biomass-based hydrogels for flexible electronic devices.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"19 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ir/CeO2 Single-Atom Nanoislands as an Atomic-Nano System for Highly Efficient Self-Cascade Glucose Oxidase and Peroxidase Mimics","authors":"Lie Wu, Yubei Zhang, Chu Li, Chaolei Hua, Chenchen Chu, Mingyang Jiang, Qiongdi Zhang, Dandan Ma, Yijie Chen, Guan Liu, Chenying He, Xin Wang, Licheng Bai, Rui He, Xue-Feng Yu, Wenhua Zhou, Shengyong Geng","doi":"10.1002/adfm.202504434","DOIUrl":"https://doi.org/10.1002/adfm.202504434","url":null,"abstract":"The stability and activity of self-cascade enzymes based on glucose oxidase (GOx) and peroxidase (POD) are usually low, which has significant limitations in tumor catalytic therapy. Building nanoislands-supported single-atom nanozymes with strong atomic-nano interaction is an effective strategy for enhancing the self-cascade enzyme-like activity. Herein, noble metal iridium (Ir) single-atoms are successfully deposited on CeO<sub>2</sub> quantum dots (QDs) nanoislands to construct Ir/CeO<sub>2</sub> single-atom nanoislands (SANIs). The CeO<sub>2</sub> QDs nanoislands with abundant oxygen vacancies facilitate efficient electron transfer of Ir single-atoms at the metal-nanoislands interface. A liposomal nano platform encapsulated with Ir/CeO<sub>2</sub> SANIs (Ir/CeO<sub>2</sub>@Lipo) is further developed for in vivo catalytic therapy. The Ir/CeO<sub>2</sub>@Lipo exhibits excellent self-cascade GOx- and POD-like activity due to its unique atomic-nano structures and the confined effect of the nanoislands. Compared with CeO<sub>2</sub>@Lipo and other reported nanozymes, Ir/CeO<sub>2</sub>@Lipo catalyzes glucose to generate more ROS with higher efficiency, demonstrating superior GOx-POD self-cascade enzyme-like activity. In vivo, experiments demonstrate that Ir/CeO<sub>2</sub>@Lipo possesses excellent tumor-targeting capability as well as nearly complete tumor ablation through ROS-mediated apoptotic pathways. Thus, this work provides a new paradigm for designing self-cascade enzymes for tumor treatment strategies.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"64 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}