Diagnostics最新文献

{"title":"Prediction of Cardiac Arrhythmias in Cancer Patients Treated with Immune Checkpoint Inhibitors Using Electrocardiogram.","authors":"Alper Coskun, Ece Celebi Coskun, Ahmet Bilgehan Sahin, Fatih Levent, Eyup Coban, Fatih Koca, Seda Sali, Omer Furkan Demir, Adem Deligonul, Erhan Tenekecioglu, Erdem Cubukcu, Fahriye Vatansever Agca, Turkkan Evrensel","doi":"10.3390/diagnostics15101235","DOIUrl":"10.3390/diagnostics15101235","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Immune checkpoint inhibitor (ICI)-associated cardiovascular adverse events are relatively uncommon; they can be life-threatening, particularly when involving malignant ventricular arrhythmias. Electrocardiographic markers such as P-wave dispersion (PWD), QT dispersion (QTd), T-peak to T-end (Tp-e) interval, and Tp-e/QT and Tp-e/QTc ratios have been linked to an elevated risk of both atrial and ventricular arrhythmias and sudden cardiac death across various cardiac conditions. Monitoring these parameters may aid in identifying the risk of arrhythmogenic events in cancer patients undergoing ICI therapy. <b>Methods</b>: This retrospective cohort study analyzed 42 patients with cancer who received ICI therapy and had serial 12-lead electrocardiograms (ECGs) performed at baseline and at three-month intervals during the first year of treatment, from May 2022 to November 2023. ECG parameters including PWD, QTd, Tp-e interval, and Tp-e/QT and Tp-e/QTc ratios were measured and compared between baseline and follow-up time points. <b>Results</b>: The median follow-up duration was 5.3 months (range: 0.5-18.9 months). No statistically significant differences were observed in any of the ECG parameters between baseline and subsequent measurements (<i>p</i> > 0.05). One patient developed atrial fibrillation during the third month of treatment. Additionally, one patient exhibited a left anterior fascicular block, and another experienced frequent ventricular extrasystoles. No malignant ventricular arrhythmias were reported throughout the study period. <b>Conclusions</b>: This study found no significant changes in electrocardiographic markers associated with arrhythmia risk during ICI treatment. Larger, multicenter, prospective studies with extended follow-up are warranted to further elucidate the cardiovascular safety profile of ICIs.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Emerging Biomarkers in Chronic Obstructive Pulmonary Disease: A Narrative Review.","authors":"Kaitlin M Phillips, Philip F Lavere, Nicola A Hanania, Muhammad Adrish","doi":"10.3390/diagnostics15101245","DOIUrl":"10.3390/diagnostics15101245","url":null,"abstract":"<p><p>The burden of chronic obstructive pulmonary disease (COPD) is increasing, especially for women in low-to-middle income countries. Biomarkers provide ever-increasing diagnostic precision for COPD and show promise for primary, secondary, and tertiary disease prevention. This review describes emerging applications for biomarkers in COPD, especially as they align with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) emphasis on prevention, early diagnosis, and response to therapy. These biomarkers include blood eosinophils; IgE; C-reactive protein; fibrinogen; procalcitonin; interleukins 6, 8, and 33; tumor necrosis factor alpha; and soluble receptor for advanced glycated products (sRAGE). They have been used in various ways to identify COPD endotypes, predict exacerbations, predict mortality, and monitor the response to therapy. The fraction of exhaled nitric oxide (FENO) is increasingly studied in eosinophilic COPD endotypes and can be a diagnostic and predictive non-invasive biomarker. Imaging biomarkers, especially the quantitative computerized tomography (QCT) assessment of airway remolding, functional small airway disease, air trapping, lung function, and volume surrogates, all serve as non-invasive biomarkers for screening, early detection, and disease progression. Biomarkers facilitate all the phases of COPD care from detecting early airflow obstruction to predicting exacerbation and mortality. Biomarkers will be increasingly used as precise diagnostic tools to improve the COPD outcomes. The aim of this narrative review is to summarize the recent investigations in COPD biomarkers and their clinical applications.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing AI to Clinicians: Simplifying Pleural Effusion Cytology Diagnosis with User-Friendly Models.","authors":"Enrico Giarnieri, Elisabetta Carico, Stefania Scarpino, Alberto Ricci, Pierdonato Bruno, Simone Scardapane, Daniele Giansanti","doi":"10.3390/diagnostics15101240","DOIUrl":"10.3390/diagnostics15101240","url":null,"abstract":"<p><p><b>Background:</b> Malignant pleural effusions (MPEs) are common in advanced lung cancer patients. Cytological examination of pleural fluid is essential for identifying cell types but presents diagnostic challenges, particularly when reactive mesothelial cells mimic neoplastic cells. AI-powered diagnostic systems have emerged as valuable tools in digital cytopathology. This study explores the applicability of machine-learning (ML) models and highlights the importance of accessible tools for clinicians, enabling them to develop AI solutions and make advanced diagnostic tools available even in resource-limited settings. The focus is on differentiating normal/reactive cells from neoplastic cells in pleural effusions linked to lung adenocarcinoma. <b>Methods:</b> A dataset from the Cytopathology Unit at the Sant'Andrea University Hospital comprising 969 raw images, annotated with 3130 single mesothelial cells and 3260 adenocarcinoma cells, was categorized into two classes based on morphological features. Object-detection models were developed using YOLOv8 and the latest YOLOv11 instance segmentation models. <b>Results:</b> The models achieved an Intersection over Union (IoU) score of 0.72, demonstrating robust performance in class prediction for both categories, with YOLOv11 showing performance improvements over YOLOv8 in different metrics. <b>Conclusions:</b> The application of machine learning in cytopathology offers clinicians valuable support in differential diagnosis while also expanding their ability to engage with AI tools and methodologies. The diagnosis of MPEs is marked by substantial morphological and technical variability, underscoring the need for high-quality datasets and advanced deep-learning models. These technologies have the potential to enhance data interpretation and support more effective clinical treatment strategies in the era of precision medicine.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasible and Rapid Screening of <i>IDH1/2</i> and <i>FLT3-TKD2</i> Mutations by High-Resolution Melting for Patients with Acute Myeloid Leukemia.","authors":"José Vicente Gil, Sandra de Las Heras, Alberto Miralles, Claudia Sargas, Marta Llop, Rebeca Rodríguez-Veiga, Laura Torres-Miñana, Blanca Boluda, Isabel Cano-Ferri, Evelyn Acuña-Cruz, Irene Navarro, Pilar Lloret-Madrid, Pau Montesinos, Eva Barragán","doi":"10.3390/diagnostics15101230","DOIUrl":"10.3390/diagnostics15101230","url":null,"abstract":"<p><p><b>Background</b>: In recent years, numerous recurrently mutated genes have been identified in acute myeloid leukemia (AML), some of which, such as <i>FLT3</i> and <i>IDH1/2</i>, serve as therapeutic targets, offering new treatment options. Rapid mutational analysis is crucial for timely and optimal therapy selection. This study aims to develop and validate a rapid, cost-effective, and sensitive screening method for detecting <i>IDH1</i>, <i>IDH2</i>, and <i>FLT3</i>-TKD2 mutations using polymerase chain reaction (PCR) and high-resolution melting curve analysis (HRM). <b>Methods</b>: A PCR-HRM assay was developed to simultaneously detect mutations in <i>IDH1</i>, <i>IDH2</i>, and <i>FLT3</i>-TKD2. The method was applied to a cohort of 1363 AML patients, and its performance, including turnaround time, was evaluated through comparison with next-generation sequencing (NGS) results. <b>Results</b>: The PCR-HRM method demonstrated a positive percent agreement of 98%, 98%, and 92% for <i>IDH1</i>, <i>IDH2</i>, and <i>FLT3-TKD2</i>, respectively, and a negative percent agreement of 100% for all three genes compared to NGS. No false positives were observed, and false negatives were detected in less than 1% of cases, mostly in <i>FLT3</i>-TKD2, all occurring below the established limit of detection. The turnaround time and cost of PCR-HRM were significantly lower than those of NGS. <b>Conclusions</b>: This method offers a highly sensitive, specific, and time-efficient approach for the simultaneous detection of <i>IDH1</i>, <i>IDH2</i>, and <i>FLT3</i>-TKD2 mutations in AML patients. Its rapid turnaround time and cost-effectiveness make it a valuable tool for routine clinical screening, facilitating timely and targeted treatment decisions.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and Immunohistochemical Support for the Origin of the Carcinoid Component in Strumal Carcinoids: A Case Report and Literature Review.","authors":"Yu Liu, Asra Feroze, Liz Yang, Ridin Balakrishnan","doi":"10.3390/diagnostics15101249","DOIUrl":"10.3390/diagnostics15101249","url":null,"abstract":"<p><p>Strumal carcinoid tumors of the ovary are rare neoplasms composed of an intimate mixture of thyroid and carcinoid tissues. Although various theories regarding their histogenesis have been proposed, evidence confirming the origin of the carcinoid component has been lacking. We report a case of a 40-year-old female with an ovarian strumal carcinoid arising in the background of a mature cystic teratoma. Morphological and immunohistochemical findings support the hypothesis that the carcinoid component originates from the thyroid follicular epithelium, undergoing neuroendocrine differentiation. A single-cell growth pattern was also identified, expanding the known histological spectrum of strumal carcinoids. Our case provides additional immunohistochemical support for the histogenetic origin of strumal carcinoids, offering new insights into their pathogenesis. Recognizing these distinct patterns of staining and unusual morphology is critical for accurate diagnosis and differentiation from metastatic disease.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Evaluation of Accuracy of CBCT-Derived Volumes in Maxillary Defects: Effects of kVp, Device, and Software.","authors":"Sema Murat, Kıvanç Kamburoğlu, Diego Vazquez, Leonardo Jorge Nart, Victoria Azcona, Lorena Elizabeth Benitez, Mohammed Awawdeh, Wael Aboelmaaty","doi":"10.3390/diagnostics15101247","DOIUrl":"10.3390/diagnostics15101247","url":null,"abstract":"<p><p><b>Objectives:</b> This study aimed to evaluate the accuracy of CBCT-based volumetric measurements of maxillary defects and to investigate the effects of different CBCT devices, kVp settings, and segmentation software on measurement accuracy. <b>Methods:</b> CBCT images from eight patients with maxillary defects were used to generate 3D-printed models for volumetric assessment. Two CBCT systems (Largev Smart and Planmeca Promax) were evaluated at three different kVp settings. Volume calculations were conducted using ITK-SNAP version 4.2.2 and 3D Doctor version 4.0 software, while micro-CT served as the gold standard (GS) for comparison. Statistical analysis included a three-way ANOVA to assess the effect of CBCT parameters and software on volumetric accuracy. Additionally, post-hoc Tukey HSD analysis was performed to identify specific differences between kVp groups, and Pearson correlation analysis was used to evaluate consistency with the GS. Significance level was set at <i>p</i> < 0.05. <b>Results:</b> Higher kVp settings significantly improved volumetric accuracy, with 100 kVp yielding the smallest deviations (-3.77%) from the GS. Tukey HSD analysis revealed significant differences between 60-80 kVp (<i>p</i> = 0.008), 60-100 kVp (<i>p</i> < 0.001), and 80-100 kVp (<i>p</i> = 0.041), confirming the influence of kVp on accuracy. No significant differences were observed between CBCT devices or software programs (<i>p</i> > 0.05). A strong positive correlation (r = 0.96) between CBCT-derived and micro-CT volumes confirmed CBCT's reliability for volumetric assessments (<i>p</i> < 0.001). <b>Conclusions:</b> CBCT provides accurate volumetric measurements of maxillary defects, particularly at higher kVp settings. These findings support its clinical application for preoperative planning and postoperative evaluation, offering a cost-effective alternative to micro-CT.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Thyroxine Replacement Therapy on Serum Maresin 1 and NF-kB Levels in Patients with Hashimoto Thyroiditis.","authors":"Meltem Yardim, Levent Deniz, Mehmet Akif Saltabas, Nilufer Celik","doi":"10.3390/diagnostics15101248","DOIUrl":"10.3390/diagnostics15101248","url":null,"abstract":"<p><p><b>Background/Objectives:</b> This study aimed to investigate the effects of thyroxine replacement therapy (TRT) on serum Maresin 1 and nuclear factor kappa beta (NF-kB) levels in patients with Hashimoto's thyroiditis (HT). <b>Methods:</b> A total of 90 patients were included in this study, 60 with HT and 30 without. Patients in the HT group were divided into two groups according to whether they received TRT. Group 1 included 30 patients who underwent TRT, and Group 2 comprised 30 patients who were newly diagnosed with HT, either euthyroid or hypothyroid. The analysis included serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody (TPOAb), Maresin 1, and NF-kB. <b>Results:</b> The serum NF-kB level in the TRT group was significantly higher than that in the control and non-TRT groups. In the subgroup analysis of patients who did not receive TRT, the serum NF-kB level in euthyroid patients was significantly lower than that in hypothyroid patients. Maresin 1 levels in the control group were significantly higher than those in patients who did and did not receive TRT. The serum Maresin 1 level in the TRT group was significantly lower than that in the untreated group. Maresin 1 levels were higher in the euthyroid group than in the hypothyroid group. TPOAb levels were positively correlated with NF-kB and negatively correlated with Maresin 1. <b>Conclusions:</b> TRT maintains the euthyroid state in patients with HT, but may not contribute positively to the pro-anti-inflammatory balance in these patients.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based Volumetry.","authors":"Federico Bruno, Cristina Fagotti, Gaspare Saltarelli, Giovanni Di Cerbo, Alessandra Sabatelli, Claudia De Felici, Antonio Innocenzi, Ernesto Di Cesare, Alessandra Splendiani","doi":"10.3390/diagnostics15101246","DOIUrl":"10.3390/diagnostics15101246","url":null,"abstract":"<p><p><b>Background</b>: Accurate assessment of brain atrophy is essential in the diagnosis and monitoring of brain aging and neurodegenerative disorders. Radiological methods range from narrative reporting to semi-quantitative visual rating scales (VRSs) and fully automated volumetric software. However, their integration and consistency in clinical practice remain limited. <b>Methods</b>: In this retrospective study, brain MRI images of 43 patients were evaluated. Brain atrophy was assessed by extrapolating findings from narrative radiology reports, three validated VRSs (MTA, Koedam, Pasquier), and Pixyl.Neuro.BV, a commercially available volumetric software platform. Agreement between methods was assessed using intraclass correlation coefficients (ICCs), Cohen's kappa, Spearman's correlation, and McNemar tests. <b>Results</b>: Moderate correlation was found between narrative reports and VRSs (ρ = 0.55-0.69), but categorical agreement was limited (kappa = 0.21-0.30). Visual scales underestimated atrophy relative to software (mean scores: VRSs = 0.196; software = 0.279), while reports tended to overestimate. Agreement between VRSs and software was poor (kappa = 0.14-0.33), though MTA showed a significant correlation with hippocampal volume. Agreement between reports and software was lowest for global atrophy. <b>Conclusions</b>: Narrative reports, while common in practice, show low consistency with structured scales and quantitative software, especially in subtle cases. VRSs improve standardization but remain subjective and less sensitive. Integrating structured scales and volumetric tools into clinical workflows may enhance diagnostic accuracy and consistency in dementia imaging.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and Grading of Textural Interface Opacities in DSAEK Grafts with the M-TIO Scale for Predicting Visual Outcomes.","authors":"Marina S Chatzea, George D Kymionis, Dionysios G Vakalopoulos, Robert C O'Brien, Daniella Mora, Katrina Llanes, Elizabeth Fout, William Buras, Concetta Triglia, Rahul S Tonk, Sonia H Yoo","doi":"10.3390/diagnostics15101241","DOIUrl":"10.3390/diagnostics15101241","url":null,"abstract":"<p><p><b>Background</b>: Textural Interface Opacities (TIOs) following Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) have become a notable postoperative concern. Several studies have attempted to identify associations between TIO development and intraoperative factors, including fluid dynamics, irregular stromal surfaces, viscoelastic usage, and recipient immunological responses. Despite these efforts, the precise etiology of TIO remains uncertain. TIO has not been considered predictable in the preoperative setting. Its detection has relied exclusively on slit-lamp biomicroscopy, a subjective approach lacking standardized diagnostic criteria, which limits diagnostic reliability and is highly susceptible to interobserver variability. <b>Methods</b>: Optical Coherence Tomography (OCT) images of DSAEK-processed corneal grafts, prepared using the same microkeratome and technique for transplantation at the Bascom Palmer Eye Institute, underwent blinded analysis using a newly developed grading scale termed \"M-TIO\". This analysis focused on DSAEK-processed grafts OCT images to evaluate and categorize the occurrence of TIO and assess the final visual acuity of the patients at the 1-year postoperative evaluation. <b>Results</b>: Based on the results, the M-TIO grading scale demonstrated strong predictive value, with higher grades on OCT of DSAEK lenticules consistently associated with worse postoperative visual acuity. The study included 221 donor corneas transplanted from 2019 to 2023. Greater TIO based on the \"M-TIO\" grading scale was associated with worse recipient logMAR VA (Mean 0.151 [99% CI: 0.077 to 0.225] for corneas with no TIO, increased to 0.680 [99% CI: 0.532 to 0.828] for corneas with the greatest TIO grade). These findings highlight the clinical utility of the M-TIO scale as an objective and reliable preoperative tool for assessing graft quality and predicting postoperative visual outcomes. <b>Conclusions</b>: This study introduces the \"M-TIO\" grading scale, which provides a standardized and objective method for evaluating Textural Interface Opacities in DSAEK grafts prior to transplantation. Our results demonstrate a clear association between the severity of TIO as graded by the M-TIO scale, and postoperative visual outcomes, with higher TIO grades correlating with worse visual acuity, emphasizing its value in improving graft selection, and clinical decision-making in DSAEK.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of a New Radiographic Technique with MRI Measurements for Tibial Tunnel Evaluation in ACL Reconstruction.","authors":"Mücahid Osman Yücel, Raşit Emin Dalaslan, Sönmez Sağlam, Zekeriya Okan Karaduman, Mehmet Arıcan, Bedrettin Akar, Volkan Tural","doi":"10.3390/diagnostics15101237","DOIUrl":"10.3390/diagnostics15101237","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The correct angular placement of the tibial tunnel is crucial to ensure graft tension, maintain knee stability, and ensure optimal clinical outcomes after anterior cruciate ligament (ACL) reconstruction. While 3D imaging methods such as MRI and CT are the gold standard for evaluating tunnel positioning, their routine use is limited by cost, availability, and time constraints. In clinical practice, 2D radiographs are more accessible but lack established reliability in accurately estimating tunnel angles. The aim of this study was to convert 2D radiographic angular measurements used in the evaluation of patients undergoing anterior cruciate ligament reconstruction into 3D values with a simple method and to compare these measurements with three-dimensional angles calculated using conventional MRI and CT. <b>Methods</b>: This retrospective study included 38 patients who underwent anatomic anterior cruciate ligament reconstruction. Postoperative radiographs and MR images were analyzed to determine the tibial tunnel angles. The angles calculated from 2D radiographs were statistically analyzed for their correlation with the actual 3D angles measured by MRI. <b>Results</b>: The analysis showed a strong correlation between tibial tunnel angles from radiographs and MRI, with minimal, non-significant differences. This suggests that radiographs can provide a reliable estimate of tibial tunnel angles. <b>Conclusions</b>: These findings suggest that radiographs can predict tibial tunnel angles in ACL reconstruction as accurately as MRI. This method can guide the correct tunnel angle and facilitate postoperative evaluation. Further studies are needed to confirm these results across various populations and techniques.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}