Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"Nomogram-Based Prediction Model for Suboptimal Weight Loss Outcomes After Metabolic Bariatric Surgery Using CT-Derived Body Composition Parameters: A Prospective Chinese Cohort Study.","authors":"Wei Zhu, Xiaoqing Yuan, Zhen Hao, Jia Li, Fengxia Yu, Weihua Li, Hongxia Yin, Peng Zhang, Zhenchang Wang, Wenmin Guan, Peng Zhang","doi":"10.2147/DMSO.S614373","DOIUrl":"https://doi.org/10.2147/DMSO.S614373","url":null,"abstract":"<p><strong>Background and aim: </strong>Metabolic bariatric surgery (MBS) provides potent and sustained efficacy in managing obesity and its associated comorbidities. Nevertheless, suboptimal weight loss outcomes persist in a notable proportion of patients after MBS. This study aimed to identify influencing risk factors and develop a predictive model to predict 1-year suboptimal weight loss outcomes following MBS in a prospective Chinese cohort.</p><p><strong>Methods: </strong>This study involved a prospective cohort of 120 patients who underwent MBS at Beijing Friendship Hospital from November 2021 to September 2023. Optimal weight loss outcome was defined as a total weight loss percentage (%TWL) ≥ 20% at the 1-year follow-up. Patient's clinical, biochemical, and CT-derived body composition parameters were collected at baseline and 1 year postoperatively. Independent predictors of suboptimal weight loss outcome were identified through univariate and multivariate logistic regression. Subsequently, a nomogram was constructed and internally validated with its discrimination, calibration, and clinical utility.</p><p><strong>Results: </strong>The study included 120 patients (77.5% female) with a mean age of 33.4 ± 8.7 years and a baseline body mass index (BMI) of 38.5 ± 7.1 kg/m². Patients' weight, BMI, glycemic control, lipid profiles, and body composition parameters were improved significantly after MBS (P < 0.05). Twenty‑two patients (18.3%) were categorized as suboptimal outcome. Univariate and multivariate logistic regression analyses revealed that higher fasting blood glucose (FBG, OR 1.284, P = 0.037), lower HDL-C (OR 0.426, P = 0.024), larger subcutaneous adipose tissue (SAT; OR 1.006, P = 0.018), and lower paraspinal muscle (PSM) area (OR 0.938, P = 0.033) were independent predictors of suboptimal outcomes. The resulting nomogram demonstrated good discrimination with an AUC of 0.801 (95% CI: 0.708-0.914) and calibration, with decision curve analysis confirming its clinical utility.</p><p><strong>Conclusion: </strong>Preoperative body composition parameters, specifically SAT and PSM, are critical determinants of weight loss outcome following MBS. The nomogram model constructed based on biochemical and body composition factors in this prospective Chinese cohort may offers great significance for preoperative assessment for MBS candidates in China. Nevertheless, further external validation in independent cohorts is warranted before its routine clinical application.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"614373"},"PeriodicalIF":3.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese Medicine Interventions for Overweight and Obesity in Adults: An Umbrella Review and Evidence Map.","authors":"Qin Qin, Yue Gou, Yunhui Xie, Hongmei Zhu, Yanjun Liu","doi":"10.2147/DMSO.S618894","DOIUrl":"https://doi.org/10.2147/DMSO.S618894","url":null,"abstract":"<p><strong>Background: </strong>Traditional Chinese medicine (TCM) is widely used for weight management, but the reliability and comparability of the available review-level evidence remain uncertain. This umbrella review evaluated the methodological quality, certainty, and quantitative findings of systematic reviews and meta-analyses of TCM interventions for adults with overweight or obesity.</p><p><strong>Methods: </strong>We searched PubMed, Embase, the Cochrane Library, CNKI, Wanfang, CBM, and VIP for systematic reviews and meta-analyses of randomized controlled trials. Methodological quality and certainty of evidence were evaluated using AMSTAR-2 and GRADE. Primary-study overlap was assessed using a citation matrix and the corrected covered area (CCA). Mean differences (MDs) were pooled only when outcome units were clinically compatible; standardized effects were reported narratively and were not combined with MDs. Random-effects models and leave-one-out analyses were used for body weight and body mass index (BMI).</p><p><strong>Results: </strong>Twelve systematic reviews or meta-analyses were retained. They contained 254 primary-study occurrences and a non-unique review-level participant total of 19,795. Citation matching identified 155 unique primary studies, producing a CCA of 5.81%, which indicated moderate overlap. In MD-only analyses, TCM interventions were associated with reductions in body weight (overall MD = -3.11 kg, 95% CI -4.05 to -2.16; I² = 90.9%) and BMI (overall MD = -1.26 kg/m², 95% CI -1.61 to -0.90; I² = 91.0%).The body-weight and BMI results remained statistically significant in leave-one-out analyses. For BMI, external therapies, TCM exercise, and the herbal-medicine subgroup all showed significant pooled effects.</p><p><strong>Conclusion: </strong>TCM interventions may improve body weight and BMI in adults with overweight or obesity. However, substantial heterogeneity, overlap between reviews, inconsistent outcome reporting, and predominantly low-to-moderate certainty limit confidence in the estimates. The current evidence is insufficient to support definitive treatment rankings or strong clinical recommendations.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"618894"},"PeriodicalIF":3.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Younger Age is Associated with Treatment and Complication Outcomes Among Type 2 Diabetes Mellitus Patients in Kigali University Teaching Hospital\" [Letter].","authors":"Marrium Sultan Dar, Rakhshanda Ayub Khan","doi":"10.2147/DMSO.S651927","DOIUrl":"https://doi.org/10.2147/DMSO.S651927","url":null,"abstract":"","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"651927"},"PeriodicalIF":3.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Patients with Rapid Progression to Diabetic Retinopathy in Type 2 Diabetes: A Simple Prediction Model for Community Settings.","authors":"Jing Zhao, Ziwei Kang, Dongling Niu, Zhi Chai, Shuang Guo, Yaping Wang, Daxi Xue, Rui Wang, Jingke Li, Jiangnan Chu, Yingnan He, Yaqi Wang, Ting Lei, Li Zhang, Hongli Liu, Yanchun Zhang","doi":"10.2147/DMSO.S624132","DOIUrl":"https://doi.org/10.2147/DMSO.S624132","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR) progression in community-based type 2 diabetes (T2D) remains challenging to predict. This multi-site cohort study aimed to identify novel metabolic risk factors beyond glucose control and develop a resource-adaptable model for prioritizing DR risk screening.</p><p><strong>Methods: </strong>A prospective, multi-site study was conducted among patients with T2D from 2021 to 2023 across 14 community health centers in Northwestern China (Shaanxi). Baseline and follow-up data on demographic, medical history, and laboratory data were collected. DR was assessed by trained retinal specialists through fundus photography and slit-lamp bio-microscopy. LASSO-penalized logistic regression with 10-fold cross-validation was first performed to identify candidate predictors, followed by multivariable logistic regression to construct the prediction model. Model discrimination was evaluated using receiver operating characteristic (ROC) curve analysis and bootstrap internal validation. Clinical characteristics before and after onset of DR were analyzed using the paired-sample Wilcoxon test.</p><p><strong>Results: </strong>Among 363 participants who completed follow-up, 50 (13.77%) patients developed DR. Patients who developed DR had longer duration of diabetes, higher HbA1c levels, poorer glycemic control, and elevated urine pH. Multivariate logistic regression identified HbA1c (OR = 1.30), urine pH (OR = 2.55), and diabetes duration (OR = 1.06) as independent risk factors. The prediction model showed moderate discrimination, with an apparent AUC of 0.72 and an optimism-corrected AUC of 0.693 after bootstrap internal validation. In paired analyses, patients exhibited significantly higher BUN and eGFR levels and lower serum creatinine after DR onset (all P < 0.05).</p><p><strong>Conclusions: </strong>In this community-based cohort, a prediction model incorporating urine pH, HbA1c, and diabetes duration showed potential for identifying individuals at high risk of incident DR. Urine pH may serve as a simple and accessible metabolic marker for risk stratification, while renal functional alterations may reflect early systemic changes beyond glycemic control.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"624132"},"PeriodicalIF":3.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Response to Letter] \"Association Between the Systemic Inflammatory Response Index and Severe Infection in Patients with Diabetic Foot\".","authors":"Ping Wu, Wendong Xu, Rui Chen, Zhenghui Xu","doi":"10.2147/DMSO.S655683","DOIUrl":"10.2147/DMSO.S655683","url":null,"abstract":"","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"655683"},"PeriodicalIF":3.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-Rich Plasma for Diabetic Foot Ulcers: A Cross-Sectional Appraisal of Overlapping Meta-Analyses.","authors":"Ying Du, Bolun Zhang, Xinxin Meng, Qiantai Gao, Xiyan Zhao, Tianlin Wen, Zhiwei Jia","doi":"10.2147/DMSO.S637616","DOIUrl":"10.2147/DMSO.S637616","url":null,"abstract":"<p><strong>Purpose: </strong>The treatment of diabetic foot ulcers (DFUs) remains challenging, and the benefits and safety of platelet-rich plasma (PRP) therapy are still debated. This study analyzed existing meta-analyses on PRP therapy for DFUs to identify the most reliable evidence source.</p><p><strong>Methods: </strong>This cross-sectional appraisal was conducted according to PRISMA 2020 guidance. PubMed, Embase, and the Cochrane Library were searched from inception to May 20, 2026, for meta-analyses comparing PRP therapy with standard or conventional care for DFUs. Only meta-analyses based exclusively on randomized controlled trials (RCTs) were included. Methodological quality was assessed using AMSTAR, evidence level was classified according to the Oxford Levels of Evidence, and discordant findings were examined using the Jadad decision algorithm.</p><p><strong>Results: </strong>Eleven meta-analyses were included in this study, all of which were categorized as Level II evidence. The AMSTAR scores ranged from 6 to 10 (median 8). The meta-analysis identified by the Jadad algorithm as the most robust source showed that autologous PRP improved complete ulcer healing rates (OR: 2.11; 95% CI: 1.55-2.86) and shortened complete healing time (MD: -19.04 days; 95% CI: -20.46 to -17.61) compared with standard care. Furthermore, the incidence of adverse events in PRP groups was not significantly different from that in standard care groups, and the results were robust in sensitivity analyses.</p><p><strong>Conclusion: </strong>PRP is an effective adjunctive therapy for DFUs, with no statistically significant increase in reported adverse events. However, further large-scale, high-quality trials are needed to standardize PRP preparation and administration, and to establish optimal treatment protocols.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"637616"},"PeriodicalIF":3.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of FATmax-Intensity Exercise on Body Composition and Cardiovascular Health in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis.","authors":"Ge Zhao, Teng Keen Khong, Yanqing Yan, Ashril Yusof","doi":"10.2147/DMSO.S619590","DOIUrl":"10.2147/DMSO.S619590","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the effects of exercising at maximal fat oxidation (FATmax) intensity on body composition, cardiorespiratory fitness, and metabolism outcomes in overweight and obese individuals through a systematic review and meta-analysis.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) were retrieved from PubMed, Web of Science, CNKI, and the Cochrane Library. Search terms included FATmax or maximal fat oxidation, obesity or overweight, BMI, [Formula: see text], diastolic blood pressure (DBP), systolic blood pressure (SBP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and homeostasis model assessment of insulin resistance (HOMA-IR). Risk of bias was assessed using Cochrane guidelines and the quality of evidence using GRADE. A random-effects model (Stata 16.0) calculated pooled mean differences for outcomes.</p><p><strong>Results: </strong>18 RCTs were finally analysed. Compared to non-exercising controls, FATmax-intensity exercise improved (i) body composition, including reduced body weight (WMD = -4.43 kg, 95% CI: -5.11, -3.75), fat mass (WMD = -3.68 kg, 95% CI: -4.31, -3.06), waist circumference (WMD = -4.36 cm, 95% CI: -6.73, -1.99), and waist-to-hip ratio (WMD=-0.04, 95% CI: -0.05, -0.03); (ii) cardiorespiratory fitness, evidenced by increased [Formula: see text] (WMD = 3.89 mL/(kg·min), 95% CI: 3.04, 4.74), reduced SBP (WMD = -1.73 mmHg, 95% CI: -6.60, 3.15) and DBP (WMD = -2.10 mmHg, 95% CI: -3.70, -0.49); (iii) metabolism outcomes, such as reduced TG (SMD = -0.80, 95% CI: -1.24, -0.36), TC (SMD = -0.37, 95% CI: -0.72, -0.02), LDL-C (SMD = -0.44, 95% CI:-0.78, -0.10), increased (HDL-C) (SMD = 0.97, 95% CI: 0.64, 1.30) and improved HOMA-IR (SMD = -0.81, 95% CI: -1.44, -0.18). Subgroup analyses suggested that age, sex, and intervention characteristics (eg, duration and frequency) moderated these outcomes to varying degrees.</p><p><strong>Conclusions: </strong>FATmax-intensity exercise confers beneficial effects on body composition, glucose and lipid metabolism, and cardiorespiratory fitness in populations with overweight and obesity. Despite outcome-specific variations and methodological heterogeneity warranting cautious interpretation, FATmax training represents a promising, individualized strategy for cardiometabolic health management.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"619590"},"PeriodicalIF":3.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrinologists' Perspectives on Early Screening for Diabetic Peripheral Neuropathy: A Phenomenological Study in Four Chinese Based Hospitals.","authors":"Haili Zhu, Wanting Xie, Xueqin Zeng, Qing Yuan, Dong Zhu, Ouying Chen, Yan Chen","doi":"10.2147/DMSO.S614369","DOIUrl":"10.2147/DMSO.S614369","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore endocrinologists' awareness and current practices regarding early screening for diabetic peripheral neuropathy (DPN), and to further analyze their experiences, barriers, and potential optimization strategies in implementing DPN screening within clinical practice.</p><p><strong>Patients and methods: </strong>Methods: A qualitative study based on Husserl's phenomenological framework was conducted. Twelve endocrinologists (3 male, 9 female; age range 29-47 years; clinical experience 3-23 years) from four tertiary hospitals in China were recruited via purposive sampling. Semi-structured in-depth interviews were used. This phenomenological approach was chosen to explore the lived experiences and subjective perceptions of physicians regarding DPN screening, as quantitative methods cannot capture such contextual richness. Data were analyzed using NVivo 20.0 with Colaizzi's seven-step method.</p><p><strong>Results: </strong>Five major themes and 11 sub-themes were identified: The most predominant finding was that, despite endocrinologists' recognition of the necessity and urgency of early DPN screening, its implementation is critically limited by three interrelated barriers: insufficient physician training and heavy workloads, limitations of screening tools (eg subjectivity of physical exams and high cost of electromyography), and poor patient compliance due to lack of awareness and financial constraints.Other themes included current screening practices and optimization strategies.</p><p><strong>Conclusion: </strong>This study indicates that despite the critical role of early DPN screening in diabetes management, its implementation remains constrained by limited healthcare resources, limitations of screening tools, and patient-related barriers, such as awareness and affordability. Therefore, it is recommended to enhance physician training, standardize screening protocols, and improve patient adherence through policy support and health education to promote the widespread adoption of DPN screening.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"614369"},"PeriodicalIF":3.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Specific Associations Between the Testosterone-to-Estradiol Ratio and Metabolic Syndrome Components in Middle-Aged and Elderly Chinese Men.","authors":"Gang Ma, Xiaodong Chen, Yanmei Miao, Xuexia Ji, Zhicheng Qiao","doi":"10.2147/DMSO.S550807","DOIUrl":"10.2147/DMSO.S550807","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) is common in aging men, but the age-specific relationship between the testosterone-to-estradiol (T/E2) ratio and metabolic abnormalities remains insufficiently characterized. This study evaluated age-stratified associations between the T/E2 ratio and MetS-related parameters in middle-aged and elderly Chinese men.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 120 Chinese men aged 46-75 years. Participants were divided into three age groups: 46-55, 56-65, and 66-75 years. Serum testosterone, estradiol, sex hormone-binding globulin (SHBG), anthropometric indices, blood pressure, fasting blood glucose, and lipid profiles were assessed. MetS components were defined according to IDF-based criteria, and TyG index and TyG-BMI were calculated. Age-stratified Pearson correlation analyses were performed, with Spearman correlation and FDR adjustment used for sensitivity analyses.</p><p><strong>Results: </strong>The T/E2 ratio decreased significantly across age groups, while SHBG increased and T/SHBG decreased with age. In the 46-55-year group, the T/E2 ratio was inversely correlated with fasting blood glucose, waist circumference, TyG-BMI, and total MetS points score. In the 66-75-year group, the main inverse association was observed between the T/E2 ratio and triglycerides. No consistent significant associations were observed in the 56-65-year group. Sensitivity analyses showed generally consistent directions for the main associations.</p><p><strong>Conclusions: </strong>The T/E2 ratio shows age-related decline and age-specific associations with selected MetS-related parameters in middle-aged and elderly Chinese men. These findings suggest that the T/E2 ratio may reflect age-related metabolic heterogeneity, but prospective studies are needed to clarify its longitudinal and clinical relevance.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"550807"},"PeriodicalIF":3.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of a Health Belief Model-Based Digital Health Intervention with Glycolipid Metabolism and Health Behaviors in Older Adults with Type 2 Diabetes: A Quasi-Experimental Before-After Study.","authors":"Mengqi Wang, Jiaqi Wang, Jinqiu Liu, Daiqing Li","doi":"10.2147/DMSO.S634248","DOIUrl":"10.2147/DMSO.S634248","url":null,"abstract":"<p><strong>Purpose: </strong>Integrated management of blood glucose and lipids reduces complications in type 2 diabetes mellitus (T2DM). However, few community-based programs combine mobile health (mHealth) technology, Health Belief Model (HBM)-based education, behavioral strategies, and family support within one framework, and evidence in Chinese community settings is limited. We examined whether a 12-month HBM-based intervention was associated with changes in glycolipid metabolism and health behaviors among community-dwelling older adults with T2DM in Tianjin, China.</p><p><strong>Patients and methods: </strong>This quasi-experimental, single-arm, uncontrolled before-after (pre-post) study included 114 T2DM patients (mean age 72.25 ± 5.63 years) managed at a community health service center; no parallel control group was enrolled. Paired samples <i>t</i>-tests and McNemar tests assessed changes in metabolic parameters and categorical health behaviors, respectively.</p><p><strong>Results: </strong>All glucose and lipid parameters improved (all P < 0.0001). The primary outcomes changed as follows: HbA1c -0.63% points (95% CI -0.80 to -0.46), 2-hour postprandial glucose -5.16 mmol/L (95% CI -5.54 to -4.78), and triglycerides -2.61 mmol/L (95% CI -2.82 to -2.40). Fasting plasma glucose, total cholesterol, and LDL-cholesterol also decreased (Tables 3 and 4). Medication adherence rose from 73.68% to 86.84% (P = 0.013), disease knowledge from 50.88% to 76.32%, and regular exercise from 28.95% to 61.40% (both P < 0.0001); smoking and alcohol use were unchanged.</p><p><strong>Conclusion: </strong>The HBM-based digital health intervention was associated with improved glycolipid metabolism and health behaviors in this cohort. Because the single-arm design lacked a control group and concurrent changes in glucose- and lipid-lowering medications were not recorded, all metabolic improvements - and the large triglyceride reduction in particular - may partly reflect pharmacological intensification; randomized controlled trials are needed to confirm these findings.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"634248"},"PeriodicalIF":3.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}