Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"Correlation Between Thyroid Hormone and Controlled Attenuation Parameters: A Cross-Sectional Population-Based Study.","authors":"Sumei Li, Xingye Wu, Jingming Yu, Jiaqin Jiang, Ruibing Qi, Bing Chen, Zhengming Li","doi":"10.2147/DMSO.S490347","DOIUrl":"10.2147/DMSO.S490347","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the present study was to investigate how thyroid hormone levels are related to controlled attenuation parameters (CAP), which may provide insights for understanding the role of these factors in hepatic steatosis.</p><p><strong>Methods: </strong>A total of 3461 participants who underwent CAP diagnosis between 2018 and 2023 were included. The associations between thyroid hormone levels and CAP were evaluated through multiple linear regression, restricted cubic splines (RCS) and threshold effect analyses.</p><p><strong>Results: </strong>Multiple linear regression analysis revealed an inverse relationship between free thyroxine (FT4) and CAP, with a coefficient of -0.855 and a confidence interval of -1.297 to -0.412. The negative connection in a subset examination persisted in males [-0.729 (-1.295, -0.162)] and females [-1.234 (-1.996, -0.473)]. A strong correlation was found between free 3,5,3'-triiodothyronine (FT3) and CAP, with values of 2.182 (1.154, 3.211). Further analysis was conducted on both male [1.626 (0.188, 3.065)] and female [2.835 (1.137, 4.533)] subgroups. In the severe liver steatosis group, there was a significant negative correlation between FT3 and CAP based on the subgroup analysis stratified by the level of liver steatosis [-3.804 (-6.711, -0.898)]. The RCS analysis showed a nonlinear association between FT4 and CAP, with a turning point at 11.14 pmol/L.</p><p><strong>Conclusion: </strong>There was a significant linear and nonlinear relationship between FT4, FT3 and CAP. Thyroid hormones could have a significant impact on liver steatosis, offering fresh perspectives on how to prevent and treat this condition.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4777-4787"},"PeriodicalIF":2.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Proteomic Markers of Iron and Risk of Diabetes in a Cohort of African American and White American Current and Former Smokers.","authors":"Rebecca Baqiyyah Conway, Katherine A Pratte, Russell Paul Bowler, Kendra A Young, Gregory L Kinney, Erin Austin, Yisha Li, Donald McClain, John Hokanson, James D Crapo","doi":"10.2147/DMSO.S492124","DOIUrl":"10.2147/DMSO.S492124","url":null,"abstract":"<p><strong>Background: </strong>Little information is available on iron with diabetes risk among African Americans, a population where both anemia and elevated ferritin are common. We tested whether plasma proteomic measurements of ferritin and transferrin were associated with increased diabetes risk in a cohort of current and former African American (NHB) and Non-Hispanic White (NHW) smokers.</p><p><strong>Methods: </strong>NHB and NHW participants from the COPDGene study who were free of diabetes (n = 4693) at baseline were followed for incident diabetes. The SomaScan was used to determine the relative amounts of natural log-transformed ferritin, transferrin, and hepcidin.</p><p><strong>Findings: </strong>During an average of 5.6 years of follow-up, diabetes incidence was 7.9%. Ferritin at follow-up was higher in NHB than NHW participants (p = <0.0001). Ferritin at follow-up was associated with increased diabetes risk (OR = 1.36, 95% CI = 1.08-1.70), while transferrin was associated with decreased risk (OR = 0.25, 95% CI = 0.08-0.77) controlling for age, sex, BMI, smoking pack-years, hepcidin, CRP, and Il-6. Race-specifically, increased risk associated with higher ferritin levels among NHB (OR = 1.56, 95% CI = 1.13-2.16) but not NHW (OR = 1.22, 95% CI = 0.89-1.68) participants. Sex-specifically, ferritin's relationship was similar among NHB men and women and NHW women (ORs ranging from 1.41-1.59); but not NHW men (OR = 0.98, 95% CI = 0.64-1.49). Similarly, transferrin ORs non-significantly ranged from 0.19-0.30 for NHB men and women and NHW women, but was significant for NHW men (OR = 0.07, 95% CI = 0.01-0.63).</p><p><strong>Interpretation: </strong>Higher body iron stores is associated with increased diabetes risk among both NHB and NHW people. Unsuspected elevated iron stores may increase diabetes risk in NHB patients and should be monitored.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4767-4776"},"PeriodicalIF":2.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Percent Body Fat Reduction and Changes of the Metabolic Score for Insulin Resistance in Overweight/Obese People with Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Yan Han, Jinhan Liu, Wenjian Li, Fan Zhang, Yonghua Mao","doi":"10.2147/DMSO.S486841","DOIUrl":"10.2147/DMSO.S486841","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the relationship between the difference in percent body fat (∆PBF) decrease and the change in the metabolic score for insulin resistance (METS-IR) in Chinese overweight/obese people with combined metabolic dysfunction-associated steatotic liver disease (MASLD) after weight loss.</p><p><strong>Patients and methods: </strong>A total of 357 overweight/obese MASLD patients were included using a retrospective study method. The subjects were divided into two groups (< 5% and ≥ 5%) based on the ∆PBF. The changes in METS-IR (∆METS-IR) and metabolic indices before and after fat loss were compared between the two groups. Spearman correlation analysis was employed to investigate the correlation between METS-IR changes and the decrease in PBF. A linear regression model was fitted using a restricted cubic spline (RCS) curve to investigate the dynamic relationship between ∆METS-IR and ∆PBF.</p><p><strong>Results: </strong>Following the fat reduction, both groups' body measurements and liver fat content exhibited a notable reduction, accompanied by a decline in METS-IR. In particular, the decrease in METS-IR was more pronounced in the group with a ≥5% decrease in PBF. Significant correlations were observed between ∆PBF and various insulin resistance indices. The correlation between ΔPBF and ∆METS-IR was noteworthy (<i>r = 0.438, p < 0.001</i>). RCS analysis revealed that when ΔPBF exceeded 3.2%, ∆METS-IR exhibited an upward trend with further reduction in PBF.</p><p><strong>Conclusion: </strong>The reduction of PBF was closely associated with changes in METS-IR, indicating that fat loss is an effective method for improving insulin resistance in overweight/obese MASLD patients.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4735-4747"},"PeriodicalIF":2.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title: A Qualitative Systematic Review of Parental Perceptions, Motivators, and Barriers to Management of Childhood Obesity.","authors":"Sarah Musa, Ayman Al-Dahshan, Vahe Kehyayan","doi":"10.2147/DMSO.S490475","DOIUrl":"10.2147/DMSO.S490475","url":null,"abstract":"<p><strong>Background: </strong>Childhood obesity is a global epidemic affecting millions worldwide. Children living with obesity face increased risks of health-related and psychosocial problems extending into adulthood. Parents and carers play a crucial role in cultivating healthy habits in their children. This review aims to synthesize qualitative research on parental perceptions, motivators, and barriers in managing childhood obesity and their views on weight management programs.</p><p><strong>Methods: </strong>This systematic review was performed in accordance with the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A variety of electronic databases were explored for qualitative studies published between 2006 and 2023. The CASP checklist was employed to assess the quality of the studies. Data extraction and synthesis were carried out utilizing thematic content analysis.</p><p><strong>Results: </strong>The search identified 20 peer-reviewed studies meeting the inclusion criteria. Key themes were mapped into five distinct groups: perceptions, facilitators and barriers influencing the management of childhood obesity, as well as facilitators and barriers to enrolment into a weight management program. Parents often perceived obesity as a temporary condition, genetically determined and believed it should not be considered as a major health concern. Identified facilitators included the restriction of screen time, school involvement, goal setting, and enhanced child-parent communication. Conversely, barriers included lack of child motivation, peer influence, easy access to junk food, as well as parental denial, insufficient knowledge or control and logistical challenges.</p><p><strong>Conclusion: </strong>To tackle childhood obesity, it is essential to adopt a comprehensive strategy that fosters a supportive family environment. Successful initiatives should encompass nutritional education for both parents and children, increase access to healthy food choices, implement home-based programs, and improve the infrastructure that encourages physical activity. Additionally, cultural factors and technological advancements should be considered when designing these interventions.</p><p><strong>Systematic review registration number: </strong>PROSPERO (CRD42024514219).</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4749-4765"},"PeriodicalIF":2.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Based Differences in the Associations Between Obesity- and Lipid-Related Indexes and Hyperuricemia Risk in Patients with Obesity.","authors":"Kelibinuer Mutailipu, Lei Du, Junwei Guo, Shuwei Liu, Yue Chen, Liesheng Lu, Shen Qu, Haibing Chen, Le Bu","doi":"10.2147/DMSO.S483638","DOIUrl":"10.2147/DMSO.S483638","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association of the triglyceride-glucose index (TyG) and its related parameters with the risk of hyperuricemia in patients with obesity of different sexes.</p><p><strong>Patients and methods: </strong>In this cross-sectional study, a total of 951 patients with obesity were included. They were divided into two groups based on their serum uric acid levels, and separate analyses were conducted for males and females. Binary logistic regression analysis using the backward likelihood ratio (LR) approach was performed to investigate the association between hyperuricemia and indicators related to obesity and lipids.</p><p><strong>Results: </strong>Multivariate logistic regression analysis indicated that, across the overall population, higher quartiles of the TyG and TyG-BMI indexes were significantly associated with an increased risk of hyperuricemia (HUA) after adjusting for confounding factors. Specifically, in the fourth quartile of the TyG index, the odds ratio (OR) for HUA was 3.16 (95% confidence interval [CI]: 1.39-7.18), and for the TyG-BMI index, the OR was 4.06 (95% CI: 1.73-9.52) in the fully adjusted model. In sex-specific analyses, for males, those in the third quartile of the TyG-WC index had a higher likelihood of HUA (OR, 8.13; 95% CI, 2.28-29.01) compared to the lowest quartile. Among females, an elevated TyG index was significantly associated with increased HUA risk, with an OR of 5.13 (95% CI: 1.66-15.92) in the fourth quartile.</p><p><strong>Conclusion: </strong>Sex-based differences exist regarding the risk factors for hyperuricemia in patients with obesity. An elevated TyG-WC index is linked to an increased risk in males, while an elevated TyG index is associated with an increased risk in females.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4721-4733"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum Uric Acid to Creatinine Ratio and Metabolic-Associated Fatty Liver Disease in Southeast China (TyG-BMI as a Potential Mediator).","authors":"Bingbing Chen, Xian-E Peng","doi":"10.2147/DMSO.S489692","DOIUrl":"10.2147/DMSO.S489692","url":null,"abstract":"<p><strong>Purpose: </strong>Serum uric acid to creatinine ratio (SUA/Cr) has been associated with an increased risk of metabolic syndrome; however, limited evidence exists regarding the relationship between SUA/Cr and metabolic-associated fatty liver disease (MAFLD). This study aims to investigate the association between SUA/Cr, TyG-BMI (triglyceride glucose-body mass index), and MAFLD in Chinese adults.</p><p><strong>Patients and methods: </strong>The data were obtained from a health examination conducted at Nanping First Hospital. Spearman correlation analysis was employed to assess the association between SUA/Cr or TyG-BMI and various risk factors pertinent to MAFLD. A multivariate logistic regression model was utilized to investigate the relationship between SUA/Cr or TyG-BMI and MAFLD. Additionally, restricted cubic splines (RCS) and receiver operating characteristic (ROC) curve analyses were applied to explore the relationship between SUA/Cr and MAFLD. Mediation models were constructed to figure out the mediating role of TyG-BMI in the association between SUA/Cr and MAFLD.</p><p><strong>Results: </strong>Spearman correlation analysis showed a significant association between SUA/Cr and multiple risk factors for MAFLD (such as BMI, SBP, DBP, TG, TC, ALT, AST, GGT, FPG, and HDL). Furthermore, SUA/Cr had a positive correlation with TyG-BMI (<i>P</i><0.05). The logistic model demonstrated that elevated levels of SUA/Cr were significantly associated with an increased risk of MAFLD, even after adjusting for confounding factors (odds ratio [OR]: 1.390; 95% confidence interval [CI]: 1.255-1.538). The RCS curves revealed a consistent and monotonic increase in the relationship between SUA/Cr levels and the occurrence of MAFLD. Moreover, SUA/Cr exhibited moderate discriminatory ability in identifying individuals with MAFLD (AUC: 0.669). Mediation analysis indicated that approximately 52.05% of the positive association between SUA/Cr and MAFLD was mediated by TyG-BMI.</p><p><strong>Conclusion: </strong>Our findings suggest a substantial association between elevated levels of SUA/Cr and an increased risk of MAFLD in the Chinese adult population, with TyG-BMI mediating this correlation.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4711-4720"},"PeriodicalIF":2.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory Fitness and Body Mass Index as Predictors of Metabolic Syndrome in Schoolchildren (PACH Study).","authors":"Jelena Raudeniece, Ilze Justamente, Liga Ozolina-Moll, Artjoms Sobolevs, Maksims Zolovs, Flemming Dela, Dace Reihmane","doi":"10.2147/DMSO.S487309","DOIUrl":"10.2147/DMSO.S487309","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic syndrome (MetS) has become a condition not rarely diagnosed in children and adolescents, leading to changes in physical and mental health. Simple and cost-effective screening methods applied in schools are needed to take preventive measures and reduce the risk of the development of MetS in children.</p><p><strong>Methods: </strong>This prospective longitudinal study aims to investigate the prevalence of MetS and its risk factors in 8-10-year-old schoolchildren (46 boys and 60 girls) over 3 consecutive years. General Linear Mixed Model (GLMM) was used to assess the effect of recommended daily levels of moderate to vigorous physical activity (MVPA), body mass index (BMI), waist circumference (WC), cardiorespiratory fitness (CRF), and obesity level on a new set of orthogonal variables formed from various parameters of MetS (eg blood pressure (BP), lipid panel and glucose homeostasis) determined by Principal Component Analysis (PCA).</p><p><strong>Results: </strong>The prevalence of MetS was 2% in the years 2017, 2018 and 2019, while in 2020 prevalence reached 7.7%. The most prevalent combination of criteria defining MetS syndrome in children was increased WC, BP, and blood triglycerides (TG). PCA identified non-high-density lipoprotein (non-HDL), low-density lipoprotein (LDL), and total cholesterol (TCHOL) as important predictors of metabolic syndrome (MetS). Additionally, cardiorespiratory fitness (CRF) and body mass index (BMI) were found to significantly influence the variance in MetS criteria. However, moderate to vigorous physical activity (MVPA) did not have a notable effect on the variance of these criteria.</p><p><strong>Conclusion: </strong>The prevalence of MetS in children is increasing with age. Non-HDL turned out to be the most influential parameter across all principal components. The CRF, being accessible, simple to use, non-invasive and cost-effective, proved to be a superior predictor of variance of glucose homeostasis compared to BMI.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4675-4687"},"PeriodicalIF":2.8,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Be Alert to Diabetes Nephropathy with Cognitive Dysfunction [Response to Letter].","authors":"Wenyi Li, Zhenguo Liu, Min Song, Zhenpeng Shi, Jihang Zhang, Junyu Zhou, Yidan Liu, Yun Qiao, Deshan Liu","doi":"10.2147/DMSO.S508433","DOIUrl":"10.2147/DMSO.S508433","url":null,"abstract":"","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4661-4662"},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and Diagnostic Value of TyG-BMI for Hyperuricemia in Patients with Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study.","authors":"Haitao Li, Ge Gao, Zhikai Xu, Lihua Zhao, Yuling Xing, Jianqiu He, Yu Gao","doi":"10.2147/DMSO.S484045","DOIUrl":"10.2147/DMSO.S484045","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between TyG-BMI and hyperuricemia in NAFLD patients and assess its potential diagnostic value compared to the TyG index.</p><p><strong>Patients and methods: </strong>This study selected the patients diagnosed with fatty liver disease at the Affiliated Hospital of Chengde Medical University between September and December 2023. These patients were divided into NAFLD without HUA (NAFLD-NUA, n=1166) and NAFLD with HUA (NAFLD-HUA, n=844) groups. Baseline characteristics between the groups were compared. Patients were divided into quartiles (Q1-Q4) according to their TyG-BMI level; the lowest quartile (Q1) was used as the reference group. Multivariate logistic regression analysis was used to investigate the association between TyG-BMI and HUA. Receiver operating characteristics curve analysis and area under the curve (AUC) were used to evaluate the diagnostic accuracy.</p><p><strong>Results: </strong>Patients in the NAFLD-HUA group had higher levels of TyG-BMI than patients in the NAFLD-NUA group(252.45±34.11VS 234.34±31.88, P<0.001). Pearson correlation analysis showed that TyG-BMI levels were positively correlated with serum uric acid (SUA) (r=0.309, P<0.001). After adjusting for potential confounders, logistic regression analysis revealed that TyG-BMI was a risk factor for HUA(OR:1.019 95% CI:(1.012, 1.027).) and shows superior diagnostic accuracy (AUC: 0.656) compared to the TyG index (AUC: 0.605).</p><p><strong>Conclusion: </strong>TyG-BMI index is a risk factor for HUA in patients with NAFLD, and demonstrates acceptable diagnostic accuracy for NAFLD-HUA. But further prospective studies are needed to confirm these findings.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4663-4673"},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Podoplanin Levels as a Potential Biomarker for Diabetic Nephropathy Progression: A Cross-Sectional Study.","authors":"Feng Huan, Xia Jiang","doi":"10.2147/DMSO.S500608","DOIUrl":"10.2147/DMSO.S500608","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to investigate the impact of serum Podoplanin levels on diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Patients and methods: </strong>Between January 2022 and December 2023, the Department of Nephrology at Nantong Second People's Hospital selected 276 patients with T2DM and 150 healthy controls for this investigation. Systematic data collection was performed to gather information on biomarkers and biochemical parameters.</p><p><strong>Results: </strong>When T2DM patients (n=276) and healthy controls (n=150) were compared, considerably lowered serum Podoplanin levels were observed. In all 276 patients, serum Podoplanin levels were negatively associated with age (r=-0.127, P=0.035), body mass index (BMI) (r=-0.292, P<0.001), duration of diabetes (r=-0.323, P<0.001), systolic blood pressure (SBP) (r=-0.255, P<0.001), diastolic blood pressure (DBP) (r=-0.138, P=0.022), fasting blood glucose (FBG) (r=-0.196, P=0.001), glycated hemoglobin (HbA1c) (r=-0.095, P=0.117), triglyceride (TG) (r=-0.157, P=0.009), total cholesterol (TC) (r=-0.126, P=0.036), low-density lipoprotein cholesterol (LDL-C) (r=-0.187, P=0.002), serum creatinine (Scr) (r=-0.500, P<0.001), neutrophil gelatinase-associated lipocalin (NGAL) (r=-0.339, P<0.001), and kidney injury molecule-1 (KIM-1) (r=-0.568, P<0.001), and was positively correlated with high-density lipoprotein cholesterol (HDL-C) (r=0.343, P<0.001) and estimated glomerular filtration rate (eGFR) (r=0.442, P<0.001). The multivariate logistic regression analysis showed that diabetic patients with DN had lowered levels of serum Podoplanin (OR=0.022, 95% CI=0.005-0.100; P<0.001), lower SBP, Scr, NGAL, and KIM-1.</p><p><strong>Conclusion: </strong>The results indicated that diabetic patients with DN have lower levels of serum Podoplanin. A more considerable population-based prospective investigation is essential to validate our findings.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4701-4710"},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}