Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"White Matter Function and Network Abnormalities in Patients with Diabetic Retinopathy.","authors":"Yu-Lin Zhong, Rui-Yang Hu, Yuan-Zhi He, Xiao-Tong Li, Zi-Cong Li, Xin Huang","doi":"10.2147/DMSO.S492099","DOIUrl":"https://doi.org/10.2147/DMSO.S492099","url":null,"abstract":"<p><strong>Background: </strong>This study aims to explore changes in white matter function and network connectivity in individuals with DR.</p><p><strong>Methods: </strong>This study included 46 patients with DR and 43 age- and gender-matched healthy control (HC) participants were enrolled in the study. The aim was to investigate inter-group differences in white matter (WM) function and to analyze changes in the WM network among DR patients.</p><p><strong>Results: </strong>Increased degree centrality (DC) values were observed in the middle cerebellar peduncle and genu of the corpus callosum, while higher fractional amplitude of low-frequency fluctuations (fALFF) values were found in the left superior corona radiata, right anterior corona radiata, and right superior longitudinal fasciculus. Conversely, reduced regional homogeneity (ReHo) values were noted in the left posterior thalamic radiation among patients with DR compared to HC, with statistical correction applied The SVM classification accuracy for distinguishing between DR and HC patients based on WM measures indicated values of 81.52%, 80.43%, and 89.13% for DC, fALFF, and ReHo, respectively, with respective area under the curve (AUC) values of 0.87, 0.85, and 0.93. Furthermore, alterations were detected within specific brain regions including the body of corpus callosum (BCC), splenium of corpus callosum (SCC), genu of corpus callosum (GCC), left posterior thalamic radiation (PTR), right anterior corona radiata (ACR), and right posterior corona radiata (PCR) in the DR group compared to HCs, with an intra-network decrease in connectivity. Interestingly, the left superior longitudinal fasciculus (SLF) within the DR group exhibited an intra-network increase compared to the HC group.</p><p><strong>Conclusion: </strong>DR exhibited abnormal white matter functional alterations, particularly affecting the fiber pathways linking the visual network to the sensory-motor network.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4149-4166"},"PeriodicalIF":2.8,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Characteristics of Ferroptosis in Kidney Tissues in Type 2 Diabetic Patients with Diabetic Kidney Disease.","authors":"Min Li, Song Zhao, Yan Liu, Qian Wang, Yongzhe Chen, Yaru Zhou","doi":"10.2147/DMSO.S489536","DOIUrl":"10.2147/DMSO.S489536","url":null,"abstract":"<p><strong>Background: </strong>Diabetes kidney disease (DKD) is a common complication of diabetes and is currently considered the primary cause of end-stage renal disease. Ferroptosis has been found to participate in the development of DKD. However, no ferroptosis-related markers have been evaluated in human DKD samples. This study aimed to examine the ferroptosis-related pathological alterations in DKD samples.</p><p><strong>Methods: </strong>This study enrolled patients with DKD at the Third Hospital of Hebei Medical University between January 2018 and December 2022, of whom 30 were diagnosed with DKD and 10 with non-DKD (CON). Clinical data of patients were collected, and hematoxylin-eosin staining (H&E), PASM, and immunohistochemical staining were performed to evaluate pathological changes and the expression of ferroptosis-related proteins, including GPX4, ACSL4, Nrf2, TfR1, FTH, and FTL.</p><p><strong>Results: </strong>Compared with the CON group, patients with DKD exhibited significantly elevated serum creatinine levels and reduced eGFR (<i>P</i> < 0.05). Iron content and the expression of the ferroptosis-related protein ACSL4 were significantly increased, while the expression of Nrf2 was significantly decreased in the renal tissues of patients with DKD (<i>P all</i> < 0.05). There were no differences in the expression of GPX4, TfR1, FTH, or FTL between the two groups. Nrf2 and ACSL4 expression were influential factors in the occurrence of DKD and both exhibited diagnostic value for DKD. Nrf2 was a protective factor (OR, < 1), whereas ACSL4 was a risk factor (OR, > 1).</p><p><strong>Conclusion: </strong>Ferroptosis-promoting gene profile was identified in DKD renal samples, indicating that ferroptosis may participate in the pathogenesis of DKD. The expression levels of Nrf2 and ASCL4 in the kidneys are related to the severity and progression of DKD.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4105-4113"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic on the Metabolic Tumor Markers: A Real-World Retrospective Study.","authors":"Song Wen, Dongxiang Xu, Yue Yuan, Zhimin Xu, Yanyan Li, Min Gong, Xinlu Yuan, Ligang Zhou","doi":"10.2147/DMSO.S487398","DOIUrl":"10.2147/DMSO.S487398","url":null,"abstract":"<p><strong>Objective: </strong>Serum tumor markers have been discovered to be elevated in individuals with diabetes mellitus (DM); however, their significance in diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemia (HHS) is unknown. We evaluated these indicators in the patients with DKA and HHS.</p><p><strong>Materials and methods: </strong>We retrospectively collected the laboratory data of 565 diabetic patients from Shanghai Pudong Hospital between Jan, 2019 and May, 2023, including 300 patients with type 2 diabetes mellitus (T2DM), 206 with DKA, and 59 with HHS. Serum tumor biomarkers and further clinical laboratory tests were compared among the three groups. Patients with conspicuous tumor evidence were excluded from the study.</p><p><strong>Results: </strong>We found significantly higher levels of carbohydrate antigen 199 (CA199) in DKA (p<0.01), carcinoembryonic antigen (CEA), complex prostate specific antigen (CPSA) (p<0.01), prostate specific antigen (PSA) (p<0.05) in HHS, as well as the plasma lipid profile, iron, and electrolytes, in addition to decreased thyroid function, hepatic and renal function, and cardiac function (p<0.05). A Spearman correlational study revealed that osmolar levels were significantly positively correlated with myoglobin (MYO) and cardiac troponin I (cTNI), whereas serum iron concentration (r=0.520) was positively correlated with CEA levels in HHS. pH was negatively correlated with CA199 (r=-0.195), while HbA1c (r=0.22), globin (r=0.341), and total cholesterol (TC) (r=0.191) were positively correlated with elevated CA199 levels. Moreover, the multilinear regression investigation identified osmolarity as a significant determinant for CEA, as well as other parameters, and all proved to be proper predictors for CEA in HHS via ROC curve establishment.</p><p><strong>Conclusion: </strong>Elevated CA199 levels in DKA were associated with acidosis, whereas HHS with elevated CEA levels may be related to iron homeostasis and could be predicted via the osmolar degree and other predictors.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4115-4133"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liraglutide Ameliorates Renal Endothelial Dysfunction in Diabetic Rats Through the Inhibition of the Dll4/Notch2 Pathway.","authors":"Yining Li, Yulin Chen, Hui Zhang, Weidong Chen, Yan Pan","doi":"10.2147/DMSO.S492252","DOIUrl":"10.2147/DMSO.S492252","url":null,"abstract":"<p><strong>Purpose: </strong>The glucagon-like peptide-1 receptor agonist (GLP-1RA) is a pharmacological agent utilized for the treatment of diabetes, known for its significant reno protective effects. This study aims to investigate the impact of liraglutide, a representative GLP-1RA medication, on early endothelial dysfunction in diabetic rats and elucidate its underlying mechanisms.</p><p><strong>Methods: </strong>The present study employed a high-fat, high-sugar diet in combination with a single intraperitoneal injection of streptozotocin (STZ) to establish an experimental rat model of diabetes. Subsequently, the therapeutic efficacy of liraglutide on renal injury in this model was evaluated using various doses.</p><p><strong>Results: </strong>Compared to the DKD rats, the rats treated with Liraglutide exhibited significant reductions in levels of blood glucose (Glu), serum creatinine (Scr), and blood urea nitrogen (BUN) (P < 0.05). Furthermore, there was a dose-dependent decrease in urinary protein levels, including 24-hour urinary protein excretion rate and microalbuminuria (m-ALB), with higher doses demonstrating more pronounced therapeutic effects (P <0.05). In addition, treatment with Liraglutide effectively improved glomerular and interstitial damage, and suppressed the expression of CD31, CD34, and VE-cadherin associated with endothelial cell injury (P < 0.05). Furthermore, Liraglutide administration significantly increased nitric oxide (NO) production (P < 0.05). Moreover, Liraglutide treatment resulted in decreased expression of vascular endothelial growth factor (VEGF), Delta-like ligand-4(Dll4), and Notch2 protein in the Notch2 signaling pathway (P < 0.05).</p><p><strong>Conclusion: </strong>The findings indicate that Liraglutide has a substantial effect on decreasing urinary protein excretion and improving vascular microinflammation, thus alleviating endothelial dysfunction in diabetic nephropathy. This observed mechanism can be attributed to the inhibition of the Dll4/Notch2 signaling pathway.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4091-4104"},"PeriodicalIF":2.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity to Reduce Pain Scale in Diabetic Neuropathy Patients: A Scoping Review.","authors":"Sandra Pebrianti, Indra Maulana, Iwan Shalahuddin, Theresia Eriyani, Bambang Aditya Nugraha","doi":"10.2147/DMSO.S483941","DOIUrl":"10.2147/DMSO.S483941","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to identify physical activity that can reduce pain scales in diabetic neuropathy patients.</p><p><strong>Patients and methods: </strong>The scoping review method was used in this research using three databases and one search engine, namely PubMed, CINAHL, Sage Journal, and Google Scholar. Inclusion criteria include full-text articles and publications in English and Indonesian between 2012-2022 with a minimal quasi-experimental design. Critical Appraisal was used to assess the article's bias.</p><p><strong>Results: </strong>Research found 12 articles discussing the effectiveness of activity training in reducing the pain scale in diabetic neuropathy patients from the results of a scoping review of 12 studies, articles were found that used pain scales such as the Visual Analog Scale (VAS), Numeric Rating Scale (NRS), Foot Health Status Questionnaire Pain Score (FHSQ), and Leeds Assessment of Neuropathic symptoms and signs Scale for pain assessment, in measuring pain intensity. Some variations of physical activity include aerobic exercise, resistance exercise, vibration, and a combination of aerobic and resistance training. 30 minutes each session for 8 weeks with a frequency of 6 days/week. These studies used various designs, namely RCT, Experiment, and Quasi-experimental Pre test-post test with control group design Physical activity improves blood circulation and minimizes peripheral nerve damage so that pain intensity can decrease.</p><p><strong>Conclusion: </strong>Conclusion: Physical activity intervention is effective in reducing pain scales in diabetic neuropathy patients and can be a supportive therapy for diabetic neuropathy patients who experience pain.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4079-4089"},"PeriodicalIF":2.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Oxidative Stress Markers in Pregnant Women of Advanced Maternal Age with Gestational Diabetes and Their Predictive Value for Neurodevelopmental Impact.","authors":"Yabing Wang, Zhenling Fan, Jianli Ren, Lin Ma","doi":"10.2147/DMSO.S475385","DOIUrl":"10.2147/DMSO.S475385","url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between changes in oxidative stress markers in pregnant women of advanced maternal age with gestational diabetes mellitus (GDM) and adverse pregnancy outcomes and neonatal neurodevelopment, as well as their predictive value.</p><p><strong>Methods: </strong>Two hundred pregnant women of advanced maternal age were selected and divided into Group A (normal blood sugar) and Group B (GDM) based on the 75 g (Oral Glucose Tolerance Test) OGTT results. Oxidative stress markers were measured, and pregnancy outcomes and neonatal Neonatal Behavioral Assessment Scale (NABA) scores were recorded.</p><p><strong>Results: </strong>Malondialdehyde (MDA) levels in Group B were higher than those in Group A, while Glutathione (GSH) and Superoxide Dismutase (SOD) levels were lower. Group B had higher rates of adverse pregnancy outcomes and neurological abnormalities than Group A. The Area Under the Curve (AUC) values for serum MDA, GSH, and SOD levels combined prediction were higher than those for individual predictions (P<0.05).</p><p><strong>Conclusion: </strong>Oxidative stress markers in pregnant women of advanced maternal age with GDM are associated with adverse pregnancy outcomes and neonatal abnormalities, and combined prediction has good predictive efficiency (AUC>0.7).</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4003-4012"},"PeriodicalIF":2.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Age at Diabetes Onset and Clinical Outcomes in Newly Diagnosed Type 2 Diabetes: A Real-World Two-Center Study.","authors":"Mengdie Chen, Ping Feng, Yao Liang, Xun Ye, Yiyun Wang, Qiao Liu, Chaoyin Lu, Qidong Zheng, Lijing Wu","doi":"10.2147/DMSO.S485967","DOIUrl":"10.2147/DMSO.S485967","url":null,"abstract":"<p><strong>Purpose: </strong>This study was developed with the goal of clarifying whether there is any relationship between type 2 diabetes mellitus (T2DM) age of onset and clinical outcomes for patients in National Metabolic Management Centers (MMC).</p><p><strong>Patients and methods: </strong>From September 2017 - June 2022, 864 total T2DM patients were recruited in MMC and assigned to those with early-onset and late-onset diabetes (EOD and LOD) based on whether their age at disease onset was ≤ 40 or > 40 years. All patients received standardized management. Baseline and 1-year follow-up data from these two groups of patients were assessed. Associations between onset age and other factors were evaluated with a multivariate linear regression approach, adjusting for appropriate covariates. Outcomes in particular subgroups were also assessed in stratified analyses.</p><p><strong>Results: </strong>Markers of dysregulated glucose metabolism and BMI values were significantly higher among EOD patients as compared to LOD patients. Subjects in both groups exhibited significant improvements in several disease-related parameters on 1-year follow-up after undergoing metabolic management. EOD patients exhibited significantly greater percentage reductions in HbA1c levels (-28.49 (-44.26, -6.45)% vs -13.70 (-30.15,-1.60)%, P =0.017) relative to LOD patients following adjustment for confounders. Significant differences were also detected between these groups when focused on subgroups of patients who were male, exhibited a BMI ≥ 25, an HbA1c ≥ 9, or had a follow-up frequency < 2.</p><p><strong>Conclusion: </strong>Data from a 1-year follow-up time point suggest that a standardized metabolic disease management model can promote effective metabolic control in newly diagnosed T2DM patients, particularly among individuals with EOD.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4069-4078"},"PeriodicalIF":2.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Disease-Specific Distress, Social Support, and Self-Efficacy to Diabetes Self-Management Behaviors in Saudi Adults: A Path Analysis.","authors":"Ali Kerari","doi":"10.2147/DMSO.S479395","DOIUrl":"10.2147/DMSO.S479395","url":null,"abstract":"<p><strong>Purpose: </strong>Disease-specific distress, social support, and self-efficacy have noticeable impacts on diabetes self-management. Although these three concepts are connected, their interplay and subsequent influence on diabetes self-management warrants further research.</p><p><strong>Patients and methods: </strong>A total of 154 individuals with type 2 diabetes mellitus were recruited to complete a survey, which included questions related to social support, diabetes self-efficacy, diabetes self-management behaviors, and disease-specific stress. The variables were examined with path analysis using Analysis of Moment Structures (AMOS) software.</p><p><strong>Results: </strong>In the final model, diabetes self-efficacy was a significant predictor of increased diabetes self-management behaviors. Lower levels of disease-specific distress were associated with higher levels of self-efficacy. Path analysis indicated that the direct effect of social support on diabetes self-management behaviors was significant, and social support indirectly affected diabetes self-management behaviors through the mediating effect of diabetes self-efficacy. Overall, the study findings indicate that social support can exert an impact on diabetes self-management behaviors through the mediating effect of diabetes self-efficacy.</p><p><strong>Conclusion: </strong>The study's findings support the use of Individual and Family Self-Management Theory to improve diabetes self-management. Further research is needed to better understand how factors related to the family support system influence diabetes self-management behaviors.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"3991-4001"},"PeriodicalIF":2.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Computerized Face and Tongue Image Segmentation and Metabolic Parameters in Patients with Type 2 Diabetes Based on Machine Learning.","authors":"Song Wen, Yanyan Li, Chenglin Xu, Jianlan Jin, Zhimin Xu, Yue Yuan, Lijiao Chen, Yishu Ren, Min Gong, Congcong Wang, Meiyuan Dong, Yingfan Zhou, Xinlu Yuan, Fufeng Li, Ligang Zhou","doi":"10.2147/DMSO.S491897","DOIUrl":"10.2147/DMSO.S491897","url":null,"abstract":"<p><strong>Objective: </strong>We aim to examine and reestablish the correlational and linear regression relationships, as well as the predictive value, between the significant facial and tongue features and the metabolic parameters in type 2 diabetes mellitus (T2DM).</p><p><strong>Materials and methods: </strong>From March to May 2024, we studied 269 patients with T2DM in the endocrinology department of Shanghai Pudong Hospital. The patients' facial and tongue characteristics were sampling by a tongue imaging device equipped with artificial intelligence (AI) (XiMaLife, Sinology, China) of automated and advanced machine learning algorithms. Then, the imaging features were examined in relation to the blood examination.</p><p><strong>Results: </strong>Multiple facial and tongue features, as well as dimensional facial and tongue color parameters, were significantly correlated with glycated hemoglobin A1c (HbA1c) (r < 0.3, p < 0.05), glycated albumin (GA) (-0.20 < 0.30, p < 0.05), C-peptide (-0.20.20, p < 0.05), plasma insulin (r < 0.30, p < 0.05), fasting plasma glucose (FPG) (r < 0.3, p < 0.05), significant hepatic and renal function indicators (-0.30 < r < 0.20, p<0.05), cardiac injury markers (-0.30 < r < 0.30, p < 0.05), tumor markers (-0.5 < r < 0.5, p < 0.05), thyroid function (-0.15 < r < 0.55, p < 0.05), and blood cell count, including white blood cells (r < 0.2, p < 0.05), and hemoglobin (Hb) (-0.30 < r < 0.3, 0.0001. The correlational results demonstrated that the tongue's characteristics and signs may be linked with the dynamic of the metabolic status of T2DM. In order to examine the causal relationships, we performed linear regression analyses, which revealed that various facial and tongue imaging parameters partially determined the metabolic indicators. The predictive value of imaging features was evaluated by receiver operating characteristic curve (ROC) to assess metabolic status in T2DM.</p><p><strong>Conclusion: </strong>This study demonstrated that metabolic status, renal and hepatic, cardiac, and thyroid function, the proportion of blood cells, and Hb in T2DM were intimately associated with facial and tongue features. The precise analysis of facial and tongue features through AI and advanced machine learning could be used to predict T2DM's conditions and progression.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4049-4068"},"PeriodicalIF":2.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Triglyceride-Glucose Index and Lung Function Parameters in the General Population Undergoing Health Examinations.","authors":"Yu Yang, Shuqi Wang, Boying Jia, Shuchun Chen","doi":"10.2147/DMSO.S487744","DOIUrl":"10.2147/DMSO.S487744","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between the triglyceride-glucose (TyG) index and pulmonary function metrics among the general population undergoing health examinations.</p><p><strong>Materials and methods: </strong>The enrollment totaled 696 participants. Fasting triglycerides and glucose levels were used to calculate the TyG index. Participants were divided into two categories according to their median TyG: one with high TyG and the other with low TyG. A portable spirometer was used to assess lung function. Fundamental clinical features and lung function indicators were compared between the two groups, and the relationship between the TyG index and lung function parameters was explored.</p><p><strong>Results: </strong>Compared with the low TyG group, the high TyG group exhibited significantly reduced levels of FEV1/FVC, FVC% pred, FEV1% pred, FEV3% pred, FEV3/FVC, FEF75, FEF75% pred, FEF25-75% pred, and MVV% pred, suggesting poor pulmonary function. The TyG index was significantly inversely correlated with multiple pulmonary function metrics, including FVC% pred, FEV1% pred, FEV3% pred, FEV1/FVC, FEV3/FVC, FEF75, FEF75% pred and FEF25-75% pred, which persisted even after accounting for confounding variables.</p><p><strong>Conclusion: </strong>In summary, the present study establishes a correlation between the TyG index and some lung function indicators, offering a new indicator of metabolic abnormalities related to lung functionality.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4031-4047"},"PeriodicalIF":2.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}