Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"Influence of the Brain-Derived Neurotrophic Factor Gene Polymorphism on Weight Loss Following Intragastric Balloon Intervention: A Cross-Sectional Study.","authors":"Ahmad Al-Serri, Hessa A Al-Janahi, Mohammad H Jamal, Dana AlTarrah, Ali H Ziyab, Suzanne A Al-Bustan","doi":"10.2147/DMSO.S481547","DOIUrl":"10.2147/DMSO.S481547","url":null,"abstract":"<p><strong>Background and aim: </strong>There is noticeable heterogeneity in weight loss outcomes following intragastric balloon (IGB) treatment, with average weight loss ranging between 11% to 15% of total body weight. Genetic variations associated with obesity have been found to influence weight loss response, however such variations are limited. Therefore, the aim of this study is to investigate the impact of the obesity associated <i>brain-derived neurotrophic factor (BDNF)</i> gene polymorphism rs11030104 with weight loss outcomes following IGB treatment.</p><p><strong>Methods: </strong>In this cross-sectional study, <i>BDNF</i> rs11030104 was analysed in 106 individuals who underwent intragastric balloon treatment. Weight loss metrics were evaluated at the three-month follow-up: percentage of total weight loss (%TWL), percentage of excess weight loss (%EWL), and percentage of body mass index loss (%EBMIL). The effects of additive and dominant genetic models were evaluated. Both linear and logistic regression were applied to assess associations between rs11030104 genotypes and weight loss metrics.</p><p><strong>Results: </strong>A total of 71 participants completed the 3-month follow-up assessment (loss to follow-up: 33%). This study found a significant association between the <i>BDNF</i> rs11030104 polymorphism and weight loss. A-allele carriers showed a better response to IGB treatment. Individuals carrying the AA genotype were found to have a greater %TWL than those carrying the GG genotype at 3 months post-IGB treatment (11.05% vs 5.09%, p=0.003).</p><p><strong>Conclusion: </strong>Our results suggest that <i>BDNF</i> rs11030104 influences the response to weight loss after IGB treatment and therefore could be added to the growing list of genetic variants that predict greater weight loss response.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4299-4306"},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Alternative Polyadenylation in Diseases Related to Glycolipid Metabolism.","authors":"Xiyao Yang, Alayi Bolatai, Jiaxin An, Na Wu","doi":"10.2147/DMSO.S470647","DOIUrl":"10.2147/DMSO.S470647","url":null,"abstract":"<p><p>With changes in lifestyle, sedentary behavior or lack of physical exercise increases the risk of various glycolipid metabolic disorders. Glycolipid metabolic dysregulation refers to abnormalities in the metabolism of carbohydrates and lipids, including diseases such as diabetes, obesity, and metabolic syndrome. In-depth research into the molecular mechanisms of glycolipid metabolic dysregulation can help develop more effective treatment strategies and preventive measures to prevent the occurrence of long-term complications such as cardiovascular diseases. Alternative polyadenylation (APA) is an important form of RNA modification that helps regulate gene expression and generate protein diversity. This modification can affect processes such as RNA stability, post-transcriptional modification, and translational regulation. Recent studies have confirmed that APA can influence the expression of genes involved in glucose and lipid metabolism, increasing the probability of developing immune, endocrine, and metabolic diseases. The review explains the research progress of APA involvement in various metabolic diseases and explores these mechanisms, providing new insights and directions for novel metabolic disorder treatment strategies.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4277-4286"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicians' Perspectives on Health-Related Quality of Life and Mental Health Aspects of People with Type 2 Diabetes Mellitus: A Cross-Sectional Study in Jeddah, Saudi Arabia.","authors":"Owiss Alzahrani, John P Fletcher, Kerry Hitos","doi":"10.2147/DMSO.S491491","DOIUrl":"10.2147/DMSO.S491491","url":null,"abstract":"<p><strong>Aim: </strong>To explore the physicians' knowledge, awareness, and perspectives on HRQoL and mental health aspects of people with T2DM in Jeddah, Saudi Arabia.</p><p><strong>Methods: </strong>A cross-sectional survey study was conducted over a three-month period (October to December 2022) on 54 physicians. Physicians were requested to respond to a 12-item researcher-designed, self-administered survey questionnaire that explored their perspectives regarding the importance of their patients' general, physical, and mental health aspects using the 12-item Short Form Health Survey Version 2 (SF-12v2).</p><p><strong>Results: </strong>Overall, 85.2% of physicians were male, with almost two-thirds (64.8%) practising in one medical and more than two-thirds (35%.2%) in the surgical specialties. Most physicians (57.4%) were consultants, which was also reflected in both subgroup specialties (54.3% versus 63.2%, respectively). The majority of physicians (83.3%) asked their patients about their general health; however, only 18.5% responded positively to questions about emotional problems. There was a low positive response to questions relating to the emotional component, such as feeling \"calm and peaceful\" (38.9%) and \"feeling a lot of energy\" (35.2%). This was even lower (25.9%) for questions related to mental health.</p><p><strong>Conclusion: </strong>Our study is a \"call for action\" for future well-designed, multidimensional, and multisectoral research studies that will help broaden knowledge about the magnitude of the current problem. This may improve overall general, physical, and mental health by enhancing patient level of care, adherence to health care plans, and reducing long-term complications.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4287-4297"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Free Triiodothyronine and Carcinoembryonic Antigen Levels in Type 2 Diabetes Mellitus Patients.","authors":"Jingxin Zhou, Can Cao, Tonghua Liu, Lili Wu, Juan Miao","doi":"10.2147/DMSO.S481433","DOIUrl":"10.2147/DMSO.S481433","url":null,"abstract":"<p><strong>Background: </strong>Thyroid dysfunction is more common in other endocrine disorders such as diabetes mellitus (DM). Carcinoembryonic antigen (CEA), a common tumor biomarker, is found elevated in patients with thyroid dysfunction. However, the relationship between thyroid hormone levels and CEA levels remains unclear.</p><p><strong>Methods: </strong>In total, 663 patients with type 2 diabetes at the Tongzhou Branch of Dongzhimen Hospital were enrolled in this retrospective study. Data were collected from inpatient electronic files between December 2011 and December 2019. Laboratory indices were statistically analyzed using logistic regression and Spearman correlation analyses.</p><p><strong>Results: </strong>In our study, total triiodothyronine (TT3), free triiodothyronine (FT3), serum albumin(ALB), total protein (TP), and triglyceride (TG) levels were significantly higher in the T2DM patients with normal values of CEA than T2DM patients who had abnormal values of CEA, whereas alkaline phosphatase (ALP), Glucose (GLU), and HbA1c levels were significantly increased in the T2DM patients with abnormal CEA level. Binary logistic regression analysis demonstrated that FT3, GLU, HbA1c, and TG levels remained as independent risk factors for CEA in patients with T2DM (β=-0.907, P =0.004; β =-1.009, P=0.004; β =0.090, P = 0001; β= 0.336, P <0.001; β= -0.293, P =0.009, resp). Spearman correlation analysis showed that CEA level was significantly positively correlated with HbA1c and GLU (r_s value: 0.265, P <0.001; r_s value: 0.270, P <0.001, resp.) and negatively correlated with FT3 and TG levels (r_s value: -0.139, P <0.001; r_s value: -0.103 P =0.008, resp). Furthermore, multivariate logistic regression analysis indicated that the FT3 quartiles were significantly associated with CEA levels before and after adjusting for confounding factors.</p><p><strong>Conclusion: </strong>Our study determined that FT3 remained an independent risk factor for CEA in patients with T2DM and was significantly negatively correlated with CEA levels.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4267-4275"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postprandial Glucose and Insulin Response to Meal Sequence Among Healthy UAE Adults: A Randomized Controlled Crossover Trial.","authors":"Ayah Shaheen, Amena Sadiya, Bashair M Mussa, Salah Abusnana","doi":"10.2147/DMSO.S468628","DOIUrl":"10.2147/DMSO.S468628","url":null,"abstract":"<p><strong>Background: </strong>Dietary patterns that lower postprandial glycemia have been effective in preventing type 2 diabetes. Consuming macronutrients in a specific sequence within a meal has been considered as a novel strategy to reduce post-meal glucose spikes. Therefore, this study aimed to investigate the effect of meal sequence on postprandial glucose and insulin response among healthy adults in the United Arab Emirates.</p><p><strong>Methods: </strong>Eighteen healthy adults participated in a cross-over randomized controlled trial. Two isocaloric meals were consumed separately in a different order: a standard mixed meal (SMM) vs vegetables and protein first followed by carbohydrates (VPF) meal. The postprandial glucose and insulin levels were determined at Fasting, 30, 60, and 120 min. Visual Analog Scale (VAS) rating was used to assess hunger at similar frequencies.</p><p><strong>Results: </strong>The mean glucose and insulin levels significantly reduced (p = 0.001) following VPF meal compared to SMM at 30 min. The incremental area under the curve (iAUC0-120) for glucose following the VPF meal sequence was 40.9% lower (p = 0.03) compared with the SMM (572.83; 95% CI 157.3 to 988.2) vs (968.5; 95% CI 692.4 to 1244.8 mg/dL). Furthermore, the iAUC0-120 for insulin following the VPF meal sequence was 31.7% lower than the SMM meal sequence. (2184; 95% CI 1638.30 to 2729) vs (3196.94; 95% CI 2328.19 to 4065.69) mIU/mL × 120 min, P = 0.023). The feeling of fullness measured by the hunger scale showed that the feeling of fullness was higher after 60 and 120 minutes (p = 0.05, p = 0.04) with the VPF meal sequence compared to the SMM sequence. Although, there is no significant difference in the Area under the curve (AUC) for hunger rating between the two meals.</p><p><strong>Conclusion: </strong>The VPF meal sequence could significantly reduce postprandial glucose and insulin levels and sustain fullness after a meal. Meal sequencing could be an effective dietary strategy for improving the postprandial glucose and insulin response in healthy adults.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4257-4265"},"PeriodicalIF":2.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Diagnostic Markers of Diabetic Retinopathy: Serum LncRNA MIAT, HOTTIP, SNHG16.","authors":"Bo Li, Yan-Jun Du, Feng Xu, Hong-Bing Li, Xu Yang","doi":"10.2147/DMSO.S470755","DOIUrl":"10.2147/DMSO.S470755","url":null,"abstract":"<p><strong>Purpose: </strong>To study the expression and diagnostic ability of the long noncoding RNAs (lncRNAs) MIAT, HOTTIP, and SNHG16 in serum of patients with diabetic retinopathy.</p><p><strong>Methods: </strong>A total of 70 healthy controls and 195 patients with Type 2 Diabetes (T2D) were collected. T2D patients include 65 patients with Nondiabetic retinopathy (NDR), 65 patients with Nonproliferative diabetic retinopathy (NPDR) and 65 patients with Proliferative diabetic retinopathy (PDR). The relative expression of MIAT, HOTTIP and SNHG16 in participant serum was measured through Real-time fluorescence quantitative polymerase chain reaction to compare the differential expression between the groups. <i>t</i> test, Mann‒Whitney <i>U</i>-test, Pearson's chi-square test and the receiver operating characteristic (ROC) curve were used to analyze the expression of these LncRNAs and their diagnostic ability for DR.</p><p><strong>Results: </strong>We compare the healthy control group with T2D group, healthy control group with NDR group, NDR group with DR (NPDR+PDR) group, and NPDR group with PDR group. When NDR group was compared with the healthy control group, there was no difference between MIAT (p>0.05)and HOTTIP (p>0.05), only the relative expression of SNHG16(p<0.05) was different and it's ROC curve had identification significance. In the remaining inter-group comparisons, the differences in the expression of MIAT (p<0.05), HOTTIP (p<0.05) and SNHG16 (p<0.05) were statistically significant, and their ROC curves were all had identification significance.</p><p><strong>Conclusion: </strong>These findings prove that serum LncRNA MIAT, HOTTIP and SNHG16 may be used as potential markers to monitor the progress of DR.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4247-4256"},"PeriodicalIF":2.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Weight-Adjusted Waist Index and Periodontitis: A Cross-Sectional Study and Mediation Analysis.","authors":"Hao Yang, Yayun Lu, Lina Zhao, Yufeng He, Yuecheng He, Dong Chen","doi":"10.2147/DMSO.S491413","DOIUrl":"10.2147/DMSO.S491413","url":null,"abstract":"<p><strong>Aim: </strong>The research examined the correlation between the weight-adjusted waist index (WWI) and periodontal disease, as well as the intermediary influence of triglyceride glucose (TyG) index-related indicators, utilizing a health examination dataset.</p><p><strong>Methods: </strong>This cross-sectional study included 39,522 subjects from health check-up database of Shanghai Health and Medical Center. The WWI was determined by applying a formula that includes dividing the waist circumference (WC) by the body weight's square root. Periodontitis diagnosis followed the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP) classification. The correlation between the WWI and periodontitis was investigated through multivariate logistic regression and smoothing curve fitting. Subgroup analysis and interaction tests were also performed to verify the stability of the results. A mediation analysis was conducted to quantify the direct and indirect influences mediated by the TyG-related indicators [TyG, TyG -body mass index (TyG-BMI), TyG -waist-to-height ratio (TyG-WHtR), and TyG-waist circumference (TyG-WC)].</p><p><strong>Results: </strong>Multivariable logistic regression analysis revealed the positive association of WWI and periodontitis (OR=1.37, 95% CI: 1.30-1.43). Compared to those in the lowest quartile of WWI, participants in the highest quartile exhibited a 82% higher likelihood of periodontitis (OR=1.82, 95% CI: 1.69-1.96). Subgroup analysis and interaction tests revealed that this positive correlation was consistent in gender, BMI, WC, smoking, drinking, hypertension, and dyslipidemia (P for interaction > 0.05), with some variations noted by age and diabetes status (P for interaction<0.05). Mediation analysis showed that the proportions mediated by TyG, TyG-BMI, TyG-WC, and TyG-WHtR on the association of WWI and periodontitis risk were 13.13%, 6.30%, 16.46% and 19.79%, respectively.</p><p><strong>Conclusion: </strong>A higher WWI in Chinese adults was linked to an increased likelihood of periodontitis, and this correlation could be partially explained by elevated levels of TyG index-related indicators.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4235-4246"},"PeriodicalIF":2.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Be Alert to Diabetes Nephropathy with Cognitive Dysfunction [Letter].","authors":"Lu Gan, Changde Wang, Xiaoying Liu","doi":"10.2147/DMSO.S503578","DOIUrl":"10.2147/DMSO.S503578","url":null,"abstract":"","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4233-4234"},"PeriodicalIF":2.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Muscle Mass is Independently Associated with an Increased Risk of Having Lower Limb Atherosclerosis in T2DM Patients.","authors":"Sijie Deng, Shishi Lv, Yiying Liu, Huiwen Xu, Hanlin Yin, Bin Xiao, Sen Wang, Dan Lu, Yun Li, Xiaoqian Wang","doi":"10.2147/DMSO.S492973","DOIUrl":"https://doi.org/10.2147/DMSO.S492973","url":null,"abstract":"<p><strong>Background and aims: </strong>Existing research suggests that low muscle mass is independently associated with carotid atherosclerosis, but its relationship with lower extremity arterial atherosclerosis in type 2 diabetes mellitus (T2DM) patients remains unclear. This study aims to investigate the association between low skeletal muscle mass and lower extremity arterial atherosclerosis in T2DM patients, in hopes of providing a scientific basis for early diagnosis and treatment.</p><p><strong>Methods: </strong>This cross-sectional study recruited a total of 276 patients with T2DM who underwent bioelectrical impedance analysis, lower limb artery ultrasonography, brachial-ankle pulse wave velocity(baPWV) arterial stiffness measurement, and blood tests. An skeletal muscle index (SMI) < 7.0kg/m2 in men and an SMI< 5.7kg/m2 in women were defined as low skeletal muscle mass. Lower limb atherosclerosis was defined as the presence of atherosclerotic plaques in the lower extremity arteries.</p><p><strong>Results: </strong>In our study of 276 T2DM patients, 224 (81.1%) presented with lower limb atherosclerosis: 194 (70.2%) with simple lower limb arterial plaques, 15 (5.4%) with lower limb arterial stenosis, and 15 (5.4%) with lower limb arterial occlusion. 52 (18.8%) were diagnosed with low skeletal muscle mass. Logistic regression analysis indicated the risk of having overall lower limbs atherosclerosis increased with the prevalence of low skeletal muscle (OR= 6.175,95% CI 1.328-28.711); Patients with a low skeletal muscle mass had a higher prevalence of simple arterial plaque (OR= 6.225,95% CI 1.339-28.935) and arterial occlusion (OR=12.345,95% CI 1.221-124.808); after the adjustment for clinical risk factors. Spearman's analysis showed significant negative correlations between total-P1NP and baPWV (r=-0.166, p=0.008), N-MID and baPWV (r=-0.163, p=0.009), and β-CTX and baPWV (r=-0.141, p=0.024).</p><p><strong>Conclusion: </strong>Low muscle mass is independently associated with an increased risk of having lower limb atherosclerosis in T2DM patients. And there may be some relationship between BTMs and arteriosclerosis of the lower limb atherosclerosis in T2DM.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4211-4221"},"PeriodicalIF":2.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated with Amputation for Patients with Diabetic Foot Ulcers: A Retrospective Study.","authors":"Bo Yang, Xuwen Zha, Yunling Ding","doi":"10.2147/DMSO.S490614","DOIUrl":"https://doi.org/10.2147/DMSO.S490614","url":null,"abstract":"<p><strong>Objective: </strong>Diabetic foot ulcer (DFU) and related amputation significantly contribute to morbidity rates. The objective of this study was to assess the risk factors correlated with amputation in Chinese patients with DFU.</p><p><strong>Methods: </strong>A prospective study was implemented on DFU patients at Third Affiliated Hospital of Anhui Medical University from February 2016 to May 2024. Patients were categorized into two groups based on whether they underwent amputation: the amputation group (n = 33) and the non-amputation group (n = 29). A comparative analysis was conducted between two groups, focusing on demographic data, disease characteristics, and laboratory indicators. Binary and multivariate logistic regressions were employed to evaluate the risk factors associated with amputation. Receiver Operating Characteristic curve analysis was used to assess the risk factors in predicting amputation in patients with DFU.</p><p><strong>Results: </strong>The incidence of history of amputation, duration of diabetes in the amputation group were significantly increased compared to the non-amputation group (<i>P</i> < 0.05). On the contrary, the red blood cell count, hemoglobin level, and hematocrit in the amputation group were significantly lower compared to the non-amputation group (<i>P</i> < 0.05). Moreover, in the bi-variable logistic regression analysis, the duration of diabetes, duration of DFU, history of amputation, and hemoglobin levels were significantly associated with amputation (<i>P</i> < 0.05). After controlling potential confounding factors in multiple logistic regression analysis, duration of DFU was identified as a determining factor for amputation (<i>P</i> < 0.05). Additionally, the values for the area under curve (AUC) in relation to the duration of diabetes, duration of DFU, history of amputation, and a combined panel in predicting the occurrence of amputation in patients with DFU were 0.890, 0.868, 0.730, and 0.916, respectively.</p><p><strong>Conclusion: </strong>Our findings indicate that duration of DFU is an independent risk factor for amputation in patients with DFU.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4201-4209"},"PeriodicalIF":2.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}