Intra-Pancreatic Fat Deposition and Pancreatitis: Insights from the COSMOS Program.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-05-07 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S400276

Juyeon Ko, Maxim S Petrov

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Abstract

The global burden of pancreatitis is substantial, bedevilled by the lack of pathogenesis-based treatments for acute pancreatitis and chronic pancreatitis. The integrated PANDORA (PANcreatic Diseases Originating from intRa-pancreatic fAt) hypothesis "moved the needle" on thinking why pancreatitis develops by bringing fat in the pancreas to the fore. A total of 20 original clinical studies exploring an uncharted territory of fat in the pancreas and pancreatitis were published between 2019 and 2024 as part of the COSMOS (Clinical and epidemiOlogical inveStigations in Metabolism, nutritiOn, and pancreatic diseaseS) program. This review concisely summarises the novel insights into the relationship of intra-pancreatic fat deposition with endocrine and exocrine pancreatic functions, behavioural and nutritional factors, as well as various biomarkers. Tapping into the wealth of knowledge derived from the COSMOS program can unlock new perspectives on the treatment of acute pancreatitis and chronic pancreatitis.

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胰腺内脂肪沉积和胰腺炎：来自COSMOS项目的见解。

由于缺乏针对急性胰腺炎和慢性胰腺炎的基于病因的治疗方法，胰腺炎的全球负担是巨大的。整合的潘多拉（胰腺疾病起源于胰腺内脂肪）假说“推动了”思考为什么胰腺炎是由胰腺脂肪引起的。作为COSMOS（代谢、营养和胰腺疾病的临床和流行病学调查）项目的一部分，在2019年至2024年期间，共有20项探索胰腺脂肪和胰腺炎未知领域的原始临床研究发表。本文简要综述了胰腺内脂肪沉积与胰腺内分泌和外分泌功能、行为和营养因素以及各种生物标志物之间关系的新见解。利用从COSMOS项目中获得的丰富知识，可以为急性胰腺炎和慢性胰腺炎的治疗提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.