Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"Electroacupuncture Reduces Waistline in Patients with Abdominal Obesity: A Randomized Controlled Trial with Mechanistic Analysis of Lipidomic and Intestinal Microbiota.","authors":"Xia Chen, Yanji Zhang, Chengwei Fu, Mengyuan Huang, Dan Wei, Wei Zhou, Yiran Liu, Bei Huang, Yingyue Rao, Yingrong Zhang, Hongjie Xia, Yaxin Hu, Hui Li, Wei Huang, Zhongyu Zhou","doi":"10.2147/DMSO.S551806","DOIUrl":"https://doi.org/10.2147/DMSO.S551806","url":null,"abstract":"<p><strong>Background: </strong>Abdominal obesity is a major risk factor for metabolic diseases and certain cancers. Although lifestyle intervention is the cornerstone of treatment, maintaining weight reduction is challenging. Electroacupuncture (EA) has shown potential in improving abdominal obesity, but its underlying mechanisms remain unclear.</p><p><strong>Objective: </strong>This randomized controlled trial evaluates the efficacy of electroacupuncture combined with lifestyle intervention for reducing waist circumference in adults with abdominal obesity, and explores potential mechanisms through lipidomics and intestinal microbiota analyses.</p><p><strong>Methods: </strong>The studies were performed in Hubei Provincial Hospital of Traditional Chinese Medicine between July 2020 and March 2023. Sixty-eight patients with abdominal obesity and 34 matched - healthy controls (HC) were recruited. After randomization, patients with abdominal obesity received an 8-week EA treatment or sham electroacupuncture (SA) treatment followed by 24-week follow-up. The change of waistline was to evaluate the efficacy of EA. Serum and stool specimen of EA group (pre- and post-treatment) and HC were collected for lipid metabolism markers and intestinal microbiota analysis.</p><p><strong>Results: </strong>Compared with baseline, the difference of waistline between EA and SA was 7.38 (95% CI, 2.88 to 11.87; P = 0.002) cm at the end of treatment (week 8) and 8.99 (95% CI, 4.48 to 13.50; P < 0.001) cm at the end of follow-up (week 32), respectively. Lipidomic analysis indicated that some lipid species previously found to differ between patients with abdominal obesity and healthy controls showed a trend toward reversal after EA treatment. Microbiota analysis showed that EA did not significantly alter overall richness, but the abundance of certain taxa changed, particularly <i>Akkermansia muciniphila</i>.</p><p><strong>Trial registration: </strong>ClinicalTrials, NCT04957134. Registered 30 June 2021, https://clinicaltrials.gov/study/NCT04957134?term=NCT04957134&rank=1.</p><p><strong>Conclusion: </strong>Our findings suggest that electroacupuncture is effective and safe in reducing waistline in patients with abdominal obesity. These results provide preliminary evidence that its benefits may be related to changes in lipid metabolism and intestinal microbiota, although further studies are warranted.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3649-3669"},"PeriodicalIF":3.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-Based Synthesis for Practice: Lifestyle Interventions in Type 2 Diabetes with Obesity.","authors":"Huan Wang, Fei Chen, Qiongdan Zhang, Juan Chen, Wenjie Zhang, Lixue Fang, Piao Xiong","doi":"10.2147/DMSO.S550776","DOIUrl":"https://doi.org/10.2147/DMSO.S550776","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic evidence synthesis evaluates lifestyle interventions for type 2 diabetes with obesity, providing clinical guidance based on rigorously appraised Chinese and international evidence to support healthcare decision-making.</p><p><strong>Methods: </strong>Two researchers independently conducted systematic searches across multiple databases including CNKI, Wanfang, PubMed and Cochrane Library. Using standardized protocols, they extracted and synthesized evidence from qualifying publications, with all included studies undergoing dual quality assessment through AGREE II and AMSTAR-2. Discrepancies were resolved through consensus discussion involving a third senior researcher.</p><p><strong>Results: </strong>The analysis incorporated thirteen high-quality evidence sources: six clinical guidelines comprising two Chinese and four international publications, three systematic reviews, three expert consensuses and one clinical decision framework. These yielded thirty-eight distinct evidence statements addressing five essential domains: the necessity of lifestyle intervention, assessment and monitoring approaches, multidisciplinary care coordination, multidimensional lifestyle components including nutrition, physical activity, stress management, sleep optimization and social support, along with long-term follow-up systems. Twenty-nine recommendations represented the highest grade of evidence, with demonstrated outcomes including clinically significant weight loss (5-15% of body weight) associated with improved metabolic control, diabetes remission in patients achieving ≥15kg weight reduction, and reduced reliance on glucose-lowering medications.</p><p><strong>Conclusion: </strong>This evidence synthesis provides healthcare systems with thirty-eight clinically validated recommendations for implementing lifestyle interventions. The findings support real-world application by standardizing protocols, training clinicians, and adapting patient education while maintaining fidelity to evidence-based core components and allowing necessary local adaptations to meet diverse patient needs across different healthcare settings.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3671-3686"},"PeriodicalIF":3.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Early Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Decrease After Continuous Positive Airway Pressure on Glycaemic Control in Type 2 Diabetes with Obstructive Sleep Apnea.","authors":"Mengmeng Zhang, Fuzai Yin","doi":"10.2147/DMSO.S533608","DOIUrl":"10.2147/DMSO.S533608","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study is to evaluate the relationship between changes in Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) within 7 days after Continuous positive airway pressure (CPAP) treatment and long-term glycaemic control.</p><p><strong>Methods: </strong>This study retrospectively included 650 Type 2 diabetes (T2DM) and Obstructive sleep apnea (OSA) patients treated with CPAP. Patients were divided into two groups based on whether long-term glycaemic control was effective or ineffective, and differences in baseline and disease-related characteristics between the two groups were compared. We constructed a multi factor logistic regression model to analyze the impact of the decrease in NLR and PLR within the first 7 days after treatment on long-term glycaemic control. We used restricted cubic spline analysis and Receiver Operating Characteristic (ROC) curve analysis to evaluate the relationship between the decrease in NLR and PLR and long-term glycaemic control.</p><p><strong>Results: </strong>In three multiple logistic regression models, it was observed that the decrease in NLR and PLR was an independent factor affecting long-term glycaemic improvement. The limited cubic spline analysis showed that the decrease in NLR and PLR was linearly or approximately linearly positively correlated with long-term glycaemic improvement. The interaction indicates that in patients who use CPAP for a longer period of time every night, the decrease in NLR has a stronger impact on long-term glycaemic improvement. The ROC curve indicates that both NLR and PLR have good and similar predictive abilities in terms of the magnitude of decline.</p><p><strong>Conclusion: </strong>The decrease in NLR and PLR within 7 days after the start of CPAP treatment is significantly correlated with long-term glycaemic improvement in T2DM patients with OSA, and there is a significant interaction with the duration of CPAP use per night. This study suggests that the decrease in NLR and PLR can serve as potential predictors of CPAP efficacy, providing new ideas for early intervention and optimization of treatment plans.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3639-3648"},"PeriodicalIF":3.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating Effects of Health Literacy Between Self-Efficacy and Quality of Life in Patients with Type 2 Diabetes Mellitus.","authors":"Jiayao Li, Yue Lin, Xiaomiao Li, Yi Cui, Qianqian Wang, Anping Ouyang, Yan Hua","doi":"10.2147/DMSO.S546698","DOIUrl":"10.2147/DMSO.S546698","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to investigate how health literacy mediates the link between type 2 diabetes mellitus patients' self-efficacy and quality of life.</p><p><strong>Methods: </strong>Between January 2025 and April 2025, researchers gathered a convenience sample of T2DM patients from six hospitals in Shaanxi Province, China. These participants completed the Diabetes-Management SE Scale, Health Literacy Scale for Chronic Patients, and the Short Form 36 Health Survey Questionnaire to assess their self-efficacy, health literacy, and quality of life. We used SPSS 27.0 and Mplus 8.3 software to perform statistical analysis of the relationships between variables.</p><p><strong>Results: </strong>Patients with T2DM had a moderate quality of life score of 59.48 ± 14.57. Self-efficacy and quality of life were positively correlated (r = 0.950, p < 0.001). Furthermore, the association between self-efficacy and quality of life was partially mediated by health literacy (β = 0.276, 95% CI = 0.201-0.346, p < 0.001), with the mediating impact explaining 36.0% of the overall effect.</p><p><strong>Conclusion: </strong>In patients with T2DM, self-efficacy and quality of life are substantially correlated, and health literacy mediates this relationship. The above findings provide scientific evidence for developing intervention strategies.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3625-3637"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Efficacy Trajectories of GLP-1 Receptor Agonists: A Systematic Review and Network Meta-Analysis.","authors":"Zixuan Li, Zhoubo Han, Rong Sun, Xiuping Xuan, Chenghu Huang","doi":"10.2147/DMSO.S539822","DOIUrl":"10.2147/DMSO.S539822","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the long-term efficacy and changing trajectories of glucagon-like peptide-1 receptor agonists (GLP-1RAs) among patients with type 2 diabetes.</p><p><strong>Methods: </strong>The PubMed, Embase and Cochrane Library databases were searched up to March 2024 to identify randomized controlled trials that assessed the efficacy of GLP-1RAs compared with placebo. To further explore the long-term trajectories of GLP-1RAs, we also conducted subgroup analyses of the placebo-subtracted groups based on the follow-up periods: 12-18 weeks, 24-30 weeks, 48-56 weeks, 68-78 weeks and ≥ 104 weeks.</p><p><strong>Results: </strong>Fifty-five trials involving 18,876 participants were included in this meta-analysis. GLP-1RAs significantly improved HbA1c levels, body weight, fasting plasma glucose (FPG), systolic blood pressure, and serum lipid levels. GLP-1RAs continuously reduced HbA1c and FPG for at least 104 weeks, with the largest reductions observed at 12-18 weeks (versus placebo, WMD -0.99 [-1.09, -0.89], P < 0.001; -1.56 [-1.82. -1.29], P < 0.001, respectively). However, the reductions in HbA1c and FPG at ≥ 104 weeks were approximately 0.36% and 0.47 mmol/L less than the reductions at 12-18 weeks, respectively. With respect to weight loss, the optimal effect was observed at 24-30 weeks (WMD -2.42 [-2.90, -1.95], P < 0.001), followed by a plateau period. In addition, GLP-1RAs were associated with a greater risk of hypoglycemia and gastrointestinal adverse events.</p><p><strong>Conclusion: </strong>GLP-1RAs are recommended for long-term treatment of patients with type 2 diabetes due to the persistent improvement in glycemic control and weight loss. However, it is important to account for the weakening effects after 2 years.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3611-3624"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Circulating Metrnl Levels are Linked to Higher Abdominal Fat in Elderly T2DM Patients: A Gender-Based Study.","authors":"Jiangli Pei, Dan Zhao, Xinhua Ye, Yunfeng Du","doi":"10.2147/DMSO.S546457","DOIUrl":"10.2147/DMSO.S546457","url":null,"abstract":"<p><strong>Objective: </strong> Our study aimed to investigate the association between serum Metrnl levels and body fat distribution in type 2 diabetes mellitus (T2DM) patients.</p><p><strong>Methodology: </strong>A total of 281 Chinese patients with type 2 diabetes mellitus (T2DM) (195 men and 86 postmenopausal women, aged 61.37 ± 6.50 years, BMI 24.88 ± 3.10 kg/m²) were included in the study. Measurements of body composition were obtained by dual-energy X-ray absorptiometry. Univariate and multivariate regression analyses were adjusted for age, sex, body mass index (BMI), and lipid levels, specifically android (waist/abdominal-dominant) and gynoid (hip/thigh-dominant) fat deposition. Gender-stratified analyses and restricted cubic spline models were employed.</p><p><strong>Results: </strong>Serum Metrnl negatively correlated with A/G ratio (β = -0.01; 95% CI: -0.02~0.00) and android fat (β = -0.77; 95% CI: -1.11~-0.42). After adjustments, associations with A/G and android fat persisted, but not with gynoid fat (P > 0.05). Gender analysis showed stronger correlations in males (A/G: β = -0.02; 95% CI: -0.04~-0.01; android fat: β = -0.85; -1.28~-0.43), but not females.</p><p><strong>Conclusion: </strong>Lower serum levels of Metrnl were significantly associated with increased abdominal adiposity in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM), with a more pronounced correlation observed in males. These findings suggest that Metrnl may play a role in regulating abdominal obesity and metabolic dysfunction in this demographic.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3601-3609"},"PeriodicalIF":3.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting HbA1c Target Achievement in Type 2 Diabetes: A Retrospective Single-Centre Nomogram Derived From National MMC-Standardised Management.","authors":"Ming Lu, Hua Zhou, Yanxing Liu, Juanjuan Song, Xiaolin Lu, Yan Liu","doi":"10.2147/DMSO.S535766","DOIUrl":"10.2147/DMSO.S535766","url":null,"abstract":"<p><strong>Background: </strong>This study assessed the effectiveness of standardized management implemented by the National Metabolic Management Center (MMC) for patients with type 2 diabetes. The goal was to develop a nomogram for predicting HbA1c target achievement.</p><p><strong>Methods: </strong>A retrospective single-centre study was conducted, including 853 type 2 diabetes patients enrolled in the National Standardized Metabolic Disease Management Center at the Third People's Hospital of Datong City from June 2019 to June 2020. After one year of MMC's standardized management, factors influencing HbA1c achievement were identified through univariate and multivariate analyses to establish a predictive model. Missing data were handled using appropriate imputation methods. Model accuracy and performance were assessed using internal validation and ROC curve analysis.</p><p><strong>Results: </strong>Significant improvements were observed following MMC's standardized management, including reductions in SBP, FBG, Hb, HCT, MPV, γ-GT, ALB, TG, TC, HbA1c, and LDL-c levels (P<0.05), and increases in AST, BUN, Cr, UA, and HDL-c levels (P<0.05). The absolute HbA1c level decreased, and the rate of achieving the HbA1c target (<7%) was significantly enhanced (P<0.05). Multivariate analysis identified FBG and HCT as independent protective factors for HbA1c achievement, while ALB was a risk factor. The developed predictive model exhibited favorable discriminative ability (c-index: 0.747, 95% CI: 0.703-0.790), confirmed by decision curve analysis.</p><p><strong>Conclusion: </strong>Standardized MMC management may guide care for type 2 diabetes patients. The predictive model established in this study may assist in improving HbA1c achievement rates, although external validation is needed.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3589-3600"},"PeriodicalIF":3.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Thyroid Hormone Sensitivity and Non-Alcoholic Fatty Liver Disease in Individuals with Normal Thyroid Function.","authors":"Tingting Xu, Tianshu Han, Jingyu Zhai, Hong Qiao","doi":"10.2147/DMSO.S538911","DOIUrl":"10.2147/DMSO.S538911","url":null,"abstract":"<p><strong>Introduction: </strong>Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent metabolic disorder that has attracted increasing clinical and public health attention. Although several studies have suggested a potential link between thyroid hormone levels and the risk of NAFLD, existing epidemiological evidence remains limited and inconsistent. Therefore, this study aims to investigate the association between thyroid hormone sensitivity and NAFLD in individuals with normal thyroid function. Furthermore, we sought to explore whether this association differs according to the presence or absence of metabolic comorbidities, particularly type 2 diabetes mellitus (T2DM) and non-diabetic (non-DM) status.</p><p><strong>Methods: </strong>We included 460 adults with normal thyroid function, comprising 229 patients with T2DM and 231 without diabetes. Steatosis was assessed using liver ultrasonography.</p><p><strong>Results: </strong>Both the thyroid feedback quantile index based on free thyroxine (TFQI-FT4) and that based on free triiodothyronine (TFQI-FT3) were positively associated with the presence of NAFLD (Q4 vs Q1, Model 3: TFQI-FT4, OR = 3.290, 95% CI: 1.390-7.787, p = 0.007; TFQI-FT3, OR = 2.344, 95% CI: 1.010-5.439, p = 0.047). Among individuals with type 2 diabetes mellitus (T2DM), a higher FT3/FT4 ratio was associated with a lower risk of NAFLD (Q3 vs Q1, Model 2: OR = 0.221, 95% CI: 0.053-0.921, p = 0.038), although the comparison between Q4 and Q1 did not reach statistical significance (OR = 0.402, 95% CI: 0.100-1.614, p = 0.199). In contrast, among non-diabetic individuals, a higher FT3/FT4 ratio was positively associated with NAFLD (Q4 vs Q1, Model 2: OR = 3.390, 95% CI: 1.003-11.463, p = 0.049).</p><p><strong>Conclusion: </strong>Thyroid hormone sensitivity is associated with the development of NAFLD development in individuals with normal thyroid function and may be influenced by the presence of T2DM.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3575-3588"},"PeriodicalIF":3.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of Artificial Intelligence-Based Health Education Interventions for Patients with Type 2 Diabetes.","authors":"Chen Li, Wei Li, Yanru Shao, Zhigang Xu, Junyan Song, Yan Wang","doi":"10.2147/DMSO.S541515","DOIUrl":"10.2147/DMSO.S541515","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) poses a critical global health burden, requiring effective health education to enhance patient self-management. Artificial intelligence (AI) offers personalized and scalable solutions; however, comprehensive syntheses of its applications in T2DM health education are scarce.</p><p><strong>Objective: </strong>Guided by the Arksey and O'Malley scoping review framework, this study maps AI-based health education interventions for T2DM by evaluating technologies, effectiveness, and challenges.</p><p><strong>Methods: </strong>Seven academic databases (PubMed, Web of Science, Embase, Scopus, EBSCO, the Cochrane Library, the Joanna Briggs Institute (JBI) Database, and Wiley Online Library) were searched for studies published from 2008 to March 2025, identifying 14 eligible interventional studies involving 32,478 adult T2DM patients receiving AI-based health education.</p><p><strong>Results: </strong>(1) Technological Diversity: Interventions included mobile apps (eg, FoodLens, TRIO system), chatbots, intelligent platforms, and machine learning algorithms, focusing on diet, glucose monitoring, and lifestyle management. (2) Effectiveness: AI interventions enhanced glycemic control, yielding reductions in glycosylated hemoglobin (HbA1c) of up to 2.59%, improved self‑management adherence (60-85%), and produced positive psychological outcomes (eg, increased self‑efficacy); efficacy varied by intervention duration and user engagement. (3) Challenges: Key barriers included technical complexity, low long-term engagement, digital literacy gaps, and data privacy concerns.</p><p><strong>Conclusion: </strong>AI holds substantial potential for T2DM health education via personalized, accessible interventions. Future research should address technological hurdles, prioritize user-centered design, and integrate AI into healthcare systems to ensure sustainability and equity.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3539-3552"},"PeriodicalIF":3.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on the Correlation Between Visceral Adiposity Index, Fatty Liver Index, and Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus.","authors":"Bojing Zheng, Tianxiao Hu, Jiaqi Yao, Zhenying Zhang, Yao Xu, Huiling Shen, Xiujing Wang, Qingying Tan","doi":"10.2147/DMSO.S544669","DOIUrl":"10.2147/DMSO.S544669","url":null,"abstract":"<p><strong>Objective: </strong>This study explores the correlations between visceral adiposity index, fatty liver indices and thyroid dysfunction in type 2 diabetes mellitus patients.</p><p><strong>Methods: </strong>This cross-sectional investigation was carried out between January 2021 and December 2022, encompassing 131 adult out-patients. Patients with other endocrine diseases, severe hepatic or renal insufficiency, or recent use of thyroid-affecting medications were excluded. Clinical and laboratory data, including body mass index, waist circumference, lipid profiles, liver function markers, and thyroid function tests, were collected.</p><p><strong>Results: </strong>Blood tests showed hepatic injury markers, alanine aminotransferase, aspartate aminotransferase, and adverse lipid profiles, elevated triglycerides, reduced high-density lipoprotein, significantly increased across fatty liver indices quartiles (P < 0.05), reflecting hepatocellular injury. Waist circumference and body mass index also increased significantly with higher fatty liver indices quartiles. Similarly, visceral adiposity index showed strong correlations with metabolic parameters, including elevated alanine aminotransferase, aspartate aminotransferase, and triglycerides levels (P < 0.05). Regarding thyroid function, TSH levels increased to some extent (P = 0.068), suggesting a potential link between fatty liver and hypothyroidism.</p><p><strong>Conclusion: </strong>This study highlights the significant role of visceral fat accumulation and liver fat deposition in contributing to insulin resistance and metabolic imbalances among individuals with type 2 diabetes. Clinicians and public health departments should promote early identification and intervention of visceral fat accumulation and fatty liver as tools to prevent metabolic syndrome and related diseases.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3553-3562"},"PeriodicalIF":3.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}