Low Circulating Metrnl Levels are Linked to Higher Abdominal Fat in Elderly T2DM Patients: A Gender-Based Study.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-09-22 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S546457

Jiangli Pei, Dan Zhao, Xinhua Ye, Yunfeng Du

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Abstract

Objective: Our study aimed to investigate the association between serum Metrnl levels and body fat distribution in type 2 diabetes mellitus (T2DM) patients.

Methodology: A total of 281 Chinese patients with type 2 diabetes mellitus (T2DM) (195 men and 86 postmenopausal women, aged 61.37 ± 6.50 years, BMI 24.88 ± 3.10 kg/m²) were included in the study. Measurements of body composition were obtained by dual-energy X-ray absorptiometry. Univariate and multivariate regression analyses were adjusted for age, sex, body mass index (BMI), and lipid levels, specifically android (waist/abdominal-dominant) and gynoid (hip/thigh-dominant) fat deposition. Gender-stratified analyses and restricted cubic spline models were employed.

Results: Serum Metrnl negatively correlated with A/G ratio (β = -0.01; 95% CI: -0.02~0.00) and android fat (β = -0.77; 95% CI: -1.11~-0.42). After adjustments, associations with A/G and android fat persisted, but not with gynoid fat (P > 0.05). Gender analysis showed stronger correlations in males (A/G: β = -0.02; 95% CI: -0.04~-0.01; android fat: β = -0.85; -1.28~-0.43), but not females.

Conclusion: Lower serum levels of Metrnl were significantly associated with increased abdominal adiposity in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM), with a more pronounced correlation observed in males. These findings suggest that Metrnl may play a role in regulating abdominal obesity and metabolic dysfunction in this demographic.

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低循环metrl水平与老年T2DM患者腹部脂肪升高有关：一项基于性别的研究

目的：探讨2型糖尿病（T2DM）患者血清Metrnl水平与体脂分布的关系。方法：共纳入281例中国2型糖尿病（T2DM）患者（男性195例，绝经后女性86例，年龄61.37±6.50岁，BMI 24.88±3.10 kg/m²）。通过双能x射线吸收仪测量身体成分。单变量和多变量回归分析调整了年龄、性别、体重指数（BMI）和脂质水平，特别是android（腰部/腹部主导）和gynoid（臀部/大腿主导）脂肪沉积。采用性别分层分析和限制三次样条模型。结果：血清Metrnl与A/G比值（β = -0.01, 95% CI: -0.02~0.00）和android脂肪（β = -0.77, 95% CI: -1.11~-0.42）呈负相关。调整后，与A/G和android脂肪的相关性仍然存在，但与雌二醇脂肪无关（P < 0.05）。性别分析显示，男性的相关性较强（A/G: β = -0.02; 95% CI: -0.04~-0.01; android fat: β = -0.85; -1.28~-0.43），但女性不存在相关性。结论：中老年2型糖尿病（T2DM）患者血清中较低的Metrnl水平与腹部脂肪增加显著相关，且在男性中更为明显。这些发现表明，在这一人群中，Metrnl可能在调节腹部肥胖和代谢功能障碍中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.