A Study on the Correlation Between Visceral Adiposity Index, Fatty Liver Index, and Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S544669

Bojing Zheng, Tianxiao Hu, Jiaqi Yao, Zhenying Zhang, Yao Xu, Huiling Shen, Xiujing Wang, Qingying Tan

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Abstract

Objective: This study explores the correlations between visceral adiposity index, fatty liver indices and thyroid dysfunction in type 2 diabetes mellitus patients.

Methods: This cross-sectional investigation was carried out between January 2021 and December 2022, encompassing 131 adult out-patients. Patients with other endocrine diseases, severe hepatic or renal insufficiency, or recent use of thyroid-affecting medications were excluded. Clinical and laboratory data, including body mass index, waist circumference, lipid profiles, liver function markers, and thyroid function tests, were collected.

Results: Blood tests showed hepatic injury markers, alanine aminotransferase, aspartate aminotransferase, and adverse lipid profiles, elevated triglycerides, reduced high-density lipoprotein, significantly increased across fatty liver indices quartiles (P < 0.05), reflecting hepatocellular injury. Waist circumference and body mass index also increased significantly with higher fatty liver indices quartiles. Similarly, visceral adiposity index showed strong correlations with metabolic parameters, including elevated alanine aminotransferase, aspartate aminotransferase, and triglycerides levels (P < 0.05). Regarding thyroid function, TSH levels increased to some extent (P = 0.068), suggesting a potential link between fatty liver and hypothyroidism.

Conclusion: This study highlights the significant role of visceral fat accumulation and liver fat deposition in contributing to insulin resistance and metabolic imbalances among individuals with type 2 diabetes. Clinicians and public health departments should promote early identification and intervention of visceral fat accumulation and fatty liver as tools to prevent metabolic syndrome and related diseases.

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2型糖尿病患者内脏脂肪指数、脂肪肝指数与甲状腺功能障碍的相关性研究

目的：探讨2型糖尿病患者内脏脂肪指数、脂肪肝指数与甲状腺功能障碍的相关性。方法：该横断面调查于2021年1月至2022年12月进行，包括131名成年门诊患者。排除其他内分泌疾病、严重肝肾功能不全或近期使用甲状腺影响药物的患者。收集临床和实验室数据，包括体重指数、腰围、脂质谱、肝功能指标和甲状腺功能检查。结果：血检显示肝损伤标志物丙氨酸转氨酶、天冬氨酸转氨酶及不良脂质谱，甘油三酯升高，高密度脂蛋白降低，各脂肪肝指标四分位数均显著升高（P < 0.05），反映肝细胞损伤。腰围和体重指数也随脂肪肝指数升高而显著增加。同样，内脏脂肪指数与代谢参数，包括谷丙转氨酶、天冬氨酸转氨酶和甘油三酯水平升高有很强的相关性（P < 0.05）。在甲状腺功能方面，TSH水平有一定程度的升高（P = 0.068），提示脂肪肝与甲状腺功能减退之间存在潜在的联系。结论：本研究强调了内脏脂肪积累和肝脏脂肪沉积在2型糖尿病患者胰岛素抵抗和代谢失衡中的重要作用。临床医生和公共卫生部门应提倡早期识别和干预内脏脂肪积累和脂肪肝，作为预防代谢综合征和相关疾病的工具。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.