Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"Effectiveness of Personalized Nutrition on Management Diabetes Mellitus Type 2 and Prediabetes in Adults: A Systematic Review.","authors":"Elisa Fauziyatul Munawaroh, Dewi Marhaeni Diah Herawati, Ginna Megawati, Andi Wijayakesuma, Lika Apriani, Yulia Sofiatin, Dani Dani","doi":"10.2147/DMSO.S528619","DOIUrl":"10.2147/DMSO.S528619","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus type 2 and prediabetes are diet-related diseases with varied individual responses to routine dietary interventions. Personalized nutrition, a novel approach tailored to individual variability in response to nutrients, may offer improved outcomes.</p><p><strong>Purpose: </strong>This systematic review analyzed the effectiveness of personalized nutrition compared to control diet for managing diabetes mellitus type 2 and prediabetes.</p><p><strong>Methods: </strong>A comprehensive search was conducted in Medline, PubMed, and Cochrane CENTRAL for randomized controlled trials (RCTs) published in English up to March 31, 2024. Studies involving humans were screened independently by two reviewers, who also extracted data and assessed study quality using the Risk of Bias 2 tool. The SWiM (Synthesis Without Meta-Analysis) approach was used to summarize effect estimates and combine p-values.</p><p><strong>Results: </strong>Eight studies, including five RCTs, met the inclusion criteria. Two studies had high risk of bias and another six had some concern bias. Personalized nutrition significantly reduced HbA1c (median mean difference: -0.925%, p < 0.01, 4 studies), though the effect was minimal in studies with some concern of bias (-0.035%). Fasting glucose showed no significant change (p = 0.12, 2 studies) in prediabetics, while PPGR improved significantly (-14.85 mg/dLxh, p < 0.01, 2 studies). Energy intake did not significantly differ (p = 0.06). Personalized nutrition reduced body weight (-0.58%) compared to control only when including high-risk studies; this effect was not significant in lower-risk studies (p = 0.06). Personalized nutrition also significantly reduced carbohydrate intake (-10.8% of energy, p = 0.02) compared to control diet. It also improved gut microbiome diversity and richness from baseline in prediabetics.</p><p><strong>Conclusion: </strong>Personalized nutrition shows promise in improving HbA1c, PPGR, and reducing carbohydrate intake, with potential effects on body weight, in adults with diabetes mellitus type 2 or prediabetes. Effects on fasting glucose and energy intake remain unclear.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2783-2796"},"PeriodicalIF":3.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric Acid Metabolism and Its Relationship with Glucose and Lipid Metabolism in Overweight and Obese Children and Adolescents: A Cross-Sectional Study in South China.","authors":"Benyu Tang, Yinya Li, Juan Lin, Yuxing Zhu, Danchun Chen, Yikun Mou, Shunye Zhu","doi":"10.2147/DMSO.S527026","DOIUrl":"10.2147/DMSO.S527026","url":null,"abstract":"<p><strong>Background: </strong>Overweight and obesity in children and adolescents have emerged as significant public health issues in China. This study aims to analyze the characteristics of serum uric acid (SUA) metabolism in overweight and obese children and adolescents in South China, exploring its associations with metabolic parameters.</p><p><strong>Methods: </strong>A single-center retrospective study was conducted, involving children and adolescents aged 3 to 18 years diagnosed with overweight and obesity. Spearman correlation coefficients were calculated to evaluate relationships between SUA and other metabolic parameters. Multivariate linear regression analyses were conducted to adjust for confounders. Comparisons were made between participants with hyperuricemia and those with normal SUA levels, and logistic regression analyses were conducted to adjust for confounders. Hierarchical clustering was performed to explore the relationships among the parameters. A dendrogram was generated to visualize the cluster structure.</p><p><strong>Results: </strong>Among 172 participants (96 males, 76 females), the mean age was 10.88±2.70 years. The prevalence of hyperuricemia was 36.30%, with 38.46% in males and 33.82% in females. Every 1 kg/m² increase in body mass index was associated with a 7.156 µmol/L increase in SUA and an 8.9% increase in hyperuricemia risk. Significant correlations were observed between SUA levels and insulin resistance (HOMA-IR), fasting insulin, and high-density lipoprotein cholesterol. Hierarchical clustering analysis revealed two distinct clusters. One cluster includes SUA along with insulin resistance and lipid metabolism parameters, while the other comprises obesity metrics, urinary microalbumin, and blood glucose.</p><p><strong>Conclusion: </strong>The findings show a high prevalence of hyperuricemia in overweight and obese children and adolescents, linked to insulin resistance and dyslipidemia. These results highlight the need for early screening and targeted interventions to improve metabolic health outcomes in this vulnerable population.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2797-2806"},"PeriodicalIF":3.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Central Network Remodeling in Diabetic Neuropathy: An Integrated MR-fMRI Study.","authors":"Xiya Li, Ling Gao","doi":"10.2147/DMSO.S525219","DOIUrl":"10.2147/DMSO.S525219","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic peripheral neuropathy (DPN) is traditionally viewed as a peripheral disorder, yet emerging evidence implicates central nervous system (CNS) network dysfunction in its pathogenesis, though causal mechanisms remain incompletely understood.</p><p><strong>Methods: </strong>Bidirectional two-sample Mendelian randomization (MR) analysis examined causal relationships between Resting-State Functional Magnetic Resonance Imaging (rs-fMRI) phenotypes (n=34,691) and DPN (n=96,474). For validation, amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) analyses were conducted using rs-fMRI scans from DPN patients (n=16), diabetic controls without DPN (NDPN, n=24), and healthy controls (HC, n=20).</p><p><strong>Results: </strong>Bidirectional MR demonstrated that: (a) reduced default mode-visual network connectivity causally elevates DPN risk (OR=0.61, P=0.04); (b) DPN promotes subcortical-cerebellar hyperconnectivity (OR=1.04, P=0.01). DPN patients exhibited significantly higher age, triglyceride levels, pain scores, and cognitive impairment relative to comparison groups (all P<0.001). Neuroimaging identified increased ALFF in the left superior frontal gyrus (LSFG) (AUC=0.79, P<0.05), which correlated positively with disease duration, accompanied by decoupled FC with the lingual gyrus but enhanced FC with the precuneus.</p><p><strong>Conclusion: </strong>This study establishes DPN as a CNS-periphery integrated network disorder: genetic drivers disrupt default mode-visual integration, while compensatory subcortical-cerebellar hyperconnectivity stabilizes motor function via adaptive mechanisms. The LSFG emerges as a neuroadaptive hub, where elevated ALFF and connectivity reorganization (↓lingual gyrus/↑precuneus) reflect dynamic rebalancing between impaired basic vision and enhanced visuospatial processing. These findings redefine DPN pathogenesis beyond pure peripheral neurodegeneration, providing a theoretical foundation for early detection and circuit-targeted neuromodulation therapies.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2753-2765"},"PeriodicalIF":3.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4'-Methoxyresveratrol Improves Hepatic Insulin Resistance Induced by a High-Fat-Diet via Anti-Oxidative-Stress Activity.","authors":"Zhimei Zhang, Xuemei Zhang, Liqun Yang, Qian Nie, Guangyao Song","doi":"10.2147/DMSO.S535103","DOIUrl":"10.2147/DMSO.S535103","url":null,"abstract":"<p><strong>Background: </strong>Obesity and a high-fat diet (HFD) are key factors contributing to hepatic fat accumulation and type 2 diabetes mellitus (T2DM). Research indicates that oxidative stress induced by HFD mediates hepatic insulin resistance (HIR) through mechanisms such as promoting inflammation and lipid accumulation. Given that 4'-methoxyresveratrol (4-MR) exhibits remarkable anti-inflammatory and antioxidant activities, it is of great research significance to explore whether it can effectively counteract HFD-induced HIR by enhancing antioxidant stress.</p><p><strong>Purpose: </strong>This study aimed to explore the effects of 4MR on liver oxidative damage and insulin sensitivity.</p><p><strong>Methods: </strong>Mice were fed a HFD for 8 weeks, followed by an intraperitoneal glucose tolerance test to assess insulin resistance. The in-vivo experiments were divided into three groups, including the control group, the HFD group, and the HFD + 4MR group. After 6 weeks of 4MR treatment, blood and liver samples were analyzed for biochemical markers, lipid peroxidation, antioxidant capacity, and liver protein levels. Insulin-resistant HepG2 cells were treated with 4MR and evaluated for proliferation and toxicity.</p><p><strong>Results: </strong>4MR reduced fasting blood glucose and lipid levels, improved insulin sensitivity, and decreased liver malondialdehyde levels, while increasing catalase and antioxidant enzyme activities. In both mice and HepG2 cells, 4MR increased Sirt1, p-FOXO1, and CAT expression levels and decreased FOXO1 expression levels.</p><p><strong>Conclusion: </strong>4MR alleviated hepatic oxidative stress, enhanced insulin sensitivity, and reduced glucose levels.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2739-2752"},"PeriodicalIF":3.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 Polyunsaturated Fatty Acids Effect on Neuropathy of the Peripheral Nervous System in Dietary Obese Rats: Is the Source of These Fatty Acids Important for Outcome?","authors":"Eric Davidson, Oleksandr Obrosov, Lawrence Coppey, Mark Yorek","doi":"10.2147/DMSO.S522285","DOIUrl":"10.2147/DMSO.S522285","url":null,"abstract":"<p><strong>Objective: </strong>To answer the question what is the best source or composition of omega-3 polyunsaturated fatty acids (PUFA) that will provide the most favorable and safe outcome for peripheral neuropathy (PN) in an animal model of obesity? Traditionally encapsulated fish oil is the primary source of omega-3 PUFA as a nutritional supplement. However, other sources exist that could be a better environmental, safety, and/or economic choice.</p><p><strong>Methods: </strong>Male Sprague Dawley rats 12 weeks of age were fed a 45% kcal diet to induce obesity and model pre-diabetes. Early and late intervention protocols were used to determine the ability of omega-3 PUFA derived from menhaden (fish) oil, krill oil, algal oils, or ethyl esters to slow the progression or reverse PN associated with pre-diabetes by examining multiple endpoints of sensory nerve function, morphometry and vascular reactivity. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the primary omega-3 PUFA, and a combination exist in fish and krill oil. However, algal oils and ethyl esters are available as EPA, DHA, or EPA & DHA and each were used in this study.</p><p><strong>Results: </strong>We report that multiple sources of omega-3 PUFA are a proactive treatment for PN that occurs with pre-diabetes including improvement in sensory nerve conduction velocity, thermal nociception and cornea sensitivity and corneal nerve fiber length. Improvement in vascular reactivity of epineurial arterioles of the sciatic nerve was observed. We also report that EPA and DHA had different outcomes for these endpoints.</p><p><strong>Conclusion: </strong>We confirm that omega-3 PUFA are an effective treatment to prevent and reverse PN associated with obesity and pre-diabetes. Additional studies will be needed to definitively determine what would be the best and most consistent source of this important nutritional supplement from an environmental and economical viewpoint.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2709-2721"},"PeriodicalIF":3.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Clinically Related Factors of Hypertriglyceridemia in Patients with Bipolar Disorder in Anhui Province, China.","authors":"Jiahuan Li, Weihong Lei, Ying Wang, Qing Wu","doi":"10.2147/DMSO.S535869","DOIUrl":"10.2147/DMSO.S535869","url":null,"abstract":"<p><strong>Purpose: </strong>The prevalence of comorbid hypertriglyceridemia in patients with bipolar disorder has received international attention. This study aims to explore the prevalence and clinical factors of comorbid hypertriglyceridemia in patients with bipolar disorder (BD) in Anhui, China.</p><p><strong>Patients and methods: </strong>A total of 1072 patients with bipolar disorder were recruited from a large specialized hospital in Anhui, China. Demographic and clinical data were collected. Univariate and multivariate regression analyses were performed to assess the association between hypertriglyceridemia and various clinical variables.</p><p><strong>Results: </strong>The prevalence of hypertriglyceridemia in patients with bipolar disorder in Anhui Province was 22.6%. Compared with patients without hypertriglyceridemia, patients with hypertriglyceridemia were older, and had higher body mass index (BMI), blood glucose, total cholesterol, alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and uric acid levels, and lower high-density lipoprotein level. Multiple Logistic regression analysis showed that BMI (OR=1.51, p<0.001, 95% CI=1.23-1.84), blood glucose (OR=1.21, p<0.001, 95% CI=1.09-1.33), total cholesterol (OR=2.88, p<0.001, 95% CI=2.34-3.55) were positively associated with the risk of hypertriglyceridemia, while high-density lipoprotein cholesterol (OR=0.07, p<0.001, 95% CI=0.03-0.15) showed the opposite association. The nomogram developed from these findings demonstrates an area under the curve (AUC) of 0.803 (95% CI: 0.772-0.834), with a sensitivity of 0.770 and a specificity of 0.727. Consequently, it serves as an effective instrument for assessing the risk of hypertriglyceridemia.</p><p><strong>Conclusion: </strong>The prevalence of hypertriglyceridemia in patients with bipolar disorder is higher than that in the general population in Anhui, China, and its prevalence is related to BMI, blood glucose and other factors, which needs to be paid attention to and relevant measures should be taken.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2695-2705"},"PeriodicalIF":3.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative Effectiveness and Safety of the GLP-1 (Glucagon-Like Peptide 1) Receptor Agonists, Semaglutide and Liraglutide in the Treatment of Obese Type 2 Diabetics: A Prospective Observational Cohort Study in Poland.","authors":"Karolina Hoffmann, Michał Michalak, Anna Paczkowska","doi":"10.2147/DMSO.S531697","DOIUrl":"10.2147/DMSO.S531697","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy and safety of semaglutide and liraglutide over one year in obese Polish patients with type 2 diabetes.</p><p><strong>Patients and methods: </strong>In this prospective, observational cohort study conducted in Poland in 2024, 460 patients aged 18-80 were enrolled: 333 received semaglutide (Group 1), and 133 received liraglutide (Group 2).</p><p><strong>Results: </strong>After 12 months, HbA1c levels significantly decreased in both groups: Group 1: from 6.09 ± 1.14% to 5.42 ± 0.82% (mean decrease: 0.67 ± 0.37%, <i>p</i><0.0001). Group 2: from 5.78 ± 0.75% to 5.17 ± 0.54% (mean decrease: 0.61 ± 0.28%, <i>p</i><0.001). BMI decreased by 5.36 ± 3.45 kg/m² in Group 1 and 4.41 ± 4.63 kg/m² in Group 2 (<i>p</i><0.0001), with greater reduction in Group 1 (<i>p</i>=0.017). Gastrointestinal adverse effects were most common, including nausea, vomiting, constipation, gastritis, and diarrhea, with higher incidence in Group 1. HbA1c reduction correlated with baseline HbA1c, age, and gender; BMI reduction correlated with baseline HbA1c and BMI.</p><p><strong>Conclusion: </strong>Semaglutide was more effective than liraglutide in reducing HbA1c and BMI. Gastrointestinal symptoms were the most frequent side effects in both groups.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2723-2738"},"PeriodicalIF":3.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Correlation of Body Mass Index with Clinicopathologic Parameters in Patients with Idiopathic Membranous Nephropathy [Corrigendum].","authors":"","doi":"10.2147/DMSO.S558515","DOIUrl":"https://doi.org/10.2147/DMSO.S558515","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/DMSO.S366100.].</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2707-2708"},"PeriodicalIF":3.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Network Pharmacology-Based Investigation into the Mechanism of Quercetin Combined with Rosuvastatin in Delaying Diabetic Nephropathy via Inhibiting NRK-52E Cell Ferroptosis.","authors":"Meishe Gan, Zhiyuan Lin, Junxue Ma, Ning Li, Biaoliang Wu","doi":"10.2147/DMSO.S524983","DOIUrl":"10.2147/DMSO.S524983","url":null,"abstract":"<p><strong>Objective: </strong>Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, and current therapeutic options are limited in effectively managing DN progression. Renal tubular epithelial cell (RTEC) ferroptosis has emerged as a critical mechanism contributing to DN pathogenesis. This study aimed to investigate the potential synergistic effects of quercetin (QCT) and rosuvastatin (RSV) on inhibiting RTEC ferroptosis and ameliorating DN progression, providing a novel combinatorial therapeutic strategy.</p><p><strong>Methods: </strong>Public database data were analyzed using network pharmacology to identify QCT-DN-related and RSV-DN-related targets, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. NRK-52E cells were cultured in vitro under high glucose conditions (30 mM glucose) to induce damage, then incubated with QCT and/or RSV. Enzyme-linked immunosorbent assay measured inflammatory cytokines (IL-6, TGF-β, TNF-α), flow cytometry detected reactive oxygen species (ROS), and colorimetric assays quantified superoxide dismutase (SOD), malondialdehyde (MDA), and iron ions. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) evaluated ferroptosis-related genes (GPX4, SLC7A11).</p><p><strong>Results: </strong>Network pharmacology analysis revealed primary enrichment of both QCT-DN-related and RSV-DN-related targets in ferroptosis-related pathways. In vitro cell experiments showed that both QCT and RSV, when used individually, significantly inhibited the expression of inflammatory cytokines (IL-6, TGF-β, and TNF-α), ROS generation, SOD levels, MDA levels, iron ion levels, and the expression of ferroptosis-related genes (GPX4 and SLC7A11) in NRK-52E cells under high-glucose conditions. Furthermore, compared to the individual use of QCT or RSV, the combined use of QCT and RSV demonstrated a more significant inhibitory effect on the inflammatory phenotype and ferroptosis levels in NRK-52E cells.</p><p><strong>Conclusion: </strong>This study highlights the potential of combining QCT and RSV for DN management. Network pharmacology confirmed associations between QCT/RSV targets and NRK-52E cell ferroptosis. In vitro experiments validated superior protective effects of co-treatment over individual treatments, warranting further in vivo investigation.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2681-2694"},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Syndrome and Associated Risk Factors in Norwegian Trauma-Exposed Inpatients: A Cross-Sectional Comparison with Blood Donors.","authors":"Grethe Emilie Roer, Ingeborg Bolstad, Dawit Shawel Abebe, Jan Aaseth, Morten Haugen, Lars Lien","doi":"10.2147/DMSO.S536015","DOIUrl":"10.2147/DMSO.S536015","url":null,"abstract":"<p><strong>Purpose: </strong>The incidence of metabolic syndrome (MetS) is increasing, and research indicates a further increased risk of MetS in trauma-exposed individuals, which is yet to be fully understood. Therefore, this study aimed to investigate the risk of MetS in trauma-exposed inpatients compared to blood donors and the influence of putative associated psychological, biological, and behavioral risk factors for MetS.</p><p><strong>Patients and methods: </strong>A cross-sectional study of trauma-exposed inpatients (n = 134) compared to blood donors (n = 68) was conducted. Clinical data, blood biomarkers, and self-administered questionnaires were collected. Descriptive statistics and multivariable logistic regression, including interaction analyses, were performed to explore the odds ratio (OR) of MetS among trauma-exposed inpatients compared to blood donors as well as the interaction effects of putative risk factors.</p><p><strong>Results: </strong>A significantly higher age- and gender adjusted OR (OR = 2.51, 95% CI 1.18-5.34) of MetS was found among trauma-exposed inpatients compared to the blood donors. Adjusted for education, cigarette smoking, symptoms of disordered eating and consumption of selected nutrients, the higher OR of MetS remained significant in the inpatients compared to the blood donors, ranging from OR = 2.27 95% CI 1.00-5.14 for symptoms of \"dieting\" to OR = 3.06 95% CI 1.16-8.10 for adult trauma. A significant interaction effect was documented only between group and age (OR = 1.07, 95% CI 1.01-1.13).</p><p><strong>Conclusion: </strong>The trauma-exposed inpatients in this study had significantly higher age- and gender adjusted risk of MetS compared to the blood donors, and psychological and behavioral lifestyle factors appeared to increase the risk of MetS.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"2667-2680"},"PeriodicalIF":3.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}