Luiza Bandeira de Mello Alves da Silva, Eduardo Nogueira Freitas Ximenes, Sergio Lincoln de Matos Arruda, João Batista de Sousa
{"title":"Determinants of Weight Loss and Regain in Men After Roux-En-Y Gastric Bypass: A Retrospective Analysis.","authors":"Luiza Bandeira de Mello Alves da Silva, Eduardo Nogueira Freitas Ximenes, Sergio Lincoln de Matos Arruda, João Batista de Sousa","doi":"10.2147/DMSO.S550725","DOIUrl":"10.2147/DMSO.S550725","url":null,"abstract":"<p><strong>Introduction: </strong>Men constitute a minority of bariatric surgery patients despite facing a high burden of obesity-related complications. Little is known about factors influencing long-term weight outcomes in male patients. We aimed to identify clinical and behavioral determinants of weight loss maintenance and weight regain in men after Roux-en-Y gastric bypass (RYGB).</p><p><strong>Methods: </strong>We retrospectively reviewed 100 men with obesity who underwent laparoscopic RYGB between 2013 and 2016. Inclusion was limited to those with ≥2 years of postoperative follow-up, yielding 43 patients for analysis. Clinical variables (age and comorbidities), behavioral factors (exercise and dumping syndrome - DS), and weight data were collected. Poisson regression identified factors associated with achieving normal body mass index (BMI) and significant weight regain. A linear regression model assessed predictors of percent excess weight loss (%EWL).</p><p><strong>Results: </strong>Paradoxically, men who achieved a normal BMI postoperatively had a higher risk of significant weight regain. Specifically, achieving a normal BMI was associated with a greater likelihood of ≥20% of total weight lost regained (adjusted prevalence ratio [PR] ~2.5, p<0.05). Longer follow-up duration was also associated with increased weight regain. On the other hand, the presence of DS was strongly associated with successful weight loss: men reporting dumping had a higher probability of attaining normal BMI (adjusted PR ~2.9, p<0.05). No other factors (age, baseline comorbidities, or exercise) showed significant associations with weight outcomes.</p><p><strong>Conclusion: </strong>RYGB is effective in men, leading to substantial weight loss and improvement in comorbidities. However, early success (achieving a normal BMI) did not guarantee long-term weight stability, as those patients were more prone to weight regain. These findings highlight the need for extended follow-up and targeted support in male bariatric patients to sustain weight loss outcomes.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3415-3425"},"PeriodicalIF":3.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dekra Ali El-Aghbary, Rashad Ali Thabet, Mohammed A W Almorish, Khaled Mohammed AlSayaghi, Ahmed M E Elkhalifa
{"title":"Exploring the Relationship Between Inflammatory Biomarkers and Anthropometric Measures of Obesity in Healthy Adults: A Case Control Study.","authors":"Dekra Ali El-Aghbary, Rashad Ali Thabet, Mohammed A W Almorish, Khaled Mohammed AlSayaghi, Ahmed M E Elkhalifa","doi":"10.2147/DMSO.S535445","DOIUrl":"10.2147/DMSO.S535445","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a critical public health issue, marked by an accumulation of adipose tissue that presents numerous health hazards, with recent focus on the link between obesity and inflammation, especially in the context of inflammatory biomarkers as indicators of metabolic abnormalities related to obesity.</p><p><strong>Objective: </strong>This study aimed to investigate the correlation between inflammatory biomarkers such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and hematological indicators of inflammation with anthropometric obesity measures in obese and non-obese healthy adults.</p><p><strong>Methods: </strong>The study employed a case control design involving both obese and non-obese healthy adults. The research evaluated anthropometric indicators. Blood samples were collected from participants to measure complete blood count (CBC), CRP and ESR. Platelet /Lymphocyte ratio (PLR), Neutrophil/Lymphocyte ratio (NLR), Monocyte/Lymphocyte ratio (MLR), and the systemic immune-inflammation index (SII) were calculated.</p><p><strong>Results: </strong>A significant association exists between familial obesity, lack of physical activity, and constipation persistence in obese individuals compared to non-obese individuals. In the obese cohort, mean values of white blood cells (TWBCs), neutrophils, monocytes, platelet count, NLR, PLR, MLR, and SII were elevated compared to the non-obese group. Statistically significant differences in ESR and CRP were noted between the two populations. A positive correlation exists between TWBCs and WHR, whereas lymphocytes correlate positively with WHR and negatively with body fat percentage. Eosinophils exhibited negative associations with obesity metrics, while ESR and CRP had significant positive correlations with obesity indicators like BMI and body fat percentage; PLR showed a negative relationship with WHR and a positive one with body fat percentage, lacking significant correlations with BMI, WC, HC, or abdominal obesity.</p><p><strong>Conclusion: </strong>The research indicates significant elevations in hematological biomarkers among obese individuals, highlighting a probable link between obesity and inflammation, with specific inflammatory markers potentially serving as predictors of obesity-related health risks.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3403-3414"},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypertension and BMI as Mediators of Type 2 Diabetes-Induced CKD: Insights from an Integrative Multi-Database Study.","authors":"Heng Wang, Keyi Fan, Yijie Ning, Yaling Li, Xiaotong Qi, Ziyan Wang, Keyang Xu, Ruijing Zhang, Yun Zhou, Honglin Dong, Guoping Zheng","doi":"10.2147/DMSO.S538554","DOIUrl":"10.2147/DMSO.S538554","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease is a major global health concern, with type 2 diabetic nephropathy (T2DN) significantly contributing to its burden. This study examines global trends, key risk factors, and clinical characteristics of T2DN to identify modifiable contributors and inform precision management.</p><p><strong>Methods: </strong>Data from the 2021 GBD Study, Mendelian randomization (MR) analyses, NHANES, and a clinical cohort were utilized. Trends in prevalence, incidence, mortality, disability-adjusted life years (DALYs), and population-attributable fractions (PAF) of T2DN risk factors were analyzed globally and across sociodemographic strata. Genetic determinants were identified via two-sample and multivariable MR, while clinical data were analyzed using regression and correlation analyses.</p><p><strong>Results: </strong>Between 1990 and 2021, T2DN prevalence, incidence, and DALYs increased globally, and the global mortality rate rose from 5.73 (4.81, 6.83) to 10.25 (8.62, 12.15). High fasting plasma glucose was the primary risk factor, with rising PAFs for high BMI and systolic blood pressure (SBP), and the global PAF for deaths due to T2DN attributed to high fasting plasma glucose increased from 0.80 to 0.90. MR analysis confirmed causal links between fasting glucose (β = 1.351, <i>P</i> = 2.78e-4), insulin (β = 2.543, <i>P</i> = 1.20e-5), T2DM (OR = 2.280, <i>P</i> = 4.14e-29) and T2DN risk, with BMI and SBP influencing disease progression. NHANES data showed BP's impact on renal function. A diagnostic model incorporating age, categorical blood pressure data, history of heart failure, and history of stroke was developed, with an AUC of 0.716. In the clinical cohort, T2DN correlated with elevated urinary albumin-to-creatinine ratio, serum creatinine, BP, and BMI variations.</p><p><strong>Conclusion: </strong>T2DM progression to T2DN is driven by hyperglycemia, BMI, and BP, highlighting the need for targeted interventions.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3343-3361"},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing-Jing Wang, Jie Hu, Yi-Fan Xu, Wu Dai, Jun-Cang Wu, Yong-Hong Cao
{"title":"Establishment and Validation of a Predictive Nomogram Model for Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus: A Retrospective Study.","authors":"Jing-Jing Wang, Jie Hu, Yi-Fan Xu, Wu Dai, Jun-Cang Wu, Yong-Hong Cao","doi":"10.2147/DMSO.S524654","DOIUrl":"10.2147/DMSO.S524654","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the correlation between blood biomarkers and blood glucose fluctuations with the risk of osteoporosis (OP) in postmenopausal women with type 2 diabetes mellitus (T2DM), and to construct a predictive nomogram for OP.</p><p><strong>Methods: </strong>Based on bone mineral density (BMD) results from dual-energy X-ray absorptiometry (DXA), participants were divided into OP (BMD T-value ≤ -2.5 SD) and Non-OP (BMD T-value > -2.5 SD) groups. Logistic analysis were used to explore the potential risk factors, following by the construction of a nomogram to predict the risk of OP. The discrimination and calibration of the nomogram were evaluated using concordance index (C-index), area under curve (AUC), and calibration curves.</p><p><strong>Results: </strong>We finally included 381 participants, with 147 in the OP group. Correlation analysis revealed a significant positive correlation between age and SII, and a negative correlation between BMI and CV. SII and CV demonstrated a positive dose-response relationship with OP, while FT3 exhibited a negative relationship. Multivariate logistic analysis showed that age (OR=1.088, 95% CI 1.052-1.125, P<0.001), BMI (OR=0.772, 95% CI 0.702-0.848, P<0.001), SII (OR=1.004, 95% CI 1.003-1.005, P<0.001), FT3 (OR=0.529, 95% CI 0.280-0.998, P=0.049), and CV (OR=1.051, 95% CI 1.007-1.097, P=0.022) were independent risk factors. The subgroup analysis showed the correlation between SII and OP occurred primarily in individuals aged ≥60 years. A predictive nomogram model was constructed based on age, BMI, SII, FT3, and CV, with a C-index of 0.842 (range 0.801-0.883). Decision Curve Analysis (DCA) demonstrated good clinical fit of the model.</p><p><strong>Conclusion: </strong>SII can predict the OP occurrence in women aged ≥60 years, while FT3 is applicable for predicting OP in women aged ≥70 years and those with a BMI <24 kg/m². The predictive nomogram demonstrated great predictive value in postmenopausal women with T2DM.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3363-3373"},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhangxuan Xu, Weihao Zhang, Shunli Chen, Bin Liu, Yuqin Sun
{"title":"Analysis of Predictive Factors for the Efficacy of Modified Three-Port Laparoscopic Sleeve Gastrectomy in Treating Type 2 Diabetes Mellitus.","authors":"Zhangxuan Xu, Weihao Zhang, Shunli Chen, Bin Liu, Yuqin Sun","doi":"10.2147/DMSO.S525774","DOIUrl":"10.2147/DMSO.S525774","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective cohort study identified predictors of treatment efficacy for modified three-port laparoscopic sleeve gastrectomy (TPLSG) in managing type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>We retrospectively analyzed clinical data from 187 T2DM patients<b> </b>who underwent modified TPLSG. Patients were categorized into effective group (those with satisfactory weight loss and diabetes remission/improvement) and ineffective group [those with insufficient weight loss and/or inadequate glycemic control (including patients meeting either or both criteria)]. After comparing baseline characteristics between groups, we performed <i>Logistic</i> regression analysis on significantly different variables to identify factors influencing treatment outcomes. A predictive nomogram was constructed and validated using calibration curves to assess the clinical value of these factors in predicting TPLSG efficacy for T2DM.</p><p><strong>Results: </strong>This study conducted a total inclusion of 187 T2DM patients who were grouped according to whether they performed effective or ineffective after treatment with modified TPLSG. 131 were included in the effective group and 56 in the other group. In respects of baseline C-peptide level, duration of diabetes, baseline triacylglycerol (TG) level, baseline homeostasis model assessment of insulin resistance (HOMA-IR) and baseline glycated hemoglobin (HbAlc) levels, the two groups displayed statistical significance (P < 0.05). Covariance analysis and <i>Logistic</i> regression equations for above factors revealed that none of them were covariate (VIF ≤ 10, tolerance ≥ 0.1) and all of them were influential factors leading to poor treatment effect after modified TPLSG, it was found that the mentioned factors boasted high application value in predicting the efficacy of patients after modified TPLSG by nomogram and calibration curves.</p><p><strong>Conclusion: </strong>Baseline C-peptide level, duration of diabetes, baseline TG, baseline HOMA-IR, and baseline HbAlc level were all relevant factors affecting the treatment effect of patients with T2DM treated with modified TPLSG, which should be focused on and interfered in a targeted way in actual clinical practice.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3375-3385"},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Characteristics and Related Risk Factors of Thyroid Dysfunction in LADA Patients: A Single-Center Cross-Sectional Study in Xuzhou, Jiangsu, China.","authors":"Dan Peng, Hua Zhang, Cheng Xu, Jing Wei, Qian Lu","doi":"10.2147/DMSO.S547172","DOIUrl":"10.2147/DMSO.S547172","url":null,"abstract":"<p><strong>Objective: </strong>The aim of our study was to further explore the clinical characteristics and related risk factors of thyroid dysfunction in latent autoimmune diabetes in adults (LADA) patients in the Xuzhou region of Jiangsu, China, to facilitate early intervention and treatment.</p><p><strong>Methods: </strong>It is conducted a single-center, cross-sectional study involving 95 hospitalized LADA patients from the Affiliated Hospital of Xuzhou Medical University between January 2024 and April 2025. The patients were divided into two groups based on the presence of thyroid dysfunction: 39 LADA patients without thyroid dysfunction and 56 LADA patients with thyroid dysfunction. Data collection included clinical indicators and thyroid function assessments. Correlation analysis and univariate binary logistic regression analysis were performed on the study data.</p><p><strong>Results: </strong>Significant differences were observed between the two groups in urinary albumin-to-creatinine ratio (UACR), fasting C-peptide (FCP), postprandial 2-hour C-peptide (P2hCP), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb), thyrotropin receptor antibody (TRAb), and insulin autoantibody (IAA). Correlation analysis revealed that FCP was positively correlated with P2hCP and FT3 but negatively correlated with IAA. FT3 was positively correlated with P2hCP and FT4. TPOAb was positively correlated with TGAb and TRAb. Univariate binary logistic regression analysis indicated that low levels of FCP, P2hCP, and FT3, as well as high levels of TPOAb and TGAb, were associated with thyroid dysfunction in LADA patients.</p><p><strong>Conclusion: </strong>Lower FCP, P2hCP, and FT3 levels, along with higher TPOAb and TGAb levels, are associated with thyroid dysfunction in LADA patients. Therefore, it is recommended that LADA patients undergo screening for thyroid antibodies and FT3 at disease onset and every 1-2 years thereafter to minimize the risk of undiagnosed thyroid dysfunction. Additionally, reassessment of pancreatic function every 3-6 months is advised to optimize the timing of insulin therapy.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3315-3321"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12430241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Renal Cell Senescence in Diabetic Kidney Disease: Mechanisms and Therapeutic Advances.","authors":"Zijie Yan, Jinghan Xu, Tianjiao Liu, Li Wang, Qi Zhang, Xiaoling Li, Bingjing Lin, Chunli Piao","doi":"10.2147/DMSO.S543814","DOIUrl":"10.2147/DMSO.S543814","url":null,"abstract":"<p><p>Diabetic Kidney Disease (DKD), one of the most severe microvascular complications of diabetes, significantly elevates risks of end-stage renal disease and mortality. Despite current therapies, its multifactorial pathogenesis limits effective renoprotection. Cellular senescence, a stable cell cycle arrest state representing an adaptive response to cumulative damage, emerges as a pivotal driver of DKD progression. Hyperglycemic environment directly interferes with cell cycle regulatory mechanisms or indirectly induces cell cycle arrest to accelerate renal cell senescence through various pathways, including mitochondrial dysfunction, impaired autophagy, endoplasmic reticulum stress, oxidative stress, disordered iron metabolism and inflammatory responses. This process ultimately compromises tissue repair mechanisms and exacerbates renal injury. The review systematically synthesizes current knowledge on the core biological hallmarks of cellular senescence and their mechanistic roles across key renal cell types (renal tubular epithelial cells, glomerular endothelial cells, mesangial cells and podocytes) in DKD pathogenesis. Furthermore, we evaluate emerging therapeutic strategies that target cellular senescence-associated pathways, with particular emphasis on the multi-target potential of natural products. By delineating the interplay between metabolic dysregulation and cellular senescence-driven renal decline, this work provides a foundational framework for developing novel interventions to halt DKD progression.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3323-3341"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12428652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yaxin Xu, Wenchang Jia, Xiaoxuan Niu, Jing Wen, Dingrong Ji, Xiaopan Li, Ming Liu, Sunfang Jiang
{"title":"Prevalence and Comorbidity Network Analysis of Obesity and Related Complications: A Real-World Study Based on 233,004 Individuals.","authors":"Yaxin Xu, Wenchang Jia, Xiaoxuan Niu, Jing Wen, Dingrong Ji, Xiaopan Li, Ming Liu, Sunfang Jiang","doi":"10.2147/DMSO.S544726","DOIUrl":"10.2147/DMSO.S544726","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the prevalence of overweight/obesity and their major complications, and to map comorbidity relationships by means of large-scale, real-world data.</p><p><strong>Patients and methods: </strong>This cross-sectional study included individuals undergoing routine health examinations from January 2021 to April 2024. Clinical and demographic data were systematically collected. Obesity-related complications were diagnosed using standardized criteria. Descriptive statistics assessed prevalence; correlation and network analyses characterized comorbidity relationships.</p><p><strong>Results: </strong>A total of 233,004 participants (57.5% male; mean age 43.51 ± 13.28 years) were enrolled. Among these, 41.1% were overweight and 6.1% had obesity. The most prevalent complications were dyslipidemia (30.9%), fatty liver disease (26.4%), and hyperuricemia (20.0%). Over 60% of participants had at least one obesity-related comorbidity. Network analysis indicated a central disease cluster comprising overweight/obesity, fatty liver disease, hypertension, diabetes, and carotid plaque, with diabetes playing a key role linking metabolic abnormalities to cardiovascular risks.</p><p><strong>Conclusion: </strong>Overweight prevalence was high in this large-scale examined population and frequently coexisted with multiple metabolic and cardiovascular conditions. Network analysis highlighted diabetes as a central condition, supporting early targeted interventions for overweight individuals to reduce obesity-related chronic disease burden.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3297-3314"},"PeriodicalIF":3.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of Hypertension Risk in Patients with Fatty Liver Disease Using the Triglyceride-Glucose-Body Mass Index.","authors":"Ge Gao, Haitao Li, Zhikai Xu, Xiaochun Ge, Shuying Li, Yu Gao","doi":"10.2147/DMSO.S535535","DOIUrl":"10.2147/DMSO.S535535","url":null,"abstract":"<p><strong>Purpose: </strong>Fatty liver disease (FLD) and hypertension (HTN) exhibit a bidirectional relationship: FLD elevates HTN risk, while HTN accelerates FLD progression to fibrosis. Research on this link is limited, with insulin resistance (IR) proposed as a key mechanism. The triglyceride-glucose-body mass index (TyG-BMI), an emerging IR marker, is poorly characterized regarding its association with FLD and HTN. This study assessed TyG-BMI's predictive value for HTN risk in FLD patients and its clinical significance.</p><p><strong>Patients and methods: </strong>A retrospective cohort of 6,257 FLD patients confirmed by ultrasonography from the Health Examination Center of Chengde Medical University was analyzed. Participants were categorized into FLD-HTN (n=2,804) and normotensive FLD (FLD-0, n=3,453) groups based on blood pressure measurements. Multivariable logistic regression models adjusted for confounders assessed TyG-BMI's independent association with HTN risk. Receiver operating characteristic (ROC) curve analysis, with DeLong's test, compared the discriminative ability of TyG-BMI against conventional indices (BMI and TyG index). Additionally, quartile-based stratification (Q1-Q4) further explored dose-response relationships.</p><p><strong>Results: </strong>Multivariable-adjusted models showed a 1.6% increase in HTN risk for each unit increase in TyG-BMI (OR=1.016, 95% CI: 1.014-1.018, <i>P</i> < 0.001). A significant positive correlation was found between TyG-BMI and both systolic (r=0.264) and diastolic blood pressure (r=0.263, both <i>P</i> < 0.001). ROC curve analysis demonstrated that TyG-BMI (AUC=0.624) outperformed BMI (AUC=0.593) and the TyG index (AUC=0.603) (DeLong's test, <i>P</i> <0.01) in discriminating HTN risk. Notably, individuals in the highest TyG-BMI quartile (Q4) had a 3.38-fold higher risk of HTN compared to those in the lowest quartile (Q1) (OR=3.380, 95% CI: 2.842-4.020).</p><p><strong>Conclusion: </strong>TyG-BMI is a significant predictor of HTN risk in FLD patients, offering a clinically useful tool for targeted prevention strategies.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3271-3281"},"PeriodicalIF":3.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yulian Wei, Jingyue Zhang, Xia Tai, Shan Weng, Yan Wang, Guohong Zhu
{"title":"Diabetes Distress and Self-Efficacy Mediate the Relationship Between Family Function and Coping in Young and Middle-Aged Patients with Type 2 Diabetes Mellitus.","authors":"Yulian Wei, Jingyue Zhang, Xia Tai, Shan Weng, Yan Wang, Guohong Zhu","doi":"10.2147/DMSO.S530882","DOIUrl":"10.2147/DMSO.S530882","url":null,"abstract":"<p><strong>Aim: </strong>To explore the parallel mediating effects of diabetes distress and self-efficacy on the relationship between family function and coping and adaptation ability in young and middle-aged patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>From February to December 2023, a convenience sample of 236 young and middle-aged patients with T2DM was recruited from the endocrinology departments of two tertiary hospitals. Questionnaires were administered to collect sociodemographic and disease characteristics, the short version of the Coping and Adaptation Processing Scale (CAPS-SF-C), the Adaptation, Partnership, Growth, Affection, and Resolve (APGAR), the Diabetes Distress Scale (DDS), and the Self-Efficacy for Diabetes (SED). The SPSS 26.0 software was used for univariate analysis and Pearson correlation analysis. Model 4 of the SPSS macro program Process v3.4.1 was used to assess parallel mediation effects, with Bootstrap resampling set to 5,000 iterations.</p><p><strong>Results: </strong>Pearson correlation analysis revealed that coping and adaptation ability was positively associated with family function (<i>r</i>=0.545, <i>P</i> < 0.01) and self-efficacy (<i>r</i>=0.578, <i>P</i> < 0.01) and negatively associated with diabetes distress (<i>r</i>=-0.508, <i>P</i> < 0.01). Additionally, diabetes distress and self-efficacy were found to play a parallel mediation between family function and coping and adaptation ability. The indirect effect of self-efficacy (0.081), and the indirect effect of diabetes distress (0.065) accounted for 19.06%, and 15.29% of the total effect (0.466).</p><p><strong>Conclusion: </strong>As the first study confirming dual-channel mediation in this population, we demonstrate that diabetes distress and self-efficacy functioned as parallel mediators in the relationship between family function and coping and adaptation ability. Healthcare professionals are encouraged to incorporate family-focused interventions into the management of T2DM. Reducing psychological stress and routinely monitoring self-efficacy levels are crucial for enhancing patients' coping and adaptation ability.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3283-3295"},"PeriodicalIF":3.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}