Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"Epidemiology of Overweight and Obesity in Early Childhood in China and Associated Factors.","authors":"Hongai Li, Wei Xiang, Yajun Yi, Xiaoyan Huang, Hailing Luo, Yuhua Cai, Li Liu, Haidan Li, Yan Huang, Qing Luo, Lichun Fan, Qiuyu Lin","doi":"10.2147/DMSO.S493135","DOIUrl":"10.2147/DMSO.S493135","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the epidemiological landscape and identify the risk factors associated with overweight and obesity in early childhood in China.</p><p><strong>Methods: </strong>We collected measurements of weight and height and calculated the body mass index (BMI) for preschool children. The overweight and obesity status of children aged 2 to 6 years was examined using the 2005 China BMI growth chart. WHO weight-for-length (WFL) charts were used to identify those at risk for early childhood overweight. Data on potential risk factors for childhood overweight/obesity were obtained through questionnaires. Multiple logistic regression analyses were conducted to determine the association between risk factors and overweight/obesity.</p><p><strong>Results: </strong>Among the 13,896 participants, 7.5% of infants and toddlers were overweight, 18.4% of preschoolers were overweight, and 10.3% of preschoolers were obese. The prevalence of obesity among preschool boys (12.6%) was significantly greater than that among preschool girls (7.7%, p<0.001). Our analysis identified nine risk factors significantly associated with an increased risk of early childhood overweight or obesity. These include guardian status, paternal height, frequency of weekly candy consumption, maternal weight, leg circumference, waist circumference, age at the onset of overweight, age group, and maternal education level. In addition, children born to overweight mothers had a 1.02-fold higher likelihood of being overweight/obese compared to children with mothers of normal weight (95% confidence interval: 1.00-1.03; p=0.0106). Upon adjustment for all potentially confounding variables, the odds ratios for the frequency of weekly candy consumption in children were negatively linked to overweight/obesity (0.98; 95% confidence interval: 0.96-1.00). In addition, gender-dietary habit interactions significantly influenced the risk of overweight/obesity in both positive and negative directions.</p><p><strong>Conclusion: </strong>Our research on the prevalence and predictors of overweight/obesity in preschool children underscores the importance of recognizing and understanding early childhood obesity within its context. Obesity prevention efforts should target key risk factors, such as parental obesity and unhealthy early childhood lifestyles.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1809-1822"},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Differences in Anthropometric and Lifestyle Factors Linked to Metabolic Syndrome in Women with Overweight and Obesity: A Cross-Sectional Study.","authors":"Edyta Łuszczki, Magdalena Zielińska, Łukasz Oleksy, Artur Stolarczyk, Katarzyna Dereń","doi":"10.2147/DMSO.S520553","DOIUrl":"10.2147/DMSO.S520553","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this cross-sectional study was to examine the relationship between age, degree of overweight and obesity, and the prevalence of metabolic syndrome (MetS) in women with excess body weight. The study also examined age-related differences in anthropometric parameters, body composition, and lifestyle factors. To our knowledge, this is the first study in Poland to investigate the relationship between dietary patterns and MetS in women with overweight and obesity.</p><p><strong>Patients and methods: </strong>A total of 141 women aged 23-85 years with overweight or obesity were included. The study was conducted in 2023 in south-eastern Poland. Participants were divided into two age groups: under 65 years and 65 years and older. Anthropometric, biochemical and blood pressure measurements were taken. The lifestyle analysis included frequency of food consumption, physical activity and sedentary behaviours, sleep duration, smoking and alcohol consumption.</p><p><strong>Results: </strong>The prevalence of MetS was higher in women with obesity, especially in women aged 65 years and older. Older women had a higher waist-to-hip ratio (WHR) and a lower fat-free mass (FFM) with no significant differences in body fat percentage. The younger women were more physically active. Women aged 65 years and older consumed honey more frequently. They were less likely than younger women to consume fresh legumes and canned vegetables, nuts and seeds, wholemeal bread, as well as sugar-sweetened beverages, energy drinks, and mayonnaise and dressings. No significant age-related differences were found in smoking, alcohol consumption, or sleep duration.</p><p><strong>Conclusion: </strong>The study suggests that obesity has a stronger impact on MetS prevalence than age alone. Differences in body composition and lifestyle patterns between age groups highlight the need for early, targeted interventions aimed at weight management and healthy behaviours, especially in younger women. Preventive strategies should be tailored to age-specific needs to effectively address metabolic risk.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1765-1781"},"PeriodicalIF":2.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasting Ramadan in Yemeni Patients with Type 1 and Type 2 Diabetes: A Comparative Study on the Ability to Fast in 2 Consecutive years.","authors":"Butheinah A Al-Sharafi, Dares Fateh Mohsen, Ahlam S Almurtadha","doi":"10.2147/DMSO.S458654","DOIUrl":"10.2147/DMSO.S458654","url":null,"abstract":"<p><strong>Background: </strong>Fasting is obligatory for all healthy adult Muslims in the month of Ramadan, one of Islam's five pillars. Over 50 million diabetics fast annually, emphasizing the necessity for specialized care.</p><p><strong>Aim: </strong>The study focused on the ability of diabetic patients in Yemen too fast for two consecutive years during Ramadan.</p><p><strong>Methodology: </strong>A total of 573 Patients (343 females and 230 males, including 19 adolescents aged 12-19 years) participated in the study. The patients answered a questionnaire regarding how they fasted in 2022 and after fasting Ramadan in 2023 they were contacted to ask how they had fasted and reasons for breaking their fast. The patients' medications were adjusted according to the Diabetes and Ramadan guidelines (DAR). Statistical analysis was used for ANOVA and chi-square tests to investigate correlations and differences. Frequencies and percentages were used to describe qualitative data. Binary logistic regression analysis was used to calculate odds ratio and 95% confidence intervals.</p><p><strong>Results: </strong>The percentage of patients that fasted all of Ramadan was 84% and among those that broke their fast, hyperglycemia and hypoglycemia were the primary reasons for this. We found that there were significant associations between breaking fasting patterns and age (p = 0.023), type 1 diabetes (p = 0.041), insulin use (p = 0.017), and those that had a history of breaking their fast in a previous year (p<0.001). The levels of HbA1c, duration of diabetes, body mass index (BMI), and level of education were not significantly related to developing hypoglycemia.</p><p><strong>Conclusion: </strong>The study shows different factors affecting fasting Ramadan in diabetic patients in Yemen over 2 years. It emphasizes the need for personalized care plans, focused educational initiatives for teenagers and adults with diabetes, and ongoing initiatives to improve the health of Yemeni people with diabetes for fasting during Ramadan.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1739-1752"},"PeriodicalIF":2.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is It Time to Revisit the Role of Interleukin-1 Inhibitors in Osteoarthritis?","authors":"Martin Brom, Franziska Saxer, Linda Mindeholm, Matthias Schieker, Philip G Conaghan","doi":"10.2147/DMSO.S520465","DOIUrl":"10.2147/DMSO.S520465","url":null,"abstract":"<p><strong>Objective: </strong>There remains a huge unmet need for new osteoarthritis (OA) therapies. A putative reason for the failure of some therapies has been the absence of well-defined phenotypes, which might be more appropriate for specific targeted treatment. Interleukin-1 (IL-1) plays a key role in the development of OA, but the results of clinical trials targeting IL-1 in OA have to date been disappointing.</p><p><strong>Methods: </strong>This narrative review is based on a literature search for publications describing interventions with direct Il-1 pathway inhibitors in patients with knee OA and substantiated by a description of key pre-clinical observations.</p><p><strong>Results: </strong>Randomized controlled studies using IL-1 inhibition as treatment approach to knee OA have read out negatively, although trends for an improvement in pain and impact on biomarkers could be observed. However, in a post-hoc analysis of the large CANTOS trial data (Canakinumab Anti-inflammatory Thrombosis Outcomes Study) testing an anti-IL-1 monoclonal antibody for the secondary prevention of cardiovascular events treatment arms receiving canakinumab demonstrated a substantial reduction in the incidence rate of joint replacement compared to those receiving placebo. Similar results have been reported from a post-hoc analysis of another cardiovascular risk reduction study, the low-dose colchicine 2 (LoDoCo 2) trial, raising the possibility of a beneficial effect of IL-1 inhibition in the subset of patients with metabolic phenotype.</p><p><strong>Conclusion: </strong>Based on the above results, it seems timely to revisit the role of IL-1 in OA, its relationship with chronic low-grade inflammation and its relevance in the subset of metabolic OA.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1753-1764"},"PeriodicalIF":2.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More Physical Exercise is Beneficial to Glycemic Control in Late Pregnancy Among Women with Gestational Diabetes Mellitus: Findings Based on Trajectory Model in a Prospective Cohort in Shanghai.","authors":"Xiuqi Zhang, Yuning Ding, Zhen Duan, Ruiqi Cai, Xiangjin Gao, Rui Zhang, Ruiping Wang","doi":"10.2147/DMSO.S524237","DOIUrl":"10.2147/DMSO.S524237","url":null,"abstract":"<p><strong>Purpose: </strong>Physical exercise effectively prevents the onset of gestational diabetes mellitus (GDM). However, the association between the daily physical exercise time (PET) and the overall trend in glycemic levels in late pregnancy among women with GDM is limited. This study aimed to explore this association using a group-based trajectory model (GBTM) among women with GDM.</p><p><strong>Patients and methods: </strong>We constructed two types of models (A and B) by applying GBTM analysis based on a series of abnormal plasma glucose (PG) prevalence values calculated at each prenatal checkup in the GDM cohort. Women with GDM were classified into good plasma glucose control (PGC) and bad PGC groups based on each trajectory model. Logistic regression was used to explore the association between daily PET and prevalence of good PGC among women with GDM. In this study, P value less than 0.05 was set as the statistical significance.</p><p><strong>Results: </strong>Among 1122 GDM women, the average age was 26.9 years. The number of women with GDM in the good PGC group was 539 (48.0%) in Model A 644 (57.4%) in Model B. The median daily PET was longer in the good PGC group (70 min in both Models A and B) than in the poor PGC group (Model A, 65 min; Model B, 64 min). Logistic regression analysis indicated that GDM women with ≥120 min/day PET had a significantly higher PGC prevalence in late pregnancy (odds ratio (OR), 1.32 (95% confidence interval (CI): 1.12-1.56) in Model A, and 1.24 (95% CI: 1.05-1.46) in Model B, even after adjusting for potential confounders (age and BMI).</p><p><strong>Conclusion: </strong>Women with GDM need ≥120 min/day PET to achieve glycemic control, especially for those who are older and have BMI ≥24kg/m².</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1723-1737"},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Association Between Uric Acid to HDL-C Ratio and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Cross-Sectional Study [Corrigendum].","authors":"","doi":"10.2147/DMSO.S542141","DOIUrl":"https://doi.org/10.2147/DMSO.S542141","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/DMSO.S520688.].</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1721-1722"},"PeriodicalIF":2.8,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Insulin Resistance in Mongolian Adults.","authors":"Galsanjigmed Narkhajid, Byambasukh Oyuntugs, Altangerel Yagaantsetseg, Enkhtuvshin Bolormaa, Erdembileg Anuurad, Byambaa Enkhmaa, Lars Berglund, Tumenbayar Bayasgalan","doi":"10.2147/DMSO.S518509","DOIUrl":"10.2147/DMSO.S518509","url":null,"abstract":"<p><strong>Introduction: </strong>While the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) is widely used to identify insulin resistance, its clinical utility can be cumbersome. An alternative, the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL) ratio, offers simplicity but may exhibit variability across different populations. This study aimed to investigate its association with HOMA-IR adjusting for waist circumference among Mongolian adults.</p><p><strong>Materials and methods: </strong>This cross-sectional study, conducted at the Mongolian National University of Medical Sciences Hospital, included 365 participants over 35 who participated in health check-up examinations (mean age 46.8 ± 8.8 years, 37.0% male). Waist circumference was categorized into tertiles. Associations between the TG/HDL ratio and HOMA-IR were meticulously assessed within the waist circumference tertiles (0-33.3%, 33.4-66.6%, and 66.7-100%), ensuring a comprehensive understanding of the data.</p><p><strong>Results: </strong>A significant positive correlation (r = 0.391, p = 0.019) was observed between the TG/HDL ratio and HOMA-IR levels in all participants. Analyses by waist circumference tertiles revealed a progressively stronger correlation (ranging from r = 0.241 to 0.469) with increasing waist circumference (p <0.05). The diagnostic accuracy of the TG/HDL ratio in identifying insulin resistance was assessed using HOMA-IR thresholds of 2.0 and 2.5, yielding AUC values of 0.693 and 0.746, respectively. When considering waist circumference thresholds (> 90 cm for men and >80 cm for women), TG/HDL ratio thresholds of 1.2 (sensitivity 56%, specificity 90%) in men and 0.69 (sensitivity 46%, specificity 80%) in women were identified.</p><p><strong>Conclusion: </strong>The study indicates that the TG/HDL ratio, adjusted for waist circumference, could be a useful marker for insulin resistance in Mongolian adults, supporting its potential in clinical practice.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1711-1719"},"PeriodicalIF":2.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Glucose Metabolic State Transition on Progression from Stage A to Stage C Heart Failure.","authors":"Mingjie Yin, Xiaoyu Xu, Jie Li, Yanan Sun, Yanfeng Zhen, Shouling Wu, Hui Fang","doi":"10.2147/DMSO.S525408","DOIUrl":"10.2147/DMSO.S525408","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) constitutes a significant global health challenge. The interplay between the dynamics of glucose metabolic status transitions and the progression of HF has been minimally explored.</p><p><strong>Objective: </strong>We assessed the impact of shifts in glucose metabolic states on the progression from stage A to stage C HF.</p><p><strong>Methods: </strong>The Kailuan Study is a large-scale prospective cohort study. Based on data from the Kailuan Study, 41,110 stage A HF patients were included and stratified into 6 groups based on alterations in glucose metabolic status: stable normoglycemic, stable pre-diabetes, diabetes, normoglycemic progressing to pre-diabetes, pre-diabetes back to normoglycemic, and normoglycemic/pre-diabetes progressing to diabetes. Utilizing the Cox proportional hazards regression model, we calculated the hazard ratios (HR) and 95% confidence intervals (CI) associated with the transition to stage C HF among patients with stage A HF with different glucose metabolic state transitions.</p><p><strong>Results: </strong>Our findings indicated a notably elevated risk for the progression to stage C HF within the diabetic group relative to the stable normoglycemic group (HR, 1.87; 95% CI, 1.66 to 2.10). Additionally, an augmented risk for the progression to stage C HF was observed in the normoglycemic/pre-diabetic to diabetic group (HR, 1.38; 95% CI, 1.15 to 1.65).</p><p><strong>Conclusion: </strong>Both diabetes and normoglycemic/pre-diabetes progressing to diabetes are associated with heightened risks of progressing from stage A to stage C HF. Conversely, the re-establishment of normoglycemic in pre-diabetes is associated with preventing HF progression.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1683-1693"},"PeriodicalIF":2.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Clinical Services for Adults with Obesity in Different Health Systems: A Scoping Review and Causal Loop Diagram.","authors":"Yan Xue, Menghuan Song, Honho Yu, Xianwen Chen, Carolina Oi Lam Ung, Hao Hu","doi":"10.2147/DMSO.S501149","DOIUrl":"10.2147/DMSO.S501149","url":null,"abstract":"<p><p>The medical needs of obesity have been underrecognized, though it has posed long-term and enormous challenges to global health. Correspondingly, clinical services for obesity are still uncommon and in their infancy across health systems. It is meaningful to sort out the implementation of such clinical services involving a multiplicity of factors to identify measures for service development, scaling-up and optimization. This study aims to generate a comprehensive understanding of key variables and factors in the utilization and delivery of clinical services for adult patients with obesity and their dynamic patterns and to explore viable options for improved implementation of such services in health systems. We conducted a scoping review of published articles in the database from the lens of system dynamics through causal loop diagramming. Based on the data obtained from the review, we employed the causal loop diagramming as a tool to capture the variables in the implementation of clinical obesity services and their causal relationships. Twenty-one studies were finally included in the review. Based on the evidence consolidated through the review, we developed a causal loop diagram containing 19 causal variables and 38 causal arrows in single directions centered around the service utilization and delivery in the clinical obesity service. The feedback loops revealed potential activation points to intervene to facilitate the service implementation, such as, promotion of obesity as a disease with medical needs and available clinical services, provision of obesity-specific medical education and training opportunities, and prioritization of obesity-specific procedures in clinical protocols. The possible intervention points identified through the causal loop analysis can facilitate the development, implementation, and optimization of clinical obesity services in health systems.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1695-1709"},"PeriodicalIF":2.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Thyroid Hormone Sensitivity in Diabetic Kidney Disease: A Paradigm Shift in Pathophysiological Understanding [Letter].","authors":"Yanni Gao, Zhenliang Fan","doi":"10.2147/DMSO.S540323","DOIUrl":"10.2147/DMSO.S540323","url":null,"abstract":"","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1671-1672"},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}