Prediction of Hypertension Risk in Patients with Fatty Liver Disease Using the Triglyceride-Glucose-Body Mass Index.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-09-06 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S535535

Ge Gao, Haitao Li, Zhikai Xu, Xiaochun Ge, Shuying Li, Yu Gao

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引用次数: 0

Abstract

Purpose: Fatty liver disease (FLD) and hypertension (HTN) exhibit a bidirectional relationship: FLD elevates HTN risk, while HTN accelerates FLD progression to fibrosis. Research on this link is limited, with insulin resistance (IR) proposed as a key mechanism. The triglyceride-glucose-body mass index (TyG-BMI), an emerging IR marker, is poorly characterized regarding its association with FLD and HTN. This study assessed TyG-BMI's predictive value for HTN risk in FLD patients and its clinical significance.

Patients and methods: A retrospective cohort of 6,257 FLD patients confirmed by ultrasonography from the Health Examination Center of Chengde Medical University was analyzed. Participants were categorized into FLD-HTN (n=2,804) and normotensive FLD (FLD-0, n=3,453) groups based on blood pressure measurements. Multivariable logistic regression models adjusted for confounders assessed TyG-BMI's independent association with HTN risk. Receiver operating characteristic (ROC) curve analysis, with DeLong's test, compared the discriminative ability of TyG-BMI against conventional indices (BMI and TyG index). Additionally, quartile-based stratification (Q1-Q4) further explored dose-response relationships.

Results: Multivariable-adjusted models showed a 1.6% increase in HTN risk for each unit increase in TyG-BMI (OR=1.016, 95% CI: 1.014-1.018, P < 0.001). A significant positive correlation was found between TyG-BMI and both systolic (r=0.264) and diastolic blood pressure (r=0.263, both P < 0.001). ROC curve analysis demonstrated that TyG-BMI (AUC=0.624) outperformed BMI (AUC=0.593) and the TyG index (AUC=0.603) (DeLong's test, P <0.01) in discriminating HTN risk. Notably, individuals in the highest TyG-BMI quartile (Q4) had a 3.38-fold higher risk of HTN compared to those in the lowest quartile (Q1) (OR=3.380, 95% CI: 2.842-4.020).

Conclusion: TyG-BMI is a significant predictor of HTN risk in FLD patients, offering a clinically useful tool for targeted prevention strategies.

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应用甘油三酯-葡萄糖-体重指数预测脂肪肝患者高血压风险

目的：脂肪肝（FLD）和高血压（HTN）表现出双向关系：FLD升高HTN的风险，而HTN加速FLD向纤维化的进展。这一联系的研究有限，胰岛素抵抗（IR）被认为是一个关键机制。甘油三酯-葡萄糖-体重指数（TyG-BMI）是一种新兴的IR标志物，但其与FLD和HTN的关系尚不明确。本研究评估TyG-BMI对FLD患者HTN风险的预测价值及其临床意义。患者与方法：回顾性分析承德医科大学健康检查中心6257例经超声确诊的FLD患者。参与者根据血压测量分为FLD- htn （n= 2804）和正常FLD （FLD-0, n= 3453）组。校正混杂因素的多变量logistic回归模型评估了TyG-BMI与HTN风险的独立关联。受试者工作特征（ROC）曲线分析，采用DeLong检验，比较TyG-BMI与常规指标（BMI和TyG指数）的判别能力。此外，基于四分位数的分层（Q1-Q4）进一步探讨了剂量-反应关系。结果：多变量调整模型显示，TyG-BMI每增加一个单位，HTN风险增加1.6% （OR=1.016, 95% CI: 1.014-1.018, P < 0.001）。TyG-BMI与收缩压（r=0.264）和舒张压（r=0.263， P均< 0.001）呈正相关。ROC曲线分析显示，TyG-BMI （AUC=0.624）优于BMI （AUC=0.593）和TyG指数（AUC=0.603）（DeLong’s test， P）。结论：TyG-BMI是FLD患者HTN风险的重要预测因子，为制定针对性的预防策略提供了临床有用的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.