Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"Antipsychotics and Change of Weight, Menstrual Cycle, and Metabolic Syndrome Components Among Schizophrenic Women: A 12-Week Longitudinal Prospective Study in Tien Giang, Vietnam.","authors":"Nhu Minh Hang Tran, Van Thanh Dung Nguyen, Quang Ngoc Linh Nguyen, Vu Quoc Huy Nguyen","doi":"10.2147/DMSO.S546206","DOIUrl":"10.2147/DMSO.S546206","url":null,"abstract":"<p><strong>Background: </strong>Antipsychotics are associated with side effects like weight gain, obesity, and menstrual disorders in Women, which can reduce treatment compliance and increase cardiovascular, metabolic risks, dementia, and other chronic diseases, as well as increase mortality, and reduce the quality of life in patients. Data on these effects in Vietnam are limited. This study evaluated changes in body weight, BMI, menstrual cycle, and metabolic syndrome components among female schizophrenic inpatients treated with antipsychotics.</p><p><strong>Methods: </strong>A total of 60 female patients were treated with antipsychotics for at least 3 months before admission. The indicators to be examined, such as weight, BMI, waist circumference, menstrual cycle, blood pressure, and some laboratory tests, including fasting blood sugar, triglycerides, HDL cholesterol, were measured at two points: at baseline and after a 12-week follow-up period.</p><p><strong>Results: </strong>Following 12 weeks of observation, the study participants exhibited significant increases in body weight and BMI as well as prevalence of amenorrhea compared to baseline (p<0.05). Additionally, the proportion of patients with a waist circumference ≥ 80 cm rose significantly from baseline. Conversely, the number of patients with HDL-C levels <50 mg/dL decreased significantly compared to baseline.</p><p><strong>Conclusion: </strong>This study showed an association between increased weight, BMI, and amenorrhea with the use of antipsychotic medications. After 12 weeks of follow-up, the rate of components of metabolic and cardiovascular diseases also increased significantly compared to the baseline. This result is consistent with previous studies. Therefore, in psychiatric clinical practice, physicians should pay attention to these undesirable effects to have appropriate management strategies for patients.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3125-3134"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Triglyceride-Glucose Index Mediates the Association Between Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Disease: Findings From Two Cross-Sectional Datasets.","authors":"Juntao Wu, Haohong Lai, Jiyuan Yin, Shan Zhu, Haidi Yang, Haiyu Hong","doi":"10.2147/DMSO.S526411","DOIUrl":"10.2147/DMSO.S526411","url":null,"abstract":"<p><strong>Purpose: </strong>Obstructive sleep apnea (OSA) contributes to non-alcoholic fatty liver disease (NAFLD) via pathways involving insulin resistance (IR). The triglyceride-glucose (TyG) index, a widely used marker of IR, is associated with both OSA and NAFLD. However, the role of the TyG index in linking OSA to NAFLD remains underexplored.</p><p><strong>Patients and methods: </strong>This study analyzed data from two cross-sectional studies: 920 participants from the Fifth Affiliated Hospital of Sun Yat-sen University and 1,603 participants from NHANES 2005-2008. Mediation analysis assessed the TyG index's role in the OSA-NAFLD relationship. Weighted multivariable logistic regression and restricted cubic spline (RCS) regression explored the association between the TyG index and NAFLD in patients with OSA.</p><p><strong>Results: </strong>Mediation analysis showed the TyG index mediated the OSA-NAFLD association, accounting for 35.33% and 20.06% in Chinese and American participants, respectively (P < 0.001). Logistic regression revealed that higher TyG index values were significantly associated with increased NAFLD risk in patients with OSA, with ORs of 2.32 (95% CI: 1.78-3.07) for Chinese and 6.80 (95% CI: 4.42-10.45) for American participants (P < 0.001). RCS regression showed a linear increase in NAFLD risk with higher TyG index values in patients with OSA.</p><p><strong>Conclusion: </strong>The TyG index significantly mediates the OSA-NAFLD relationship. Elevated TyG index values are significantly associated with NAFLD risk in patients with OSA. The TyG index is a biologically meaningful and effective biomarker of IR in the association between OSA and NAFLD, with potential for early identification of NAFLD in patients with OSA.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3111-3123"},"PeriodicalIF":3.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Additional Chinese Herbal Medicines Treatment in Patients with Type 2 Diabetes Mellitus Combined with Stable Angina Pectoris: A Retrospective Cohort Study.","authors":"Xunjia Xu, Shi Yin, Huijuan Liu, Ruixia Zhao, Weifeng Cui, Mingyi Shao, Haibin Yu, Shuxun Yan, Yu Fu","doi":"10.2147/DMSO.S541164","DOIUrl":"10.2147/DMSO.S541164","url":null,"abstract":"<p><strong>Background: </strong>Chinese herbal medicines (CHMs) are used for type 2 diabetes mellitus combined with stable angina pectoris (T2DM-SAP), but their long-term effects lack real-world evidence.</p><p><strong>Objective: </strong>To evaluate the effects of additional CHMs on angina readmission rates compared to standard treatment alone in patients with T2DM-SAP.</p><p><strong>Methods: </strong>This retrospective cohort study included 704 patients with T2DM-SAP. Participants were stratified into two groups based on cumulative CHMs use (≥ 3 months). The CHMs group included 115 patients, while the non-CHMs group included 589 patients. A 1:1 propensity score matching (PSM) was used to balance differences between groups. The primary outcome was angina readmission. The secondary outcomes were SAP readmission and unstable angina pectoris (UA) readmission. Kaplan-Meier survival curves were plotted before and after matching. Sensitivity analysis was performed using Cox proportional hazards model. Baseline prescriptions were collected and herbal frequency and efficacy were counted.</p><p><strong>Results: </strong>After matching, there were 106 patients in each of the two groups. Before matching, compared with the non-CHMs group, the adjusted hazard ratio (aHR) of angina readmission in the CHMs group was 0.49 [95% confidence interval (CI): 0.34, 0.71, <i>P</i><0.001]. After matching, the aHR was 0.37 [95% CI: 0.22, 0.60, <i>P</i><0.001]. The reliability of the results was confirmed by sensitivity analyses adjusted for different covariates. The CHMs group demonstrated a significantly longer median time to angina readmission compared to the non-CHMs group (55.66 vs 13.90 months, <i>P</i><0.001). Similar results were also shown after matching. 115 prescriptions involving 220 herbs were collected.</p><p><strong>Conclusion: </strong>Additional CHMs treatment can significantly reduce the incidence of angina readmission and prolongs the interval to recurrent events in T2DM-SAP patients.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3135-3148"},"PeriodicalIF":3.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Counseling Practice, Perceived Barriers, and Clinical Decision-Making of Community Pharmacists in Saudi Arabia Regarding Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors.","authors":"Ibrahim S Alhomoud, Sura A Aldakhil, Reema F Alhosan, Hanan S Alrashidi, Nada S Alsaqabi, Arjwan M Aldugishem, Abdulrahman A Alsuhibani, Alian A Alrasheedy","doi":"10.2147/DMSO.S552287","DOIUrl":"10.2147/DMSO.S552287","url":null,"abstract":"<p><strong>Purpose: </strong>Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors represent major advancements in the management of type 2 diabetes. However, many patients remain suboptimally managed with these therapies. This underutilization highlights the need for practical implementation strategies in real-world settings. Community pharmacists can play a crucial role in integrating these therapies into diabetes care. This study aimed to evaluate community pharmacists' knowledge, counseling practices, perceived barriers, and clinical decision-making regarding these therapies.</p><p><strong>Methods: </strong>A cross-sectional, questionnaire-based survey was conducted among licensed community pharmacists in the Qassim region, Saudi Arabia.</p><p><strong>Results: </strong>A total of 211 community pharmacists participated in this study. Of these, 83.4% were male and 16.6% were female. The participants' perceived levels of knowledge of the pharmacology and basic concepts of GLP-1 receptor agonists and SGLT-2 inhibitors were high, with mean scores (± SD) of 13.41 ± 2.43 and 13.36 ± 2.59, respectively, out of a maximum of 16. However, knowledge related to clinical therapeutics and evidence-based decision-making was low, with only 24.2%, 23.7%, and 32.2% of the participants correctly answering the three patient-based case scenarios. Many participants counseled and discussed these therapies in patients with type 2 diabetes. However, the participants reported several barriers, including high medication costs (67.3%), concerns about side effects (33.2%), challenges with patient adherence (28.4%), and limited time to engage in discussions with patients (22.7%). Notably, 88.2% of the participants indicated that continuing professional development in diabetes therapy is required.</p><p><strong>Conclusion: </strong>Many participants had substantial gaps in their applied knowledge of clinical therapeutics and persistent barriers to clinical engagement remained. Targeted educational strategies and system-level support are crucial for enhancing the role of community pharmacists in managing type 2 diabetes.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3093-3107"},"PeriodicalIF":3.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: The Efficacy of Diabetic Foot Treatment in a \"TOSF\" Pattern: A Five-Year Retrospective Study [Corrigendum].","authors":"","doi":"10.2147/DMSO.S563501","DOIUrl":"10.2147/DMSO.S563501","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/DMSO.S461112.].</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3109-3110"},"PeriodicalIF":3.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous Glucose Monitoring During Recreational Diving in Type 1 Diabetes: Navigating Clinical and Technical Uncertainties.","authors":"Djordje S Popovic, Theocharis Koufakis, Dimitrios Patoulias, Anca Pantea Stoian, Nikolaos Papanas","doi":"10.2147/DMSO.S538152","DOIUrl":"10.2147/DMSO.S538152","url":null,"abstract":"<p><p>Recreational diving with self-contained underwater breathing devices is gaining popularity worldwide as a sport and leisure activity. People living with type 1 diabetes mellitus (PLT1D) are no exception, although historically diabetes mellitus, especially insulin-treated, has been described as an absolute contra-indication for diving. However, based on observational data collected by the Divers Alert Network, the presence of background diabetes mellitus became only a relative contraindication for those without significant co-morbidities or long-term complications. Regarding diving activities among PLT1D, the primary concern is the risk of hypoglycaemia, especially in those with impaired awareness. Furthermore, symptoms consistent with hypoglycaemia could be confused with those originating from other factors related to diving. Although avoidance of hypoglycaemia is imperative among PLT1D practicing diving, the risk of severe hyperglycaemia should also be minimised. Continuous glucose monitoring (CGM) nowadays represents the standard of care for PLT1D, but its accuracy during diving activities is still a matter of debate. This commentary aims to summarize the existing data on accuracy, durability, and underwater performance of different CGM devices among PLT1D who engage in diving, and to call for additional research in the field. Based on available results, the application of real-time CGM still requires extreme caution since none of the existing systems has so far met the standards for accurate use in underwater conditions. Further improvements of contemporary CGM devices, validated through large-scale trials, are necessary before their widespread implementation among PLT1D practicing diving. Such advances should further enhance safety during this popular activity.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3089-3092"},"PeriodicalIF":3.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Exercise Interventions on Health Status in Overweight and Obese Children and Adolescents: A Network Meta-Analysis.","authors":"Xiaoye Cai, Yujun Cai, Yingjuan Da, Feng Wang, Yu Wu, Kexin Dong","doi":"10.2147/DMSO.S528948","DOIUrl":"10.2147/DMSO.S528948","url":null,"abstract":"<p><strong>Background: </strong>While numerous studies have explored the effectiveness of exercise interventions in improving health outcomes in populations with obesity, comparisons of different exercise modalities remain limited. This study aimed to address this gap through a network meta-analysis (NMA) to evaluate the impact of various exercise modalities on health status in children and adolescents with overweight and obesity.</p><p><strong>Methods: </strong>Two researchers (XC and KD) systematically searched databases including PubMed, Cochrane Library, Embase and others for randomized controlled trials (RCTs) published up to May 2024. The studies analyzed the effects of exercise interventions on body composition, lipid profiles, glucose metabolism, and cardiorespiratory fitness (CRF) in children and adolescents with overweight and obesity. Study quality was assessed using the Cochrane tools, and the random-effects NMA was conducted within a Bayesian framework.</p><p><strong>Results: </strong>A total of 51 studies with 2263 participants were included, covering four exercise modalities: aerobic exercise (AE), resistance exercise (RE), combined exercise (CE), and high-intensity interval training (HIIT). HIIT was relatively more effective for improving CRF, including oxygen uptake peak (VO_2peak) [MD = 3.33, 95% CI (2.36, 4.26)] and heart rate (HR) [MD = -8.09, 95% CI (-10.92, -5.37)]. AE demonstrated substantial reductions in weight, body mass index (BMI), and waist circumference (WC). CE may be most effective in reducing body fat percentage (BF%), waist-to-hip ratio (WHR), and improving fat-free mass (FFM), as well as controlling fasting glucose (FG) and insulin resistance. RE showed a significant impact on improving lipid profiles.</p><p><strong>Conclusion: </strong>HIIT is the relatively effective modality for enhancing CRF, while AE and CE are notably effective for improving body composition. RE is regarded as a preferable choice for lipid regulation, and CE tends to provide superior outcomes for glucose and insulin control. These findings provide comparative evidence for clinical and policy recommendations, though further high-quality research is needed for validation.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3053-3074"},"PeriodicalIF":3.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of GLP-1RA Treatment on Long-Term Post-PCI Prognosis in T2DM Patients: A Propensity Score Matching Study.","authors":"Binbin Fang, Fen Liu, Junyi Luo, Ning Song, Chang Liu, Wei Ji, Xin An, Qian Xie, Yining Yang, Xiaomei Li","doi":"10.2147/DMSO.S535325","DOIUrl":"10.2147/DMSO.S535325","url":null,"abstract":"<p><strong>Purpose: </strong>Data on the effect of GLP-1RA treatment on the long-term prognosis of patients with diabetes after percutaneous coronary intervention (PCI) are scant. The purpose of this study was to evaluate the effect of GLP-1RA treatment on the long-term prognosis in T2DM patients after PCI.</p><p><strong>Patients and methods: </strong>Data on T2DM patients who underwent PCI from January 2019 to December 2020 were retrospectively analyzed. Clinical data and the use of hypoglycaemic drugs were collected. Patients were divided into 2 groups based on whether they were treated with GLP-1RAs: the control group and the GLP-1RA group. PSM was used to match the control group at a 1:1 ratio. Survival curve and univariate and multivariate Cox regression analyses were used to compare the effects of GLP-1RA treatment on prognosis.</p><p><strong>Results: </strong>A total of 981 patients were enrolled, and 277 pairs (554 patients) were matched with propensity scores. The balance between two groups improved after PSM (<i>P</i>>0.05). Compared with the control group, patients in the GLP-1RA group had lower TC, LDL-C, and HbA1c levels (<i>P</i><0.05). After 24 months of follow-up, a total of 93 patients experienced adverse cardiovascular events. The survival curve revealed that the event-free survival rate in the GLP-1RA group was greater than that in the control group (log rank <i>P</i>=0.012). Univariate and multivariate Cox regression analyses revealed that BMI (HR: 1.055, 95% CI=1.007-1.105), HDL-C levels (HR: 0.236, 95% CI=0.095-0.583) and GLP-1RA use (HR: 0.617, 95% CI=0.403-0.943) were independent influencing factors of post-PCI major adverse cardiovascular event (MACE) risk in T2DM patients (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>GLP-1RA treatment demonstrates cardiovascular benefits in T2DM patients following PCI, effectively reducing the risk of MACE, and enhancing long-term prognosis.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3031-3040"},"PeriodicalIF":3.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Chronic Inflammatory Indicators and Diabetic Peripheral Neuropathy in Hospitalized Elderly Patients with Type 2 Diabetes.","authors":"Wang Chang, Xinyue Li, Yingjuan Ma, Ting Bai, Limin Jia","doi":"10.2147/DMSO.S534724","DOIUrl":"10.2147/DMSO.S534724","url":null,"abstract":"<p><strong>Purpose: </strong>Investigate the correlation between chronic inflammatory indicators and DPN in hospitalized elderly patients with Type 2 diabetes mellitus (T2DM), and to build a prediction model to provide scientific basis for early identification of high-risk groups.</p><p><strong>Patients and methods: </strong>Clinical data of 270 elderly T2DM patients hospitalized in the People's Hospital of Ningxia Hui Autonomous Region from January 2021 to December 2024 were selected and classified into a diabetic peripheral neuropathy group (DPN, n=163) and a non-diabetic peripheral neuropathy group (NDPN, n=107) depending on the presence of DPN. Clinical features, biochemical indicators and peripheral blood inflammatory indicators (PLR, NLR, MLR, SII, SIRI) of patients were collected, and a predictive model was constructed by logistic regression analysis.</p><p><strong>Results: </strong>The age, duration of diabetes, retinopathy, HbA1c, fasting blood glucose (FBG) and 2hPPG in DPN group were all higher than those in nonDPN group (P<0.05). In addition, the levels of PLR, NLR, MLR, SII and SIRI in DPN group were significantly higher than those in NDPN group (P<0.05). Multivariate Logistic regression analysis showed that the duration of diabetes, accompanying retinopathy, HbA1c and NLR were independent risk factors for DPN. The area under ROC curve (AUC) of the combined predictor constructed based on these factors was 0.802, which showed good prediction efficiency.</p><p><strong>Conclusion: </strong>Chronic inflammatory indicators such as PLR, NLR, MLR, SII and SIRI are closely related to elderly T2DM patients with DPN. Comprehensive evaluation of these indicators and key factors such as diabetes course can effectively predict the risk of elderly T2DM patients with DPN, which is conducive to early intervention and management, thereby improving patient prognosis. Reduce hospitalization rates and medical costs. This study provides a new perspective for understanding the role of chronic inflammation in DPN and lays the foundation for further research.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3075-3088"},"PeriodicalIF":3.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic Combined Index is Independently Associated with MASLD in Type 2 Diabetes: A Cross-Sectional Study.","authors":"Jie Sheng, Shuwei Shi, Xuan Ma, Hongyan Zhao, Guanqi Gao, Baolan Ji","doi":"10.2147/DMSO.S523139","DOIUrl":"10.2147/DMSO.S523139","url":null,"abstract":"<p><strong>Aim: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is commonly associated with metabolic disorders such as obesity, diabetes and dyslipidemia. Previous studies have explored the relationship between traditional lipid parameters and MASLD. The atherogenic combined index (ACI), a novel non-traditional lipid marker, has recently been proposed as a potential indicator of coronary artery disease. The relationship between the ACI and MASLD remains unclear. This study aims to investigate this relationship in patients with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>This cross-sectional study analyzed 2703 patients with T2D. Ultrasound was used to assess MASLD. The clinical and biochemical data were gathered. The ACI was calculated as the base-10 logarithm of the product of triglyceride and non-high-density lipoprotein cholesterol divided by high-density lipoprotein cholesterol. Statistical analyses explored the association between the ACI and MASLD.</p><p><strong>Results: </strong>Compared to the non-MASLD group, the ACI was higher in the MASLD group (P < 0.001). Spearman correlation analysis revealed a positive association between ACI and MASLD (P < 0.001). Logistic regression analysis showed that the ACI was independently associated with MASLD. Compared with participants in the lowest ACI quartile (Q1), Q4 (OR: 3.636, 95% CI: 2.361-5.601) showed significantly increased risks of MASLD (P < 0.001). Subgroup analyses confirmed that the significant association between ACI and MASLD was consistent across sex (females and males), body mass index (BMI < 24 kg/m² and BMI ≥ 24 kg/m²) and age groups (age < 60 years and age ≥ 60 years).</p><p><strong>Conclusion: </strong>The ACI is independently correlated with MASLD in T2D patients, supporting its potential as a useful marker for MASLD screening and management in this population.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"3041-3052"},"PeriodicalIF":3.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}