Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy最新文献

{"title":"Sex-Based Differences in the Associations Between Obesity- and Lipid-Related Indexes and Hyperuricemia Risk in Patients with Obesity.","authors":"Kelibinuer Mutailipu, Lei Du, Junwei Guo, Shuwei Liu, Yue Chen, Liesheng Lu, Shen Qu, Haibing Chen, Le Bu","doi":"10.2147/DMSO.S483638","DOIUrl":"10.2147/DMSO.S483638","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association of the triglyceride-glucose index (TyG) and its related parameters with the risk of hyperuricemia in patients with obesity of different sexes.</p><p><strong>Patients and methods: </strong>In this cross-sectional study, a total of 951 patients with obesity were included. They were divided into two groups based on their serum uric acid levels, and separate analyses were conducted for males and females. Binary logistic regression analysis using the backward likelihood ratio (LR) approach was performed to investigate the association between hyperuricemia and indicators related to obesity and lipids.</p><p><strong>Results: </strong>Multivariate logistic regression analysis indicated that, across the overall population, higher quartiles of the TyG and TyG-BMI indexes were significantly associated with an increased risk of hyperuricemia (HUA) after adjusting for confounding factors. Specifically, in the fourth quartile of the TyG index, the odds ratio (OR) for HUA was 3.16 (95% confidence interval [CI]: 1.39-7.18), and for the TyG-BMI index, the OR was 4.06 (95% CI: 1.73-9.52) in the fully adjusted model. In sex-specific analyses, for males, those in the third quartile of the TyG-WC index had a higher likelihood of HUA (OR, 8.13; 95% CI, 2.28-29.01) compared to the lowest quartile. Among females, an elevated TyG index was significantly associated with increased HUA risk, with an OR of 5.13 (95% CI: 1.66-15.92) in the fourth quartile.</p><p><strong>Conclusion: </strong>Sex-based differences exist regarding the risk factors for hyperuricemia in patients with obesity. An elevated TyG-WC index is linked to an increased risk in males, while an elevated TyG index is associated with an increased risk in females.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4721-4733"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum Uric Acid to Creatinine Ratio and Metabolic-Associated Fatty Liver Disease in Southeast China (TyG-BMI as a Potential Mediator).","authors":"Bingbing Chen, Xian-E Peng","doi":"10.2147/DMSO.S489692","DOIUrl":"10.2147/DMSO.S489692","url":null,"abstract":"<p><strong>Purpose: </strong>Serum uric acid to creatinine ratio (SUA/Cr) has been associated with an increased risk of metabolic syndrome; however, limited evidence exists regarding the relationship between SUA/Cr and metabolic-associated fatty liver disease (MAFLD). This study aims to investigate the association between SUA/Cr, TyG-BMI (triglyceride glucose-body mass index), and MAFLD in Chinese adults.</p><p><strong>Patients and methods: </strong>The data were obtained from a health examination conducted at Nanping First Hospital. Spearman correlation analysis was employed to assess the association between SUA/Cr or TyG-BMI and various risk factors pertinent to MAFLD. A multivariate logistic regression model was utilized to investigate the relationship between SUA/Cr or TyG-BMI and MAFLD. Additionally, restricted cubic splines (RCS) and receiver operating characteristic (ROC) curve analyses were applied to explore the relationship between SUA/Cr and MAFLD. Mediation models were constructed to figure out the mediating role of TyG-BMI in the association between SUA/Cr and MAFLD.</p><p><strong>Results: </strong>Spearman correlation analysis showed a significant association between SUA/Cr and multiple risk factors for MAFLD (such as BMI, SBP, DBP, TG, TC, ALT, AST, GGT, FPG, and HDL). Furthermore, SUA/Cr had a positive correlation with TyG-BMI (<i>P</i><0.05). The logistic model demonstrated that elevated levels of SUA/Cr were significantly associated with an increased risk of MAFLD, even after adjusting for confounding factors (odds ratio [OR]: 1.390; 95% confidence interval [CI]: 1.255-1.538). The RCS curves revealed a consistent and monotonic increase in the relationship between SUA/Cr levels and the occurrence of MAFLD. Moreover, SUA/Cr exhibited moderate discriminatory ability in identifying individuals with MAFLD (AUC: 0.669). Mediation analysis indicated that approximately 52.05% of the positive association between SUA/Cr and MAFLD was mediated by TyG-BMI.</p><p><strong>Conclusion: </strong>Our findings suggest a substantial association between elevated levels of SUA/Cr and an increased risk of MAFLD in the Chinese adult population, with TyG-BMI mediating this correlation.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4711-4720"},"PeriodicalIF":2.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory Fitness and Body Mass Index as Predictors of Metabolic Syndrome in Schoolchildren (PACH Study).","authors":"Jelena Raudeniece, Ilze Justamente, Liga Ozolina-Moll, Artjoms Sobolevs, Maksims Zolovs, Flemming Dela, Dace Reihmane","doi":"10.2147/DMSO.S487309","DOIUrl":"10.2147/DMSO.S487309","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic syndrome (MetS) has become a condition not rarely diagnosed in children and adolescents, leading to changes in physical and mental health. Simple and cost-effective screening methods applied in schools are needed to take preventive measures and reduce the risk of the development of MetS in children.</p><p><strong>Methods: </strong>This prospective longitudinal study aims to investigate the prevalence of MetS and its risk factors in 8-10-year-old schoolchildren (46 boys and 60 girls) over 3 consecutive years. General Linear Mixed Model (GLMM) was used to assess the effect of recommended daily levels of moderate to vigorous physical activity (MVPA), body mass index (BMI), waist circumference (WC), cardiorespiratory fitness (CRF), and obesity level on a new set of orthogonal variables formed from various parameters of MetS (eg blood pressure (BP), lipid panel and glucose homeostasis) determined by Principal Component Analysis (PCA).</p><p><strong>Results: </strong>The prevalence of MetS was 2% in the years 2017, 2018 and 2019, while in 2020 prevalence reached 7.7%. The most prevalent combination of criteria defining MetS syndrome in children was increased WC, BP, and blood triglycerides (TG). PCA identified non-high-density lipoprotein (non-HDL), low-density lipoprotein (LDL), and total cholesterol (TCHOL) as important predictors of metabolic syndrome (MetS). Additionally, cardiorespiratory fitness (CRF) and body mass index (BMI) were found to significantly influence the variance in MetS criteria. However, moderate to vigorous physical activity (MVPA) did not have a notable effect on the variance of these criteria.</p><p><strong>Conclusion: </strong>The prevalence of MetS in children is increasing with age. Non-HDL turned out to be the most influential parameter across all principal components. The CRF, being accessible, simple to use, non-invasive and cost-effective, proved to be a superior predictor of variance of glucose homeostasis compared to BMI.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4675-4687"},"PeriodicalIF":2.8,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Be Alert to Diabetes Nephropathy with Cognitive Dysfunction [Response to Letter].","authors":"Wenyi Li, Zhenguo Liu, Min Song, Zhenpeng Shi, Jihang Zhang, Junyu Zhou, Yidan Liu, Yun Qiao, Deshan Liu","doi":"10.2147/DMSO.S508433","DOIUrl":"10.2147/DMSO.S508433","url":null,"abstract":"","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4661-4662"},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and Diagnostic Value of TyG-BMI for Hyperuricemia in Patients with Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study.","authors":"Haitao Li, Ge Gao, Zhikai Xu, Lihua Zhao, Yuling Xing, Jianqiu He, Yu Gao","doi":"10.2147/DMSO.S484045","DOIUrl":"10.2147/DMSO.S484045","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between TyG-BMI and hyperuricemia in NAFLD patients and assess its potential diagnostic value compared to the TyG index.</p><p><strong>Patients and methods: </strong>This study selected the patients diagnosed with fatty liver disease at the Affiliated Hospital of Chengde Medical University between September and December 2023. These patients were divided into NAFLD without HUA (NAFLD-NUA, n=1166) and NAFLD with HUA (NAFLD-HUA, n=844) groups. Baseline characteristics between the groups were compared. Patients were divided into quartiles (Q1-Q4) according to their TyG-BMI level; the lowest quartile (Q1) was used as the reference group. Multivariate logistic regression analysis was used to investigate the association between TyG-BMI and HUA. Receiver operating characteristics curve analysis and area under the curve (AUC) were used to evaluate the diagnostic accuracy.</p><p><strong>Results: </strong>Patients in the NAFLD-HUA group had higher levels of TyG-BMI than patients in the NAFLD-NUA group(252.45±34.11VS 234.34±31.88, P<0.001). Pearson correlation analysis showed that TyG-BMI levels were positively correlated with serum uric acid (SUA) (r=0.309, P<0.001). After adjusting for potential confounders, logistic regression analysis revealed that TyG-BMI was a risk factor for HUA(OR:1.019 95% CI:(1.012, 1.027).) and shows superior diagnostic accuracy (AUC: 0.656) compared to the TyG index (AUC: 0.605).</p><p><strong>Conclusion: </strong>TyG-BMI index is a risk factor for HUA in patients with NAFLD, and demonstrates acceptable diagnostic accuracy for NAFLD-HUA. But further prospective studies are needed to confirm these findings.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4663-4673"},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Podoplanin Levels as a Potential Biomarker for Diabetic Nephropathy Progression: A Cross-Sectional Study.","authors":"Feng Huan, Xia Jiang","doi":"10.2147/DMSO.S500608","DOIUrl":"10.2147/DMSO.S500608","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to investigate the impact of serum Podoplanin levels on diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Patients and methods: </strong>Between January 2022 and December 2023, the Department of Nephrology at Nantong Second People's Hospital selected 276 patients with T2DM and 150 healthy controls for this investigation. Systematic data collection was performed to gather information on biomarkers and biochemical parameters.</p><p><strong>Results: </strong>When T2DM patients (n=276) and healthy controls (n=150) were compared, considerably lowered serum Podoplanin levels were observed. In all 276 patients, serum Podoplanin levels were negatively associated with age (r=-0.127, P=0.035), body mass index (BMI) (r=-0.292, P<0.001), duration of diabetes (r=-0.323, P<0.001), systolic blood pressure (SBP) (r=-0.255, P<0.001), diastolic blood pressure (DBP) (r=-0.138, P=0.022), fasting blood glucose (FBG) (r=-0.196, P=0.001), glycated hemoglobin (HbA1c) (r=-0.095, P=0.117), triglyceride (TG) (r=-0.157, P=0.009), total cholesterol (TC) (r=-0.126, P=0.036), low-density lipoprotein cholesterol (LDL-C) (r=-0.187, P=0.002), serum creatinine (Scr) (r=-0.500, P<0.001), neutrophil gelatinase-associated lipocalin (NGAL) (r=-0.339, P<0.001), and kidney injury molecule-1 (KIM-1) (r=-0.568, P<0.001), and was positively correlated with high-density lipoprotein cholesterol (HDL-C) (r=0.343, P<0.001) and estimated glomerular filtration rate (eGFR) (r=0.442, P<0.001). The multivariate logistic regression analysis showed that diabetic patients with DN had lowered levels of serum Podoplanin (OR=0.022, 95% CI=0.005-0.100; P<0.001), lower SBP, Scr, NGAL, and KIM-1.</p><p><strong>Conclusion: </strong>The results indicated that diabetic patients with DN have lower levels of serum Podoplanin. A more considerable population-based prospective investigation is essential to validate our findings.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4701-4710"},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the Trajectories of the Atherogenic Index of Plasma and Prediabetes Progression to Diabetes: A Retrospective Cohort Study.","authors":"XiXuan Cai, MingYing Xu, JieRu Chen, YueChun Mao, JingYu Hu, LuSha Li, JianJiang Pan, MengQi Jin, LiYing Chen","doi":"10.2147/DMSO.S481578","DOIUrl":"10.2147/DMSO.S481578","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to analyze baseline profiles and longitudinal changes in Atherogenic Index of Plasma (AIP) among individuals with prediabetes to identify distinct AIP trajectories and assess their significance in predicting diabetes onset.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed data from 8346 participants who underwent multiple general health checks. Utilizing latent class trajectory modeling and Cox proportional hazards analyses, it examined the association between the AIP index and health outcomes.</p><p><strong>Results: </strong>Over about 2 years, 2897 people progressed from prediabetes to diabetes. Individuals in the highest quartile of AIP had a higher diabetes risk compared to the lowest quartile (HR = 1.138, 95% CI1.013-1.278). Trajectory analysis revealed three groups: low-stable, moderate-stable, and high-stable, based on AIP index. The moderate-stable group showed a 1.117-fold risk of diabetes progression (95% CI1.026-1.217), while the high-stable group had an elevated risk (HR = 1.224, 95% CI1.059-1.415).</p><p><strong>Conclusion: </strong>The study highlights a clear association between higher AIP index levels at baseline and an increased risk of diabetes progression. It underscores the significance of utilizing the AIP index as a predictive tool to identify those at risk, emphasizing the need for targeted preventive measures in managing diabetes progression.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4689-4699"},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Disorders in BDNF-Deficient Rats: Limited Recovery Post-Moderate Endurance Training.","authors":"Norbert Grzelak, Dominik Kaczmarek, Krystian Marek Poziemba, Włodzimierz Mrówczyński","doi":"10.2147/DMSO.S486807","DOIUrl":"10.2147/DMSO.S486807","url":null,"abstract":"<p><strong>Introduction: </strong>The study aimed to determine whether heterozygous BDNF-deficient (BDNF-knockout, SD-BDNF) rats exhibit pathological changes in the myocardium and to assess whether a 5-week moderate-intensity endurance training program can reverse adverse changes in the heart muscle.</p><p><strong>Methods: </strong>Experiments were conducted on four groups of rats: control wild-type, control BDNF knockout, trained wild-type and trained BDNF knockout. Knockout rats were selected due to the presence of symptoms resembling metabolic syndrome in serum and liver while 5-week moderate endurance training was used as an intervention targeted at restoring heart function. Measurements of BDNF/Trk-B concentrations and molecules levels and activities, such as cardiac specific enzymes like creatine kinase and creatine kinase myocardial band, lipids as total cholesterol, low-density lipoprotein and triglycerides, metabolic enzymes including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase and lactate dehydrogenase and interleukin-1 were carried out in myocardium homogenates.</p><p><strong>Results: </strong>In BDNF-deficient rats, the myocardium showed significantly reduced lipid concentrations, decreased metabolic and cardiac enzyme activity, and elevated Trk-B levels, all of which are indicative of myocardial ischemia or hypoxia. These changes in critical biomarkers were consistent with those earlier observed in the livers of BDNF-deficient rats, suggesting a link between the liver and cardiac function. Moderate endurance training led to an increase in creatine kinase activity in the myocardium of trained rats, suggesting increased production and utilization of energy required for myocardial contraction in trained wild-type and knockout populations of rats.</p><p><strong>Discussion: </strong>BDNF-deficient rats exhibited numerous myocardial abnormalities, most of which were not reversible after moderate-intensity endurance training. These findings provide a basis for a deeper understanding of the mechanisms underlying myocardial disorders in BDNF-deficient rats, which appear to be a suitable model for studying various aspects of metabolic disorders.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4649-4660"},"PeriodicalIF":2.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Oxidative Stress and OGTT: Are Pregnant Women's Fears Justified?","authors":"Serife Ozlem Genc, Huseyin Erdal","doi":"10.2147/DMSO.S494913","DOIUrl":"10.2147/DMSO.S494913","url":null,"abstract":"<p><strong>Purpose: </strong>Pregnancy induces significant metabolic, immunological, and endocrinological changes to support fetal growth. The 75-gram oral glucose tolerance test (OGTT) is standard for gestational diabetes screening, but concerns exist about its potential to induce oxidative stress, affecting both maternal and fetal health. The aim of the study is examining changes in oxidative stress markers and thiol/disulfide homeostasis in pregnant women to evaluate these concerns.</p><p><strong>Patients and methods: </strong>Thirty pregnant women undergoing gestational diabetes screening between the 24th and 28th weeks participated. Blood samples were collected at 0, 60, and 120 minutes as part of the OGTT protocol. Oxidative stress markers were analyzed only in samples from 0 and 120 minutes, while the 60-minute sample was used solely for glucose measurement.</p><p><strong>Results: </strong>Results showed a significant increase in TOS (p = 0.008) and OSI (p = 0.035) post-OGTT, indicating an acute oxidative stress response. Thiol and disulfide levels showed non-significant changes, suggesting that antioxidant mechanisms were largely unaffected.</p><p><strong>Conclusion: </strong>Further research is necessary to explore the long-term implications of these findings and develop strategies to mitigate oxidative stress during pregnancy. This study provides insights into the acute oxidative stress response caused by OGTT in pregnant women. Although the OGTT induces oxidative stress, it does not significantly disrupt the body's antioxidant capacity in the short term. These results highlight the need for more research to understand the effects of heightened oxidative stress on maternal and fetal health.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4641-4648"},"PeriodicalIF":2.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for a Longitudinal Cohort Study to Understand Characteristics and Risk Factors Underlying Vibration-Controlled Transient Elastography-Diagnosed Metabolic Dysfunction-Associated Fatty Liver Disease Children.","authors":"Fan Yang, Mengyuan Hu, Haoyang Zhang, Xiaowei Zheng, Limei Chen, Lihong Zhu, Le Zhang","doi":"10.2147/DMSO.S492809","DOIUrl":"10.2147/DMSO.S492809","url":null,"abstract":"<p><strong>Background: </strong>Metabolic-associated steatotic liver disease (MASLD) is a novel term proposed in 2023 to replace non-alcoholic fatty liver disease (NAFLD) with the aim of better reflecting its pathogenesis and clinical manifestations. Vibration-controlled transient elastography (VCTE) is an evidence-based, non-invasive imaging device used to evaluate liver fat deposition and fibrosis. It can effectively detect liver fat infiltration greater than 5%, which is much higher than the previous ultrasound detection rate (it is difficult to detect liver fat deposition below 30%). Nevertheless, the prevalence and characteristics of MASLD children diagnosed based on these updated criteria are currently not well established.</p><p><strong>Methods: </strong>Currently, a prospective multi-center population-based cohort study is being conducted in Wuxi, China, spanning from 2023 to 2035, involving 5600 children from four primary schools. Throughout the study's baseline and follow-up periods, yearly physical examinations, laboratory tests, VCTE assessments, and bioelectrical impedance analysis are being conducted to measure MASLD-related biomarkers. Additionally, a questionnaire is being administered to inquire about dietary habits. MASLD is being diagnosed based on clinical and laboratory criteria, and the corresponding prevalence is being assessed.</p><p><strong>Results: </strong>Recruitment began in March 13, 2023. To date, 1475 participants have completed the physical examination and questionnaire survey.</p><p><strong>Discussion: </strong>Our study investigated the prevalence of MASLD and its influencing factors in Chinese school-age children and adolescents. By collecting and analyzing data from physical examinations and survey questionnaires, it may propose new avenues for guiding the treatment and early-stage prevention of MASLD in children.</p><p><strong>Trial registration: </strong>Chinese Clinical Trials Registry (NO. ChiCTR2400080508).</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4627-4639"},"PeriodicalIF":2.8,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}