Current topics in medicinal chemistry最新文献

{"title":"Exploring the Therapeutic Potential of Ginger (Zingiber officinale) Against Type 2 Diabetes: A Bioinformatic Approach.","authors":"Fernando Martínez-Esquivias, Edar O Pech-Santiago, Juan Manuel Guzmán-Flores, Luis Miguel Anaya-Esparza, Maria Dolores Mendez-Robles, Ismael Fernando Chávez-Díaz","doi":"10.2174/0115680266443762260418092136","DOIUrl":"https://doi.org/10.2174/0115680266443762260418092136","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes (T2D) is a multifactorial disease characterized by insulin resistance and chronic low-grade inflammation. Although treatments are available, they are often ineffective and cause side effects in patients. Ginger (Zingiber officinale) has demonstrated antidiabetic potential; however, the molecular mechanisms underlying its bioactive compounds remain incompletely understood.</p><p><strong>Methods: </strong>Compounds present in Ginger were obtained from the Traditional Chinese Medicine Systems Pharmacology Database. Targets for T2D were then obtained from the MalaCards and DisGeNET, and intersecting targets were identified using a Venn diagram. Targets for Ginger components were obtained from the SwissTargetPrediction and PharmMapper, and common targets were searched for. The ShinyGO0.80 database was used for gene ontology, and Cytoscape software was used for protein-protein interaction networks and compound-target-pathway analysis. Molecular docking was performed using AutoDock Vina and UCSF-Chimera software, and GROMACS for molecular dynamics.</p><p><strong>Results: </strong>Of 265 identified compounds, 27 met pharmacological and bioavailability criteria. A total of 27 overlapping targets between ginger and T2D were identified, with SHBG, ESR1, NR1H3, ESR2, and PPARA emerging as hub genes. Enrichment analyses highlighted insulin signaling, lipid metabolism, and inflammatory pathways. Docking results showed strong binding affinities, and three complexes were selected for molecular dynamics. Simulations and MM-PBSA analysis confirmed the stability of ESR1-C018, ESR2-C008, and SHBG-C010.</p><p><strong>Discussion: </strong>Ginger compounds exhibit multitarget potential in T2D by modulating insulin signaling, lipid metabolism, and inflammation; however, these findings are predictive and require experimental studies.</p><p><strong>Conclusions: </strong>These findings provide insights into the multitarget mechanisms of Ginger, supporting its potential therapeutic role in T2D.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Antioxidant and Anti-breast Cancer Effects of Two Prunus avium L. Varieties: A Comparison between the Sweet Cherry Fruit and its By-products.","authors":"Ziad Chebaro, Adnan Badran, Serine Baydoun, Joelle Edward Mesmar, Elias Baydoun","doi":"10.2174/0115680266437698260420200934","DOIUrl":"https://doi.org/10.2174/0115680266437698260420200934","url":null,"abstract":"<p><strong>Introduction: </strong>Prunus avium L. (sweet cherry) is a widely grown fruit crop that has witnessed a rapid increase in production worldwide. Of particular interest are the Moukahal and Taliani varieties, which are widely consumed in the Middle East. The sweet cherry fruit and its by-products (stems and kernels) have been reported to have important pharmacological value; nevertheless, their effects on breast cancer remain poorly investigated.</p><p><strong>Methods: </strong>Phytochemical constituents of ethanolic extracts from Moukahal and Taliani fruit, stem, and kernel were analyzed using total phenolic and total flavonoid contents assays. The antioxidant potential was evaluated using the DPPH assay. The extracts were tested for their antiproliferative activity against the human breast carcinoma MCF-7 cell line through the MTT assay. Further analysis of metabolites in the stems was carried out via HPLC-PDA-MS/MS.</p><p><strong>Results: </strong>Cherry by-product extracts, particularly stems, had higher phenolic and flavonoid contents as well as stronger antioxidant capacity than fruit extracts. Consistently, stem extracts exhibited the strongest inhibitory effects on MCF-7 cell proliferation, whereas fruit and kernel extracts showed weaker activity. LC-MS/MS analysis revealed distinct phytochemical profiles for each cultivar's stem extract.</p><p><strong>Discussion: </strong>Sweet cherry stems showed strong antioxidant and antiproliferative effects, potentially associated with antioxidant mechanisms. Their chemical profile aligns with previous reports, supporting their potential as natural anti-breast cancer agents.</p><p><strong>Conclusion: </strong>These findings highlight the potential of P. avium by-products, particularly the stems, as a potential source of anticancer compounds. Collectively, this work emphasizes the value of sweet cherry by-products as sustainable and underexplored resources for drug discovery.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning for Targeted Nano Medicine in Parkinson's Disease: A Data-Driven Approach for Diagnosis and Treatment.","authors":"Rachit Manchanda, Hardik Doshi, M M Rekha, G Nancy Priscilla, Rajashree Panigrahi, Jayant Jagtap, Abhijit Bhowmik, Rupesh Gupta, Jigna Prajapati, Biswajit Basu","doi":"10.2174/0115680266418706260310070233","DOIUrl":"https://doi.org/10.2174/0115680266418706260310070233","url":null,"abstract":"<p><strong>Introduction: </strong>Parkinson's Disease (PD) is a progressive neurodegenerative disorder that impairs motor and cognitive functioning, making early diagnosis and patient-specific treatment essential; however, traditional clinical assessments often delay detection and lack consistency.</p><p><strong>Methods: </strong>This paper proposes TriFusion-PD, a multimodal Machine-Learning-Driven Targeted Nanomedicine (ML-TN) framework designed to improve early PD diagnosis and personalized therapy. The methodology integrates Transformers for analyzing temporal voice and speech patterns, Convolutional Neural Networks (CNNs) for extracting spatial biomarkers from MRI and spiral-drawing images, and Reinforcement Learning (RL) for optimizing individualized treatment recommendations. Three publicly available datasets-voice recordings, speech-signal features, and drawing/imaging data-were pre-processed, feature-engineered, and evaluated through a unified ML pipeline using metrics such as accuracy, precision, recall, F1-score, Matthews Correlation Coefficient (MCC), robustness, computational efficiency, and ROC-AUC.</p><p><strong>Results: </strong>The findings show that TriFusion-PD significantly outperforms baseline models including CNN, SVM-KNN, XGBoost, LSTM, and Random Forest, achieving up to 12.5% higher accuracy, 14.2% higher precision, 15.0% higher recall, and 13.8% higher F1-score, with the highest improvement observed in MCC (16.4%), indicating more balanced and reliable PD classification across modalities.</p><p><strong>Discussion: </strong>These performance gains arise from the complementary strengths of multimodal fusion, which enhances sensitivity to subtle PD symptoms, while RL-based optimization reduces misclassification and improves predictive stability under noisy or incomplete data conditions.</p><p><strong>Conclusion: </strong>Overall, TriFusion-PD presents a robust and clinically relevant data-driven solution for early PD detection and personalized treatment planning, demonstrating strong potential for integration into next-generation clinical decision-support systems.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on the Development of Targeting Arginine Methyltransferase PRMT5 in Cancer Research.","authors":"Hongyu Zeng, Yiyu Long, Yangrui Peng, Yihua Chen","doi":"10.2174/0115680266473173260408073728","DOIUrl":"https://doi.org/10.2174/0115680266473173260408073728","url":null,"abstract":"<p><p>Protein Arginine Methyltransferase 5 (PRMT5), the predominant type II PRMT, catalyzes symmetric dimethylation of both histone and non-histone substrates, thereby coordinating key cellular processes including gene expression, Ribonucleic Acid (RNA) splicing, cell cycle progression, and Deoxyribonucleic Acid (DNA) repair. Its frequent overexpression in various solid and hematologic malignancies contributes to tumorigenesis by promoting proliferation, metastasis, and immune evasion-mechanisms that involve silencing tumor suppressor genes, activating oncogenic signaling pathways such as PI3K-AKT, WNT-β-catenin, and NF-κB. These welldocumented oncogenic functions establish PRMT5 as a high-priority therapeutic target and highlight its synthetic lethal vulnerability in Methylthioadenosine Phosphorylase (MTAP)-deficient tumors, where accumulation of the endogenous PRMT5 inhibitor Methylthioadenosine (MTA) creates a unique therapeutic opportunity. Although PRMT5 is a well-validated oncogenic driver and more than a dozen inhibitors have entered clinical trials, none have yet gained regulatory approval. The lack of approved inhibitors underscores the urgent need for next-generation strategies, such as novel modulators with improved selectivity and reduced toxicity. Recent advances have led to the development of Proteolysis-Targeting Chimeras (PROTACs) that catalytically degrade PRMT5, which offers a mechanistically distinct avenue to overcome intrinsic and acquired resistance associated with conventional PRMT5 catalytic inhibitors. This review synthesizes current insights into PRMT5-driven tumorigenesis and tumor immunology, dissects structure-activity relationships, and charts the clinical progress of S-Adenosylmethionine (SAM)-competitive, substrate- competitive, MTA-cooperative, and PROTAC-based modalities. Finally, we outline precision medicine and combination strategies that could unlock the full therapeutic potential of PRMT5 targeting in oncology.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Ethnopharmacology, Phytochemistry, Geographic Distribution, and Pharmacological Properties of the Genus Mangifera.","authors":"Zulfa Nooreen, S Renuka Jyothi, Poonam Jaisal, Mamata Chahar, K N V Chenchu Lakshmi, Anup Patil, Amin Gasmi","doi":"10.2174/0115680266395099251203084914","DOIUrl":"https://doi.org/10.2174/0115680266395099251203084914","url":null,"abstract":"<p><p>The genus Mangifera (Anacardiaceae) is widely distributed across most tropical and subtropical regions and has long been used in traditional medicine for its nutritional value and for treating aging-related conditions, parasitic infections, diabetes, and dysentery. Nearly every part of the plant, leaves, seeds, fruits, stems, pulp, and peel, has been investigated for various research purposes. These plants have been used therapeutically for decades. Using databases, such as PubMed/MEDLINE, Scopus, EBSCO, Europe PMC, and Google Scholar, all relevant research articles were thoroughly reviewed, with emphasis on pharmacology and bioactive plant constituents. Among all species, Mangifera indica has been the most extensively studied in recent years. Mangiferin is recognized as one of the most potent and widely investigated bioactive compounds in the genus. The phytochemical profile includes flavonoids, terpenoids, alkaloids, tannins, resins, sterols, and other classes of secondary metabolites. Pharmacological findings compiled in this review encompass its antioxidant, anticancer, hepatoprotective, cardioprotective, antiulcer, neuroprotective, antidiabetic, antitumor, antiviral, anti-inflammatory, antiarthritic, and additional biological activities. This study also discusses novel drug-delivery strategies related to the genus, including nanoparticle- based formulations of Mangifera indica and mangiferin. Overall, this review aims to provide an updated overview of developments in the genus Mangifera, covering traditional uses, chemical constituents, pharmacological effects, and therapeutic applications. This comprehensive assessment may offer new perspectives for future research on the genus Mangifera.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight into the Structural Modification and Mechanism of Ursolic Acid at C-3 and C-28: Strategy for Searching Anti-Cancer Therapeutics.","authors":"Divya Pratap Rav, Saurabh Kumar, Salahuddin, Rajnish Kumar, Avijit Mazumder, Abhijit Debnath, Siddharth, Pooja Kumari","doi":"10.2174/0115680266414397251127060056","DOIUrl":"https://doi.org/10.2174/0115680266414397251127060056","url":null,"abstract":"<p><strong>Introduction: </strong>Ursolic acid (UA), a pentacyclic triterpenoid abundantly found in botanical sources, has emerged as a promising anticancer agent. However, its clinical translation is hindered by poor water solubility and limited bioavailability, necessitating the development of structural optimisation strategies.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted using PubMed, Scopus, ScienceDirect, Google Scholar, and Crossref databases. Search terms included \"ursolic acid,\" \"anticancer,\" \"C-3 modification,\" \"C-28 modification,\" \"antitumor,\" \"cell cycle,\" and \"mechanism.\" Peer-reviewed publications discussing structural modifications and therapeutic applications with experimental validation were included, while articles lacking empirical evidence were excluded.</p><p><strong>Results: </strong>Structural modifications at C-3 (oxidation, esterification, and hydroxylation) and C-28 (amide/ester formation) significantly enhanced the anticancer activity of UA. C-3-modified derivatives demonstrated 2- to 3-fold increased cytotoxicity against KB, HepG2, MCF7, and LU cell lines. C-28 modifications, particularly piperidine-containing derivatives, exhibited IC₅₀ values of 2.50-11.4 μM against various cancer cell lines. These derivatives induced apoptosis through caspase activation, caused cell cycle arrest (G1, G2/M, and Sub-G1 phases), and modulated key survival pathways, including PI3K/Akt/mTOR, NF-κB, and MAPK/ERK.</p><p><strong>Discussion: </strong>Strategic modifications at C-3 and C-28 positions address pharmacokinetic limitations of UA while preserving and enhancing its multi-targeted anticancer properties. These derivatives demonstrate superior cellular membrane permeability, target affinity, and cytotoxic potential across haematological and solid malignancies.</p><p><strong>Conclusion: </strong>C-3 and C-28 modifications represent viable strategies for developing next-generation UA-based anticancer therapeutics. Future research should focus on comprehensive pharmacokinetic studies, toxicological evaluations, and clinical translation through advanced delivery systems and combination therapy approaches.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-Derived Pathway Modulators: A Natural Strategy to Combat Cervical Cancer.","authors":"Md Zamshed Alam Begh, Mehrukh Zehravi, Sherouk Hussein Sweilam, Thukani Sathanantham Shanmugarajan, Uppuluri Varuna Naga Venkata Arjun, Susithra Ethiraj, Ponnammal Ganesan Mahesh, E Thilagam, Baghyashree Muniappan, Sharukh L Khan, Ali Audah Fahaid Al Fahaid, Safia Obaidur Rab, Talha Bin Emran","doi":"10.2174/0115680266411142251201065848","DOIUrl":"https://doi.org/10.2174/0115680266411142251201065848","url":null,"abstract":"<p><p>Cervical Cancer (CC) is a significant global health concern due to its high death rate, necessitating the development of effective therapeutic, diagnostic, and preventative substances. The current treatment methods for advanced metastatic CC include surgery, radiotherapy, and chemotherapy. Plants and phytocompounds have emerged as promising options for preventing CC. This review provides a comprehensive overview of the molecular mechanisms by which various phytocompounds exert their anticancer properties. It explores the impact of key signaling pathways, molecular interactions, and substances on metastasis inhibition, cell cycle control, and apoptosis. Additionally, it presents promising preclinical and clinical findings highlighting the potential of phytochemicals as adjuvant therapy in standard CC treatment. This summary highlights the effectiveness and well-tolerated potential of plant-based interventions and phytocompounds in CC therapy. Furthermore, it demonstrates the therapeutic potential of phytochemicals in CC, integrating molecular biology with clinical evidence and paving the way for further research and clinical applications. This review aims to advance innovative treatment methodologies for CC prophylaxis and therapy, emphasizing the need for further research into plant-based treatments to enhance patient outcomes.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Mechanisms of Neurodegeneration: A Focus on Cholinergic Dysfunction and the Therapeutic Potential of Rivastigmine Derivatives.","authors":"Kuldeep Singh, Pranshul Sethi, Divya Jain, Jeetendra Kumar Gupta, Zaid Waqar, Bhupendra Singh, Rukhsar Syed, Mohammad Tabish, Mukesh Chandra Sharma","doi":"10.2174/0115680266380856251204044937","DOIUrl":"https://doi.org/10.2174/0115680266380856251204044937","url":null,"abstract":"<p><p>Neurodegenerative diseases progressively impair neuronal structure and function, leading to cognitive decline, motor dysfunction, and paralysis. Among the underlying mechanisms, cholinergic dysfunction-characterized by degeneration of cholinergic neurons and reduced acetylcholine (ACh) levels-plays a central role in disease progression, particularly in Alzheimer's disease (AD) and Parkinson's disease (PD). According to the cholinergic hypothesis, memory loss and cognitive impairment are directly linked to disrupted ACh-mediated neurotransmission. Rivastigmine, a dual acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor, enhances synaptic ACh levels but is limited by a short half-life, modest efficacy, and gastrointestinal side effects. This review highlights the molecular mechanisms underlying cholinergic dysfunction, including oxidative stress, mitochondrial impairment, protein aggregation, neuroinflammation, and synaptic dysregulation, while emphasizing rivastigmine and its derivatives as emerging therapeutic candidates. Structural modifications of rivastigmine have yielded multifunctional derivatives with improved selectivity, blood-brain barrier penetration, and neuroprotective properties, including antioxidant, anti-amyloid, and anti-inflammatory activities. These advances suggest that rivastigmine derivatives could serve as promising multi-targeted agents for neurodegenerative disorders. Future directions include integrating these compounds with nanotechnology-based delivery systems and precision medicine approaches to overcome pharmacokinetic limitations and optimize patient outcomes.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI & ML Utilisation in the Discovery of Antimicrobial Drug Design, Application, Current Trends, and Future Perspective: An Extensive Review.","authors":"Riya Sharma, Anjuman, Garvit Raj, Ranveer Singh Pawar, Vivek Kumar Chauhan, Ruhi Ali","doi":"10.2174/0115680266463188260507074917","DOIUrl":"https://doi.org/10.2174/0115680266463188260507074917","url":null,"abstract":"<p><p>The application of Artificial Intelligence (AI) and other technologies in drug discovery has received substantial attention, as they streamline the process and overcome challenges that traditionally make it time-consuming and resource-intensive. Research in antimicrobial drug discovery has become increasingly urgent due to the accelerating emergence of antimicrobial resistance (AMR), a significant threat to public health worldwide that makes existing antibiotics less effective. To address this demanding need, ML algorithms are being applied to design novel drug candidates at various stages of drug design. To enhance efficiency, accuracy, and overall quality of results, ML and Deep Learning (DL) algorithms are increasingly used in structure-based drug development, drug target identification, and novel drug development. Recurrent Neural Networks (RNNs), Adversarial Autoencoders (AAEs), Support Vector Machines (SVMs), and other AI models have shown valuable in de novo drug design, physicochemical and pharmacokinetic parameter (ADMET) analysis, drug repurposing, and ligand- and structure-based virtual screening. Drug discovery has become increasingly accessible with the emergence of open-source AI platforms and software, which enable researchers worldwide to create and validate new-generation compounds in a cost-effective and collaborative manner. Drugs like Halicin and Abaucin, which have considerable potential against resistant infections, have recently been discovered using AI-assisted methods. However, challenges remain, including restricted datasets, model interpretability, and integration into experimental processes despite these advancements. Future advancements are likely to focus on expanding open-access datasets, advancing AI-driven AMR prevention strategies, and improving predictive accuracy.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scopoletin as a Potential Therapeutic Agent for Neurodegenerative Disorders: Mechanisms and Perspectives.","authors":"Manvi Karayat, Niranjan Kaushik, Deepika Paliwal","doi":"10.2174/0115680266399675251201111538","DOIUrl":"https://doi.org/10.2174/0115680266399675251201111538","url":null,"abstract":"<p><p>Neurodegenerative diseases, such as Alzheimer's and Parkinson's, continue to pose significant challenges due to their complex aetiology and limited treatment options. Scopoletin, a naturally occurring coumarin found in a variety of medicinal plants, is being explored as a potential therapeutic agent because of its broad pharmacological profile. This review investigates scopoletin's neuroprotective potential, with particular emphasis on its antioxidant, anti-apoptotic, and cholinergic-regulating properties. It also highlights its ability to reduce oxidative stress, modulate neurotransmitter balance, and prevent protein aggregation, which are key pathological features of neurodegeneration. Despite promising preclinical findings, further research is required to establish its efficacy, optimise its bioavailability, and evaluate its safety in clinical settings. Overall, scopoletin demonstrates considerable potential as a neuroprotective compound, offering new avenues for the development of innovative therapeutics for neurodegenerative disorders. This comprehensive review aims to provide a foundation for future research and the advancement of scopoletin as a promising agent against neurodegeneration.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}