Santheraleka Ramanathan, Hemamalini Rawindran, Subash C B Gopinath, Chai Pui Van
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Microalgae and Human Disorders: Mechanistic Insights and Therapeutic Potential.
Microalgae, which are primarily autotrophic organisms, have caught the spotlight due to their impressive growth rates and broad distribution. They're particularly exciting because of their biocompatibility and the wide range of biological activities they offer. Species like Spirulina and Chlorella exhibit high antioxidant, anti-inflammatory, antimicrobial, anticancer, antihypertensive, anti-lipidemic, and anti-diabetic properties, making them a promising element in therapeutics. This review discusses the bioactive compounds present in microalgae, including peptides, polysaccharides, and lipids, and their mechanisms of action in disease diagnosis and prognosis. In addition, emerging reports on the synergistic effects of microalgae bioactive compounds in enhancing immune and gut health are discussed. Despite this, challenges in the extraction, cultivation, and commercialization of microalgae-based bioactive compounds remain significant hurdles for a great extent of application. This review examines the challenges and proposes relevant approaches to improve bioavailability and to optimize the cultivation of microalgae. The review underscores the significance of microalgae-derived bioactive agents for pharmaceutical and biomedical applications.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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